Current Projects Impact of actin and tropomyosin isoforms on nonsarcomeric myosin mechanochemical transduction pathways and cellular localization Myosins are cytoskeleton-based molecular motors that d

Thesis Documents PhD Thesis Documents • Johannes Roeles, Dr. med. (2021) Actin During Meiosis: A Confocal Laser-Scanning Microscopy Study on the Role of Actin in Spindle Assembly and Chromosome Segreg

Collaborations Medizinische Hochschule Hannover (MHH) Dynamik der Interaktion von Forminen mit Aktin: TIRF-mikroskopische, spektroskopische und kinetische Studien. Prof. Dr. Peter Claus , Institut für

Methods Protein biochemistry: recombinant protein production in prokaryotic ( E. coli ) and eukaryotic ( D. discoideum , Baculovirus/ Sf 9 insect cells) systems; isolation and purification of native p

Group Members Dr. rer. nat. Peter Franz Despoina Kyriazi Claudio Salinas Lea Voth Franca Seidensticker Luise Epler Fanny Major Alumni • Dr. rer. nat. Almke Bader • Dr. rer. nat. Ralph Diensthuber • B.

Teaching Bachelor Biochemie Vorlesung Stoffwechselbiochemie (3. Fachsemester, Modul BCB P 13) Vorlesung Molekulare Biochemie und Methoden (4. Fachsemester, Modul BCB P 15) Laborpraktika in Biochemie u

Current Projects Current Projects Enzyme Kinetics and Mechanisms of Energetic Coupling in Motor Proteins Cytoskeleton Dynamics and Motility of Cellular Systems Protein Engineering and Design of Tunabl

Alumni Graduate Students Graduate Students Dr. Steve Ludbrook (1993-1996 PhD in the Eccleston and Manstein groups) Director Molecular Pharmacology, Bicycle Therapeutics, Cambridge, England, United Kin

Methods Methods Molecular and Cell Biology: mammalian cell cultures; human oocytes; primary neuronal and glial cells; D. discoideum ; immunohictochemistry; transfection Spectroscopy: Absorption and Fl

Research Interests Actin Myosin Dynamin Tropomyosin Cell motility and cytoskeletal dynamics Intracellular pathogen sensors Protein structure, dynamics, reaction mechanisms, and allostery Small-molecul