Schmalkuche K, Rother T, Besli S, Schwinzer R, Blasczyk R, Petersen B, Figueiredo C. Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys. Front Immunol. 2024 Jan 30;15:1279050. doi: 10.3389/fimmu.2024.1279050. PMID: 38352884; PMCID: PMC10861674.


von Scheidt W, Reichart B, Meiser B, von Scheidt M, Sen P, Schwarz F, Harmel E, Bengel FM, Dick A, Ueberfuhr P, Reichenspurner H, Jaeckel E, Schwinzer R, Hagl C. Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance. Clin Res Cardiol. 2023 Nov 20. doi: 10.1007/s00392-023-02341-x. Epub ahead of print. PMID: 37982861.


Neonatal islets from hPD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized NSG mice.
Lei Y, Buerck LW, Honarpisheh M, Zhang Y, Schwinzer R, Petersen B, Seissler J. Am J Transplant. 2023 Aug 31:S1600-6135(23)00664-0. doi: 10.1016/j.ajt.2023.08.026. Online ahead of print.PMID: 37659605

Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells.Schmalkuche K, Schwinzer R, Wenzel N, Valdivia E, Petersen B, Blasczyk R, Figueiredo C. Int J Mol Sci. 2023 Aug 12;24(16):12711. doi: 10.3390/ijms241612711.PMID: 37628892 Free PMC article

Pathways to Clinical Cardiac Xenotransplantation.
Reichart B, Längin M, Denner J, Schwinzer R, Cowan PJ, Wolf E.
Transplantation. 2021 Sep 1;105(9):1930-1943. doi: 10.1097/TP.0000000000003588.

Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation
Carvalho Oliveira M, Valdivia E, Verboom M, Yuzefovych Y, Sake HJ, Pogozhykh O, Niemann H, Schwinzer R, Petersen B, Seissler J, Blasczyk R, Figueiredo C
J Cell Mol Med. 2020 May; 24(9): 5070–5081. Published online 2020 Mar 25. doi: 10.1111/jcmm.15136

Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses.
Hein R, Sake HJ, Pokoyski C, Hundrieser J, Brinkmann A, Baars W, Nowak-Imialek M, Lucas-Hahn A, Figueiredo C, Schuberth HJ, Niemann H, Petersen B, Schwinzer R.
Am J Transplant. 2020 Apr;20(4):988-998. doi: 10.1111/ajt.15710. Epub 2019 Dec 28.

Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2.
Fischer K, Rieblinger B, Hein R, Sfriso R, Zuber J, Fischer A, Klinger B, Liang W, Flisikowski K, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Rieben R, Schwinzer R, Kind A, Schnieke A.
Xenotransplantation. 2020 Jan;27(1):e12560. doi: 10.1111/xen.12560. Epub 2019 Oct 8.

Possible detrimental effects of beta-2-microglobulin knockout in pigs.
Sake HJ, Frenzel A, Lucas-Hahn A, Nowak-Imialek M, Hassel P, Hadeler KG, Hermann D, Becker R, Eylers H, Hein R, Baars W, Brinkmann A, Schwinzer R, Niemann H, Petersen B.
Xenotransplantation. 2019 May 22:e12525. doi: 10.1111/xen.12525. [Epub ahead of print]

Role of human and porcine MHC DRB1 alleles in determining the intensity of individual human anti-pig T-cell responses.
Hundrieser J, Hein R, Pokoyski C, Brinkmann A, Düvel H, Dinkel A, Trautewig B, Siegert JF, Römermann D, Petersen B, Schwinzer R.
Xenotransplantation. 2019 Jul;26(4):e12523. doi: 10.1111/xen.12523. Epub 2019 May 9.

Pigs expressing the human inhibitory ligand PD-L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties.
Buermann A, Petkov S, Petersen B, Hein R, Lucas-Hahn A, Baars W, Brinkmann A, Niemann H, Schwinzer R.
Xenotransplantation. 2018 Sep;25(5):e12387. doi: 10.1111/xen.12387. Epub 2018 Feb 15.