Regenerative Medicine Further publications: Gene Therapy Vectorology / Biosafety Hematopoiesis 2022 Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies Wunderlich [...] Geis FK, Lange L, Müller FJ, Lenz D, Zychlinski D, Steinemann D, Morgan M, Moritz T, Schambach A. Gene Ther 2017;24(5):298-307 TALEN-mediated functional correction of human iPSC-derived macrophages in [...] Beh-Pajooh A, Fiedler J, Pfanne A, Schambach A, Thum T, Cantz T, Moritz T. Stem Cell Res 2017;20:70-75 Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem

2018; 50(3): e453 Anwar SL, Lehmann U : Detection of Aberrant DNA Methylation Patterns in the RB1 Gene. Methods Mol Biol. 2018; 1726: 35-47 Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A [...] 556-558 Bartels S , Schipper E , Hasemeier B , Kreipe H , Lehmann U : Hotspot mutations in cancer genes may be missed in routine diagnostics due to neighbouring sequence variants. Exp Mol Pathol. 2018; [...] Persing S , Henkel D , Lehmann U , Kreipe H : Activating human epidermal growth factor receptor 2 (HER2) gene mutation in bone metastases from breast cancer. Virchows Arch. 2018; 473(5): 577-582 Cramer L, Brix

pathologic gene-expression after myocardial infarction in mice. J Mol Cell Cardiol. 2018. www.ncbi.nlm.nih.gov/pubmed/30118791 Bauersachs J, Heymans S. Scientific updates on the interaction of genes, epigenetics [...] Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Muller OJ, Bauersachs J, Heineke J. A gene therapeutic approach to inhibit CIB1 ameliorates maladaptive remodeling in pressure overload. Cardiovasc

1038/s41416-022-01908-1. Epub 2022 Jul 23. PMID: 35871236 Free PMC article. [Genes and pathways: FGFR2 translocations and gene fusion analysis]. Neumann O, Ball M, Lehmann U, Schirmacher P, Stenzinger A [...] Epub 2022 Jul 4. PMID: 35925311 German. No abstract available. [Erratum to: Genes and pathways: FGFR2 translocations and gene fusion analysis]. Neumann O, Ball M, Lehmann U, Schirmacher P, Stenzinger A [...] Xanthouli P, Egenlauf B, Seeger R, Hoeper MM, Jonigk D, Grünig E, Eichstaedt CA. Genes (Basel). 2022 Apr 26;13(5):759. doi: 10.3390/genes13050759. PMID: 35627145 Free PMC article. AGO Recommendations for the Diagnosis

Methionine Adenosyltransferase I/III Deficiency Detected by Newborn Screening. Genes (Basel). 2022 Jun 27;13(7). doi: 10.3390/genes13071163. PubMed PMID: 35885946; PubMed Central PMCID: PMC9323693. Mütze U

h S, Davis MJ, Pearson RB, Sanij E, Alexander WS, Ng AP. (2024) ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B-cell acute lymphoblastic leukaemia. Science Advances 10(10): 1126. Deng [...] H, Koch J, Serve H, Bonig H, Stocking C, Rieger MA, Lausen J. (2015) RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation. Blood 125(23): 3570-9. Skokowa J, Steinemann

questions remain unanswered. For example, in the majority of cases, it is unknown how and if the marker genes or regions are functionally involved in the cancerogenesis or progression. Likewise, it is unclear

r-Rezeptor-2. Bei Gallenwegstumoren ist FGFR2 aufgrund einer genetischen Fehlbildung mit anderen Genen sozusagen verschmolzen. Diese Fusionsumlagerungen führen zu einer dauerhaften Aktivierung von Signalwegen

herausragende Rolle. Aufgrund des erheblichen Polymorphismus der dem HLA-Komplex zugrunde liegenden Gene können derzeit an den transplantationsrelevanten HLA-Genorten A, B, C, DRB1, DQB1 und DPB1 mehr als

organized by the European Society of Gene and Cell Therapy (ESGCT). The program brought together early-career researchers to expand their knowledge of current gene and cell therapy developments, while [...] during the poster session. New AAV vectors for cardiac-directed gene therapy July 2022 AAV vectors are promising delivery tools for human gene therapy. However, broad tissue tropism and pre-existing immunity [...] regulatory elements of hypoxia-sensitive genes in silico predicted the transcription factors SP1 and KLF5 as potential orchestrators in human endothelial hypoxic gene expression. Further studies revealed that