Veröffentlichungen 2022

Microvascular placental alterations in maternal COVID-19.

Ackermann M, Jonigk DD. Am J Obstet Gynecol. 2022 Jan;226(1):135-136. doi: 10.1016/j.ajog.2021.06.098. Epub 2021 Jul 3. PMID: 34228972 Free PMC article. No abstract available.

The Bronchial Circulation in COVID-19 Pneumonia.

Ackermann M, Tafforeau P, Wagner WL, Walsh CL, Werlein C, Kühnel MP, Länger FP, Disney C, Bodey AJ, Bellier A, Verleden SE, Lee PD, Mentzer SJ, Jonigk DD. Am J Respir Crit Care Med. 2022 Jan 1;205(1):121-125. doi: 10.1164/rccm.202103-0594IM. PMID: 34734553 Free PMC article. No abstract available.

Reply to Bush et al. and to Persson.

Ackermann M, Mentzer SJ, Jonigk DD. Am J Respir Crit Care Med. 2022 Jul 15;206(2):229-230. doi: 10.1164/rccm.202201-0122LE. PMID: 35533391 Free PMC article. No abstract available.

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling.

Ackermann M, Kamp JC, Werlein C, Walsh CL, Stark H, Prade V, Surabattula R, Wagner WL, Disney C, Bodey AJ, Illig T, Leeming DJ, Karsdal MA, Tzankov A, Boor P, Kühnel MP, Länger FP, Verleden SE, Kvasnicka HM, Kreipe HH, Haverich A, Black SM, Walch A, Tafforeau P, Lee PD, Hoeper MM, Welte T, Seeliger B, David S, Schuppan D, Mentzer SJ, Jonigk DD. EBioMedicine. 2022 Nov;85:104296. doi: 10.1016/j.ebiom.2022.104296. Epub 2022 Oct 4. PMID: 36206625 Free PMC article.

Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study.

Acs B, Leung SCY, Kidwell KM, Arun I, Augulis R, Badve SS, Bai Y, Bane AL, Bartlett JMS, Bayani J, Bigras G, Blank A, Buikema H, Chang MC, Dietz RL, Dodson A, Fineberg S, Focke CM, Gao D, Gown AM, Gutierrez C, Hartman J, Kos Z, Lænkholm AV, Laurinavicius A, Levenson RM, Mahboubi-Ardakani R, Mastropasqua MG, Nofech-Mozes S, Osborne CK, Penault-Llorca FM, Piper T, Quintayo MA, Rau TT, Reinhard S, Robertson S, Salgado R, Sugie T, van der Vegt B, Viale G, Zabaglo LA, Hayes DF, Dowsett M, Nielsen TO, Rimm DL; International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group (BIG-NABCG). Mod Pathol. 2022 Oct;35(10):1362-1369. doi: 10.1038/s41379-022-01104-9. Epub 2022 Jun 21. PMID: 35729220 Free PMC article.

Intra-abdominal EWSR1/FUS-CREM-rearranged malignant epithelioid neoplasms: two cases of an emerging aggressive entity with emphasis on misleading immunophenotype.

Agaimy A, Stoehr R, Otto M, Bräsen JH, Pfarr N, Konukiewitz B, Kasajima A, Hartmann A, Klöppel G. Virchows Arch. 2022 Feb;480(2):481-486. doi: 10.1007/s00428-021-03140-3. Epub 2021 Jul 6. PMID: 34228212 Free PMC article.

Interleukin-17A and interleukin-22 production by conventional and non-conventional lymphocytes in three different end-stage lung diseases.

Albrecht M, Halle O, Gaedcke S, Pallenberg ST, Camargo Neumann J, Witt M, Roediger J, Schumacher M, Jirmo AC, Warnecke G, Jonigk D, Braubach P, DeLuca D, Hansen G, Dittrich AM. Clin Transl Immunology. 2022 Jun 16;11(6):e1398. doi: 10.1002/cti2.1398. eCollection 2022. PMID: 35757569 Free PMC article.

AGO Recommendations for the Surgical Therapy of Breast Cancer: Update 2022.

Banys-Paluchowski M, Thill M, Kühn T, Ditsch N, Heil J, Wöckel A, Fallenberg E, Friedrich M, Kümmel S, Müller V, Janni W, Albert US, Bauerfeind I, Blohmer JU, Budach W, Dall P, Fasching P, Fehm T, Gluz O, Harbeck N, Huober J, Jackisch C, Kolberg-Liedtke C, Kreipe HH, Krug D, Loibl S, Lüftner D, Lux MP, Maass N, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Untch M, Witzel I, Gerber B. Geburtshilfe Frauenheilkd. 2022 Sep 30;82(10):1031-1043. doi: 10.1055/a-1904-6231. eCollection 2022 Oct. PMID: 36186147 Free PMC article.

Sustained response to bevacizumab in a patient with mosaic neurofibromatosis type 2 carrying the NF2:c.784C>T p.(Arg262*) variant.

Basenach E, Förster A, Raab P, Alzein S, Schmidt G, Krauss JK, Schlegelberger B, Heidenreich F, Auber B, Hartmann C, Wiese B, Weber RG. Clin Neuropathol. 2022 Jul-Aug;41(4):162-167. doi: 10.5414/NP301464. PMID: 35445657

Elevated fractional donor-derived cell-free DNA during subclinical graft injury after liver transplantation.

Baumann AK, Beck J, Kirchner T, Hartleben B, Schütz E, Oellerich M, Wedemeyer H, Jaeckel E, Taubert R. Liver Transpl. 2022 Dec;28(12):1911-1919. doi: 10.1002/lt.26479. Epub 2022 May 9. PMID: 35429207

COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis.

Becker S, Jonigk D, Luft A, Dübbel L, Werlein C, Malik E, Schild-Suhren M. J Reprod Immunol. 2022 Dec;154:103763. doi: 10.1016/j.jri.2022.103763. Epub 2022 Nov 9. PMID: 36399874 Free PMC article.

Complications and Disasters After Minimally Invasive Tissue Augmentation with Different Types of Fillers: A Retrospective Analysis.

Bingoel AS, Dastagir K, Neubert L, Obed D, Hofmann TR, Krezdorn N, Könneker S, Vogt PM, Mett TR. Aesthetic Plast Surg. 2022 Jun;46(3):1388-1397. doi: 10.1007/s00266-021-02691-9. Epub 2021 Dec 22. PMID: 34939150 Free PMC article.

Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice.

Bormann T, Maus R, Stolper J, Tort Tarrés M, Brandenberger C, Wedekind D, Jonigk D, Welte T, Gauldie J, Kolb M, Maus UA. Respir Res. 2022 Jul 8;23(1):180. doi: 10.1186/s12931-022-02105-7. PMID: 35804363 Free PMC article.

[Current insights on monitoring of renal transplants-Banff and beyond].

Bräsen JH. Pathologie (Heidelb). 2022 Aug;43(Suppl 1):134-136. doi: 10.1007/s00292-022-01148-3. Epub 2022 Nov 15. PMID: 36378289 Review. German.

CDH1 (E-cadherin) Gene Methylation in Human Breast Cancer: Critical Appraisal of a Long and Twisted Story.

Bücker L, Lehmann U. Cancers (Basel). 2022 Sep 8;14(18):4377. doi: 10.3390/cancers14184377. PMID: 36139537 Free PMC article. Review.

Evolution of severe (transfusion-dependent) anaemia in myelodysplastic syndromes with 5q deletion is characterized by a macrophage-associated failure of the eythropoietic niche.

Buesche G, Teoman H, Schneider RK, Ribezzo F, Ebert BL, Giagounidis A, Göhring G, Schlegelberger B, Bock O, Ganser A, Aul C, Germing U, Kreipe H. Br J Haematol. 2022 Jul;198(1):114-130. doi: 10.1111/bjh.18163. Epub 2022 Apr 1. PMID: 35362549

Functional characterization of a JAG1 5'UTR variant in a patient with clinically observed Alagille syndrome.

