Supportive & Palliative Care 2021 , PLoS ONE 2024 Sterben wie ein Hund Konvergenzen und Divergenzen im human- und veterinärmedizinethischen Diskurs zum Lebensende von Menschen bzw. Heimtieren und Folgen für

Parasitologie) sowie die mikrobiologische Diagnostik im Rahmen der Krankenhaushygiene vor. Alle humanpathogenen Bakterien, Pilze, Viren und Parasiten werden im Rahmen der allgemeinen Diagnostik in einem auf

Promotion, Habilitation Promotion 2004 „Untersuchungen zur Expression und Funktion des transgenen humanen Komplementregulators hCD59 in porcinen Nieren im diskordanten ex vivo Hämoperfusionsmodell“; Betreuer:

furthermore perform patch clamp analyses on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to support projects that investigate diverse human cardiac diseases (e.g. Brugada syndrome [...] on-exchangers (ClC-3 through ClC-7). Dysfunction of these anion transport proteins cause diverse human diseases including myotonia, aldosteronism, epilepsy, salt-wasting nephropathies with and without

vivo models, with a particular focus on living myocardial slice. In a translational perspective, human myocardial slices are also extensively used. The multicellular environment and preserved functionality [...] Methodology Myocardial slices (LMS) Myocardial slice preparation and ex vivo culture (mouse, rat, pig, human) Minituarization of LMS for high throughput approaches Isometric force measurement in LMS Calcium [...] and intracellular calcium transients (IonOptix, Coop Prof. T. Kraft, Dr. M. Ricke-Hoch) Models with human induced pluripotent stem cell-derived cardiomyocytes hiPSC-CM differentiation and culture (Coop Dr

Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Römermann, Dipl.-Biologin Denise Schlösser, PhD Studentin Josephin Scholz, Assistenzärztin Georgina Schumann, PhD Studentin Dr. rer. nat. Sven Schüngel, PhD-Student 2005 - 2010 Dr. med. Nora Schweitzer, A

Jordans S, Dilloo D. J Cell Mol Med 2022;26(23):5832-5845 DOI: 10.1111/jcmm.17604 Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli [...] Hochschule Hannover, 2022 2021 Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids. Völkner M, Pavlou M, Büning H, Michalakis S, Karl MO. Hum Gene Ther 2021;32(13 [...] Galla M. Mol Ther Nucleic Acids 2022;27:810-823 DOI: 10.1016/j.omtn.2021.12.033 Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. Hamann MV, Beschorner N, Vu XK, Hauber

G, Guengoer C, Wagener C, Schumacher U, Lange T (2020). Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. Glycobiology. 2020 [...] S, Fenske A , Jang MS, Jirmo AC, Abeln M, Hansen G, Lachmann N (2024). Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under [...] PMID: 39227460 Plötz T , Lenzen S (2024). Mechanisms of lipotoxicity-induced dysfunction and death of human pancreatic beta cells under obesity and type 2 diabetes conditions. Obes Rev. 2024 May;25(5):e13703

H. C. ; Bergforth,W. ; Przykopanski,A. ; Rummel,A. ; Klawonn,F. ; Seeger,B. Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1, Switzerland,Toxins (Basel),2021;13(8):585- [...] Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ; Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo Eur.Heart J., 2024, 45(22), 2016- 2018, Originalpublikation Albers,Marco [...] Tsikas,Dimitrios ; Kuczyk,Markus A. ; Ückert,Stefan ; Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion

Stippel D, Flemming P, Nussbaum T, Caselmann WH, Haab BB, Schirmacher P: Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth [...] Mengel M, Merkel S, Banas B, Luft FC, Haller H: Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases. Am J Kidney Dis 2004; 43(2): Giagounidis AA, Germing U, Haase S, Hildebrandt [...] W, Wagner S: Effect of H. pylori on the expression of TRAIL, FasL and their receptor subtypes in human gastric epithelial cells and their role in apoptosis. Helicobacter 2004; 9(5): 371-86 Mengel M, Jonigk