already many research results on the effects and therapeutic factors of psychotherapy, comparatively little is known about this for certain therapeutic services. These include, for example, body-oriented [...] Our research group aims to develop suitable instruments with which the effect and therapeutic factors of these therapeutic offers, which have so far been too little considered by research, can be tested [...] questions about its effect and therapeutic factors are still unanswered. A questionnaire has therefore been developed to help patients evaluate the effects and therapeutic factors of CBT in group setting

Figueiredo (Transfusion Medicine) Project: Correction of monogenetic kidney diseases using a gene therapeutic approach Aavani Biju Sindhu INDIA; Sindhu.Aavani @ mh-hannover.de Supervisor: Prof. Dr. Anke Bergmann [...] Supervisors: Dr. Natalie Weber/ Prof. Dr. Thomas Thum (Institute of Molecular and Translational Therapeutic Strategies IMTTS and Fraunhofer ITEM) Project: Integration and maturation of human stem cell-derived [...] Thum (Fraunhofer ITEM) Project: Cardiac fibrosis fingerprints and pre-clinical development of therapeutic approaches Maria is class speaker! Isabel Klefenz GERMANY; Klefenz.Isabel @ mh-hannover.de Supervisor:

Dr. Christian Bär (Institute of Molecular and Translational Therapeutic Strategies, IMTTS) Project: Investigating circular RNA as therapeutic targets in ischemic heart disease [...] Dr. Natalie Weber, PhD / Prof. Dr. Dr. Thomas Thum (Institute of Molecular and Translational Therapeutic Strategies IMTTS and Fraunhofer ITEM) Project: Investigation of novel therapies in hypertrophic [...] @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär (Institute of Molecular and Translational Therapeutic Strategies, IMTTS) Project: Elucidating the role of circRNAs in cardiomyocyte proliferation and

in a mouse model of myocardial infarction (MI). Therapeutic miR-24 antagonism counteracted loss of vascular structures and highlights novel therapeutic potential after MI. In addition miR-24 has been shown [...] Identification of druggable non-coding RNAs (ncRNAs) and novel therapeutic entities in the cardiopulmonary system The role of small non-coding microRNAs (miRs) in ischemic cardiac injury has been studied [...] molecules regulating fibroblast biology which is part of our research. Conclusively, miR-based therapeutic strategies are of great importance for basic translational research and novel non-coding RNA key

and Translational Therapeutic Strategies (IMTTS) was founded in 2009 at the Hannover Medical School by Prof. Thomas Thum. A main group’s focus is the development of RNA-based therapeutic strategies in c [...] g and Translational Strategies Identification of druggable non-coding RNAs (ncRNAs) and novel therapeutic entities in the cardiopulmonary system The non-coding genome in cardiac ageing and regeneration

worldwide. Development of therapeutic approaches depends on suitable small and large animal models that replicate pathogenesis in humans. Non-coding RNAs are novel therapeutic targets as master regulators

develop and test new therapeutic strategies. Ongoing research projects Investigating of microRNA and non-coding RNAs in Hypertrophic Cardiomyopathy for development of novel therapeutic approaches HCM is the [...] regeneration and the evaluation of both structural and functional parameters which are affected by the therapeutic treatments. The group uses several in vitro and ex vivo models, with a particular focus on living [...] which are linked to cardiomyocyte dysfunction, hypertrophy and fibrosis. We aim to develop novel therapeutic strategies to prevent HCM initiation and progression. Investigating the regenerative potential

divided into a non-obstructive (HNCM) and obstructive form (HOCM) therefore requiring personalized therapeutic therapies. HOCM differs from HNCM clinically by the presence of a pathological increased gradient [...] RNAs (ncRNAs) and cardiometabolic proteins as potential biomarkers for HCM identifying novel therapeutic targets in HCM is an important part of our translational research and a vision of our group. Fabry [...] relevance of ncRNAs to control endothelial function in adults with congenital heart disease. 4. Therapeutic targeting of ncRNAs in endothelial dysfunction in patients with heart failure.

stiffening and impairment of the heart muscle. At present, HF remains a deadly disease with limited therapeutic options to treat cardiac fibrosis, which underlines the need for innovative therapies. In previous [...] Council (EIC). Contact: Hannover Medical School, The Institute of Molecular and Translational Therapeutic Strategies (IMTTS) Director: Prof. Dr. Dr. med. Thomas Thum Phone: +49 (0)511 532-9174 Email: Thum

initiated numerous retrospective and prospective collaborative studies that both evaluate existing therapeutic approaches in large patient collectives as well as investigate novel treatment options in patients [...] mortality. Based on this finding we have conducted a series of experiments exploring potential therapeutic strategies (antibody, siRNA etc.) to eliminate or block the injurious Angpt-2 protein in sepsis [...] of singular mediators such as TLR4 or TNF was so far not effective in humans. We believe that therapeutic plasma exchange (TPE) might eliminate numerous circulating injurious mediators in a short intervention