Buhl N, Pfister ED, Bohne J, Baumann U, Hartleben B, Schlegelberger B, Illig T, Skawran B, Stalke A. Clin Genet. 2022 Sep;102(3):248-250. doi: 10.1111/cge.14179. Epub 2022 Jun 27. PMID: 35761784 Free PMC article.

Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma.

Christgen M, Kandt LD, Antonopoulos W, Bartels S, Van Bockstal MR, Bredt M, Brito MJ, Christgen H, Colpaert C, Cserni B, Cserni G, Daemmrich ME, Danebrock R, Dedeurwaerdere F, van Deurzen CH, Erber R, Fathke C, Feist H, Fiche M, Gonzalez CA, Ter Hoeve ND, Kooreman L, Krech T, Kristiansen G, Kulka J, Laenger F, Lafos M, Lehmann U, Martin-Martinez MD, Mueller S, Pelz E, Raap M, Ravarino A, Reineke-Plaass T, Schaumann N, Schelfhout AM, De Schepper M, Schlue J, Van de Vijver K, Waelput W, Wellmann A, Graeser M, Gluz O, Kuemmel S, Nitz U, Harbeck N, Desmedt C, Floris G, Derksen PW, van Diest PJ, Vincent-Salomon A, Kreipe H. J Pathol Clin Res. 2022 Mar;8(2):191-205. doi: 10.1002/cjp2.253. Epub 2021 Dec 10. PMID: 34889530 Free PMC article.

Competitive fitness of Pseudomonas aeruginosa isolates in human and murine precision-cut lung slices.

Cramer N, Nawrot ML, Wege L, Dorda M, Sommer C, Danov O, Wronski S, Braun A, Jonigk D, Fischer S, Munder A, Tümmler B. Front Cell Infect Microbiol. 2022 Aug 23;12:992214. doi: 10.3389/fcimb.2022.992214. eCollection 2022. PMID: 36081773 Free PMC article.

Idiopathic Aneurysm of the Aortic Arch in an Infant.

Cvitkovic T, Petena E, Sarikouch S, Neubert L, Beerbaum P, Horke A, Bobylev D. Thorac Cardiovasc Surg Rep. 2022 Sep 19;11(1):e54-e57. doi: 10.1055/s-0042-1750426. eCollection 2022 Jan. PMID: 36134142 Free PMC article.

Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.

de Buhr N, Baumann T, Werlein C, Fingerhut L, Imker R, Meurer M, Götz F, Bronzlik P, Kühnel MP, Jonigk DD, Ernst J, Leotescu A, Gabriel MM, Worthmann H, Lichtinghagen R, Tiede A, von Köckritz-Blickwede M, Falk CS, Weissenborn K, Schuppner R, Grosse GM. Front Immunol. 2022 May 10;13:879157. doi: 10.3389/fimmu.2022.879157. eCollection 2022. PMID: 35619694 Free PMC article.

The impact of anthracyclines in intermediate and high-risk HER2-negative early breast cancer-a pooled analysis of the randomised clinical trials PlanB and SUCCESS C.

de Gregorio A, Janni W, Friedl TWP, Nitz U, Rack B, Schneeweiss A, Kates R, Fehm T, Kreipe H, Christgen M, Kümmel S, Trapp E, Wuerstlein R, Hartkopf A, Clemens M, Reimer T, Häberle L, Fasching PA, Gluz O, Harbeck N. Br J Cancer. 2022 Jun;126(12):1715-1724. doi: 10.1038/s41416-021-01690-6. Epub 2022 Feb 22. PMID: 35194193 Free PMC article.

The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution.

de Rooij LPMH, Becker LM, Teuwen LA, Boeckx B, Jansen S, Feys S, Verleden S, Liesenborghs L, Stalder AK, Libbrecht S, Van Buyten T, Philips G, Subramanian A, Dumas SJ, Meta E, Borri M, Sokol L, Dendooven A, Truong ACK, Gunst J, Van Mol P, Haslbauer JD, Rohlenova K, Menter T, Boudewijns R, Geldhof V, Vinckier S, Amersfoort J, Wuyts W, Van Raemdonck D, Jacobs W, Ceulemans LJ, Weynand B, Thienpont B, Lammens M, Kuehnel M, Eelen G, Dewerchin M, Schoonjans L, Jonigk D, van Dorpe J, Tzankov A, Wauters E, Mazzone M, Neyts J, Wauters J, Lambrechts D, Carmeliet P. Cardiovasc Res. 2022 Aug 23:cvac139. doi: 10.1093/cvr/cvac139. Online ahead of print. PMID: 35998078 Free PMC article.

Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer.

De Schepper M, Vincent-Salomon A, Christgen M, Van Baelen K, Richard F, Tsuda H, Kurozumi S, Brito MJ, Cserni G, Schnitt S, Larsimont D, Kulka J, Fernandez PL, Rodríguez-Martínez P, Olivar AA, Melendez C, Van Bockstal M, Kovacs A, Varga Z, Wesseling J, Bhargava R, Boström P, Franchet C, Zambuko B, Matute G, Mueller S, Berghian A, Rakha E, van Diest PJ, Oesterreich S, Derksen PWB, Floris G, Desmedt C. Mod Pathol. 2022 Dec;35(12):1812-1820. doi: 10.1038/s41379-022-01135-2. Epub 2022 Aug 3. PMID: 35922548 Free PMC article.

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2022.

Ditsch N, Wöcke A, Untch M, Jackisch C, Albert US, Banys-Paluchowski M, Bauerfeind I, Blohmer JU, Budach W, Dall P, Fallenberg EM, Fasching PA, Fehm TN, Friedrich M, Gerber B, Gluz O, Harbeck N, Heil J, Huober J, Kreipe HH, Krug D, Kühn T, Kümmel S, Kolberg-Liedtke C, Loibl S, Lüftner D, Lux MP, Maass N, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Witzel I, Müller V, Janni W, Thill M. Breast Care (Basel). 2022 Aug;17(4):403-420. doi: 10.1159/000524879. Epub 2022 May 5. PMID: 36156915 Free article. Review.

Pseudomonas aeruginosa Affects Airway Epithelial Response and Barrier Function During Rhinovirus Infection.

Endres A, Hügel C, Boland H, Hogardt M, Schubert R, Jonigk D, Braubach P, Rohde G, Bellinghausen C. Front Cell Infect Microbiol. 2022 Feb 21;12:846828. doi: 10.3389/fcimb.2022.846828. eCollection 2022. PMID: 35265536 Free PMC article.

IgG4-related hypertrophic pachymeningitis with tumor-like intracranial and intracerebral lesions.

Esmaeilzadeh M, Dadak M, Atallah O, Möhn N, Skripuletz T, Hartmann C, Banan R, Krauss JK. Acta Neurochir (Wien). 2022 Oct;164(10):2781-2787. doi: 10.1007/s00701-022-05340-5. Epub 2022 Aug 17. PMID: 35974231 Free PMC article.

Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany.

Frank C, Wickel J, Brämer D, Matschke J, Ibe R, Gazivoda C, Günther A, Hartmann C, Rehn K, Cadar D, Mayer TE, Pörtner K, Wilking H, Schmidt-Chanasit J, Tappe D. Emerg Microbes Infect. 2022 Dec;11(1):6-13. doi: 10.1080/22221751.2021.2007737. PMID: 34783638 Free PMC article.

Donor-transmitted extramedullary acute myeloid leukaemia after living donor kidney transplantation.

Ghandili S, Kluger MA, Leitner T, Grahammer F, Kirchner L, Modemann F, Achilles EG, Kreipe HH, Klein J, Steinemann D, Wolschke C, Fischer L, Bokemeyer C, Fiedler W, Huber TB, Alsdorf WH, Mahmud M. Br J Haematol. 2022 Jul;198(1):199-202. doi: 10.1111/bjh.18194. Epub 2022 Apr 15. PMID: 35428972 Free PMC article. No abstract available.

