furthermore perform patch clamp analyses on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to support projects that investigate diverse human cardiac diseases (e.g. Brugada syndrome [...] on-exchangers (ClC-3 through ClC-7). Dysfunction of these anion transport proteins cause diverse human diseases including myotonia, aldosteronism, epilepsy, salt-wasting nephropathies with and without
vivo models, with a particular focus on living myocardial slice. In a translational perspective, human myocardial slices are also extensively used. The multicellular environment and preserved functionality [...] Methodology Myocardial slices (LMS) Myocardial slice preparation and ex vivo culture (mouse, rat, pig, human) Minituarization of LMS for high throughput approaches Isometric force measurement in LMS Calcium [...] and intracellular calcium transients (IonOptix, Coop Prof. T. Kraft, Dr. M. Ricke-Hoch) Models with human induced pluripotent stem cell-derived cardiomyocytes hiPSC-CM differentiation and culture (Coop Dr
Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Römermann, Dipl.-Biologin Denise Schlösser, PhD Studentin Josephin Scholz, Assistenzärztin Georgina Schumann, PhD Studentin Dr. rer. nat. Sven Schüngel, PhD-Student 2005 - 2010 Dr. med. Nora Schweitzer, A
Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Aresniev L, Ott M: Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol [...] Rudolph KL, Wilkens L: Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma. Hepatology 2005; 42(3): 522-6 Preda-Pais A, Stan AC, Casares S, Bona CA [...] Kreipe HH and Pich A: SELDI-MS-based expression profiling of ductal invasive and lobular invasive human breast carcinomas. Pathol Res Pract 2005; 201(12): 763-70 Verhulst A, Asselman M, De Naeyer S, Vervaet
Jordans S, Dilloo D. J Cell Mol Med 2022;26(23):5832-5845 DOI: 10.1111/jcmm.17604 Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli [...] Hochschule Hannover, 2022 2021 Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids. Völkner M, Pavlou M, Büning H, Michalakis S, Karl MO. Hum Gene Ther 2021;32(13 [...] Galla M. Mol Ther Nucleic Acids 2022;27:810-823 DOI: 10.1016/j.omtn.2021.12.033 Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. Hamann MV, Beschorner N, Vu XK, Hauber
Stippel D, Flemming P, Nussbaum T, Caselmann WH, Haab BB, Schirmacher P: Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth [...] Mengel M, Merkel S, Banas B, Luft FC, Haller H: Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases. Am J Kidney Dis 2004; 43(2): Giagounidis AA, Germing U, Haase S, Hildebrandt [...] W, Wagner S: Effect of H. pylori on the expression of TRAIL, FasL and their receptor subtypes in human gastric epithelial cells and their role in apoptosis. Helicobacter 2004; 9(5): 371-86 Mengel M, Jonigk
G, Guengoer C, Wagener C, Schumacher U, Lange T (2020). Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. Glycobiology. 2020 [...] S, Fenske A , Jang MS, Jirmo AC, Abeln M, Hansen G, Lachmann N (2024). Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under [...] PMID: 39227460 Plötz T , Lenzen S (2024). Mechanisms of lipotoxicity-induced dysfunction and death of human pancreatic beta cells under obesity and type 2 diabetes conditions. Obes Rev. 2024 May;25(5):e13703
Sarikouch, Hannover Medical School, GER Yoji Sato, National Institute of Health Sciences, JP Gerald Schumann, Paul Ehrlich Institut, GER Henrik Semb, Helmholtz Center, GER Joost Sluijter, University Medical
Werdegang: 1994 Abitur 1994–1996 Ersatzdienst als Zivildienstleistender 1996–2003 Studium der Humanmedizin an der Medizinischen Hochschule Hannover 08–10/2000 Douglas Hospital of Mental Health der McGill
Rita Beier – Curriculum Vitae Copyright: Christian Wyrwa / wyrwa fotografie Rita Beier studierte Humanmedizin an der Medizinischen Hochschule Hannover mit Auslandsaufenthalten in Österreich, Großbritannien