Local

IMMUWIN
A phase II study of immunotherapy with Durvalumab (MEDI4736) and Tremelimumab in combination with either Y-90
SIRT or TACE for intermediate stage HCC with pick-the-winner design

ABC-HCC
A Phase IIIb, randomized, multicenter, open-label trial of Atezolizumab plus Bevacizumab versus trans arterial Chemoembolization (TACE) in intermediate-stage
HCC

Erstlinientherapie

ARTEMIDE
A Phase III, Randomised, Open-label, Sponsor-blinded, Multicentre Study of Rilvegostomig in Combination with Bevacizumab with or without Tremelimumab as First-line
Treatment in Patients with advanced Hepatocellular Carcinoma

Zweitlinientherapie

GDFATHER-HCC-01 (CTL-002-005)
A Phase 2b, Randomized, Blinded Trial Investigating the Efficacy and Safety of Visugromab in combination with Nivolumab and Lenvatinib compared to
Double Placebo and Lenvatinib in Participants with Unresectable or Metastatic Hepatocellular Carcinoma and Compensated Liver Function
(Child-Pugh A) after Failure of First-Line Treatment that Included an Anti-PD-(L)1 Compound (GDFATHER-HCC-01)

Erstlinientherapie

HLX-GC-301
A Randomized, Double-blinded, Multicenter, Phase Ⅲ Clinical Study of HLX22 (Recombinant Humanized Anti-HER2 Monoclonal Antibody Injection) in Combination with Trastuzumab and Chemotherapy (XELOX) versus Trastuzumab and Chemotherapy (XELOX) with or without Pembrolizumab for the First Line
Treatment of Locally Advanced or Metastatic Gastroesophageal Junction and Gastric Cancer

LUCERNA (8951-CL-0305)
A Phase 3, Double-blind, Randomized Study of Zolbetuximab in Combination with Pembrolizumab and Chemotherapy (CAPOX or mFOLFOX6) in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma in Participants Whose Tumors are HER2-negative, Claudin (CLDN) 18.2-positive and Programmed Death-ligand 1 (PD-L1)-positive. A Study of Zolbetuximab together with Pembrolizumab and Chemotherapy in Adults with Gastric Cancer LUCERNA ISN/Protocol 8951-CL-0305.

Adjuvant

FIRE-9 / PORT
Prospective, randomized, open-multicenter Phase III to investigate the efficacy of active post-resection/ablation therapy in patients with metastatic colorectal cancer, R0/R1 reseziert

Erstlinientherapie

MOUNTAINEER-03 (SGNTUC-029)
An open label Randomized Phase 3 Study of Tucatinib in Combination with Trastuzumab and mFOLFOX6 versus mFOLFOX6 given with or without either Cetuximab or Bevacizumab as First-Line Treatment for Subjects with HER2+ Metastatic Colorectal cancer

Zweitlinientherapie

QUINTIS (AIO-KRK-0324)
A Randomized Phase II Trial Evaluating Fruquintinib in Combination with Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR)
Metastatic Colorectal Cancer without Active Liver Metastases

Drittlinientherapie

PHP-CRC-201
An open-label randomized, Multi-Center Study to Evaluate the Efficacy and Safety of Induction Treatment with Melphalan/HDS.Followed by Consolidation
Treatment with Trifuridine-tipiracil plus Bevacizumab plus Bevacizumab versus Trifluridine-tipiracil plus Bevacizumab alone in Patients with refractory metastatic Colorectal Cancer with Liver dominat Disease

Lokal

Clean-Duct/ TRITICC-3
Phase IIa, prospective, single arm, open label, non-randomized, multi-center pilot study of durvalumab (MEDI4736) + intraductal radiofrequency ablation (ID-RFA) in extrahepatic cholangiocarcinoma

Acticca-2
Radiofrequency ablation via catheter and  transpapillary access  in patients with cholangiocarcinoma (ACTICCA-2 trial) . A randomized, open-label investigator-initiated trial

Erstlinientherapie

S095031-210
A Phase 1b/2, Safety Lead-in and Dose-Expansion, Open label, Multicenter Trial Investigating the Safety, Tolerability, and Preliminary Activity of Ivosidenib in Combination with Durvalumab and Gemcitabine/Cisplatin as First-line Therapy in Participants with Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma with an IDH1 Mutation

JZP598-302
An open-label randomized trial of the efficacy and safety of Zanidatamab with standard-of-care therapy against standard-of-care therapy alone for advanced HER2-positive biliary tract cancer