Institut für Molekularbiologie Research profile of the department In our institute independent groups address basic questions concerning organ and tissue development and cell differentiation using the [...] mouse as model organism and a variety of modern biochemical, molecular genetic, and transgenic methods and technologies. The institute participates in the following study programs: BSc Biology, Leibniz-University [...] offer individual lab rotations (≥6 weeks) for bachelor and master students, and the possibility to perform Bachelor and Master Theses (please inquire). For open PhD positions please inquire or see the

FAD and FMN analogues and their application for probing stereo-specificities of flavin cofactors in enzymatic reactions. Pioneering work on the molecular genetic manipulation of the model organism Dictyostelium [...] structural biology approaches for the elucidation of myosin and dynamin function, structure, and regulation. Establishment of the first recombinant expression system for the production of functional myosin [...] motors with enhanced stability and motility for use in biohybrid devices. Structural characterization of the actomyosin complexes produced in Dictyostelium and human cells and elucidation of their involvement

the same institute. Professor Figueiredo is highly interested in cell and gene therapeutic approaches in the field of transfusion and transplantation. She has a long-term expertise in the genetic engineering [...] 2008 Post-Doctoral training, Institute of Transfusion Medicine, Hannover Medical School, Germany Since 2008 Research Group Leader – Allogeneic Cell Therapy at the Institute of Transfusion Medicine and [...] Engineering Transplant Immunology Genetic Engineering Cell Pharming PubMed Constanca Figueiredo Publication list (PubMed-Link) CONTACT Professor Constanca Figueiredo, PhD Institute of Transfusion Medicine and

campus. Substantial recent progress in i) human induced pluripotent stem cell (hiPSC) reprogramming and tailored genetic engineering (RG Martin), ii) novel methods for hiPSC mass production in controlled b [...] TECHNOBEAT Tools and Techno logies for B reakthrough in H ea rt Therapies- in short TECHNOBEAT is part of the Horizon 2020 funding programme of the European Commission. TECHNOBEAT is rooted in the extensive [...] , stem cell processing and clinical translation. Together we aim to provide new treatment options for patients suffering from heart failure due to the loss of heart muscle tissue following myocardial

important for formation and function of motile cilia. Cell-to–cell communication plays a pivotal role in regulating growth and differentiation in multicellular organisms. One highly conserved pathway for com [...] importance for the regulation of developmental processes and tissue homeostasis. Using the mouse as the animal model of choice, and employing a combination of biochemical, molecular genetic, and transgenic [...] affects important signaling pathways and leads to human diseases collectively referred to as ciliopathies. Disruption of motile cilia function in humans causes a subgroup of ciliopathies called Primary

Tissue procurement for molecular studies using laser-assisted microdissection In: Methods in Molecular Biology, Vol. 506, "Genetic Modification of Hematopoietic Stem Cells." Ed.: C. Baum Humana Press, Totawa [...] population phenotype in human tumor cell cultures. In: Methods in Molecular Biology, Vol. 878, "Metastasis Research Protocols." Ed.: Miriam Dwek, Susan A. Brooks, Udo Schumacher Humana Press, Springer Group [...] animal model for oral infection with O157 and non-O157 serotypes of STEC. In: Methods in Molecular Medicine, vol 73: E. coli, Shiga Toxin Methods and Protocols. Eds.: D. Philipott and F. Ebel Humana Press, Totawa

laboratory into clinical application in humans. "Not only scientific success, but also transfer competence is a key success criterion for a Fraunhofer institute. For this reason, I am extremely pleased to [...] group of the Institute for Molecular and Translational Therapeutic Strategies has now discovered a way to block this way for the corona virus. The study under the direction of the institute director Professor [...] modified viral vector for the therapy, which acts as a gene shuttle transporting the genetic information for H19 selectively into the heart muscle cells, where the blueprint for the lncRNA is directly

Weiterbildung zum Facharzt für Humangenetik bei Prof. Dr. Claus R. Bartram, Institut für Humangenetik der Ruprecht-Karls-Universität Heidelberg und Habilitation für das Fach Humangenetik mit dem Thema „Genomische [...] g. Qualifikation: Fachärztin für Humangenetik Mitgliedschaften: Deutsche Gesellschaft für Humangenetik GfH European Society of Human Genetics ESHG European Society for Paediatric Nephrology ESPN Gesellschaft [...] Hannover Institut für Humangenetik OE 6300 Carl-Neuberg-Str. 1 D-30625 Hannover Tel.: +49 511 532-7751 Fax: +49 511 532-18520 E-Mail Team Lebenslauf (CV) Ruthild Weber studierte Humanmedizin an der Ru

Supplementary Material Christgen et al. (2008) Comprehensive genetic and functional characterization of IPH-926: A novel CDH1-Null tumor cell line from human lobular breast cancer GLAD_allData_IPH-926.xls GLAD [...] associated with the invasive lobular subtype DAP_K_CAN.htm Startseite Veröffentlichungen Startseite Institut für Pathologie

senescence in human iPSC-derived endothelial cells Induced pluripotent stem cells (iPSCs) are considered as potentially superior cell source for in vitro assays & cell therapies. Since protocols for differentiation [...] premature senescence in hiPSC-ECs for improving differentiation protocols and overcoming senescence for production of better proliferating ECs lacking senescence phenotype for use in cell therapy. Our studies [...] as a modifier for Cystic Fibrosis lung phenotype utilizing CF-patient specific human induced pluripotent stem cells Cystic fibrosis (CF), also known as Mucoviscidosis, is a rare genetic disorder that causes