AG Sodeik
Research summary
The Cell Biology of Viral Infections:
Herpes Simplex Virus - a hitch hiker’s guide to epithelial cells, neurons and immune cells
Our group is interested in the cell biology of alpha herpesviruses. How does a virus get access to a cell, disassemble to release its genome for transcription and replication, and how is - within a couple of hours - the viral program switched to virus assembly and egress?
Our focus is to analyze all virus-host interactions of Herpes Simplex Virus Type 1 (HSV-1) in cell types that it also interacts with in the human host: epithelial cells, neurons and immune cells. Towards this end, we investigate the virus-host cell interactions that are required for efficient HSV1 cell entry, nuclear targeting of the viral genome, viral gene expression, virus assembly, egress and spread. We use HSV1 mutants as well as state-of-the-art biochemical, life-cell imaging approaches and electron microscopy to characterize how HSV1 activates cellular signal transduction cascades to utilize the actin cytoskeleton, the microtubule transport machinery, the nuclear import machinery, and the membranes of the secretory pathway during HSV1 cell entry as well as assembly.
Group members
Team leader
- Prof. Dr. rer. nat. Beate Sodeik
Medizinische Hochschule Hannover (Hannover Medical School)
Institute of Virology, OE5230
Carl-Neuberg-Str. 1
30625 Hannover
Phone +49 511 532 2846
Departmental Secretary +49 511 532 6736
Laboratory +49 511 532 - 2845 / -4225 | FAX +49 511 532 8736
Email Sodeik.Beate@MH-Hannover.de
--> https://www.resist-cluster.de/wp-content/uploads/2019/09/CV_Sodeik.pdf
Dr. Sodeik studied biology in Bonn (1982-88), and obtained a Diploma in Cell Biology analyzing autophagy in the single cell animal Amoeba proteus. She then trained as a DAAD fellow (German Academic Exchange Service; 1988/89) at Columbia University Medical School, College of Physicians & Surgeons, New York, USA working on integrin receptors of human neutrophils. For her PhD project in cell biology (1989-93), she moved to the European Molecular Biology Laboratory (EMBL) in Heidelberg, and initiated a project on the assembly of vaccinia virus in the laboratory of Dr. Gareth Griffiths. She later joined the group of Prof. Ari Helenius at Yale University, New Haven, CT, USA as an EMBO postdoctoral fellow and later associate, to set up the analysis of virus-host interactions during the early phase of herpes simplex virus infection (1993-97). From 1997 until 2002 she was a senior scientist and research group leader at Hannover Medical School in the Institute of Physiological Chemistry. After her postdoctoral thesis in biochemistry ("Habilitation"), she became Assistant Professor in 2002, and Associate Professor in 2007 at the Institute of Virology at Hannover Medical School.
Alumni of the Group
Hickford Martinez, Ana - MSc, Predoctoral Scientist (2014-2019)
Buch, Anna - Dipl.-Biotechnol., Predoctoral Scientist (2008-2018)
Hinz, Angelika - MSc, Predoctoral Scientist (2012-2016)
Prank, Ute - Research Assistant (1998-2016)
Hinz, Angelika - MSc, Predoctoral Scientist (2012-2016)
Ivanova, Lyudmila - MSc, Predoctoral Scientist (2011-2016)
Bialy, Dagmara - Postdoctoral Scientist (2010-2015)
Koithan, Thalea - Dipl.-Biotechnol., Predoctoral Scientist (2007-2014)
Devadas, Deepika - MSc, Predoctoral Scientist (2009-2013)
Daniela Kieneke - Postdoctoral Scientist (2008-2012)
Malte Sandbaumhüter - Postdoctoral Scientist (2008-2012)
Randi Diestel - Postdoctoral Scientist (2011-2012)
Maike Hegemann – MSc Biomedicine (2012)
Katharina Goris - Postdoctoral Scientist (2010-2012)
Yuan Zhao – Postdoctoral Scientist (2010-2012)
Lisa Oestereich - Diplom Biochemistry (2010-2011)
Julia Schipke - Dr. rer. nat. Pre and Postdoctoral Scientist (2005-2010)
Sandra Oetjen - MSc Biomedizin, MSc student (2010)
Michela Cappucci - MSc Animal Biology & MSc student (2010)
Kathrin Rode - Dr. rer. nat., Pre- and Postdoctoral Scientist (2003-2009)
Tanja Bosse - Dr. rer. nat., Postdoctoral Scientist (2007 - 2009)
Sandra Rittweger – Human biology Diploma Student (2008 - 2009)
Janus, Jessica - Dr. rer. nat., Predoctoral Scientist (2005-2009)
Kerstin Radtke - Dr. rer. nat., Pre- and Postdoctoral Scientist (2004-2009)
Bastian Schirmer - Dipl.-Biochem., Diploma Student (2008-2009)
Volker Rust - Dipl.-Biol., Diploma Student (2007-2008)
Claus-Henning Nagel - Dr. rer nat., Pre- and Postdoctoral Scientist (2002-2008)
Christof Bohnen - Dipl.-Biochem., Diploma Student (2006-2007)
Mojgan Fathollahy - Research Assistant (2001-2007)
Kristina Theusner - Dr. rer. nat., Predoctoral Scientist (2003-2007)
Klaas Mulder - Visiting Master Student from Amsterdam, The Netherlands (2006)
Michaela Nygårdas - Visiting DAAD PhD Fellow from Turku, Finland (2006)
André Wolfstein - Dr. rer. nat., Pre- and Postdoctoral Scientist (1998-2006)
Falk Büttner - Dr. rer. nat., Diploma Student (2004)
Simone Schmidt - Veterinary Doctor, Predoctoral Scientist (2001-2003)
Stefan Borsutzky - Dr. rer. nat., Diploma Student (2002)
Sabrina Marozin - Veterinary Doctor, Predoctoral Scientist (2001-2002)
Tanja Strive - Dr. rer. nat., Postdoctoral Scientist (2001-2002)
Kirstin Suck (nee Kitzler) - Dr. rer. nat., Diploma Student (2001-2002)
Doris Meder - Dr. rer. nat., Diploma Student (1999)