BPC Media

Nucleotide-dependent assembly behaviour of purified dynamin A. Published in: Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002) The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes EMBO J. 21, 240-250.
Nucleotide-dependent changes in the diameter of the dynamin A ring complex. Published in: Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002) The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes EMBO J. 21, 240-250.
Averaged images of the top view and side view lead to the three-dimensional map of the nucleotide-free dynamin A ring complex. Published in: Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002) The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes EMBO J. 21, 240-250.
Model of the mechanochemical cycle of dynamin A. Published in: Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., & Manstein, D.J. (2002) The dynamin a ring complex: molecular organization and nucleotide-dependent conformational changes EMBO J. 21, 240-250.
Interaction of dynamin A with lipids. Published in: Wienke, D.C., Knetsch, M.L.W., Neuhaus, E.M., Reedy, M.C. & Manstein, D.J. (1999) Disruption of a dynamin homologue affects en­docytosis, organelle morphology and cytokinesis in Dictyostelium discoideum Mol. Biol. Cell 10, 225-243.
Dynamin 1. Published in: Reubold, T. F., Eschenburg, S., Becker, A., Leonard, M., Schmid, S. L., Vallee, R. B., Kull, F. J. and Manstein, D. J. (2005). Crystal structure of the GTPase domain of rat dynamin 1 Proc. Natl. Acad. Sci. U.S.A.102, 13093-13098
Dynamin 1. Published in: Reubold, T. F., Eschenburg, S., Becker, A., Leonard, M., Schmid, S. L., Vallee, R. B., Kull, F. J. and Manstein, D. J. (2005). Crystal structure of the GTPase domain of rat dynamin 1 Proc. Natl. Acad. Sci. U.S.A.102, 13093-13098
Structure of the dynamin-3 tetramer. Published in: Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noe, F., Haucke, V., Daumke, O., and Eschenburg, S. (2015) Crystal structure of the dynamin tetramer. Nature 525, 404, rdcu.be/mD09, doi: 10.1038/nature14880
Assembly of the stalks leads to a right-handed dynamin-3 helix. Published in: Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noe, F., Haucke, V., Daumke, O., and Eschenburg, S. (2015) Crystal structure of the dynamin tetramer. Nature 525, 404, rdcu.be/mD09, doi:10.1038/nature14880
Crystals of Myosin motor domain fused to the dynamin-1 GTPase domain
Mechanical models for myosin-based forwards and backwards movement. Published in: Tsiavaliaris, G., Fujita-Becker, S., and Manstein, D.J. (2004). Molecular engineering of a backwards moving myosin motor. Nature, 427, 558-561.
Model describing the modulation of NM-2A motor activity by Tpm4.2. Published in: Hundt, N., Steffen, W., Pathan-Chhatbar, S., Taft, M. H., and Manstein, D. J. (2016) Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2. Sci Rep 6, 20554, doi:10.1038/srep20554
NM-2A moves processively on F-actin. Published in: Hundt, N., Steffen, W., Pathan-Chhatbar, S., Taft, M. H., and Manstein, D. J. (2016) Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2. Sci Rep 6, 20554, doi:10.1038/srep20554
EMD 57033 Binding Pocket. Published in: Radke, M. B., M. H. Taft, B. Stapel, D. Hilfiker-Kleiner, M. Preller, and D. J. Manstein (2014) Small molecule-mediated Refolding and Activation of Myosin Motor Function eLife, doi: 10.7554/eLife.01603
Schematic illustration of NM-2 cellular functions in cell migration, secretion and receptor positioning. Published in: Heissler SM, Manstein DJ (2012) Functional characterization of the human myosin-7a motor domain. Cell Mol Life Sci., doi:10.1007/s00018-011-0749-8, rdcu.be/mD3m
Regulation of mammalian NM-2 enzymatic activity and assembly state. Published in: Heissler SM, Manstein DJ (2012) Functional characterization of the human myosin-7a motor domain. Cell Mol Life Sci., doi:10.1007/s00018-011-0749-8, rdcu.be/mD3m
Phylogenetic tree of the myosin-2 subfamily in humans. Published in: Heissler SM, Manstein DJ (2012) Functional characterization of the human myosin-7a motor domain. Cell Mol Life Sci., doi: 10.1007/s00018-011-0749-8, rdcu.be/mD3m
D. discoideum myosin heavy chain A null cells
Ribbon representation of the myosin-2 head fragment. Published in: Preller, M. and Manstein, D. J. (2017) Myosin Motors: Structural Aspects and Functionality. In Reference Module in Life Sciences, (Egelman, E. H., ed.) Elsevier, Amsterdam dx.doi.org/10.1016/B978-0-12-809633-8.08058-4
Topology map -Myosin Motor Helices A-to-T. Published in: Preller, M. and Manstein, D. J. (2017) Myosin Motors: Structural Aspects and Functionality. In Reference Module in Life Sciences, (Egelman, E. H., ed.) Elsevier, Amsterdam dx.doi.org/10.1016/B978-0-12-809633-8.08058-4
Myosin ATPase cycle. Published in: Preller, M. and Manstein, D. J. (2017) Myosin Motors: Structural Aspects and Functionality. In Reference Module in Life Sciences, (Egelman, E. H., ed.) Elsevier, Amsterdam dx.doi.org/10.1016/B978-0-12-809633-8.08058-4