vivo models, with a particular focus on living myocardial slice. In a translational perspective, human myocardial slices are also extensively used. The multicellular environment and preserved functionality [...] Methodology Myocardial slices (LMS) Myocardial slice preparation and ex vivo culture (mouse, rat, pig, human) Minituarization of LMS for high throughput approaches Isometric force measurement in LMS Calcium [...] and intracellular calcium transients (IonOptix, Coop Prof. T. Kraft, Dr. M. Ricke-Hoch) Models with human induced pluripotent stem cell-derived cardiomyocytes hiPSC-CM differentiation and culture (Coop Dr

Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Römermann, Dipl.-Biologin Denise Schlösser, PhD Studentin Josephin Scholz, Assistenzärztin Georgina Schumann, PhD Studentin Dr. rer. nat. Sven Schüngel, PhD-Student 2005 - 2010 Dr. med. Nora Schweitzer, A

Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Aresniev L, Ott M: Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol [...] Rudolph KL, Wilkens L: Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma. Hepatology 2005; 42(3): 522-6 Preda-Pais A, Stan AC, Casares S, Bona CA [...] Kreipe HH and Pich A: SELDI-MS-based expression profiling of ductal invasive and lobular invasive human breast carcinomas. Pathol Res Pract 2005; 201(12): 763-70 Verhulst A, Asselman M, De Naeyer S, Vervaet

Jordans S, Dilloo D. J Cell Mol Med 2022;26(23):5832-5845 DOI: 10.1111/jcmm.17604 Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli [...] Hochschule Hannover, 2022 2021 Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids. Völkner M, Pavlou M, Büning H, Michalakis S, Karl MO. Hum Gene Ther 2021;32(13 [...] Galla M. Mol Ther Nucleic Acids 2022;27:810-823 DOI: 10.1016/j.omtn.2021.12.033 Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. Hamann MV, Beschorner N, Vu XK, Hauber

Stippel D, Flemming P, Nussbaum T, Caselmann WH, Haab BB, Schirmacher P: Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth [...] Mengel M, Merkel S, Banas B, Luft FC, Haller H: Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases. Am J Kidney Dis 2004; 43(2): Giagounidis AA, Germing U, Haase S, Hildebrandt [...] W, Wagner S: Effect of H. pylori on the expression of TRAIL, FasL and their receptor subtypes in human gastric epithelial cells and their role in apoptosis. Helicobacter 2004; 9(5): 371-86 Mengel M, Jonigk

G, Guengoer C, Wagener C, Schumacher U, Lange T (2020). Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. Glycobiology. 2020 [...] S, Fenske A , Jang MS, Jirmo AC, Abeln M, Hansen G, Lachmann N (2024). Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under [...] PMID: 39227460 Plötz T , Lenzen S (2024). Mechanisms of lipotoxicity-induced dysfunction and death of human pancreatic beta cells under obesity and type 2 diabetes conditions. Obes Rev. 2024 May;25(5):e13703

H. C. ; Bergforth,W. ; Przykopanski,A. ; Rummel,A. ; Klawonn,F. ; Seeger,B. Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1, Switzerland,Toxins (Basel),2021;13(8):585- [...] Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ; Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo Eur.Heart J., 2024, 45(22), 2016- 2018, Originalpublikation Albers,Marco [...] Tsikas,Dimitrios ; Kuczyk,Markus A. ; Ückert,Stefan ; Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion

Sarikouch, Hannover Medical School, GER Yoji Sato, National Institute of Health Sciences, JP Gerald Schumann, Paul Ehrlich Institut, GER Henrik Semb, Helmholtz Center, GER Joost Sluijter, University Medical

Werdegang: 1994 Abitur 1994–1996 Ersatzdienst als Zivildienstleistender 1996–2003 Studium der Humanmedizin an der Medizinischen Hochschule Hannover 08–10/2000 Douglas Hospital of Mental Health der McGill

Rita Beier – Curriculum Vitae Copyright: Christian Wyrwa / wyrwa fotografie Rita Beier studierte Humanmedizin an der Medizinischen Hochschule Hannover mit Auslandsaufenthalten in Österreich, Großbritannien