where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype. In humans there are four homologs of DPY-19, which are called DPY19L1, DPY19L2, DPY19L3, and DPY19L4.
alveolar lung organoids obtained either from murine adult stem cells or via directed differentiation of human iPS cells into functional type 2 alveolar epithelial cells. By co-culturing immune and structural [...] H. B. 2020. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Nat Commun 11, no. 1:3559. https://doi.org/10.1038/s41467-020-17358-3 .
occurring endogenous and adoptively transferred antiviral T cells in optimizing T-cell immunity against human polyomavirus 1 (BKPyV, BKV) to avoid allograft dysfunction in kidney transplant recipients Friederike [...] speaker! Lily Sophie Rose , GERMANY, Rose.Lily@mh-hannover.de Supervisor: Prof. Dr. Ruthhild Weber (Human Genetics) Project: Ribosomal biogenesis genes and predisposition to brain tumors Tirthankar Saha
Thum / Dr. Christian Bär (IMTTS) Project: Screening and validation of natural compound libraries in human iPSC-cardiomyocytes for the treatment of Fabry disease Final exam June 2024 Bushra Khan INDIA khan [...] Jonathan Lühmann GERMANY Luehmann.Jonathan @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Optical Mapping to detect structural genomic variants in cancer Jonathan was class
P, Fieguth HG, Wilkens L, Braun A, Hessel EM, Sewald K; U-BIOPRED Study Group. Rhinovirus-induced Human Lung Tissue Responses Mimic COPD and Asthma Gene Signatures. Am J Respir Cell Mol Biol. 2021 Jun 28 [...] Martin C, Braun A, Sewald K. Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices. J Vis Exp. 2018 May 9;(135):57042. doi: 10.3791/57042. PMID: 29806827;
Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie und der Institute Pathologie und Humangenetik wollen in ihrem Projekt den Mehrwert von unterschiedlichen liquid biopsies aus der Gallenflüssigkeit [...] und es kann Krebs entstehen. Zu den häufigsten viralen Verursachern für Krebserkrankungen zählen humane Papillomaviren (HPV), das Epstein-Bar-Virus (EBV) und Hepatitis-Viren (HBV/ HCV). Ein Forschungsteam
Investigation of noncoding RNA pathways for the treatment of Fabry disease using patient-derived human iPSC-cardiomyocytes. Final exam June 2023 Mi-Sun Jang GERMANY Jang.Mi-Sun@mh-hannover.de Supervisor: [...] Prof. Dr. Nico Lachmann, Pediatric Pneumology Project: Dissecting the onset of macrophages from human iPSC for disease modelling and therapeutic applications Juliette Nowak GERMANY Supervisors: from September
Rahmen der Lehrveranstaltung bekannt gegeben. WP 31 - Molekulare Humangenetik Human molecular genetics Strachan, T. Molekulare Humangenetik Strachan, T. WP 32 - Molekulare Mikrobiologie für Biochemiker Biology
Kipke (Betreuung seit 2015) Alumni 2025 Klara Leuckefeld: Altersbedingte Dezidualisierungsdefekte in humanen endometrialen Stromazellen (B.Sc. Biochemie) Eva Scheer: Inwiefern beeinflusst das Wetter die Ergebnisse [...] (Wissenschaftsmodul) Clara Springer: Investigations on in vitro decidualization and relaxin effects in human endometrial stromal cells to elucidate mechanisms in the pathophysiology of preeclampsia (Dr. med [...] wed Embryo Transfer in the Absence of a Corpus Luteum (Dr. med., Hannover, 2023) Ina Sejko, Bsc: Human endometrial stromal cell decidualization (Universität Göttingen, Gastwissenschaftlerin 12/2022 bis
PYA, Zattelman L, Fedorov R, Henn A, Taft MH & Manstein DJ. (2020). Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. [...] n R, and Fedorov R. A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism. (2015) Sci. Rep . 5 , 9618; DOI:10 [...] Schneider J, Münster-Kühnel AK, Gerardy-Schahn R. Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. (2013) Glycobiology . 23 (4):426-37. Heissler SM, Selvadurai J, Bond