Publications
Since 2007, when it started under the umbrella of REBIRTH xPa supported 38 research projects from 21 different working groups and departments of the Hannover Medical School. Out of these cooperation 24 publications were generated.
1. Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES, Martin U. Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium. Stem Cell Res. 2010 Jul;5(1):51-64.
2. Bisdas T, Bredt M, Pichlmaier M, Aper T, Wilhelmi M, Bisdas S, Haverich A, Teebken OE:Eight-year experience with cryopreserved arterial homografts for the in situ reconstruction of abdominal aortic infections. J Vasc Surg. 2010; 52(2):323-30
3. Christgen M, Geffers R, Ballmaier M, Christgen H, Poczkaj J, Krech T, Kreipe H, Lehmann U: Down-regulation of the fetal stem cell factor SOX17 by H33342: a mechanism responsible for differential gene expression in breast cancer side population cells. J Biol Chem. 2010; 285(9):6412-8
4. Poehnert D, Broecker V, Mengel M, Nashan B, Koch M: Induction of chronic renal allograft dysfunction in a rat model with complete and exclusive MHC incompatibility. Transpl Immunol. 2010; 22(3-4):137-43.
5. Wicke DC, Meyer J, Buesche G, Heckl D, Kreipe H, Li Z, Welte KH, Ballmaier M, Baum C, Modlich U:Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia. Mol Ther. 2010; 18(2):343-52
6. Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest. 2009 Mar;119(3):540-50.
7. Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Schöler HR, Martin U. Generation of induced pluripotent stem cells from human cord blood.Cell Stem Cell. 2009 Oct 2;5(4):434-41.
8. Fischer K, Wolenski M, Manns MP, Jaeckel E. A new animal model of chronic autoimmune hepatitis mediated by the adaptive immune system. Paper presented at: 2008 EASL Monothematic Conference: Immune Mediated Liver Injury; Hamburg, Dec. 4-6, 2008
9. Warnecke G, Hutchinson JA, Riquelme P, Kruse B, Thissen S, Avsar M, Zehle G, Steinkamp T, Peters C, Baumann R, Gövert F, Ungefroren H, Länger F, Simon AR, Karstens JH, Kaever V, Haverich A, Fändrich F, Strüber M. Postoperative intravenous infusion of donor-derived transplant acceptance-inducing cells as an adjunct immunosuppressive therapy in a porcine pulmonary allograft model. Transpl Int. 2009 Mar;22(3):332-41. Epub 2008 Oct 21
10. Kruse B, Thissen S, Warnecke G, Avsar M, Gottlieb J, Hohlfeld JM, Karstens JH, Kaever V, Länger F, Pabst B, Ungefroren H, Haverich A, Strüber M. Correlation of donor leukocyte chimerism with pulmonary allograft survival after immunosuppressive drug withdrawal in a porcine model. Transplantation. 2009 May 27;87(10):1468-77.
11. Wiegmann B, Zardo P, Dickgreber N, Länger F, Fegbeutel C, Haverich A, Fischer S. Biological materials in chest wall reconstruction: initial experience with the Peri-Guard Repair Patch((R)). Eur J Cardiothorac Surg. 2010 Mar;37(3):602-5.
12. Schmitt R, Jacobi C, Susnik N, Broecker V, Haller H, Melk A. Ageing mouse kidney--not always the SAME old story. Nephrol Dial Transplant. 2009 Oct;24(10):3002-5.
13. Huber TB, Hartleben B, Winkelmann K, Schneider L, Becker JU, Leitges M, Walz G, Haller H, Schiffer M. Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol. 2009 Apr;20(4):798-806. Epub 2009 Mar 11.
14. Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar B, Sauer M. Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft versus leukemia effects across MHC barriers in full chimeras. Blood. 2009 Apr 30;113(18):4440-8. Epub 2009 Jan 30.2009
15. Kocks JR, Adler H, Danzer H, Hoffmann K, Jonigk D, Lehmann U, Förster R. Chemokine receptor CCR7 contributes to a rapid and efficient clearance of lytic murine gamma-herpes virus 68 from the lung, whereas bronchus-associated lymphoid tissue harbors virus during latency. J Immunol. 2009 Jun 1;182(11):6861-9.
16. Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JS, Hoeper MM, Wollert KC. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2008 Sep 1;178(5):534-41. Epub 2008 Jun 19.
17. Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar B, Sauer M. Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft versus leukemia effects across MHC barriers in full chimeras. Blood. 2009 Apr 30;113(18):4440-8. Epub 2009 Jan 30.2009
18. 13. Kocks JR, Adler H, Danzer H, Hoffmann K, Jonigk D, Lehmann U, Förster R. Chemokine receptor CCR7 contributes to a rapid and efficient clearance of lytic murine gamma-herpes virus 68 from the lung, whereas bronchus-associated lymphoid tissue harbors virus during latency. J Immunol. 2009 Jun 1;182(11):6861-9
19. Hesse E, Kluge G, Atfi A, Correa D, Haasper C, Berding G, Shin HO, Viering J, Länger F, Vogt PM, Krettek C, Jagodzinski M. Repair of a segmental long bone defect in human by implantation of a novel multiple disc graft. Bone. 2010 Feb 12. [Epub ahead of print]
20. Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JS, Hoeper MM, Wollert KC. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2008 Sep 1;178(5):534-41. Epub 2008 Jun 19.
21. Winter C, Taut K, Srivastava M, Länger F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, Maus UA Lung-specific overexpression of CCL2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol, 2007 178: 5828-5838
22. Winter C, Taut K, Länger F, Mack M, Briles DE, Paton JC, Maus R, Srivastava M, Welte T, Maus UA FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: role of dendritic cells. J Immunol. 2007 179:3099-108
23. Mrigank Srivastava, Kathrin Steinwede, Riku Kiviranta, Jukka Morko, Heinz G Hoymann, Florian Laenger, Frank Buehling, Tobias Welte, Ulrich A Maus. Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis. Respiratory Research 2008, 9:54
24. Schreiber O, Steinwede K, Ding N, Srivastava M, Maus R, Länger F, Prokein J, Ehlers S, Welte T, Gunn MD, Maus UA. Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin. J Infect Dis 2008 198(7):1044-1054
25. Winter C, Herbold W, Maus R, Länger F, Briles DE, Paton JC, Welte T, Maus UA. Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J Immunol. 2009 Apr 15;182(8):4931-7.
26. Nolff MC, Kokemueller H, Hauschild G, Fehr M, Bormann KH, Spalthoff S, Rohn K, Ruecker M, Gellrich NC. J Craniomaxillofac Surg. 2010 Jan;38(1):38-46. Epub 2009 Aug 22. Comparison of computed tomography and microradiography for graft evaluation after reconstruction of critical size bone defects using beta-tricalcium phosphate.
27. Kokemueller H, Spalthoff S, Nolff M, Tavassol F, Essig H, Stuehmer C, Bormann KH, Rücker M, Gellrich NC. Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction: experimental pilot study in sheep and first clinical application. Int J Oral Maxillofac Surg. 2010 Feb 16. [Epub ahead of print]
28. Zhao F, Vermeer B, Lehmann U, Kreipe H, Manns MP, Korangy F, Greten TF. Identification of a novel murine pancreatic tumour antigen, which elicits antibody responses in patients with pancreatic carcinoma. Immunology. 2009 Sep;128(1):134-40
29. Wicke DC, Heckl D, Wintterle S, Buesche G, Meyer J, Kreipe H, Welte KH, Ballmaier M, Baum C, Modlich U. Ectopic expression of the extracellular domain of Mpl is sufficient to induce a hematopoietic population crisis. Submitted
30. Heckl D, Wicke DC, Schambach A, Büsche G, Meyer J, Kreipe H, Ballmaier M, Baum C, Modlich U. Correction of Mpl deficiency by lentiviral vectors with lineage-specific expression. Submitted
31. Heckl D, Wicke DC, Meyer J, Büsche G, Meyer J, Kreipe H, Baum C, Modlich U. Jak/Stat signal transduction and Ras activation are both essential for Mpl induced leukemogenicity. Submitted
32. Lenarz M, Lim HH, Lenarz T, Reich U, Marquardt N, Klingberg MN, Paasche G, Reuter G, Stan AC. Auditory midbrain implant: histomorphologic effects of long-term implantation and electric stimulation of a new deep brain stimulation array. Eur Arch Otorhinolaryngol. 2007 May;264(5):569-71