March 17, 2025

Diseases manifest themselves both in the visible body and at the microscopic level in tissue. However, conventional histological methods only use two-dimensional tissue sections. The interdisciplinary QUADRANT project, a collaboration between Histomography GmbH, Hannover Medical School and the University of Göttingen, aims to develop non-destructive quantitative 3D analyses of larger tissue samples for (bio)medical research and diagnostics. To this end, questions from the fields of developmental biology, regenerative medicine, anatomy and pathology are answered using a 3D X-ray microscope specially developed for kerosene tissue blocks as well as morphometric quantification of tissue architecture using 3D image processing and artificial intelligence methods.