am Institut für Humangenetik der Medizinischen Hochschule Hannover (MHH) über die Analyse des TSPY-Promotors und die Rolle von TSPY bei der spermatogonialen Proliferation . Es folgten Stationen als wis

Rho-Kinase (genannt: ROCK), der durch Stabilisierung des Zytoskeletts (Zellgerüst) den Untergang von motorischen Nervenzellen hemmen soll. ClinicalTrials.gov Identifier: NCT03792490 REFALS: Effects of oral L [...] pathologische Ablagerung von spezifischen Eiweißen (Proteinaggregation von TDP-43, SOD-1 und FUS) in motorischen Nervenzellen verzögern soll. ClinicalTrials.gov Identifier: NCT03491462 Post-Polio-Syndrom: Mu

1038/s41467-019-12674-9 . Transformation of the nonprocessive fast skeletal myosin II into a processive motor. Amrute-Nayak, M., Nayak, A., Steffen, W., Tsiavaliaris, G., Scholz, T., and Brenner, B. (2019). Small [...] 1096/fj.14-263988 Kinetic mechanism of Nicotiana tabacum myosin-11 defines a new type of a processive motor. Diensthuber, R.P., Tominaga, M., Preller, M., Hartmann, F.K., Orii, H., Chizhov, I., Oiwa, K., and [...] .1242/jcs.084335 Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. Chinthalapudi, K., Taft, M. H., Martin, R., Heissler, S. M., Preller, M., Hartmann, F. K

zum Doktor rer. nat. (Universität Hannover), Thema: Mechanische Charakterisierung einzelner Motorprotein-Moleküle mit Hilfe des Photonischen Kraftmikroskops Habilitation / Venia Legendi im Fach „Physiologie [...] „Physiologie“ PD, Thema: Funktionelle Charakterisierung individueller Zytoskelett-assoziierter und Motorproteinmoleküle Aktuelle Forschungsschwerpunkte Einflüsse des mit der Alzheimer-Krankheit assoziierten Tau [...] Brenner, B. (2019) Transformation of the non-processive fast skeletal myosin II into a processive motor. Small. Jan 18:e1804313. Doi: 10.1002/smll.201804313. Behrens, V.A., Walter, W.J., Peters, C., Wang

stress fibers and the thick filaments of sarcomeres to cross-link actin filaments, modulate myosin-2 motor function and support myofibril maturation (further reading: Latham et al., Cell Rep. 2020; https://pubmed [...] cytoskeletal and sarcomeric protein complexes. We work towards understanding basic mechanisms of motor function, regulation and disease-related alterations, as well as the characterization of small molecule

Current Projects Current Projects Enzyme Kinetics and Mechanisms of Energetic Coupling in Motor Proteins Cytoskeleton Dynamics and Motility of Cellular Systems Protein Engineering and Design of Tunable

actin–tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes. iScience 25(7):104484. doi: 10.1016/j.isci.2022.104484 Greve, J. N., Schwäbe, F. V., Pokrant [...] 7 Münnich, S., Taft, M. H. , and Manstein, D. J. (2014) Crystal Structure of Human Myosin 1c-The Motor in GLUT4 Exocytosis: Implications for Ca(2+) Regulation and 14-3-3 Binding., J. Mol. Biol. 426, 2070-81 [...] Preller, M., and Manstein, D. J. (2014) Small molecule-mediated refolding and activation of myosin motor function., eLife 3, e01603. *equal contribution Taft, M. H.# , Behrmann, E., Munske-Weidemann, L.-C

diseases The works on the allosteric regulation of myosin-2 motor activity revealed novel links between the allostery of the myosin motor domain and its catalytic activity. In particular, the pentabr [...] allosteric site and the relay pathway, connecting this site with the catalytic center of the myosin-2 motor domain, were discovered. The PBP allosteric site can be used to develop specific allosteric inhibitors

cell biology, biochemistry or structural biology, with topics including, amongst others, molecular motors, cell movement and drug design. The following positions are currently vacant:

Biochemistry at MHH Research Focus: The objective of my work is the characterization of molecular motors and proteins that regulate dynamic changes of cytoskeletal and membranous structures. The coordinated [...] . At the single molecule level, the work examines the basic design and function of the molecular motors, actin filaments, and regulatory proteins using highly-sensitive and fast techniques to follow chemical