De-escalated Neoadjuvant Chemotherapy in Early Triple-Negative Breast Cancer (TNBC): Impact of Molecular Markers and Final Survival Analysis of the WSG-ADAPT-TN Trial.

Gluz O, Nitz U, Kolberg-Liedtke C, Prat A, Christgen M, Kuemmel S, Mohammadian MP, Gebauer D, Kates R, Paré L, Grischke EM, Forstbauer H, Braun M, Warm M, Hackmann J, Uleer C, Aktas B, Schumacher C, Wuerstlein R, Graeser M, Pelz E, Jóźwiak K, Zu Eulenburg C, Kreipe HH, Harbeck N; ADAPT TN investigators. Clin Cancer Res. 2022 Nov 14;28(22):4995-5003. doi: 10.1158/1078-0432.CCR-22-0482. PMID: 35797219

Amyloidogenicity assessment of transthyretin gene variants.

Grether NB, Napravnik F, Imhof T, Linke RP, Bräsen JH, Schmitz J, Dohrn M, Schneider C, Svačina MKR, Stetefeld J, Koch M, Lehmann HC. Ann Clin Transl Neurol. 2022 Aug;9(8):1252-1263. doi: 10.1002/acn3.51626. Epub 2022 Jul 29. PMID: 35903975 Free PMC article.

Circulating Cytokines and Growth Factors in Acute Cerebral Large Vessel Occlusion-Association with Success of Endovascular Treatment.

Grosse GM, Werlein C, Blume N, Abu-Fares O, Götz F, Gabriel MM, Ernst J, Leotescu A, Worthmann H, Kühnel MP, Jonigk DD, Falk CS, Weissenborn K, Schuppner R. Thromb Haemost. 2022 Apr;122(4):623-632. doi: 10.1055/a-1544-5431. Epub 2021 Aug 5. PMID: 34225367 Free PMC article.

ERBB2 mutation is associated with sustained tumor cell proliferation after short-term preoperative endocrine therapy in early lobular breast cancer.

Grote I, Bartels S, Christgen H, Radner M, Gronewold M, Kandt L, Raap M, Lehmann U, Gluz O, Graeser M, Kuemmel S, Nitz U, Harbeck N, Kreipe H, Christgen M. Mod Pathol. 2022 Dec;35(12):1804-1811. doi: 10.1038/s41379-022-01130-7. Epub 2022 Jul 16. PMID: 35842479 Free PMC article.

Pulmonary Arterial Hypertension and Consecutive Right Heart Failure Lead to Liver Fibrosis.

Hamberger F, Legchenko E, Chouvarine P, Mederacke YS, Taubert R, Meier M, Jonigk D, Hansmann G, Mederacke I. Front Cardiovasc Med. 2022 Mar 17;9:862330. doi: 10.3389/fcvm.2022.862330. eCollection 2022. PMID: 35369312 Free PMC article.

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC.

Hasselblatt M, Thomas C, Federico A, Bens S, Hellström M, Casar-Borota O, Kordes U, Neumann JE, Dottermusch M, Rodriguez FJ, Lo AC, Cheng S, Hendson G, Hukin J, Hartmann C, Koch A, Capper D, Siebert R, Paulus W, Nemes K, Johann PD, Frühwald MC, Kool M. Neuropathol Appl Neurobiol. 2022 Jun;48(4):e12797. doi: 10.1111/nan.12797. Epub 2022 Feb 18. PMID: 35152461

Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies.

Heinemann F, Gross P, Zeveleva S, Qian HS, Hill J, Höfer A, Jonigk D, Diehl AM, Abdelmalek M, Lenter MC, Pullen SS, Guarnieri P, Stierstorfer B. Sci Rep. 2022 Nov 10;12(1):19236. doi: 10.1038/s41598-022-23905-3. PMID: 36357500 Free PMC article.

Correction of heat-induced susceptibility changes in respiratory-triggered 2D-PRF-based thermometry for monitoring of magnetic resonance-guided hepatic microwave ablation in a human-like in vivo porcine model.

Hensen B, Hellms S, Werlein C, Jonigk D, Gronski PA, Bruesch I, Rumpel R, Wittauer EM, Vondran FWR, Parker DL, Wacker F, Gutberlet M. Int J Hyperthermia. 2022;39(1):1387-1396. doi: 10.1080/02656736.2022.2138987. PMID: 36336401 Free article.

Convolutional Neural Networks for the Evaluation of Chronic and Inflammatory Lesions in Kidney Transplant Biopsies.

Hermsen M, Ciompi F, Adefidipe A, Denic A, Dendooven A, Smith BH, van Midden D, Bräsen JH, Kers J, Stegall MD, Bándi P, Nguyen T, Swiderska-Chadaj Z, Smeets B, Hilbrands LB, van der Laak JAWM. Am J Pathol. 2022 Oct;192(10):1418-1432. doi: 10.1016/j.ajpath.2022.06.009. Epub 2022 Jul 16. PMID: 35843265 Free article.

Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis.

Hesse C, Beneke V, Konzok S, Diefenbach C, Bülow Sand JM, Rønnow SR, Karsdal MA, Jonigk D, Sewald K, Braun A, Leeming DJ, Wollin L. Respir Res. 2022 Aug 4;23(1):201. doi: 10.1186/s12931-022-02116-4. PMID: 35927669 Free PMC article.

Giant cell myocarditis after first dose of BNT162b2 - a case report.

Hirsch VG, Schallhorn S, Zwadlo C, Diekmann J, Länger F, Jonigk DD, Kempf T, Schultheiss HP, Bauersachs J. Eur J Heart Fail. 2022 Jul;24(7):1319-1322. doi: 10.1002/ejhf.2590. Epub 2022 Jul 11. PMID: 35733299 Free PMC article.

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

Hoang ON, Ermund A, Jaramillo AM, Fakih D, French CB, Flores JR, Karmouty-Quintana H, Magnusson JM, Fois G, Fauler M, Frick M, Braubach P, Hales JB, Kurten RC, Panettieri R, Vergara L, Ehre C, Adachi R, Tuvim MJ, Hansson GC, Dickey BF. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1081-1095. doi: 10.1164/rccm.202202-0309OC. PMID: 35776514

Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers.

Hochnadel I, Hoenicke L, Petriv N, Neubert L, Reinhard E, Hirsch T, Alfonso JCL, Suo H, Longerich T, Geffers R, Lichtinghagen R, Guzmán CA, Wedemeyer H, Lenzen H, Manns MP, Bruder D, Yevsa T. Oncogene. 2022 Apr;41(14):2039-2053. doi: 10.1038/s41388-022-02222-z. Epub 2022 Feb 16. PMID: 35173308 Free PMC article.

Correction: Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers.

Hochnadel I, Hoenicke L, Petriv N, Neubert L, Reinhard E, Hirsch T, Alfonso JCL, Suo H, Longerich T, Geffers R, Lichtinghagen R, Guzmán CA, Wedemeyer H, Lenzen H, Manns MP, Bruder D, Yevsa T. Oncogene. 2022 May;41(19):2787. doi: 10.1038/s41388-022-02261-6. PMID: 35418693 Free PMC article. No abstract available.

The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation.

Hoff U, Markmann D, Thurn-Valassina D, Nieminen-Kelhä M, Erlangga Z, Schmitz J, Bräsen JH, Budde K, Melk A, Hegner B. PLoS One. 2022 Apr 21;17(4):e0266319. doi: 10.1371/journal.pone.0266319. eCollection 2022. PMID: 35446876 Free PMC article.

Neutrophilic Pleuritis Is a Severe Complication of Klebsiella pneumoniae Pneumonia in Old Mice.

Hollwedel FD, Maus R, Stolper J, Jonigk D, Hildebrand CB, Welte T, Brandenberger C, Maus UA. J Immunol. 2022 Oct 19:ji2200413. doi: 10.4049/jimmunol.2200413. Online ahead of print. PMID: 36261170

Neutrophilic Pleuritis Is a Severe Complication of Klebsiella pneumoniae Pneumonia in Old Mice.

