pseudomembrnösen Kolitis. C. difficiole produziert drei Enterotoxine, Toxin A (tcdA), Toxin B (TcdB) sowie das C. difficile Toxin (CDT). TcdA (307 kDa) und TcdB (270 kDa) sind große, einkettige Proteintoxine, die [...] Forschung (1) Toxin binds to (non-internalizing) binding receptors. (2) The binding receptors form a heterodimer with an internalizing receptor. (3) The toxin is released from the binding receptor, allowing [...] in ihre Zielzellen selbst einschleusen. In der Zelle mono-O-glucosylieren (damit inaktivieren) TcdA und TcdB niedermolekulare GTP bindende Proteine der Rho- und Ras-Familien, in dessen Folge der Barr

Why a structured PhD? A structured PhD in HBRS has many advantages compared to a "normal" PhD (Dr.rer.nat.) at MHH: -> Please see also the table below! 1. Overall : HBRS ensures that your PhD is completed [...] of all personal matters. You'll be assigned a main supervisor and two co-supervisors to provide guidance and support throughout your PhD journey. You'll have a support system in place, with access to your

Station 27 Privatstation 18 und die Kinderstation 66a Die Stationen 17 und 27 befinden sich in der 7. Etage des Bettenhauses und sind über die Aufzugknoten A und B zu erreichen. Die Unterbringung erfolgt in [...] gerne zu berücksichtigen. Die Station 18 befindet sich in der 8. Etage des Bettenhauses, Aufzugknoten A. Es sind hier, je nach gewünschter Unterbringung, Ein- oder Zweibettzimmer verfügbar. Kinder und Jugendliche [...] Jugendliche bis zum 18. Lebensjahr werden auf der interdisziplinären chirurgischen Kinderstation, Station 66a, die in der Kinderklinik untergebracht ist, versorgt. Ab ca. 6.30 Uhr verteilt das Pflegepersonal M

disseminate latest findings, TECHNOBEAT hosted a workshop at this year's GSCN Conference. Hosted by Robert zweigerdt (MHH) and Dirk Strunk (PMU) the session started with a special keynote by Prof. Michael Laflamme [...] Community Day—A Review On April 24, 2018, the second international Stem Cell Community Day took place in Düsseldorf, Germany. More than 150 participants from 16 countries—22 of them presenting a poster—attended [...] “fills a gap in the European conference landscape”. The program covered some of the most important challenges in stem cell bioprocessing today: Process design, scale-up, and product safety. After a warm

the heart during pathological overload Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund A, Abouissa A, Derlin K, Meier M, Holler T , Korf-Klingebiel M, Völker K, Garfias Macedo T [...] myosin heavy chain protein and mRNA expression N. Weber*, K. Kowalski*, T. Holler , K. Schwanke, A. Radocaj, A. Lingk, U. Krumm, M. Wendland, U. Zywietz, B. Chichkov, U. Martin, R. Zweigerdt, B. Brenner, T [...] of the same human embryonic stem cell derived cardiomyocyte N. Weber*, K. Kowalski*, T. Holler, A. Lingk, A. Radocaj, U. Krumm, M. Wendland, U. Zywietz, B. Chichkov, K. Schwanke, U. Martin, R. Zweigerdt

Bauersachs J, Haverich A. Eur J Cardiothorac Surg. 2021 Jun 14;59(6):1155-1163. 2. Left Ventricular Assist Devices for Advanced Heart Failure. Schmitto JD, Rojas SV, Haverich A. N Engl J Med. 2017 May [...] ventricular assist device thrombosis. Schmitto JD, Avsar M, Haverich A. N Engl J Med. 2014 Apr 10;370(15):1463-4. 4. Long-term evaluation of a fully magnetically levitated circulatory support device for advanced [...] dieser AG. Ausgewählte Publikationen 1. Five-year outcomes of patients supported with HeartMate 3: a single-centre experience. Schmitto JD, Mariani S, Li T, Dogan G, Hanke JS, Bara C, Pya Y, Zimpfer D

Electromagnetic ventilation: first evaluation of a new method for artificial ventilation in humans. Björn H Sander , Thorben Dieck , Felix Homrighausen , Christoph A Tschan , Jan Steffens , Konstantinos Raymondos [...] 1371/journal.pone.0040903 Paediatric airway management in mucopolysaccharidosis 1: a retrospective case review. Wilhlem A Osthaus , Thomas Harendza , Lars H Witt , Björn Jüttner , Thorben Dieck , Lorenz [...] 1055/s-0033-1358622 The intubation scoop (i-scoop) - a new type of laryngoscope for difficult and normal airways. K Raymondos , T Seidel , B Sander , A Gerdes , F Goetz , V Helmstädter , B Panning , T Dieck

differences in the ExTEM parameters. FibTEM measurements showed a significant difference at the A10 value (13.0 vs. 14.0 mm, P = 0.014) and a trend at the maximum amplitude (maximum clot firmness [MCF] 13 [...] W, Johanning K, Werwitzke S, Trummer A, Bröcker V, Klempnauer J, Winkler M, Tiede A. Recombinant human antithrombin prevents xenogenic activation of hemostasis in a model of pig-to-human kidney transplantation [...] wine, whisk(e)y, or vodka to a target blood alcohol concentration of 1 ‰ within one hour, calculated with the Widmark formula. Blood samples were collected before drinking, at a breath alcohol concentration

it is estimated that a total of 27 to 36 million people suffer from a rare disease in Europe. Typically, rare diseases manifest early in life, sending children and their parents on a diagnostic odyssey for [...] actinopathies, genetic alterations are associated with a wide range of clinical manifestations. Although patients are diagnosed with the same disorder, only a subset exhibit specific symptoms. The underlying [...] rare diseases are caused by genetic alterations, making genetic testing the most promising tool for a fast and accurate diagnosis. The integrated use of third-generation sequencing techniques allows us

Mitarbeiter der AG Lochner Wichtigste Publikationen: Beckstette M, C Lu, S Herppich, EC Diem, A Ntalli, A Ochel, F Kruse F, B Pietzsch, K Neumann, J Huehn, S Floess, M Lochner. 2022. Profiling of epigenetic [...] Fohse, I Prinz, J Pezoldt, S Suerbaum, T Sparwasser, A Hamann, S Floess, J Huehn, M Lochner. 2016. Foxp3(+) T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced [...] Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium . Mucosal Immunol. 7(6):1290-1301. Berod, L, C Friedrich, A Nandan, J Freitag, S Hagemann