Greve, J. N., Schwäbe, F. V., Taft, M. H., Manstein, D. J. (2024) Biochemical characterization of cardiac α-actin mutations A21V and D26N implicated in hypertrophic cardiomyopathy. Cytoskeleton (Hoboken). doi: 10.1002/cm.21852.

Greve, J. N., Marquardt, A., Heiringhoff, R., Reindl, T., Thiel, C., Di Donato, N., Taft, M. H., Manstein, D. J. (2024) The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins. Elife. 12:RP93013. doi: 10.7554/eLife.93013.

Sulewska, M., Berger, M., Damerow. M., Schwarzer, D., Buettner, F. F. R., Bethe, A., Taft, M. H., Bakker, H., Mühlenhoff, M., Gerardy-Schahn, R., Priem, B., Fiebig, T. (2023) Extending the enzymatic toolbox for heparosan polymerization, depolymerization, and detection. Carbohydr Polym. 319:121182. doi: 10.1016/j.carbpol.2023.121182.

 

Reboll, M. R., Klede, S., Taft, M. H., Cai, C. L., Field, L. J., Lavine, K. J., Koenig, A. L., Fleischauer, J., Meyer, J., Schambach, A., Niessen, H. W., Kosanke, M., van den Heuvel, J., Pich, A., Bauersachs, J., Wu, X., Zheng, L., Wang, Y., Korf-Klingebiel, M., Polten, F., Wollert, K. C. (2022) Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. Science 376(6599):1343-1347. doi: 10.1126/science.abn3027

 

Reindl, T., Giese, S., Greve, J. N., Reinke, P. Y., Chizhov, I., Latham, S. L., Mulvihill, D. P., Taft, M. H., Manstein, D. J. (2022) Distinct actin–tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes. iScience 25(7):104484. doi: 10.1016/j.isci.2022.104484

 

Greve, J. N., Schwäbe, F. V., Pokrant, T., Faix, J., Di Donato, N., Taft, M. H., Manstein, D. J. (2022) Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics. Eur J Cell Biol. 101(2):151216. doi: 10.1016/j.ejcb.2022.151216

 

Schwäbe, F. V., Peter, E. K., Taft, M. H., and Manstein, D. J. (2021) Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin-Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy-Causing Double Mutation MYBPC3Δ25bp/D389V. Int J Mol Sci. 22(21):11949. doi: 10.3390/ijms222111949

 

Rai, A., Klare, J. P., Reinke, P. Y. A., Englmaier, F., Fohrer, J., Fedorov, R., Taft, M. H., Chizhov, I., Curth, U., Plettenburg, O., and Manstein, D. J. (2021) Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum. Int J Mol Sci. 22(12):6265. doi: 10.3390/ijms22126265.

 

Pertici, I.*, Taft, M. H.*, Greve, J. N., Fedorov, R., Caremani, M., and Manstein, D. J. (2021) Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. J Physiol. doi: 10.1113/JP281563. *equal contribution

Pertici, I., Bianchi, G., Bongini, L., Cojoc, D., Taft, M. H., Manstein, D. J., Lombardi, V., and Bianco, P. (2021) Muscle myosin performance measured with a synthetic nanomachine reveals a class-specific Ca(2+) -sensitivity of the frog myosin II isoform. J Physiol. 599(6):1815-1831. doi: 10.1113/JP280976.

Giese, S., Reindl, T., Reinke, P. Y. A., Zattelman, L., Fedorov, R., Henn, A., Taft, M. H.#, and Manstein, D. J.# (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. 296:100128. doi: 10.1074/jbc.RA120.015187. #corresponding authors

 

Latham, S. L., Weiß, N., Schwanke, N., Thiel, C., Croucher, D. R., Zweigerdt, R., Manstein, D. J., and Taft, M. H. (2020) Myosin-18B regulates higher order organization of the cardiac sarcomere through thin filament cross-linking and thick filament dynamics. Cell Rep. 32(9):108090. doi: 10.1016/j.celrep.2020.108090

 

Wollenberg, R. D., Donau, S. S., Taft, M. H., Balázs, Z., Giese, S., Thiel, C., Sørensen, J. L., Nielsen, T. T., Giese, H., Manstein, D. J., Wimmer, R., Sondergaard, T. E. (2020) Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium. PLoS One. 15(6):e0235568. doi: 10.1371/journal.pone.0235568.

 

Taft, M. H. and Latham, S. L. (2020) Myosin XVIII. In: Coluccio L. (eds) Myosins. Advances in Experimental Medicine and Biology, vol 1239. Springer, Cham. doi: 10.1007/978-3-030-38062-5_19 (book chapter)

 

Shcherbakova, A., Preller, M., Taft, M. H., Pujols, J., Ventura, S., Tiemann, B., Buettner, F. F. R., and Bakker H. (2019) C-Mannosylation supports folding and enhances stability of thrombospondin repeats. eLife 8. pii: e52978. doi: 10.7554/eLife.52978.