Hollwedel FD, Maus R, Stolper J, Jonigk D, Hildebrand CB, Welte T, Brandenberger C, Maus UA. J Immunol. 2022 Dec 1;209(11):2172-2180. doi: 10.4049/jimmunol.2200413. PMID: 36426980

Stereotactic biopsy of a brain lesion caused by hormographiella aspergillata.

Hounchonou FH, Runge J, Ganser A, Hartmann C, Raab P, Krauss JK. Surg Neurol Int. 2022 Dec 31;13:596. doi: 10.25259/SNI_576_2022. eCollection 2022. PMID: 36761261 Free PMC article.

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis.

Jaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, Lienenklaus S, Garrels W, Nazarenko I, Jonigk D, Wygrecka M, Klatt D, Schambach A, Kaminski N, Prasse A. Nat Commun. 2022 Sep 26;13(1):5637. doi: 10.1038/s41467-022-33193-0. PMID: 36163190 Free PMC article.

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, Barth P, Bohle RM, Büttner A, Büttner R, Dettmeyer R, Eichhorn P, Elezkurtaj S, Esposito I, Evert K, Evert M, Fend F, Gaßler N, Gattenlöhner S, Glatzel M, Göbel H, Gradhand E, Hansen T, Hartmann A, Heinemann A, Heppner FL, Hilsenbeck J, Horst D, Kamp JC, Mall G, Märkl B, Ondruschka B, Pablik J, Pfefferle S, Quaas A, Radbruch H, Röcken C, Rosenwald A, Roth W, Rudelius M, Schirmacher P, Slotta-Huspenina J, Smith K, Sommer L, Stock K, Ströbel P, Strobl S, Titze U, Weirich G, Weis J, Werner M, Wickenhauser C, Wiech T, Wild P, Welte T, von Stillfried S, Boor P. Virchows Arch. 2022 Aug;481(2):139-159. doi: 10.1007/s00428-022-03319-2. Epub 2022 Apr 1. PMID: 35364700 Free PMC article. Review.

Pulmonary and Systemic Pathology in COVID-19—Holistic Pathological Analyses.

Jonigk D, Werlein C, Lee PD, Kauczor HU, Länger F, Ackermann M. Dtsch Arztebl Int. 2022 Jun 24;119(25):429-435. doi: 10.3238/arztebl.m2022.0231. PMID: 35698804 Free PMC article. Review.

Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19.

Kamp JC, Neubert L, Ackermann M, Stark H, Werlein C, Fuge J, Haverich A, Tzankov A, Steinestel K, Friemann J, Boor P, Junker K, Hoeper MM, Welte T, Laenger F, Kuehnel MP, Jonigk DD. Int J Mol Sci. 2022 Jan 29;23(3):1583. doi: 10.3390/ijms23031583. PMID: 35163504 Free PMC article.

Comparative Analysis of Gene Expression in Fibroblastic Foci in Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis.

Kamp JC, Neubert L, Stark H, Hinrichs JB, Boekhoff C, Seidel AD, Ius F, Haverich A, Gottlieb J, Welte T, Braubach P, Laenger F, Hoeper MM, Kuehnel MP, Jonigk DD. Cells. 2022 Feb 14;11(4):664. doi: 10.3390/cells11040664. PMID: 35203313 Free PMC article.

A Morphomolecular Approach to Alveolar Capillary Dysplasia.

Kamp JC, Neubert L, Ackermann M, Stark H, Plucinski E, Shah HR, Janciauskiene S, Bergmann AK, Schmidt G, Welte T, Haverich A, Werlein C, Braubach P, Laenger F, Schwerk N, Olsson KM, Fuge J, Park DH, Schupp JC, Hoeper MM, Kuehnel MP, Jonigk DD. Am J Pathol. 2022 Aug;192(8):1110-1121. doi: 10.1016/j.ajpath.2022.05.004. Epub 2022 May 29. PMID: 35649494 Free article.

Combination of PI-RADS score and mRNA urine test-A novel scoring system for improved detection of prostate cancer.

Katzendorn O, von Klot CAJ, Mahjoub S, Faraj Tabrizi P, Harke NN, Tezval H, Hellms S, Hennenlotter J, Baig MS, Stenzl A, Seith F, Lafos M, Kuczyk MA, Rausch S, Peters I. PLoS One. 2022 Aug 12;17(8):e0271981. doi: 10.1371/journal.pone.0271981. eCollection 2022. PMID: 35960727 Free PMC article.

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.

Kemps PG, Picarsic J, Durham BH, Hélias-Rodzewicz Z, Hiemcke-Jiwa L, van den Bos C, van de Wetering MD, van Noesel CJM, van Laar JAM, Verdijk RM, Flucke UE, Hogendoorn PCW, Woei-A-Jin FJSH, Sciot R, Beilken A, Feuerhake F, Ebinger M, Möhle R, Fend F, Bornemann A, Wiegering V, Ernestus K, Méry T, Gryniewicz-Kwiatkowska O, Dembowska-Baginska B, Evseev DA, Potapenko V, Baykov VV, Gaspari S, Rossi S, Gessi M, Tamburrini G, Héritier S, Donadieu J, Bonneau-Lagacherie J, Lamaison C, Farnault L, Fraitag S, Jullié ML, Haroche J, Collin M, Allotey J, Madni M, Turner K, Picton S, Barbaro PM, Poulin A, Tam IS, El Demellawy D, Empringham B, Whitlock JA, Raghunathan A, Swanson AA, Suchi M, Brandt JM, Yaseen NR, Weinstein JL, Eldem I, Sisk BA, Sridhar V, Atkinson M, Massoth LR, Hornick JL, Alexandrescu S, Yeo KK, Petrova-Drus K, Peeke SZ, Muñoz-Arcos LS, Leino DG, Grier DD, Lorsbach R, Roy S, Kumar AR, Garg S, Tiwari N, Schafernak KT, Henry MM, van Halteren AGS, Abla O, Diamond EL, Emile JF. Blood. 2022 Jan 13;139(2):256-280. doi: 10.1182/blood.2021013338. PMID: 34727172 Free PMC article.

Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs.

Kerslake R, Randeva HS, Jonigk D, Werlein C, Robertus JL, Katopodis P, Jasker P, Spandidos DA, Kyrou I, Karteris E. Mol Med Rep. 2022 Apr;25(4):138. doi: 10.3892/mmr.2022.12654. Epub 2022 Feb 25. PMID: 35211765 Free PMC article.

Liver Transplantation After Organ Donation Due to Hydrogen Sulfide Intoxication: Report of the First Case.

Kettler B, Jaeckel E, Taubert R, Wedemeyer HH, Klempnauer J, Richter N, Neubert L, Vondran FWR. Transplantation. 2022 Apr 1;106(4):e247-e248. doi: 10.1097/TP.0000000000004018. PMID: 35333851 No abstract available.

Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo.

Khan P, Fytianos K, Blumer S, Roux J, Gazdhar A, Savic S, Knudsen L, Jonigk D, Kuehnel MP, Mykoniati S, Tamm M, Geiser T, Hostettler KE. Front Bioeng Biotechnol. 2022 Mar 8;10:844119. doi: 10.3389/fbioe.2022.844119. eCollection 2022. PMID: 35350187 Free PMC article.

Alveolar Basal Cells Differentiate towards Secretory Epithelial- and Aberrant Basaloid-like Cells In Vitro.

Khan P, Roux J, Blumer S, Knudsen L, Jonigk D, Kuehnel MP, Tamm M, Hostettler KE. Cells. 2022 Jun 2;11(11):1820. doi: 10.3390/cells11111820. PMID: 35681516 Free PMC article.

AA-amyloidosis in captive northern tree shrews (Tupaia belangeri).

Klein A, Radespiel U, Felmy F, Brezina T, Ciurkiewicz M, Schmitz J, Bräsen JH, Linke RP, Reinartz S, Distl O, Beineke A. Vet Pathol. 2022 Mar;59(2):340-347. doi: 10.1177/03009858211066847. Epub 2021 Dec 21. PMID: 34931557

[Obituary for Wolfgang Remmele : 16 May 1930-16 October 2021].

