Allergie und Toleranz

Publikationen

Highlights

B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammationC. Happle, A. C. Jirmo, A. Meyer-Bahlburg, A. Habener, H. G. Hoymann, C. Hennig, J. Skuljec, G. Hansen. J Allergy Clin Immunol. 2018. 141: 685-696. IF: 10.2

Pulmonary Transplantation of human induced pluripotent stem cell derived macrophages ameliorates pulmonary alveolar proteinosis. C. Happle, N. Lachmann, M. Ackermann, A. Mirenska, G. Göhring, K. Thomay, A. Mucci, M. Hetzel, T. Glomb, T. Suzuki, C. Chalk, S. Glage, O. Dittrich-Breiholz, B. Trapnell, T. Moritz, G. Hansen. Am J Respir Crit Care Med. 2018. 198: 350-360. IF: 17.4

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosisC. Happle, N. Lachmann, J. Škuljec, M. Wetzke, M. Ackermann, S. Brennig, A. Mucci, A. C. Jirmo, S. Groos, A. Mirenska, C. Hennig, T. Rodt, J. P. Bankstahl, N. Schwerk, T. Moritz, G. Hansen.  Science Transl Med. 2014. 6(250):250ra113. IF:16.3

Basophils from humans with systemic lupus erythematosus do not express MHC-II. D. Dijkstra, C. Hennig, T. Witte, G. Hansen.  Nature Medicine. 2012. 18:488-489; IF: 36.1

Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. T. Polte, C. Hennig, G. Hansen.  J Allergy Clin Immunol. 2008. 122:1022-1030
IF: 10.2

 

Asthma und Allergie

The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study. O. Fuchs, T. Bahmer, M. Weckmann, A.-M. Dittrich, B. Schaub, B. Rösler, C. Happle, F. Brinkmann, I. Ricklefs, I. R König, H. Watz, K. F. Rabe, M. V Kopp, G. Hansen, E. von Mutius,ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)  [published correction appears in BMC Pulm Med. 2018 Nov 7;18(1):165]. BMC Pulm Med. 2018;18(1):140. Published 2018 Aug 20. doi:10.1186/s12890-018-0705-6

IL-17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma. A. Chari Jirmo, M. Busse, C. Happle, J. Skuljec, K. Dalüge, A. Habener, R. Grychtol, D. S. DeLuca, O. D. Breiholz, I. Prinz, G. Hansen. IL-17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma. Eur J Immunol. 2020 Mar 6.

IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod). A. Chari Jirmo, K. Daluege, C. Happle, M. Albrecht, A.-M. Dittrich, M. Busse, A. Habener, J. Skuljec, G. Hansen. J Immunol. 2016 Dec 1;197(11):4219-4227

Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model. T. Polte, L. Fuchs, A.-K. Behrendt, G. Hansen.  Eur J Immunol. 2009 Jul;39(7):1736-42

CD137-mediated immunotherapy for allergic asthma. T. Polte, J. Foell, C. Werner, H.-G.erd Hoymann, A. Braun, S. Burdach, R. S. Mittler, G. Hansen. Version 2. J Clin Invest. 2006 Apr;116(4):1025-36

Identification and quantification of basophils in the airways of asthmatics following segmental allergen challenge. D. Dijkstra, C. Hennig, G. Hansen, H. Biller, N. Krug, J. M. Hohlfeld. Cytometry A. 2014 Jul;85(7):580-7

Absence of Regulatory T Cells Causes Phenotypic and Functional Switch in Murine Peritoneal Macrophages. J. Skuljec, A. Chari Jirmo, A. Habener, S. R. Talbot, R. Pul, R. Grychtol, M. Aydin, C. Kleinschnitz, C. Happle, G. Hansen. Front Immunol. 2018 Oct 31;9:2458

B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. A. Habener, A.-K. Behrendt, J. Skuljec, A. Chari Jirmo, A. Meyer-Bahlburg , G. Hansen. Eur J Immunol. 2017 Mar;47(3):552-562

ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance. M. Busse, M. Krech, A. Meyer-Bahlburg, C. Hennig, G. Hansen.  J Immunol. 2012

CD27 costimulation is not critical for the development of asthma and respiratory tolerance in a murine model. A.-K. Behrendt, G. Hansen. Immunol Lett. 2010

 

Respiratorische Infektionen

PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents. M. Wetzke, M. Volkmar Kopp, J. Seidenberg, C. Vogelberg, T. Ankermann, C. Happle, G. Voigt, H. Köster, T. Illig, C. Lex, A. Schuster, M. Panning, G. Barten, G. Rohde, T. Welte, G. Hansen, pedCAPNETZ Study Group. BMC Pulmonary Medicine. 2019

Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease. C. Baier, S. Haid, A. Beilken, A. Behnert, M. Wetzke, R.J. P. Brown, C. Schmitt, E. Ebadi, G. Hansen, T. F. Schulz, T. Pietschmann, F.-C. Bange Antimicrob Resist Infect Control. 2018;7:21. Published 2018

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry. S. Blockus, S. M. Sake, M. Wetzke, C. Grethe, T. Graalmann, M. Pils, R. Le Goffic, M. Galloux, H. Prochnow, K. Rox, S. Hüttel, Z. Rupcic, B. Wiegmann, R. Dijkman, M.-A. Rameix-Welti, J.-F. Eléouët, W. P.aul Duprex, V. Thiel, G. Hansen, M. Brönstrup, S. Haid, T. Pietschmann. Antiviral Res. 2020

 

Seltene Lungenerkrankungen

Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. N. Lachmann, M. Ackermann, E. Frenzel, S. Liebhaber, S. Brennig, C. Happle, D. Hoffmann, O. Klimenkova, D. Lüttge, T. Buchegger, M. P. Kühnel, A. Schambach, S. Janciauskiene, C. Figueiredo, G. Hansen, J. Skokowa, T. Moritz. Stem Cell Reports. 2015

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
A. Mucci, E. Lopez-Rodriguez, M. Hetzel, S. Liu, T. Suzuki, C. Happle, M. Ackermann, H. Kempf, R. Hillje, J. Kunkiel, E. Janosz, S. Brennig, S. Glage, J.P. Bankstahl, S. Dettmer, T. Rodt, G. Gohring, B. Trapnell, G. Hansen, C. Trapnell, L. Knudsen, N. Lachmann, T. Moritz.  Stem Cell Reports. 2018

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. A. Mucci, J.Kunkiel, T. Suzuki, S. Brennig, S. Glage, M. P. Kühnel, M. Ackermann, C. Happle, A. Kuhn, A. Schambach, B. C Trapnell, G. Hansen, T. Moritz, N. Lachmann. Stem Cell Reports. 2016

Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice. J. Skuljec, M. Cabanski, E. Surdziel, N. Lachmann, S. Brennig, R. Pul, A. C. Jirmo, A. Habener, J. Visic, K. Dalüge, C. Hennig, T. Moritz, C. Happle, G. Hansen . Eur J Immunol. 2016

Pulmonary Transplantation of Human Induced Pluripotent Stem Cell-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis. C. Happle, N. Lachmann, M. Ackermann, A. Mirenska, G. Göhring, K. Thomay, A. Mucci, M. Hetzel, T. Glomb, T. Suzuki, C. Chalk, S. Glage, O. Dittrich-Breiholz, B. Trapnell, T. Moritz, G. Hansen.  Am J Respir Crit Care Med. 2018

Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis. M. Hetzel, E. Lopez-Rodriguez, A. Mucci, A. Hai Ha Nguyen, T. Suzuki, K. Shima, T. Buchegger, S. Dettmer, T. Rodt, J. P. Bankstahl, P. Malik, L. Knudsen, A. Schambach, G. Hansen, B.C. Trapnell, N. Lachmann, T. Moritz. Haematologica 2020

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