city to improve graft survival after allogeneic or xenogeneic transplantation. Advanced gene regulatory and gene editing approaches, ex situ perfusion as well as tissue and organ engineering strategies

Azriel S, Rokney A, Valinsky L, Rahav G, Grassl GA*, Gal-Mor O*.Differences in the expression of SPI-1 genes pathogenicity and epidemiology between the emerging Salmonella enterica serovar Infantis and the model [...] Bleich A, Johnsen JM, Vallance BA, Baines JF, Grassl GA. 2015. Expression of the blood-group-related gene B4galnt2 alters susceptibility to Salmonella infection. PLoS Pathogens. 11 e1005008. Grassl GA*, Valdez

Hepatology and Endocrinology, OE 6810, Project: Identification and Functional Characterization of Cancer Genes in Pancreatic Cancer. Final exam November 2019 Sofia Gialesaki GREECE Supervisor: PD Dr. Jan-Henning [...] Project: Identification and functional characterization of novel cervical cancer susceptibility genes. Final exam June 2020. Theresia Reindl GERMANY Supervisor: Prof. Dr. Dietmar Manstein, Bio-physical

Klein, Pediatric Hematology and Oncology, OE 6780, project: The use of morpholino based knockdown gene technology as well as genetic studies to determine the function of HAX1 in zebrafish Final exam November [...] mouse models of leukemia; 2.Mechanisms of induction of immunologic tolerance by leukemic cells; 3.Gene therapy for hematologic disorders Final exam November 2012 Theodros Solomon Tsegaye (MD) ETHIOPIA

supervisor: Prof. Dr. Rudolph, now University of Ulm project: Analysis of the role of stanniocalcins genes and apoptosis pathways during cellular and organismal ageing Final exam June 2009 Lydia Asrat Haile [...] INDIA supervisor: Prof. Dr. Kispert, Molecular Biology, OE 5250, project: Functional analysis of Tbx gene in heart development Final exam November 2009 Inga Sörensen-Zender GERMANY supervisor: Prof. Dr. Gossler

Ramesh Pandey (Vet.) INDIA superrvisor: Prof. Dr. Kabesch, Paediatric Pneumology, project: TLR pathway genes and susceptibility for allergy and atopic diseases Final exam January 2013 Ruhi Phaltane INDIA supervisor: [...] project: Humanized models to assess the genotoxicity of viral vectors in the context of hematopoietic gene therapy and in vivo selection Final exam November 2013. Georgios Sogkas GREECE supervisor: Prof. Dr

Gentransfer zur genetischen Manipulation hämatopoetischer Zellen. Dazu gehört die Überexpression von Genen und miRNAs ebenso wie die spezifische Inhibition der Genexpression durch RNA-Interferenz (RNAi). Daneben [...] Identifizierung möglicher potentieller Zielstrukturen in Leukämiezellen In bisherigen Arbeiten wurden gen-spezifische, synthetische siRNAs (transiente RNAi) sowie lentiviral-codierte shRNAs (stabile RNAi)

ysen konnte Dr. Zhong nachweisen, dass insbesondere das Hormon Östrogen zahlreiche krebsrelevante Gene bei weiblichen Tieren aktiviert, darunter Onkogene, Zellzyklusgene und Signalwege, die das Tumorwachstum [...] weiblichen Tieren, deutlich und führte zur geschlechtsspezifischen Regulation weiterer krebsrelevanter Gene. Die Ergebnisse zeigen: Sowohl diagnostisch als auch therapeutisch sollten Geschlechtsunterschiede

zusätzlichen Speichervolumen wächst mit dem Ausbau digitaler Analyseverfahren z.B. durch den Einsatz von Gen-Sequenzern oder im Rahmen von rechenintensiven Forschungsprojekten. Dafür stehen moderne Speichert

acquisition of additional mutational events promoting clonal evolution and disease development. The genes most frequently affected by age-related somatic variants in blood cells are coding for the DNA-methylation [...] complex as well as the histone demethylase LSD1, are critical for the establishment of pathogenic gene expression programs in clonal subpopulations of blood cells. Based on published and our preliminary [...] selective inhibitors of these chromatin binding proteins can reverse the aberrant chromatin state and gene expression signatures in a genotype selective manner and target pathogenic clones in xenograft models