Klöppel G, Fisseler-Eckhoff A, Kreipe HH. Pathologie (Heidelb). 2022 Aug;43(Suppl 1):192-194. doi: 10.1007/s00292-022-01122-z. Epub 2022 Sep 26. PMID: 36156133 German. No abstract available.

PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.

Knoell J, Chillappagari S, Knudsen L, Korfei M, Dartsch R, Jonigk D, Kuehnel MP, Hoetzenecker K, Guenther A, Mahavadi P. Cell Mol Life Sci. 2022 Feb 25;79(3):151. doi: 10.1007/s00018-022-04189-2. PMID: 35212819 Free PMC article.

Impact of stromal tumor-infiltrating lymphocytes (sTILs) on response to neoadjuvant chemotherapy in triple-negative early breast cancer in the WSG-ADAPT TN trial.

Kolberg-Liedtke C, Feuerhake F, Garke M, Christgen M, Kates R, Grischke EM, Forstbauer H, Braun M, Warm M, Hackmann J, Uleer C, Aktas B, Schumacher C, Kuemmel S, Wuerstlein R, Graeser M, Nitz U, Kreipe H, Gluz O, Harbeck N. Breast Cancer Res. 2022 Sep 2;24(1):58. doi: 10.1186/s13058-022-01552-w. PMID: 36056374 Free PMC article. Clinical Trial.

Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury.

Kolbrink B, von Samson-Himmelstjerna FA, Messtorff ML, Riebeling T, Nische R, Schmitz J, Bräsen JH, Kunzendorf U, Krautwald S. Cell Mol Life Sci. 2022 Jun 28;79(7):387. doi: 10.1007/s00018-022-04416-w. PMID: 35763128 Free PMC article.

Preliminary application of native Nephila edulis spider silk and fibrin implant causes granulomatous foreign body reaction in vivo in rat's spinal cord.

Koop F, Strauß S, Peck CT, Aper T, Wilhelmi M, Hartmann C, Hegermann J, Schipke J, Vogt PM, Bucan V. PLoS One. 2022 Mar 14;17(3):e0264486. doi: 10.1371/journal.pone.0264486. eCollection 2022. PMID: 35286342 Free PMC article.

Differential Treatment Effects for Renal Transplant Recipients With DSA-Positive or DSA-Negative Antibody-Mediated Rejection.

Koslik MA, Friebus-Kardash J, Heinemann FM, Kribben A, Bräsen JH, Eisenberger U. Front Med (Lausanne). 2022 Jan 31;9:816555. doi: 10.3389/fmed.2022.816555. eCollection 2022. PMID: 35174191 Free PMC article.

[Drug-induced bone marrow changes].

Kreipe HH. Pathologie (Heidelb). 2022 Jul;43(4):256-262. doi: 10.1007/s00292-022-01082-4. Epub 2022 Jun 9. PMID: 35925223 Free PMC article. Review. German.

[Second opinions and reference pathology].

Kreipe HH. Pathologie (Heidelb). 2022 Aug;43(Suppl 1):71-73. doi: 10.1007/s00292-022-01145-6. Epub 2022 Oct 18. PMID: 36255445 Review. German.

[Second opinions and reference pathology in breast cancer].

Kreipe HH. Pathologie (Heidelb). 2022 Aug;43(Suppl 1):74-80. doi: 10.1007/s00292-022-01144-7. Epub 2022 Oct 21. PMID: 36269419 Review. German.

Clinical validity and clinical utility of Ki67 in early breast cancer.

Kreipe H, Harbeck N, Christgen M. Ther Adv Med Oncol. 2022 Sep 8;14:17588359221122725. doi: 10.1177/17588359221122725. eCollection 2022. PMID: 36105888 Free PMC article. Review.

Development and characterization of anti-fibrotic natural compound similars with improved effectivity.

Kreutzer FP, Meinecke A, Mitzka S, Hunkler HJ, Hobuß L, Abbas N, Geffers R, Weusthoff J, Xiao K, Jonigk DD, Fiedler J, Thum T. Basic Res Cardiol. 2022 Mar 2;117(1):9. doi: 10.1007/s00395-022-00919-6. PMID: 35235052 Free PMC article.

Interstitial lung disease in infancy and early childhood: a clinicopathological primer.

Laenger FP, Schwerk N, Dingemann J, Welte T, Auber B, Verleden S, Ackermann M, Mentzer SJ, Griese M, Jonigk D. Eur Respir Rev. 2022 Mar 9;31(163):210251. doi: 10.1183/16000617.0251-2021. Print 2022 Mar 31. PMID: 35264412 Free PMC article. Review.

Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection.

Lee AJ, Feng E, Chew MV, Balint E, Poznanski SM, Giles E, Zhang A, Marzok A, Revill SD, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath JJC, Ritchie TM, Jordana M, Jonigk DD, Ackermann M, Ask K, Miller M, Richards CD, Ashkar AA. PLoS Pathog. 2022 May 5;18(5):e1010471. doi: 10.1371/journal.ppat.1010471. eCollection 2022 May. PMID: 35512020 Free PMC article.

[The molecular pathology breviary: read depth and coverage in NGS analysis].

Lehmann U, Stenzinger A. Pathologe. 2022 Feb;43(1):65-66. doi: 10.1007/s00292-021-01009-5. Epub 2021 Oct 13. PMID: 34643752 German. No abstract available.

[The molecular pathological breviary: allele frequencies in NGS analysis].

Lehmann U, Stenzinger A. Pathologe. 2022 Mar;43(2):154-156. doi: 10.1007/s00292-021-01003-x. Epub 2021 Oct 13. PMID: 34643753 German. No abstract available.

[The molecular pathology breviary: what do hybrid capture, anchored multiplex PCR and amplicon-based mean?].

Lehmann U, Stenzinger A. Pathologe. 2022 May;43(3):229-230. doi: 10.1007/s00292-021-01036-2. Epub 2022 Jan 4. PMID: 34982211 German. No abstract available.

[The molecular pathology breviary: What do "WGS, WES, transcriptome, RNAseq" mean?].

Lehmann U, Stenzinger A. Pathologie (Heidelb). 2022 Jul;43(4):317-318. doi: 10.1007/s00292-022-01058-4. Epub 2022 Mar 8. PMID: 35258653 German. No abstract available.

[Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents - Tailored Diagnostic and Operative Concepts in Four Patients].

Madadi-Sanjani O, Zöller C, Beilken A, Pfister ED, Sander B, Ure B, Dingemann J. Klin Padiatr. 2022 Jul;234(4):228-235. doi: 10.1055/a-1733-2229. Epub 2022 Feb 21. PMID: 35189655 German.

Congenital deficiency reveals critical role of ISG15 in skin homeostasis.

Malik MNH, Waqas SF, Zeitvogel J, Cheng J, Geffers R, Gouda ZA, Elsaman AM, Radwan AR, Schefzyk M, Braubach P, Auber B, Olmer R, Müsken M, Roesner LM, Gerold G, Schuchardt S, Merkert S, Martin U, Meissner F, Werfel T, Pessler F. J Clin Invest. 2022 Feb 1;132(3):e141573. doi: 10.1172/JCI141573. PMID: 34847081 Free PMC article.

FDA-Approved Inhibitors of RTK/Raf Signaling Potently Impair Multiple Steps of In Vitro and Ex Vivo Influenza A Virus Infections.

Meineke R, Stelz S, Busch M, Werlein C, Kühnel M, Jonigk D, Rimmelzwaan GF, Elbahesh H. Viruses. 2022 Sep 16;14(9):2058. doi: 10.3390/v14092058. PMID: 36146864 Free PMC article.

Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19.

Mentzer SJ, Ackermann M, Jonigk D. Cold Spring Harb Perspect Med. 2022 Oct 3;12(10):a041157. doi: 10.1101/cshperspect.a041157. PMID: 35534210 Review.

