randomisierten, kontrollierten Pilotstudie, in welcher ein additiver Therapeutischer Plasmaaustausch (Therapeutic Plasma Exchange (TPE)) bei Patienten mit schwerem refraktärem septischem Schock untersucht wurde [...] doi: 10.1186/s13054-022-04003-2. PMID: 35551628 Free PMC article. Clinical Trial. 2. Adjuvant therapeutic plasma exchange in septic shock. David S, Bode C, Putensen C, Welte T, Stahl K; EXCHANGE study

loading, or cryoinjury – researchers can investigate disease mechanisms and assess potential therapeutic strategies in a setting that closely mimics in vivo conditions. In our projects LMS have been [...] Using our advanced physiological disease models, we assess novel compounds for their potential as therapeutic treatments in hypertrophic cardiomyopathy, myocardial infarction, and pathological remodeling in

further expanded the applications of iPSCs to elucidate developmental pathways, disease modeling and therapeutic applications. CRISPR-Cas enables precise gene modifications, allowing researchers to correct d [...] mechanisms that contribute to disease pathology and identify potential intervention points for therapeutic development. Key references: Chatterjee S, Leach-Mehrwald M, Huang CK, Xiao K, Fuchs M, Otto M

ERC Consolidator Grant LONGHEART : Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure (2015 – 2020) EU funding via N-Bank - im Rahmen des Niedersächsischen [...] (2020 – 2021) Leducq Foundation: Trans-Atlantic Network and Training Program on MicroRNA-Based Therapeutic Strategies in Vascular Disease (MIRVAD, 2014 – 2019) DFG: TH903/18-1 (with ANR): Regulation, d

“Development of a hiPSC-based cystic fibrosis lung disease model to study TMEM16A as an alternative therapeutic target in cystic fibrosis” Mikhail Magdei (AG Hilfiker): “Analysis of xenoantigen burden in de

remote idea more than twenty years ago. Meanwhile, the human kinome is known and the spectacular therapeutic results obtained with STI571 (Gleevec) , suggested that compounds that modulate the activities

transplant engineering. His work centers around the alloimmune response in organ transplantation and therapeutic interventions to combat rejection and infection. This includes cellular and humoral immunotherapy [...] structure, molecular function and regulation of histocompatibility systems in order to identify therapeutic targets for graft engineering to substantially improve clinical outcome of transplantation. Professor

transplant engineering. His work centers around the alloimmune response in organ transplantation and therapeutic interventions to combat rejection and infection. This includes cellular and humoral immunotherapy [...] structure, molecular function and regulation of histocompatibility systems in order to identify therapeutic targets for graft engineering to substantially improve clinical outcome of transplantation. Professor

transplant engineering. His work centers around the alloimmune response in organ transplantation and therapeutic interventions to combat rejection and infection. This includes cellular and humoral immunotherapy [...] structure, molecular function and regulation of histocompatibility systems in order to identify therapeutic targets for graft engineering to substantially improve clinical outcome of transplantation. Professor

patients with heart failure still have a poor prognosis, creating an unmet clinical need for novel therapeutic approaches in heart failure. Therefore, one of our research interests is to study cardiac remodeling [...] (e.g. pressure overload-induced left ventricular cardiac remodeling). Non-coding RNAs are novel therapeutic targets as critical regulators of gene expression, controlling many physiological and pathological