Prof. Dr. Halyna Shcherbata EMBO Young Investigator Research Group Gene Expression and Signaling Institute of Cell Biochemistry Hannover Medical School Carl-Neuberg-Strasse 1 30625 Hannover Germany OE

acquisition of additional mutational events promoting clonal evolution and disease development. The genes most frequently affected by age-related somatic variants in blood cells are coding for the DNA-methylation [...] complex as well as the histone demethylase LSD1, are critical for the establishment of pathogenic gene expression programs in clonal subpopulations of blood cells. Based on published and our preliminary [...] selective inhibitors of these chromatin binding proteins can reverse the aberrant chromatin state and gene expression signatures in a genotype selective manner and target pathogenic clones in xenograft models

sowie der Charakterisierung von genetischen Polymorphismen von mit der Immunantwort assoziierten Genen. Sie beschäftigt sich außerdem mit erworbenen Gerinnungsstörungen im Kindesalter, z.B. dem von-Wi

family. The name DPY-19 comes from the worm C. elegans, where mutations in the C-mannosyltransferase gene lead to a temperature-sensitive DumPY phenotype. In humans there are four homologs of DPY-19, which

Master thesis work MDPhD Molecular Medicine, Hannover Medical School Lecture and seminar: "T-box genes in development and disease", 2nd semester PhD thesis PhD Regenerative Sciences, Hannover Medical School

(Experimental Hematology) Project: Development of novel tissue-specific AAV vectors for neuromuscular gene therapies Subham Rana , INDIA, Subham.Rana @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär / [...] Lily@mh-hannover.de Supervisor: Prof. Dr. Ruthhild Weber (Human Genetics) Project: Ribosomal biogenesis genes and predisposition to brain tumors Tirthankar Saha , INDIA, Saha.Tirthankar@mh-hannover.de Supervisor:

REBIRTH, OE 8882, project: Transgenic expression of cytidine deaminase (CDD) and multidrug resistance gene 1 (MDR1) to optimise treatment strategies for acute leukemias and the myelodysplastic syndrome (MDS) [...] Dr. Anuhar Chaturvedi, Molecular Therapy, OE 6864, project: Transcriptional control of MN1 target genes Final exam June 2016. Eileen Hübschen (nee Frenzel) GERMANY supervisor: Prof. Dr. Janciauskiene,

Leistungsförderung (HiLF): “Untersuchung zur Veränderlichkeit der Methylierung des Proopiomelanocortin-GenPromotors und der konsekutiven Expression seines Derivats, AlphaMelanozytenstimulierendes-Hormon, bei [...] Analyseverfahren Erforschung der Alkoholabhängigkeit und anderer stofflichen Drogen Regulation von Genen in Blut und Gehirn Publikationen: Pubmed Prof. Dr. med. Thomas Hillemacher Ärztlicher Leiter der

Schweitzer N, Vogel A, Kreipe H , Lehmann U : Concordant hypermethylation of intergenic microRNA genes in human hepatocellular carcinoma as new diagnostic and prognostic marker. Int J Cancer 2013; 133(3): [...] Länger F , Kreipe H , Lehmann U : Oncogenic PIK3CA mutations in lobular breast cancer progression. Genes Chromosomes Cancer 2013; 52(1): 69-80 Eminaga O, Hinkelammert R, Abbas M , Titze U, Eltze E, Bettendorf [...] Transplantation 2013; 95(2): 285-292 Hussein K , Granot G, Shpilberg O, Kreipe H : Clinical utility gene card for: familial polycythaemia vera. Eur J Hum Genet 2013; 21(6). doi: 10.1038/ejhg.2012.216. No

Leszek Lisowski „The future is here! The next generation of AAV vector as a foundation of cell and gene therapeutics of the future“ Außerordentlicher Professor Lisowski promovierte an der Weill Cornell