Gentransfer zur genetischen Manipulation hämatopoetischer Zellen. Dazu gehört die Überexpression von Genen und miRNAs ebenso wie die spezifische Inhibition der Genexpression durch RNA-Interferenz (RNAi). Daneben [...] Identifizierung möglicher potentieller Zielstrukturen in Leukämiezellen In bisherigen Arbeiten wurden gen-spezifische, synthetische siRNAs (transiente RNAi) sowie lentiviral-codierte shRNAs (stabile RNAi)
Clinial Translation“ The publication „Hahn/Pollmann et al. 2020“ sets the foundation for the first gene therapy of IFNgR1-deficient MSMD. The authors reverse cells from patients with lentiviral vectors [...] targeting infections of the lower respiratory tract. Excellence in Research Award The American Society for Gene and Cell Therapy (ASGCT) awards the work of Kathrin Haake with an “Excellence in Research” award.
Azriel S, Rokney A, Valinsky L, Rahav G, Grassl GA*, Gal-Mor O*.Differences in the expression of SPI-1 genes pathogenicity and epidemiology between the emerging Salmonella enterica serovar Infantis and the model [...] Bleich A, Johnsen JM, Vallance BA, Baines JF, Grassl GA. 2015. Expression of the blood-group-related gene B4galnt2 alters susceptibility to Salmonella infection. PLoS Pathogens. 11 e1005008. Grassl GA*, Valdez
Klein, Pediatric Hematology and Oncology, OE 6780, project: The use of morpholino based knockdown gene technology as well as genetic studies to determine the function of HAX1 in zebrafish Final exam November [...] mouse models of leukemia; 2.Mechanisms of induction of immunologic tolerance by leukemic cells; 3.Gene therapy for hematologic disorders Final exam November 2012 Theodros Solomon Tsegaye (MD) ETHIOPIA
supervisor: Prof. Dr. Rudolph, now University of Ulm project: Analysis of the role of stanniocalcins genes and apoptosis pathways during cellular and organismal ageing Final exam June 2009 Lydia Asrat Haile [...] INDIA supervisor: Prof. Dr. Kispert, Molecular Biology, OE 5250, project: Functional analysis of Tbx gene in heart development Final exam November 2009 Inga Sörensen-Zender GERMANY supervisor: Prof. Dr. Gossler
Ramesh Pandey (Vet.) INDIA superrvisor: Prof. Dr. Kabesch, Paediatric Pneumology, project: TLR pathway genes and susceptibility for allergy and atopic diseases Final exam January 2013 Ruhi Phaltane INDIA supervisor: [...] project: Humanized models to assess the genotoxicity of viral vectors in the context of hematopoietic gene therapy and in vivo selection Final exam November 2013. Georgios Sogkas GREECE supervisor: Prof. Dr
Hepatology and Endocrinology, OE 6810, Project: Identification and Functional Characterization of Cancer Genes in Pancreatic Cancer. Final exam November 2019 Sofia Gialesaki GREECE Supervisor: PD Dr. Jan-Henning [...] Project: Identification and functional characterization of novel cervical cancer susceptibility genes. Final exam June 2020. Theresia Reindl GERMANY Supervisor: Prof. Dr. Dietmar Manstein, Bio-physical
en, liebe Patienten/innen und Angehörige, nach der großen Teilnehmerzahl und positiven Rückmeldun gen zu unseren Online-Angeboten zur Corona-Impfung wol len wir dieses Konzept eines Online-Arzt-Patien
the small GTPase Rac1 is activated after receptor internalization which is key for the IL-1-induced gene expression. The small GTPase Rac1 is an endosome-specific “sorting adaptor” in IL-1 signaling. However
characterization and subtyping of breast cancer cell lines provide novel insight into cancer relevant genes. Cells 13:301 Schaumann N, Bartels S, Kuehnle E, Kreipe H, and Christgen M* (2024). Malignant phyllodes [...] (2024). Frequency of genetic alterations differs in advanced breast cancer between metastatic sites. Genes Chromosomes Cancer 63:e23199 Cserni G, Kalman E, Udvarhelyi N, Papp E, Grote I, Bartels S, Christgen [...] Wurstlein R, Shak S, Baehner F, Kreipe HH, and Harbeck N (2022). Endocrine Therapy Response and 21-Gene Expression Assay for Therapy Guidance in HR+/HER2- Early Breast Cancer. J Clin Oncol 40:2557-2567