stiffening and impairment of the heart muscle. At present, HF remains a deadly disease with limited therapeutic options to treat cardiac fibrosis, which underlines the need for innovative therapies. In previous [...] Council (EIC). Contact: Hannover Medical School, The Institute of Molecular and Translational Therapeutic Strategies (IMTTS) Director: Prof. Dr. Dr. med. Thomas Thum Phone: +49 (0)511 532-9174 Email: Thum

Project: Exploring the concept of antigen-decorated Adeno-associated virus (AAV) vector vaccines as therapeutic and-tumor vaccine Laxmi Lokeshwarrao Kata , INDIA, Kata.Laxmi @ mh-hannover.de Supervisor: Dr. [...] Hemostaseology, Oncology and Stem Cell Transplantation) Project: Epigenetic Alterations as Drivers and Therapeutic Targets in Myeloproliferative Neoplasms Class speaker Annika Strauß , GERMANY, Strauss.Annika @ [...] Evaluation of physiological activities of commensal microbiota-modulating IgA antibodies and their therapeutic potential

their broad tropism. It results in undesired gene expression in non-target organs, which reduces therapeutic efficacy. Higher doses are often required to achieve sufficient gene delivery to target tissues [...] we aim to enhance the specificity of gene delivery, minimizing off-target effects and improving therapeutic efficacy. Through these approaches, we strive to advance the precision and safety of AAV-mediated [...] delivery mechanisms, and transgene expression, we contribute to the development of innovative therapeutic strategies that have the potential to improve patient outcomes and pave the way for more effective

rapie des Hepatozellulären Karzinoms (HCC). In der aktuell in dem wissenschaftlichen Journal „Therapeutic Advances in Medical Oncology“ publizierten Artikel “ Atezolizumab and bevacizumab in patients with [...] prior therapies. "Studies under controlled conditions are important to ensure comparability of therapeutic options, and new treatment concepts are nowadays usually approved based on data from these trials [...] prior systemic therapy: a real-world experience" , recently published in the scientific journal "Therapeutic Advances in Medical Oncology", the group led by Arndt Vogel and Anna Saborowski addresses the question

cardiomyocytes from our reporter cell lines. We are focusing on using relevant ncRNAs or telomerase as therapeutic targets in heart failure by promoting cardiac regeneration. While tissue engineering in the form [...] cell cycle pathway modulation, regulation of oxidative stress, and prevention of apoptosis. These therapeutic ncRNA strategies or telomerase therapy are then tested in our in vitro reporter cell line, which

mechanism of enzymes, the mode of action of small-molecule effectors, and support the development of therapeutic drugs. Hybrid approaches, which combine analysis by X-ray crystallography with cryo-electron microscopy [...] specific contractile proteins in supporting motile functions and the potential of small ligands as therapeutic drugs. To follow dynamic events in cells and externally triggered changes, we use fluorescence-based

Excellence Initiative as a Full Professor and Director of the Institute of Molecular and Translational Therapeutic Strategies (IMTTS; Hannover Medical School). In June 2013, he was appointed as a Visiting Professor [...] evaluation of patients (Circ Res, 2014). Thum also pioneered the use of lncRNAs and circRNAs as therapeutic targets (Science Trans Med. 2016, Eur Heart J. 2022). Academic Distinctions Awards and Prizes

künstliche Organe. Philippe Alexandre Vollmer Barbosa verteidigte seine Arbeit: „Lung models and therapeutic development for pulmonary antiviral RNAi" am 19.01.2023. Er fertigte diese am Institut für Exp

particular emphasis on psychiatric care research ) and aims to 1) develop and establish novel therapeutic interventions , and 2) to foster precision medicine for mental health diseases. To achieve these

Superparamagnetic Nanoparticles The therapeutic potential of superparamagnetic nanoparticles has attracted great scientific interest. So far, research has been devoted to the concept of magnetic hyperthermia