Schmidt lab

Research summary

When invading viruses are sensed by the host cell this leads to the activation of a powerful antiviral defense program, which counteracts viral replication at many different levels. My lab is interested in the role of RNA binding proteins in orchestrating antiviral defense mechanisms by modulating RNA functions. We employ state-of-the-art sequencing and mass spectrometry techniques, as well as classical virological assays.

Publications

Aydin J, Gabel A, Zielinski S, Ganskih S, Schmidt N, Hartigan CR, Schenone M, Carr SA, Munschauer M. SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells.
Nucleic Acids Res. (2024). www.ncbi.nlm.nih.gov/pubmed/38281241

Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, Krey K, Hennig T, Stegmaier S, Moyon L, Horlacher M, Werner S, Aydin J, Olguin-Nava M, Potabattula R, Kibe A, Dolken L, Smyth RP, Caliskan N, Marsico A, Krempl C, Bodem J, Pichlmair A, Carr SA, Chlanda P, Erhard F, Munschauer M. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.
Cell. (2023). www.ncbi.nlm.nih.gov/pubmed/37794589

Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deak F, Puchinger K, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wieser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hoelscher M, Massberg S, Stark K, Nicolai L. Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Nat Commun. (2022). www.ncbi.nlm.nih.gov/pubmed/35197461

Schmidt N, Lareau CA, Keshishian H, Ganskih S, Schneider C, Hennig T, Melanson R, Werner S, Wei Y, Zimmer M, Ade J, Kirschner L, Zielinski S, Dolken L, Lander ES, Caliskan N, Fischer U, Vogel J, Carr SA, Bodem J, Munschauer M. The SARS-CoV-2 RNA-protein interactome in infected human cells.
Nat Microbiol. (2021). www.ncbi.nlm.nih.gov/pubmed/33349665

Borold J, Eletto D, Busnadiego I, Mair NK, Moritz E, Schiefer S, Schmidt N, Petric PP, Wong WW, Schwemmle M, Hale BG. BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity.
EMBO Rep. (2021). www.ncbi.nlm.nih.gov/pubmed/34397140

Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham MH, Hay RT, Hale BG. An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity.
Proc Natl Acad Sci U S A. (2019). www.ncbi.nlm.nih.gov/pubmed/31391303

Sekine E, Schmidt N, Gaboriau D, O'Hare P. Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy.
PLoS Pathog. (2017). www.ncbi.nlm.nih.gov/pubmed/29121649

Schmidt N, Hennig T, Serwa RA, Marchetti M, O'Hare P. Remote Activation of Host Cell DNA Synthesis in Uninfected Cells Signaled by Infected Cells in Advance of Virus Transmission.
J Virol. (2015). www.ncbi.nlm.nih.gov/pubmed/26311877