 

Wollenberg, R. D. *, Taft, M. H.*, Giese, S , Thiel, C., Balázs, Z., Giese, H., Manstein, D. J., Sondergaard, T. E. (2019) Phenamacril is a reversible and non-competitive inhibitor of Fusarium class I myosin. J Biol Chem. pii: jbc.RA118.005408. doi: 10.1074/jbc.RA118.005408. *equal contribution

 

Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Eicke, D., Reindl, T., Stenzel, W., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruhwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Niehaus, I., Sarnow, K., Grutzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Figueiredo, C., Knofler, R., Manstein, D. J., and Di Donato, N. (2018) Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat. Commun. 9(1):4250, doi: 10.1038/s41467-018-06713-0

 

Meiring, J. C. M., Bryce, N. S., Wang, Y., Taft, M. H., Manstein, D. J., Liu Lau, S., Stear, J., Hardeman, E. C. and Gunning, P. W. (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337.e5. doi: 10.1016/j.cub.2018.05.053.

 

Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruehwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Sarnow, K., Gruetzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Knoefler, R., Manstein, D. J., and Di Donato, N. (2018). Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated with ACTB mutations. bioRxiv. DOI: 10.1101/303909.

 

Pathan-Chhatbar, S.*, Taft, M. H.*, Reindl, T., Hundt, N., Latham, S. L., and Manstein, D. J. (2018) Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous beta-actin in vitro. J. Biol. Chem. pii: jbc.M117.806521. doi: 10.1074/jbc.M117.806521. *equal contribution

 

Meents, A., Wiedorn, M. O., Srajer, V., Henning, R., Sarrou, I., Bergtholdt, J., Barthelmess, M., Reinke, P. Y. A., Dierksmeyer, D., Tolstikova, A., Schaible, S., Messerschmidt, M., Ogata, C. M., Kissick, D. J., Taft, M. H., Manstein, D. J., Lieske, J., Oberthuer, D., Fischetti, R. F., and Chapman, H. N. (2017) Pink-beam serial crystallography. Nat. Commun. 8, 1281; doi: 10.1038/s41467-017-01417-3.

 

Zattelman, L., Regev, R., Ušaj, M., Reinke, P. Y. A., Giese, S., Samson, A. O., Taft, M. H., Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii: jbc.M117.794008. doi: 10.1074/jbc.M117.794008.

 

Behrens, V. A., Münnich, S., Adler-Gunzelmann, G., Thiel, C., Henn, A., Latham, S. L., and Taft, M. H. (2017) The Conserved Lysine-265 Allosterically Modulates Nucleotide- and Actin-binding Site Coupling in Myosin-2., Sci. Rep. 7, 7650; doi:10.1038/s41598-017-07933-y

 

Schuster-Gossler, K., Cordes, R., Müller, J., Geffers, I., Delany-Heiken, P., Taft, M. H., Preller, M., and Gossler, A. (2016) Context-dependent sensitivity to mutations disrupting the structural integrity of individual EGF repeats in the mouse Notch ligand DLL1., Genetics 202, 1119-33.

Hundt, N., Steffen, W., Pathan-Chhatbar, W., Taft, M. H., and Manstein, D. J. (2016) Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2., Sci. Rep. 6, 20554; doi: 10.1038/srep20554

Abbey, M., Hakim, C., Anand, R., Lafera, J., Schambach, A., Kispert, A., Taft, M. H., Kaever, V., Kotlyarov, A., Gaestel, M., and Menon, M. (2015) GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis., Sci. Rep. 6, 20007, doi:10.1038/srep20007

Münnich, S., Taft, M. H., and Manstein, D. J. (2014) Crystal Structure of Human Myosin 1c-The Motor in GLUT4 Exocytosis: Implications for Ca(2+) Regulation and 14-3-3 Binding., J. Mol. Biol. 426, 2070-81.

Radke, M. B.*, Taft, M. H.*, Stapel, B., Hilfiker-Kleiner, D., Preller, M., and Manstein, D. J. (2014) Small molecule-mediated refolding and activation of myosin motor function., eLife 3, e01603. *equal contribution

Taft, M. H.#, Behrmann, E., Munske-Weidemann, L.-C., Thiel, C., Raunser, S., and Manstein, D. J. (2013) Functional Characterization of Human Myosin-18A and Its Interaction with F-actin and GOLPH3., J. Biol. Chem. 288, 30029-41. #corresponding author

Müller, M., Diensthuber, R. P., Chizhov, I., Claus, P., Heissler, S. M., Preller, M., Taft, M. H., and Manstein, D. J. (2013) Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins., PLoS ONE 8, e70636.

