Ausgewählte Publikationen

 

2023

 

p38 MAPK /MK2 signaling stimulates host cells autophagy pathways to restrict Salmonella infection

Suwandi A, Menon MB, Kotlyarov A, Grassl GA & Gaestel M

Front. Immunol Volume 14 doi: 10.3389/fimmu.2023.1245443

 

5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling

Chauhan C, Kraemer A, Knapp S, Windheim M, Kotlyarov A, Menon MB & Gaestel M

Cell Death Discov 9: 262

 

On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer

Boudghene-Stambouli F, Soulez M, Ronkina N, Dörrie A, Kotlyarov A, Seternes O-M, Gaestel M & Meloche S

Cancers 15: 25

 

PRMT5-mediated regulatory arginine methylation of RIPK3

Chauhan C, Martinez-Val A, Niedenthal R, Olsen JV, Kotlyarov A, Bekker-Jensen S, Gaestel M & Menon MB

Cell Death Discov 9: 14

 

2022

 

MAPK-Activated Protein Kinases: Servant or Partner?

Ronkina N, Gaestel M.

Annu Rev Biochem. 2022 Feb 18. doi: 10.1146/annurev-biochem-081720-114505.

 

Lyz2-Cre-Mediated Genetic Deletion of Septin7 Reveals a Role of Septins in Macrophage Cytokinesis and Kras-Driven Tumorigenesis.

Menon MB, Yakovleva T, Ronkina N, Suwandi A, Odak I, Dhamija S, Sandrock I, Hansmann F, Baumgärtner W, Förster R, Kotlyarov A, Gaestel M.

Front Cell Dev Biol. 2022 Jan 6;9:795798. doi: 10.3389/fcell.2021.795798.

 

2021

 

Cytokine Storm.

Gaestel M, Nebreda AR, Yaffe MB.

N Engl J Med. 2021 Apr 22;384(16):e59. doi: 10.1056/NEJMc2036236. PMID: 33882214

 

MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate.

Gutierrez-Prat N, Cubillos-Rojas M, Cánovas B, Kuzmanic A, Gupta J, Igea A, Llonch E, Gaestel M, Nebreda AR.

Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2024562118.

 

2020

 

Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription.

Shrestha A, Bruckmueller H, Kildalsen H, Kaur G, Gaestel M, Wetting HL, Mikkola I, Seternes OM.

Sci Rep. 2020 Jul 9;10(1):11388.

 

2019

 

The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

Ronkina N, Shushakova N, Tiedje C, Yakovleva T, Tollenaere MAX, Scott A, Batth TS, Olsen JV, Helmke A, Bekker-Jensen SH, Clark AR, Kotlyarov A, Gaestel M.

J Immunol. 2019 Oct 15;203(8):2291-2300. doi: 10.4049/jimmunol.1801221.

 

Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3

Natalia Ronkina, Karin Schuster-Gossler, Florian Hansmann, Heike Kunze-Schumacher, Inga Sandrock, Tatiana Yakovleva, Juri Lafera, Wolfgang Baumgärtner, Andreas Krueger, Immo Prinz, Achim Gossler, Alexey Kotlyarov, Matthias Gaestel

bioRxiv 467597; doi: doi.org/10.1101/467597

Now published in Molecular and Cellular Biology doi: 10.1128/mcb.00516-18

 

Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

Philipp Trulley, Goda Snieckute, Dorte Bekker-Jensen, Manoj B. Menon, Robert Freund, Alexey Kotlyarov, Jesper V. Olsen, Manuel D. Diaz-Munoz, Martin Turner, Simon Bekker-Jensen, Matthias Gaestel, Christopher Tiedje

bioRxiv 429696; doi: doi.org/10.1101/429696

Now published in Cell Reports doi: 10.1016/j.celrep.2019.05.024

 

2018

 

MK2-TNF-Signaling Comes Full Circle

Menon MB, Gaestel M.

Trends Biochem Sci. 43, 158-167.

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2017

 

p38 MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection

Menon MB*, Gropengießer J*, Fischer J, Novikova L, Deuretzbacher A, Lafera J, Schimmeck H, Czymmeck N, Ronkina N, Kotlyarov A, Aepfelbacher M, Gaestel M* & Ruckdeschel K* (2017)(* equal contribution)

Nat Cell Biol. 19:1248-59.

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