ankungen im europäischen Raum. In über 80 % der Fälle liegt eine homozygote C282Y-Mutation im HFE-Gen vor, welche eine Fehlfaltung des HFE Proteins verursacht. Dies wiederum hat eine gestörte Expression [...] klassische CRISPR/Cas Technologie im Labor zu einem nützlichen Werkzeug für die Ausschaltung von Genen macht. Deutlich schwieriger gestaltet sich allerdings die Korrektur einer Punktmutation oder gar das
bestimmten Mutationen des CFTR-Gens steigt die Hoffnung, bald auch eine ursächliche Therapie für mehr Patienten zu finden. Mehr als 2.000 verschiedene Mutationen des CFTR-Gens sind für unterschiedliche Defekte
Clinial Translation“ The publication „Hahn/Pollmann et al. 2020“ sets the foundation for the first gene therapy of IFNgR1-deficient MSMD. The authors reverse cells from patients with lentiviral vectors [...] targeting infections of the lower respiratory tract. Excellence in Research Award The American Society for Gene and Cell Therapy (ASGCT) awards the work of Kathrin Haake with an “Excellence in Research” award.
expression and contractile function are altered by replating stem cell–derived cardiomyocytes, (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377 , Online ahead of print [...] protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes. J. Biol. Chem., 282, 7265-7275. da Costa, N., Edgar, J., Ooi, P.-T., Su, Y. [...] Meissner, J.D. , and Chang, K.-C., 2007. Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell Tissue Res., 329, 515-27. Hanke, N., Meissner, J.D
Rahav G, Grassl GA, Gal-Mor O. The emerging Salmonella infantis expresses lower levels of SPI-1 genes and causes milder colitis in mice and lower rates of invasive disease in humans than Salmonella T [...] The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori . Nucleic Acids Res 2019; 47(5):2336-2348. Farowski F, Solbach P [...] 309(6):151336. Selvakumar, Tharini Ashtalakshmi (Dr. rer. nat.). Interferon mediated intestinal epithelial gene expression under homeostatic and inducible conditions. - 201 Blätter: Illustrationen, Diagramme. Suwandi
CRISPR/Cas9-vermittelte Genom-Editing-Tools zur Überprüfung von Chromatin-Ereignissen eines einzelnen Gens, Epigenomik (ChIPseq, Chromosomenkonformationserfassung usw.), Zellschrittmacherexperimente, Messung [...] induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes . iScience 27: 110913 Wang T, Nayak A , Kraft T, Amrute-Nayak M (2024) Single-Molecule Investigation [...] S (2017) Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin 10: 15 Jung J, Nayak A , Schaeffer V, Starzetz T, Kirsch AK, Muller S, Dikic
killer (NK) cells. A few E3 genes are unique to a particular species and hence may allow for species-specific immunomodulation and differential disease outcome. One of these genes, designated E3/49K, is only [...] infections. E3 is one of the most divergent regions of the Ad genome, differing considerably in size, gene composition and sequence between and within an Ad species. Species D Ads have the largest E3 region
Wageningen University & Research, The Netherlands Xiangming Han Research Topic : Cell type-specific HCMV gene expression and its consequences for the MHC-I immunopeptidome Supervisor : Prof. Dr. Lars Dölken, [...] Research Topic : Development of a screening platform for fine mapping of functional herpes simplex virus gene elements by MuA transposon mutagenesis Supervisor: Prof. Dr. Lars Dölken, Institute of Virology, MHH [...] Immunology, Philipps University Marburg Yan Zheng Research Topic : Functional analysis of cytomegalovirus gene products and cellular effectors during lytic infection Supervisor: Prof. Dr. Lars Dölken, Institute
microRNAs in the inhibition of fibrosis is due to the fact that a single miRNA can regulate multiple genes and pathways involved in the development of fibrosis, and therefore using only two microRNAs for therapy [...] therapy of liver fibrosis is advantageous instead of sequentially or simultaneously modulating several genes”. Prof. Sharma states, “we are very excited about the anti-fibrotic potential of miR-190b-5p and
induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, Bushra Khan , Chiara Lanzuolo, Valentina Rosti, Philina Santarelli, Andreas Pich, Theresia Kraft [...] Nayak , Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio Francesco Retta, Genes & Diseases , Available online 3 April 2023 ScienceDirect, doi.org/10.1016/j.gendis.2023.02.045 , PubMed