Rump, A., Scholz, T., Thiel, C., Hartmann, F. K., Uta, P., Hinrichs, M. H., Taft, M. H., and Tsiavaliaris, G. (2011) Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division., J. Cell. Sci. 124, 2521-8.

Chinthalapudi, K., Taft, M. H., Martin, R., Heissler, S. M., Preller, M., Hartmann, F. K., Brandstaetter, H., Kendrick-Jones, J., Tsiavaliaris, G., Gutzeit, H. O., Fedorov, R., Buss, F., Knölker, H.-J., Coluccio, L. M., and Manstein, D. J. (2011) Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity., J. Biol. Chem. 286, 29700-8.

Diensthuber, R. P., Müller, M., Heissler, S. M., Taft, M. H., Chizhov, I., and Manstein, D. J. (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin., FEBS Lett. 585, 767-71.

Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F. K., Taft, M. H., Baruch, P., Brenner, B., Martin, R., Knölker, H.-J., Gutzeit, H. O., and Manstein, D. J. (2009) The mechanism of pentabromopseudilin inhibition of myosin motor activity., Nat. Struct. Mol. Biol. 16, 80-8.

Taft, M. H., Hartmann, F. K., Rump, A., Keller, H., Chizhov, I., Manstein, D. J., and Tsiavaliaris, G. (2008) Dictyostelium myosin-5b is a conditional processive motor., J. Biol. Chem. 283, 26902-10.

Sharissa L. Latham, Kristin Schwanke, Nadine Weiß, Claudia Thiel, Robert Zweigerdt, Dietmar J. Manstein and Manuel H. Taft (2019). Myosin-18b regulates sarcomeric myosin dynamics and actin thin filament organization during cardiac myofibril assembly. J Muscle Res Cell Motil 40, 233

 

Manuel H. Taft, Giulia Falorsi, Michael B. Radke, Salma Pathan-Chhatbar, Nikolas Hundt, Claudia Thiel, Mirco Müller, Vincenzo Lombardi, Dietmar J. Manstein (2016). Arachidonic Acid Directly Binds and Activates Beta-Cardiac Myosin in the Regulated Cardiac Actomyosin Complex. Biophys J 110, issue 3, 614a

 

Manuel H. Taft, Michael B. Radke, Michal Stanczak, Claudia Thiel, Dietmar J. Manstein (2014). Human Myosin-18B - A Versatile Actin Binding Protein. Biophys J 106, issue 2, 179a - 180a

 

Stefan Münnich, Manuel H. Taft, Salma Pathan-Chhatbar, Dietmar J. Manstein (2014). Structural Basis of Myosin 1C Ca2+ Regulation. Biophys J 106, issue 2, 179a – 180a

 

Salma Pathan-Chhatbar, Stefan Münnich, Nikolas Hundt, Manuel H. Taft, Dietmar Manstein (2014). Structural and Functional Characterization of Nonmuscle Myosin-2B in the Presence of Regulated Actin Filaments. Biophys J 106, issue 2, 179a - 180a

 

Ralph P. Diensthuber, Falk K. Hartmann, Daniela Kathmann, Katharina Stahl, Manuel H. Taft, Georgios Tsiavaliaris (2013). Mechanisms of Mechanochemical Coupling in Low and High Duty Ratio Myosins. Biophys J 104, Issue 2, 3a - 4a

 

Manuel H. Taft, Elmar Behrmann, Lena-Christin Weidemann, Stefan Raunser and Dietmar J. Manstein (2012). Functional Characterization of Human Myosin-18A and its Interaction Partners. Biophys J 102, Issue 3, 570a

 

Michael B. Radke, Manuel H. Taft, Matthias Preller, Sarah M. Heissler, Nicola Steinke and Dietmar J. Manstein (2012). EMD57033 Acts as a Pharmacological Chaperone Stabilizing and Activating Myosin Motor Activity. Biophys J 102, Issue 3, 354a

 

Manuel H. Taft, Falk K. Hartmann, Agrani Rump, Igor Chizhov, Dietmar J. Manstein and Georgios Tsiavaliaris (2008). The Conditional Processive Mechanism of Dictyostelium Myosin-5b Is Required for Contractile Vacuole Function. Mol Biol Cell 19 (suppl), 323/B267. (CD-ROM)

 

Manuel H. Taft, Heiko Keller, Setsuko Fujita-Becker, Dietmar J. Manstein and Georgios Tsiavaliaris (2006). Regulation of Myosin-V Motor Activity by free Magnesium-Ions. J Muscle Res Cell Mot 27, 489