Publications

Dirr L, Cleeves S, Ramón Roth I, Li L, Fiebig T, Ve T, Häussler S, Braun A, von Itzstein M, Führing JI (2024). Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase. mBio. 2024 Mar 12:e0211423. doi: 10.1128/mbio.02114-23. Online ahead of print. PMID: 38470050

Han X, D'Angelo C, Otamendi A, Cifuente JO, de Astigarraga E, Ochoa-Lizarralde B, Grininger M, Routier FH, Guerin ME, Fuehring J, Etxebeste O, Connell SR (2023). CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function. mBio. 2023 Aug 31;14(4):e0041423. doi: 10.1128/mbio.00414-23. Epub 2023 Jul 6. PMID: 37409813

Litschko C, Budde I, Berger M, Bethe A, Schulze J, Alcala Orozco EA, Mahour R, Goettig P, Führing JI, Rexer T, Gerardy-Schahn R, Schubert M, Fiebig T (2021). Mix-and-Match System for the Enzymatic Synthesis of Enantiopure Glycerol-3-Phosphate-Containing Capsule Polymer Backbones from Actinobacillus pleuropneumoniae, Neisseria meningitidis, and Bibersteinia trehalosi. mBio. 2021 Jun 29;12(3):e0089721. doi: 10.1128/mBio.00897-21. Epub 2021 May 26. PMID: 34076489

Budde I, Litschko C, Führing JI, Gerardy-Schahn R, Schubert M, Fiebig T (2020). An enzyme-based protocol for cell-free synthesis of nature-identical capsular oligosaccharides from Actinobacillus pleuropneumoniae serotype 1. J Biol Chem. 2020 Apr 24;295(17):5771-5784. doi: 10.1074/jbc.RA120.012961. Epub 2020 Mar 9. PMID: 32152227

Durrant C, Fuehring JI, Willemetz A, Chrétien D, Sala G, Ghidoni R, Katz A, Rötig A, Thelestam M, Ermonval M, Moore SEH (2020). Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium. Int J Mol Sci. 2020 Mar 16;21(6):2028. doi: 10.3390/ijms21062028. PMID: 32188137

Fiebig T, Cramer JT, Bethe A, Baruch P, Curth U, Führing JI, Buettner FFR, Vogel U, Schubert M, Fedorov R, Mühlenhoff M (2020). Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A, Nat Commun. 2020 Sep 18;11(1):4723. doi: 10.1038/s41467-020-18464-y

Prakash O, Fuehring J, Post J, Shepherd S, Eadsforth T, Gray D, Fedorov R, Routier F (2019). Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. Molecules. 2019 Mar 12;24(5):996. doi: 10.3390/molecules24050996. PMID: 30871023

Cramer JT, Führing JI, Baruch P, Brütting C, Knölker H-J, Gerardy-Schahn R, Fedorov R (2018). Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies. ACS Catal 8:2683–2692. doi: 10.1021/acscatal.7b03714

Führing JI*, Cramer JT*, Schneider J, Baruch P, Gerardy-Schahn R, Fedorov R (2015). A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism. Sci Rep. 2015 Apr 10;5:9618. doi: 10.1038/srep09618. PMID: 25860585 (* equally contributing authors)

Führing J, Cramer JT, Routier FH, Lamerz A-C, Baruch P, Gerardy-Schahn R, Fedorov R (2013). Catalytic Mechanism and Allosteric Regulation of UDP-Glucose Pyrophosphorylase from Leishmania major. ACS Catal 3:2976–2985. doi: 10.1021/cs4007777

Führing J, Damerow S, Fedorov R, Schneider J, Münster-Kühnel AK, Gerardy-Schahn R (2013). Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. Glycobiology. 2013 Apr;23(4):426-37. doi: 10.1093/glycob/cws217. Epub 2012 Dec 18. PMID: 23254995

Damerow S, Lamerz AC, Haselhorst T, Führing J, Zarnovican P, von Itzstein M, Routier FH (2010). Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage? J Biol Chem. 2010 Jan 8;285(2):878-87. doi: 10.1074/jbc.M109.067223. Epub 2009 Nov 11. PMID: 19906649