From 2010 - Present

  1. Davenport, C.F.; Scheithauer, T.; Dunst, A.; Bahr, F.S.; Dorda, M.; Wiehlmann, L.; Tran, D.D.H. Genome-Wide Methylation Mapping Using Nanopore Sequencing Technology Identifies Novel Tumor Suppressor Genes in Hepatocellular Carcinoma. Int. J. Mol. Sci. 2021, 22, 3937.
  2. Sebastian Burbano De Lara, Doan Duy Hai Tran, Aldrige Bernardus Allister, Mareike Polenkowski, Björn Nashan, Martina Koch and Teruko Tamura. C20orf204, a hepatocellular carcinoma-specific protein interacts with nucleolin and promotes cell proliferation. Oncogenesis 10, 31 (2021).
  3. Niehus, S.E.*, Allister A.B*,  Hoffmann A,  Wiehlmann L,  Tamura T, and  Tran DD. Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Scientific Reports 9, 17319, doi:10.1038/s41598-019-53944-2 (2019) (*equal contribution)
  4. Tran DDH*, Kessler C*, Niehus SE, Mahnkopf M, Koch A, Tamura T. Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs. Oncogene. 2018 Jan 4;37(1):75-85. PubMed PMID: 28869604. (*equal contribution)
  5. Niehus, S. E., Tran, D. D. H., Mischak, M. & Koch, A. Colony-stimulating factor-1 receptor provides a growth advantage in epithelial cancer cell line A431 in the presence of epidermal growth factor receptor inhibitor gefitinib. Cellular signalling 51, 191-198, doi:10.1016/j.cellsig.2018.07.014 (2018).
  6. Tran DDH, Koch, A., Allister, A., Saran, S., Ewald, F., Koch, M., Nashan, B., Tamura, T. Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP). Cellular signalling. 2016 Dec;28(12):1872-80. PubMed PMID: 27619201.
  7. Tran DDH, Koch, A., Saran, S., Armbrecht, M., Ewald, F., Koch, M., Wahlicht, T., Wirth, D., Braun, A., Nashan, B., Gaestel, M., Tamura, T. Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture. Cellular signalling. 2016 May;28(5):438-47. PubMed PMID: 26876787.
  8. Tran DD, Saran S, Koch A, Tamura T. mRNA export protein THOC5 as a tool for identification of target genes for cancer therapy. Cancer letters. 2016 Apr 10;373(2):222-6. PubMed PMID: 26828015.
  9. Saran S*, Tran DD*, Ewald, F., Koch, A., Hoffmann, A., Koch, M., Nashan, B., and Tamura, T. Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. Oncogene. 2016 Jul 21;35(29):3872-9. PubMed PMID: 26549021. (*equal contribution)
  10. Tran DD, Koch A, Tamura T. THOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation. Cell communication and signaling : CCS. 2014 Jan 10;12:3. PubMed PMID: 24410813. Pubmed Central PMCID: 3899923.
  11. Tran DD, Saran, S., Williamson, AJK. , Pierce A., Dittrich-Breiholz, O., Wiehlmann, L.,, Koch, A., Whetton, AD., Tamura, T. THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100). Nucleic acids research. 2014 Oct 29;42(19):12249-60. PubMed PMID: 25274738. Pubmed Central PMCID: 4231767.
  12. Saran S*, Tran DD*, Klebba-Farber, S., Wiehlmann, L., Koch, A., Chopra, H., Pabst, O., Hoffmann, A., Klopfleisch, R., Tamura, T. THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier. BMC cell biology. 2013 Nov 22;14:51. PubMed PMID: 24267292. Pubmed Central PMCID: 4222586. (*equal contribution)
  13. Tran, DDH., Saran, S., Dittrich-Breiholz, O.,  Williamson , A.J.K, Klebba-Färber, S.,  Koch, A., Kracht, M., Whetton, A.D., Tamura, T. Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell death & disease. 2013 Oct 24;4:e879. PubMed PMID: 24157873. Pubmed Central PMCID: 3920956.
  14. Koch A., Saran S., Tran DD., Klebba-Färber S, Thiesler H, Sewald K, Schindler S, Braun A, Klopfleisch R, Tamura T. Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo. Cell communication and signaling : CCS 12, 73, doi:10.1186/s12964-014-0073-7 (2014).
  15. Griaud F, Pierce A, Gonzalez Sanchez MB, Scott M, Abraham SA, Holyoake TL, Tran DD, Tamura T, Whetton AD. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukemia. Apr;27(4):932-40. doi: 10.1038/leu.2012.283. Epub 2012 Oct 3 (2013).
  16. Guria A*, Tran DD*, Ramachandran S*, Koch, A., El Bounkari O., Dutta, P., Hauser, H., Tamura, T. Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts. Rna. 2011 Jun;17(6):1048-56. PubMed PMID: 21525145. Pubmed Central PMCID: 3096037. (*equal contribution)
  17. Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T. An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA. Nov;17(11):1957-66. doi: 10.1261/rna.2820911. Epub 2011 Sep 21. (2011).
  18. Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Färber S, Koch A, Jaworska E, Spooncer E, Gruber AD, Whetton AD, Tamura T. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol. 2010 Jan 5;8:1. doi: 10.1186/1741-7007-8-1.