Deep learning for fully-automated nuclear pleomorphism scoring in breast cancer.

Mercan C, Balkenhol M, Salgado R, Sherman M, Vielh P, Vreuls W, Polónia A, Horlings HM, Weichert W, Carter JM, Bult P, Christgen M, Denkert C, van de Vijver K, Bokhorst JM, van der Laak J, Ciompi F. NPJ Breast Cancer. 2022 Nov 8;8(1):120. doi: 10.1038/s41523-022-00488-w. PMID: 36347887 Free PMC article.

Hepatocellular Carcinoma Is a Natural Target for Adeno-Associated Virus (AAV) 2 Vectors.

Meumann N, Schmithals C, Elenschneider L, Hansen T, Balakrishnan A, Hu Q, Hook S, Schmitz J, Bräsen JH, Franke AC, Olarewaju O, Brandenberger C, Talbot SR, Fangmann J, Hacker UT, Odenthal M, Ott M, Piiper A, Büning H. Cancers (Basel). 2022 Jan 15;14(2):427. doi: 10.3390/cancers14020427. PMID: 35053588 Free PMC article.

B Cells Are Not Involved in the Regulation of Adenoviral TGF-β1- or Bleomycin-Induced Lung Fibrosis in Mice.

Moog MT, Hinze C, Bormann T, Aschenbrenner F, Knudsen L, DeLuca DS, Jonigk D, Neubert L, Welte T, Gauldie J, Kolb M, Maus UA. J Immunol. 2022 Mar 1;208(5):1259-1271. doi: 10.4049/jimmunol.2100767. Epub 2022 Feb 11. PMID: 35149532

Clinically latent and autopsy-verified inflammatory disorders and malignant tumours in transplant patients.

Mund E, Salem J, Kreipe HH, Hussein K. J Clin Pathol. 2022 Feb;75(2):112-116. doi: 10.1136/jclinpath-2020-207080. Epub 2020 Dec 28. PMID: 33372107

Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity.

Naasner L, Froese N, Hofmann W, Galuppo P, Werlein C, Shymotiuk I, Szaroszyk M, Erschow S, Amanakis G, Bähre H, Kühnel MP, Jonigk DD, Geffers R, Seifert R, Ricke-Hoch M, Wende AR, Blaner WS, Abel ED, Bauersachs J, Riehle C. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1352-H1364. doi: 10.1152/ajpheart.00514.2022. Epub 2022 Nov 18. PMID: 36399384

The Idiopathic Pulmonary Fibrosis-Associated Single Nucleotide Polymorphism RS35705950 Is Transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1).

Neatu R, Enekwa I, Thompson DJ, Schwalbe EC, Fois G, Abdelaal G, Veuger S, Frick M, Braubach P, Moschos SA. Noncoding RNA. 2022 Dec 8;8(6):83. doi: 10.3390/ncrna8060083. PMID: 36548182 Free PMC article.

Genomic architecture of FGFR2 fusions in cholangiocarcinoma and its implication for molecular testing.

Neumann O, Burn TC, Allgäuer M, Ball M, Kirchner M, Albrecht T, Volckmar AL, Beck S, Endris V, Goldschmid H, Lehmann U, Seker-Cin H, Uhrig S, Roessler S, Budczies J, Fröhling S, Longerich T, Wagner AH, Vogel A, Schirmacher P, Stenzinger A, Kazdal D. Br J Cancer. 2022 Nov;127(8):1540-1549. doi: 10.1038/s41416-022-01908-1. Epub 2022 Jul 23. PMID: 35871236 Free PMC article.

[Genes and pathways: FGFR2 translocations and gene fusion analysis].

Neumann O, Ball M, Lehmann U, Schirmacher P, Stenzinger A, Kazdal D. Pathologie (Heidelb). 2022 Sep;43(5):384-386. doi: 10.1007/s00292-022-01080-6. Epub 2022 Jul 4. PMID: 35925311 German. No abstract available.

[Erratum to: Genes and pathways: FGFR2 translocations and gene fusion analysis].

Neumann O, Ball M, Lehmann U, Schirmacher P, Stenzinger A, Kazdal D. Pathologie (Heidelb). 2022 Sep;43(5):387. doi: 10.1007/s00292-022-01091-3. PMID: 35925318 German. No abstract available.

Corrigendum to "De-escalation strategies in HER2-positive early breast cancer (EBC): final analysis of the WSG-ADAPT HER2+/HR- phase II trial: efficacy, safety, and predictive markers for 12weeks of neoadjuvant dual blockade with trastuzumab and pertuzumab ± weekly paclitaxel": [Annals of Oncology 28 (2017) 2768-2772].

Nitz UA, Gluz O, Christgen M, Grischke EM, Augustin D, Kuemmel S, Braun M, Potenberg J, Kohls A, Krauss K, Stefek A, Schumacher C, Forstbauer H, Reimer T, Fischer H, Liedtke C, Wuerstlein R, Schumacher J, Kates R, Kreipe H, Harbeck N; West-German Study Group (WSG)-ADAPT Investigators. Ann Oncol. 2022 Mar;33(3):355. doi: 10.1016/j.annonc.2021.12.008. Epub 2022 Jan 7. PMID: 35012798 No abstract available.

Endocrine Therapy Response and 21-Gene Expression Assay for Therapy Guidance in HR+/HER2- Early Breast Cancer.

Nitz UA, Gluz O, Kümmel S, Christgen M, Braun M, Aktas B, Lüdtke-Heckenkamp K, Forstbauer H, Grischke EM, Schumacher C, Darsow M, Krauss K, Nuding B, Thill M, Potenberg J, Uleer C, Warm M, Fischer HH, Malter W, Hauptmann M, Kates RE, Gräser M, Würstlein R, Shak S, Baehner F, Kreipe HH, Harbeck N. J Clin Oncol. 2022 Aug 10;40(23):2557-2567. doi: 10.1200/JCO.21.02759. Epub 2022 Apr 11. PMID: 35404683

De-escalated neoadjuvant pertuzumab plus trastuzumab therapy with or without weekly paclitaxel in HER2-positive, hormone receptor-negative, early breast cancer (WSG-ADAPT-HER2+/HR-): survival outcomes from a multicentre, open-label, randomised, phase 2 trial.

Nitz U, Gluz O, Graeser M, Christgen M, Kuemmel S, Grischke EM, Braun M, Augustin D, Potenberg J, Krauss K, Schumacher C, Forstbauer H, Reimer T, Stefek A, Fischer HH, Pelz E, Zu Eulenburg C, Kates R, Wuerstlein R, Kreipe HH, Harbeck N; WSG-ADAPT investigators. Lancet Oncol. 2022 May;23(5):625-635. doi: 10.1016/S1470-2045(22)00159-0. Epub 2022 Apr 8. PMID: 35405088 Clinical Trial.

Cigarette smoke alters inflammatory genes and the extracellular matrix - investigations on viable sections of peripheral human lungs.

Obernolte H, Niehof M, Braubach P, Fieguth HG, Jonigk D, Pfennig O, Tschernig T, Warnecke G, Braun A, Sewald K. Cell Tissue Res. 2022 Feb;387(2):249-260. doi: 10.1007/s00441-021-03553-1. Epub 2021 Nov 25. PMID: 34820703 Free PMC article.

Immune cell infiltration pattern in non-small cell lung cancer PDX models is a model immanent feature and correlates with a distinct molecular and phenotypic make-up.

Oswald E, Bug D, Grote A, Lashuk K, Bouteldja N, Lenhard D, Löhr A, Behnke A, Knauff V, Edinger A, Klingner K, Gaedicke S, Niedermann G, Merhof D, Feuerhake F, Schueler J. J Immunother Cancer. 2022 Apr;10(4):e004412. doi: 10.1136/jitc-2021-004412. PMID: 35483746 Free PMC article.

High Macrophage Densities in Native Kidney Biopsies Correlate With Renal Dysfunction and Promote ESRD.

