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org/10.5966/sctm.2015-0253 . Merkert, S., and Martin, U. 2016. Targeted genome engineering using designer nucleases: State of the art and practical guidance for application in human pluripotent stem cells [...] Dreyer, A.-K., Schwanke, K., Meyer, J., Göhring, G., Cathomen, T., and Martin, U. 2014. Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprint less targeted