Local

ABC-HCC
A Phase IIIb, randomized, multicenter, open-label trial of Atezolizumab plus Bevacizumab versus trans arterial Chemoembolization (TACE) in intermediate-stage
HCC

Erstlinientherapie

ARTEMIDE
A Phase III, Randomised, Open-label, Sponsor-blinded, Multicentre Study of Rilvegostomig in Combination with Bevacizumab with or without Tremelimumab as First-line
Treatment in Patients with advanced Hepatocellular Carcinoma

Zweitlinientherapie

GDFATHER-HCC-01 (CTL-002-005)
A Phase 2b, Randomized, Blinded Trial Investigating the Efficacy and Safety of Visugromab in combination with Nivolumab and Lenvatinib compared to
Double Placebo and Lenvatinib in Participants with Unresectable or Metastatic Hepatocellular Carcinoma and Compensated Liver Function
(Child-Pugh A) after Failure of First-Line Treatment that Included an Anti-PD-(L)1 Compound (GDFATHER-HCC-01)

Erstlinientherapie

HLX-GC-301
A Randomized, Double-blinded, Multicenter, Phase Ⅲ Clinical Study of HLX22 (Recombinant Humanized Anti-HER2 Monoclonal Antibody Injection) in Combination with Trastuzumab and Chemotherapy (XELOX) versus Trastuzumab and Chemotherapy (XELOX) with or without Pembrolizumab for the First Line
Treatment of Locally Advanced or Metastatic Gastroesophageal Junction and Gastric Cancer

Adjuvant

FIRE-9 / PORT
Prospective, randomized, open-multicenter Phase III to investigate the efficacy of active post-resection/ablation therapy in patients with metastatic colorectal cancer, R0/R1 reseziert

Erstlinientherapie

MOUNTAINEER-03 (SGNTUC-029)
An open label Randomized Phase 3 Study of Tucatinib in Combination with Trastuzumab and mFOLFOX6 versus mFOLFOX6 given with or without either Cetuximab or Bevacizumab as First-Line Treatment for Subjects with HER2+ Metastatic Colorectal cancer

Zweitlinientherapie

QUINTIS (AIO-KRK-0324)
A Randomized Phase II Trial Evaluating Fruquintinib in Combination with Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR)
Metastatic Colorectal Cancer without Active Liver Metastases

Drittlinientherapie

PHP-CRC-201
An open-label randomized, Multi-Center Study to Evaluate the Efficacy and Safety of Induction Treatment with Melphalan/HDS.Followed by Consolidation
Treatment with Trifuridine-tipiracil plus Bevacizumab plus Bevacizumab versus Trifluridine-tipiracil plus Bevacizumab alone in Patients with refractory metastatic Colorectal Cancer with Liver dominat Disease

Lokal

Clean-Duct/ TRITICC-3
Phase IIa, prospective, single arm, open label, non-randomized, multi-center pilot study of durvalumab (MEDI4736) + intraductal radiofrequency ablation (ID-RFA) in extrahepatic cholangiocarcinoma

Acticca-2
Radiofrequency ablation via catheter and  transpapillary access  in patients with cholangiocarcinoma (ACTICCA-2 trial) . A randomized, open-label investigator-initiated trial