Pfenning MB, Schmitz J, Scheffner I, Schulte K, Khalifa A, Tezval H, Weidemann A, Kulschewski A, Kunzendorf U, Dietrich S, Haller H, Kielstein JT, Gwinner W, Bräsen JH. Kidney Int Rep. 2022 Nov 29;8(2):341-356. doi: 10.1016/j.ekir.2022.11.015. eCollection 2023 Feb. PMID: 36815108 Free PMC article.

The Challenge of Long-Term Cultivation of Human Precision-Cut Lung Slices.

Preuß EB, Schubert S, Werlein C, Stark H, Braubach P, Höfer A, Plucinski EKJ, Shah HR, Geffers R, Sewald K, Braun A, Jonigk DD, Kühnel MP. Am J Pathol. 2022 Feb;192(2):239-253. doi: 10.1016/j.ajpath.2021.10.020. Epub 2021 Nov 10. PMID: 34767811 Free PMC article.

Differences in the MRI Signature and ADC Values of Diffuse Midline Gliomas with H3 K27M Mutation Compared to Midline Glioblastomas.

Raab P, Banan R, Akbarian A, Esmaeilzadeh M, Samii M, Samii A, Bertalanffy H, Lehmann U, Krauss JK, Lanfermann H, Hartmann C, Brüning R. Cancers (Basel). 2022 Mar 9;14(6):1397. doi: 10.3390/cancers14061397. PMID: 35326549 Free PMC article.

IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues.

Radtke AJ, Chu CJ, Yaniv Z, Yao L, Marr J, Beuschel RT, Ichise H, Gola A, Kabat J, Lowekamp B, Speranza E, Croteau J, Thakur N, Jonigk D, Davis JL, Hernandez JM, Germain RN. Nat Protoc. 2022 Feb;17(2):378-401. doi: 10.1038/s41596-021-00644-9. Epub 2022 Jan 12. PMID: 35022622 Review.

Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types.

Reinhardt A, Pfister K, Schrimpf D, Stichel D, Sahm F, Reuss DE, Capper D, Wefers AK, Ebrahimi A, Sill M, Felsberg J, Reifenberger G, Becker A, Prinz M, Staszewski O, Hartmann C, Schittenhelm J, Gramatzki D, Weller M, Olar A, Rushing EJ, Bergmann M, Farrell MA, Blümcke I, Coras R, Beckervordersandforth J, Kim SH, Rogerio F, Dimova PS, Niehusmann P, Unterberg A, Platten M, Pfister SM, Wick W, Herold-Mende C, von Deimling A. Neuropathol Appl Neurobiol. 2022 Dec;48(7):e12847. doi: 10.1111/nan.12847. Epub 2022 Sep 16. PMID: 35977725 Free article.

Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy.

Reinhard L, Machalitza M, Wiech T, Gröne HJ, Lassé M, Rinschen MM, Ferru N, Bräsen JH, Drömann F, Rob PM, Sethi S, Hoxha E, Stahl RAK. J Am Soc Nephrol. 2022 Oct;33(10):1823-1831. doi: 10.1681/ASN.2022050608. Epub 2022 Aug 19. PMID: 35985817

High phosphate-induced progressive proximal tubular injury is associated with the activation of Stat3/Kim-1 signaling pathway and macrophage recruitment.

Richter B, Kapanadze T, Weingärtner N, Walter S, Vogt I, Grund A, Schmitz J, Bräsen JH, Limbourg FP, Haffner D, Leifheit-Nestler M. FASEB J. 2022 Jul;36(7):e22407. doi: 10.1096/fj.202200167RR. PMID: 35713543

The Gene Expression Landscape of Prostate Cancer BM Reveals Close Interaction with the Bone Microenvironment.

Saraji A, Duan K, Watermann C, Hempel K, Roesch MC, Krupar R, Stegmann-Frehse J, Jonigk D, Kuehnel MP, Klapper W, Merseburger AS, Kirfel J, Perner S, Offermann A, Sailer V. Int J Mol Sci. 2022 Oct 27;23(21):13029. doi: 10.3390/ijms232113029. PMID: 36361816 Free PMC article.

Increased regional ventilation as early imaging marker for future disease progression of interstitial lung disease: a feasibility study.

Scharm SC, Schaefer-Prokop C, Willmann M, Vogel-Claussen J, Knudsen L, Jonigk D, Fuge J, Welte T, Wacker F, Prasse A, Shin HO. Eur Radiol. 2022 Sep;32(9):6046-6057. doi: 10.1007/s00330-022-08702-w. Epub 2022 Mar 31. PMID: 35357537 Free PMC article.

Renal medullary osmolytes NaCl and urea differentially modulate human tubular cell cytokine expression and monocyte recruitment.

Schmitz J, Brauns N, Hüsing AM, Flechsig M, Glomb T, Bräsen JH, Haller H, von Vietinghoff S. Eur J Immunol. 2022 Aug;52(8):1258-1272. doi: 10.1002/eji.202149723. Epub 2022 May 17. PMID: 35527392

Induction of pulmonary HLA-G expression by SARS-CoV-2 infection.

Seliger B, Jasinski-Bergner S, Massa C, Mueller A, Biehl K, Yang B, Bachmann M, Jonigk D, Eichhorn P, Hartmann A, Wickenhauser C, Bauer M. Cell Mol Life Sci. 2022 Nov 5;79(11):582. doi: 10.1007/s00018-022-04592-9. PMID: 36334153 Free PMC article.

Identification of a Novel Renal Metastasis Associated CpG-Based DNA Methylation Signature (RMAMS).

Serth J, Peters I, Katzendorn O, Dang TN, Moog J, Balli Z, Reese C, Hennenlotter J, Grote A, Lafos M, Tezval H, Kuczyk MA. Int J Mol Sci. 2022 Sep 23;23(19):11190. doi: 10.3390/ijms231911190. PMID: 36232491 Free PMC article.

Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context.

Setten E, Castagna A, Nava-Sedeño JM, Weber J, Carriero R, Reppas A, Volk V, Schmitz J, Gwinner W, Hatzikirou H, Feuerhake F, Locati M. Nat Commun. 2022 Oct 30;13(1):6499. doi: 10.1038/s41467-022-34241-5. PMID: 36310236 Free PMC article.

ScoMorphoFISH: A deep learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometry.

Siegerist F, Hay E, Dikou JS, Pollheimer M, Büscher A, Oh J, Ribback S, Zimmermann U, Bräsen JH, Lenoir O, Drenic V, Eller K, Tharaux PL, Endlich N. J Cell Mol Med. 2022 Jun;26(12):3513-3526. doi: 10.1111/jcmm.17392. Epub 2022 May 20. PMID: 35593050 Free PMC article.

CD20/CD79a/PAX5/CD3-negative post-transplant lymphoma with aberrant actin and desmin co-expression-a potential differential diagnostic pitfall between PTLD and PTSMT.

Suhren JT, Schlué J, Kreipe H, Hussein K. Ann Hematol. 2022 Apr;101(4):881-883. doi: 10.1007/s00277-021-04394-2. Epub 2022 Feb 18. PMID: 35179642 Free PMC article. No abstract available.

Oligosarcomas, IDH-mutant are distinct and aggressive.

Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE. Acta Neuropathol. 2022 Feb;143(2):263-281. doi: 10.1007/s00401-021-02395-z. Epub 2021 Dec 30. PMID: 34967922 Free PMC article.

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis.

Taubert R, Engel B, Diestelhorst J, Hupa-Breier KL, Behrendt P, Baerlecken NT, Sühs KW, Janik MK, Zachou K, Sebode M, Schramm C, Londoño MC, Habes S; UK-AIH Consortium; Oo YH, Lalanne C, Pape S, Schubert M, Hust M, Dübel S, Thevis M, Jonigk D, Beimdiek J, Buettner FFR, Drenth JPH, Muratori L, Adams DH, Dyson JK, Renand A, Graupera I, Lohse AW, Dalekos GN, Milkiewicz P, Stangel M, Maasoumy B, Witte T, Wedemeyer H, Manns MP, Jaeckel E. Hepatology. 2022 Jan;75(1):13-27. doi: 10.1002/hep.32134. Epub 2021 Dec 5. PMID: 34473365

Reduction of BMPR2 mRNA Expression in Peripheral Blood of Pulmonary Arterial Hypertension Patients: A Marker for Disease Severity?

