Ausgewählte Publikation

2011-2020

Sikorra S, Donald S, Elliott M, Schwede S, Coker SF, Kupinski AP, Tripathi V, Foster K, Beard M, Binz T. (2020): Engineering an effective human SNAP-23 cleaving botulinum neurotoxin A variant. Toxins 12, 804.
PubMed-Link

Leese C, Bresnahan R, Doran C, Simsek D, Fellows AD, Restani L, Caleo M, Schiavo G, Mavlyutov T, Henke T, Binz T, Davletov B. (2020): Duplication of clostridial binding domains for enhanced macromolecular delivery into neurons. Toxicon X 5:100019.
PubMed-Link

Sikorra S, Skiba M, Dorner MB, Weisemann J, Weil M, Valdezate S, Davletov B, Rummel A, Dorner BG, Binz T. (2018): Botulinum neurotoxin F subtypes cleaving the VAMP-2 Q58-K59 peptide bond exhibit unique catalytic properties and substrate specificities. Toxins (Basel) 10, 311.
PubMed-Link

Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R. (2018): Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA. Pathog Dis 76, fty044
PubMed-Link

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M. (2017): Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS Pathog 13, e1006567.
PubMed-Link

Zornetta I, Azarnia Tehran D, Arrigoni G, Anniballi F, Bano L, Leka O, Zanotti G, Binz T, Montecucco C. (2016): The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain. Sci Rep 6, 30257.
PubMed-Link

Sikorra S, Litschko C, Müller C, Thiel N, Galli T, Eichner T, Binz T (2016): Identification and characterization of botulinum neurotoxin A substrate binding pockets and their re-engineering for human SNAP-23. J Mol Biol 428, 372-384.
PubMed-Link

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T (2013): Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain. FEBS Lett 587, 3831-3836.
PubMed-Link

Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T (2013): Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. Biochemistry 52, 3930-3938.
PubMed-Link

Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks, JD, Rummel A, Binz T (2013): Identification of the SV2-Protein Receptor Binding Site of Botulinum Neurotoxin Type E. Biochem J 453, 37-47.
PubMed-Link

Binz T (2013): Clostridial neurotoxin light chains: devices for SNARE cleavage mediated blockade of neurotransmission. Curr Top Microbiol Immunol 364, 139-157.
Review
PubMed-Link

Strotmeier J, Willjes G, Binz T, Rummel A (2012): Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity. FEBS Lett 586, 310-313.
PubMed-Link

Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T (2011): The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol Microbiol 81, 143-156.
PubMed-Link