particular emphasis on psychiatric care research ) and aims to 1) develop and establish novel therapeutic interventions , and 2) to foster precision medicine for mental health diseases. To achieve these
of lesion-induced plasticity and network reorganization. These findings will help to identify therapeutic targets that improve post-lesion network reorganization. 2) Sensory deprivation is a major trigger [...] ultrastructural reorganizations of synapses. Since retinoid metabolism represents a potential therapeutic target, the clinical potential of these signaling pathways will be evaluated. In conclusion, this
ERC Consolidator Grant LONGHEART : Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure (2015 – 2020) EU funding via N-Bank - im Rahmen des Niedersächsischen [...] (2020 – 2021) Leducq Foundation: Trans-Atlantic Network and Training Program on MicroRNA-Based Therapeutic Strategies in Vascular Disease (MIRVAD, 2014 – 2019) DFG: TH903/18-1 (with ANR): Regulation, d
“Development of a hiPSC-based cystic fibrosis lung disease model to study TMEM16A as an alternative therapeutic target in cystic fibrosis” Mikhail Magdei (AG Hilfiker): “Analysis of xenoantigen burden in de
remote idea more than twenty years ago. Meanwhile, the human kinome is known and the spectacular therapeutic results obtained with STI571 (Gleevec) , suggested that compounds that modulate the activities
and research. To gain a deeper understanding of complex diseases and establish novel innovative therapeutic interventions, joint strengths are required. Our research groups do thus collaborate with ample [...] aims to find out which intervention is most suitable for which patient and which factors cause therapeutic success. E.g., as part of moderator analyzes, this study aims to answer whether early traumatic [...] A follow-up survey after 48 weeks will provide valuable data regarding the sustainability of therapeutic improvements. Finally, the health economic potential of the interventions is examined with the
transplant engineering. His work centers around the alloimmune response in organ transplantation and therapeutic interventions to combat rejection and infection. This includes cellular and humoral immunotherapy [...] structure, molecular function and regulation of histocompatibility systems in order to identify therapeutic targets for graft engineering to substantially improve clinical outcome of transplantation. Professor
transplant engineering. His work centers around the alloimmune response in organ transplantation and therapeutic interventions to combat rejection and infection. This includes cellular and humoral immunotherapy [...] structure, molecular function and regulation of histocompatibility systems in order to identify therapeutic targets for graft engineering to substantially improve clinical outcome of transplantation. Professor
Frahm M, Heise U, Zimmermann K, Erhardt M, Weiss S. Oncotarget. 2017 Jul 25;8(30):49988-50001. Therapeutic benefit of Salmonella attributed to LPS and TNF-α is exhaustible and dictated by tumor susceptibility [...] Falk CS, Seidler U, Hornef MW, Goethe R, Weiss S. Front Cell Infect Microbiol. 2017 Mar 16;7:75. Therapeutic Potential of Bacteria against Solid Tumors. Hatzikirou H, López Alfonso JC, Leschner S, Weiss S
transplant engineering. His work centers around the alloimmune response in organ transplantation and therapeutic interventions to combat rejection and infection. This includes cellular and humoral immunotherapy [...] structure, molecular function and regulation of histocompatibility systems in order to identify therapeutic targets for graft engineering to substantially improve clinical outcome of transplantation. Professor