Theobald V, Benjamin N, Seyfarth HJ, Halank M, Schneider MA, Richtmann S, Hinderhofer K, Xanthouli P, Egenlauf B, Seeger R, Hoeper MM, Jonigk D, Grünig E, Eichstaedt CA. Genes (Basel). 2022 Apr 26;13(5):759. doi: 10.3390/genes13050759. PMID: 35627145 Free PMC article.

AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2022.

Thill M, Lüftner D, Kolberg-Liedtke C, Albert US, Banys-Paluchowski M, Bauerfeind I, Blohmer JU, Budach W, Dall P, Fallenberg EM, Fasching PA, Fehm T, Friedrich M, Gerber B, Gluz O, Harbeck N, Heil J, Huober J, Jackisch C, Kreipe HH, Krug D, Kühn T, Kümmel S, Loibl S, Lux M, Maass N, Mundhenke C, Nitz U, Park-Simon TW, Reimer T, Rhiem K, Rody A, Schmidt M, Schneeweiss A, Schütz F, Sinn HP, Solbach C, Solomayer EF, Stickeler E, Thomssen C, Untch M, Witzel I, Wöckel A, Müller V, Janni W, Ditsch N. Breast Care (Basel). 2022 Aug;17(4):421-429. doi: 10.1159/000524789. Epub 2022 May 2. PMID: 36156913 Free article. Review.

Cutaneous thrombotic microangiopathy due to mixed cryoglobulinemia in a young woman.

Traidl S, Bräsen JH, Schefzyk M. J Dtsch Dermatol Ges. 2022 Jun;20(6):878-880. doi: 10.1111/ddg.14772. Epub 2022 Apr 29. PMID: 35486029 No abstract available.

Kutane thrombotische Mikroangiopathie bei gemischter Kryoglobulinämie bei einer jungen Frau.

Traidl S, Bräsen JH, Schefzyk M. J Dtsch Dermatol Ges. 2022 Jun;20(6):877-879. doi: 10.1111/ddg.14772_g. PMID: 35711052 No abstract available.

CycleGAN for virtual stain transfer: Is seeing really believing?

Vasiljević J, Nisar Z, Feuerhake F, Wemmert C, Lampert T. Artif Intell Med. 2022 Nov;133:102420. doi: 10.1016/j.artmed.2022.102420. Epub 2022 Oct 7. PMID: 36328671

From Macroscopy to Ultrastructure: An Integrative Approach to Pulmonary Pathology.

Verleden SE, Braubach P, Werlein C, Plucinski E, Kuhnel MP, Snoeckx A, El Addouli H, Welte T, Haverich A, Laenger FP, Dettmer S, Pauwels P, Verplancke V, Van Schil PE, Lapperre T, Kwakkel-Van-Erp JM, Ackermann M, Hendriks JMH, Jonigk D. Front Med (Lausanne). 2022 Mar 16;9:859337. doi: 10.3389/fmed.2022.859337. eCollection 2022. PMID: 35372395 Free PMC article.

Radiologic and Histologic Correlates of Early Interstitial Lung Changes in Explanted Lungs.

Verleden SE, Vanstapel A, Jacob J, Goos T, Hendriks J, Ceulemans LJ, Van Raemdonck DE, De Sadeleer L, Vos R, Kwakkel-van Erp JM, Neyrinck AP, Verleden GM, Boone MN, Janssens W, Wauters E, Weynand B, Jonigk DD, Verschakelen J, Wuyts WA. Radiology. 2022 Dec 20:221145. doi: 10.1148/radiol.221145. Online ahead of print. PMID: 36537894

Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis.

Verstockt B, Volk V, Jaeckel C, Alsoud D, Sabino J, Nikolaus S, Outtier A, Krönke N, Feuerhake F, De Hertogh G, Rosenstiel P, Vermeire S, Schreiber S, Ferrante M, Aden K. Aliment Pharmacol Ther. 2022 Jul;56(2):282-291. doi: 10.1111/apt.16955. Epub 2022 Apr 28. PMID: 35484689

Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report.

von Stillfried S, Bülow RD, Röhrig R, Meybohm P, Boor P; German Registry of COVID-19 Autopsies (DeRegCOVID), DeRegCOVID Collaborators#. Crit Care. 2022 Mar 28;26(1):83. doi: 10.1186/s13054-022-03945-x. PMID: 35346314 Free PMC article.

First report from the German COVID-19 autopsy registry.

von Stillfried S, Bülow RD, Röhrig R, Boor P; German Registry of COVID-19 Autopsies (DeRegCOVID), DeRegCOVID Collaborators. Lancet Reg Health Eur. 2022 Feb 18;15:100330. doi: 10.1016/j.lanepe.2022.100330. eCollection 2022 Apr. PMID: 35531493 Free PMC article.

[Update on collaborative autopsy-based research in German pathology, neuropathology, and forensic medicine].

von Stillfried S, Freeborn B, Windeck S, Boor P; DeRegCOVID und NATON. Pathologie (Heidelb). 2022 Aug;43(Suppl 1):101-105. doi: 10.1007/s00292-022-01117-w. Epub 2022 Sep 16. PMID: 36114379 Free PMC article. Review. German.

Phenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases.

Wan R, Fänder J, Zakaraia I, Lee-Kirsch MA, Wolf C, Lucas N, Olfe LI, Hendrich C, Jonigk D, Holzinger D, Steindor M, Schmidt G, Davenport C, Klemann C, Schwerk N, Griese M, Schlegelberger B, Stehling F, Happle C, Auber B, Steinemann D, Wetzke M, von Hardenberg S. Front Immunol. 2022 Oct 6;13:1029423. doi: 10.3389/fimmu.2022.1029423. eCollection 2022. PMID: 36275728 Free PMC article.

Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses.

Weil T, Kirupakaran A, Le MH, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Müller JA, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Pålsson SA, Uhlig N, Eberlein V, Wöll H, Klärner FG, Stenger S, Kümmerer BM, Streeck H, Fois G, Frick M, Braubach P, Spetz AL, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Münch J. JACS Au. 2022 Sep 6;2(9):2187-2202. doi: 10.1021/jacsau.2c00220. eCollection 2022 Sep 26. PMID: 36186568 Free PMC article.

Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience.

Welland S, deCastro T, Bathon M, Wirth TC, Reineke-Plaaß T, Saborowski M, Lehmann U, Saborowski A, Vogel A. J Cancer Res Clin Oncol. 2022 Aug;148(8):2137-2144. doi: 10.1007/s00432-021-03774-5. Epub 2021 Aug 26. PMID: 34436668 Free PMC article.

Inflammation and vascular remodeling in COVID-19 hearts.

Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ, Boor P, Black SM, Länger F, Kuehnel M, Jonigk D. Angiogenesis. 2022 Nov 12:1-16. doi: 10.1007/s10456-022-09860-7. Online ahead of print. PMID: 36371548 Free PMC article.

Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance.

Yaseen I, White SA, Torres-Garcia S, Spanos C, Lafos M, Gaberdiel E, Yeboah R, El Karoui M, Rappsilber J, Pidoux AL, Allshire RC. Nat Struct Mol Biol. 2022 Aug;29(8):745-758. doi: 10.1038/s41594-022-00801-y. Epub 2022 Jul 25. PMID: 35879419 Free PMC article.

A multiscale X-ray phase-contrast tomography dataset of a whole human left lung.

Xian RP, Walsh CL, Verleden SE, Wagner WL, Bellier A, Marussi S, Ackermann M, Jonigk DD, Jacob J, Lee PD, Tafforeau P. Sci Data. 2022 Jun 2;9(1):264. doi: 10.1038/s41597-022-01353-y. PMID: 35654864 Free PMC article.