Es zählt zu den Krebsprädispositionssyndromen und wird durch krankhafte genetische Veränderungen im Gen TP53 verursacht. Eine Definition, die das breite Erkrankungsspektrum widerspiegelt, fehlte bislang [...] n, bei denen mit hoher Wahrscheinlichkeit ein LFS zugrunde liegt. Mit zunehmender Erforschung des Gens wurde in den vergangenen Jahren jedoch deutlich, dass auch Menschen, die diese Kriterien nicht erfüllen
supervisor: PD Dr. Michael Ott, Gastro-Hepa-Endo, OE 6810, Dr. Jens Bohne, Virology, OE 5230, project: Gene therapy of hereditary metabolic liver diseases by targeted genome editing Final exam June 2020. Maurice [...] Heckl, Ped. Hematology, OE 6780, project: High-throughput functional characterization of mutated genes in acute megakaryoblastic leukemia using CRISPR-Cas9 genome editing Final exam January 2019. Marcel
Charakterisierung von DNA-Proben. Zur Analyse der Methylierungsmuster in der Promotorregion bestimmter Gene kam in den letzten 10 Jahren vor allem die Bisulfit-Sequenzierung (nach Sanger) zum Einsatz. Aktuell [...] psychometrischen Daten korreliert. Dadurch können Zusammenhänge zwischen der Regulation relevanter Gene und der Ausprägung psychisch auffälliger Verhaltensmuster nachgewiesen werden. Das Labor für Molekulare
2015 Apr 24. PMID: 25911549 Free PMC article. Clinical Trial. No abstract available. A novel G6PC3 gene mutation in severe congenital neutropenia: pancytopenia and variable bone marrow phenotype can also [...] Mutat. 2013 Jun;34(6):905-14. doi: 10.1002/humu.22308. Epub 2013 Apr 2. PMID: 23463630 A novel G6PC3 gene mutation in a patient with severe congenital neutropenia. Aytekin C, Germeshausen M, Tuygun N, Dogu [...] Sep;37(6):673-81. doi: 10.1055/s-0031-1291377. Epub 2011 Nov 18. PMID: 22102270 Review. Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.
Mohr I. Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes & Dev . 2021 https://doi.org/10.1101/gad.348320.121 Ouwendijk WJD*, Depledge DP* , Rajbhandari L, [...] GMGM, Sadaoka T. Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency. Nature Comms. 2020. https://doi.org/10.1038 [...] L, Mohr I. RNA m6A modification enzymes shape innate responses to DNA by regulating interferon β. Genes & Dev. 2018. https://doi.org/10.1101/gad.319475.118 Depledge DP* , Ouwendijk WJD*, Sadaoka T*, Braspenning
S Table 2 S Lehmann et al. (2002) Promoter hypermethylation in the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype DAP_K_CAN.htm Startseite Veröffe
characterization and subtyping of breast cancer cell lines provide novel insight into cancer relevant genes. Cells 13:301 Schaumann N, Bartels S, Kuehnle E, Kreipe H, and Christgen M* (2024). Malignant phyllodes [...] (2024). Frequency of genetic alterations differs in advanced breast cancer between metastatic sites. Genes Chromosomes Cancer 63:e23199 Cserni G, Kalman E, Udvarhelyi N, Papp E, Grote I, Bartels S, Christgen [...] Wurstlein R, Shak S, Baehner F, Kreipe HH, and Harbeck N (2022). Endocrine Therapy Response and 21-Gene Expression Assay for Therapy Guidance in HR+/HER2- Early Breast Cancer. J Clin Oncol 40:2557-2567
Lehrgang/Course State Approved Course §28 GenTSV for Project Leaders and Biosafety Officer (in English) Biologische Sicherheit Unsere Aufgaben Koordinierung von Sicherheitsanforderungen für Laboratorien
OE 6710, project: Pseudomonas aeruginosa - mammalian host cell interaction: Phagocyte-sensitizing genes of P. aeruginosa Final exam November 2006 Anuhar Chaturvedi INDIA supervisor: PD Dr. Eder, Hematology [...] 2006 Eric Hesse (Dr. med.) GERMANY supervisor: Prof. Dr. Krettek; Trauma Surgery, OE6230, project: Gene-expression analysis of mesenchymal stem cells and their matrix synthesis Final exam November 2007
Dr. Schambach / Dr. Adrian Schwarzer, Experimental Hematology, OE 6960, project: Using inducible gene expression and RNAi to investigate murine models of acute T-cell leukemia in vivo Final exam November [...] Pediatric Pneumology, OE 6710, project: Functional analysis of regulatory variants of modifying genes that determine the outcome of the monogenic disease cystic fibrosis Final exam November 2016. Nurullah