Publikationen des Instituts seit 1997 2026 Froese,Natali ; Shymotiuk,Ivanna ; Froese,Alexander ; Polten,Felix ; Jablinski,Jonas ; Scholz,Tim ; Korf-Klingebiel,Mortimer ; Werlein,Christopher ; Galuppo,Paolo ; Gigina,Anna ; Wihler,Katharina ; Schneider,Johanna ; Erschow,Sergej ; Heimerl,Maren ; Szaroszyk,Malgorzata ; Hegermann,Jan ; Wrede,Christoph ; Schweitzer,Theresa ; Pich,Andreas ; Geffers,Robert ; Ricke-Hoch,Melanie ; Kühnel,Mark P. ; Jonigk,Danny D. ; Wende,Adam R. ; Abel,E. Dale ; Nikolaev,Viacheslav O. ; Wollert,Kai C. ; Bauersachs,Johann ; Riehle,Christian ; RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation Circ.Res., 2026, 138(9), e327297-, Originalpublikation Hartmann,Carla ; Haferkamp,Undine ; Appelt-Menzel,Antje ; Barenberg,Janica ; Brachner,Andreas ; Ehrhard,Toni ; Feldhaus,Julia ; Gerhartl,Anna ; Hollemann,Thomas ; Kulka,Linda Anna Michelle ; Leckzik,Selin ; Leu,Jennifer ; Woo,Marcel Seungsu ; Friese,Manuel Alexander ; Initiative,Alzheimer's Disease Neuroimaging ; Metzger,Marco ; Neuhaus,Winfried ; Oerter,Sabrina ; Olzscha,Heidi ; Pich,Andreas ; Riemann,Dagmar ; Pless,Ole ; Rujescu,Dan ; Jung,Matthias ; Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease Fluids Barriers CNS, 2026, 23(1), 11- , Originalpublikation Kampelmann,Morten ; Pich,Andreas ; Mühlfeld,Christian ; Schipke,Julia ; Diet-induced obesity alleviates epithelial damage in hyperoxic acute lung injury (HALI) in mice Respir.Res., 2026, (), - , Originalpublikation Langejürgen,Anna ; Schmidt,Gudula ; Unsöld,Leon ; Tatge,Helma ; Oyson,Ethel ; Gerhard,Ralf ; Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes Toxins (Basel), 2026, 18(4), 186- , Originalpublikation Langejürgen,Anna ; Characterizing endosomal homeostasis disruption and lysosomal dysfunction triggered by endosomal escape of AB toxins : a study on clostridioides difficile toxin B, 2025, Dissertation Polten,Felix ; Sandu,Mircea-Andrei ; Faix,Jan ; Hegermann,Jan ; Kriedemann,Nils ; Zweigerdt,Robert ; Thum,Thomas ; Bauersachs,Johann ; Niessen,Hans W. ; Koenig,Andrew L. ; Lavine,Kory J. ; Pich,Andreas ; Wang,Yong ; Reboll,Marc R. ; Korf-Klingebiel,Mortimer ; Wollert,Kai C. ; Extracellular BRICK1 drives heart repair after myocardial infarction in mice, United States,Sci.Transl.Med.,2026;18(831):eadx2876 Originalpublikation Schenke,Maren ; Westphal,Alice ; Weisemann,Jasmin ; Rummel,Andreas ; Dorner,Brigitte G. ; Klawonn,Frank ; Seeger,Bettina ; High sensitivity of iPSC-derived motor neurons to the human-relevant botulinum neurotoxin serotypes E and F Neurotoxicology, 2026, 114(), 103446- , Originalpublikation 2025 Bai,Yiling ; Wu,Zhaojia ; Leary,Scot C. ; Fang,Chen ; Yu,Michelle ; Genth,Harald ; Xie,Yufeng ; Shi,Jinhui ; Xiang,Jim ; Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways, Switzerland,Int.J.Mol.Sci.,2025;26(4):1669 Originalpublikation Bellmann,Denise ; Evaluation of the neutralizing activity of newly developed equine antibodies against C. botulinum neurotoxins using in vitro differentiated P19 neurons, Hannover,,2025;() Masterarbeit Bollenbach,Alexander ; Beckmann,Bibiana ; Tsikas,Dimitrios ; Quality control in GC-MS analysis of amino acids in human urine and plasma: Possible implications for targeted and untargeted metabolomics, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124661 Originalpublikation Bünermann,Ines ; Detering,Nora ; Tapken,Ines ; Kuhn,Daniela ; Jahn,Kirsten ; Burkert,Alexandra ; Naczinsky,Sarah ; Hensel,Niko ; Schüning,Tobias ; Dittrich-Breiholz,Oliver ; Pich,Andreas ; Claus,Peter ; Alterations along the neuroendocrine axis of leptin homeostasis: white adipose tissue and hypothalamus in a severe SMA mouse model, England,Hum.Mol.Genet.,2025;():- Originalpublikation Chung,Bomee ; Jonas,Wenke ; Rostami,Fatemeh ; Malik,Zulaikha ; Szaroszyk,Malgorzata ; Levay,Magdolna ; Thackeray,James ; Ost,Mario ; Nowak,Steven ; Hegermann,Jan ; Wieland,Thomas ; Pich,Andreas ; Bengel,Frank M. ; Bauersachs,Johann ; Wollert,Kai C. ; Heineke,Joerg ; Schürmann,Annette ; Kempf,Tibor Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure England,Cardiovasc.Res.,2025;() Originalpublikation Chung,Soo-Young ; Die Bedeutung konservierter Cysteine für die Funktion der Clostridium difficile Toxine A und B, Hannover,,2024;():4 ungezählte Blätter, 45 Blätter Dissertation Dastagir,Nadjib ; Liebsch,Christina ; Kutz,Jaqueline ; Wronski,Sabine ; Pich,Andreas ; Obed,Doha ; Vogt,Peter Maria ; Bucan,Vesna ; Strauß,Sarah ; Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity, United States,PLoS One,2025;20(3):-e0316257 Originalpublikation Dettmann,Paulin ; Skiba,Martin ; Stern,Daniel ; Weisemann,Jasmin ; Mages,Hans Werner ; Krez,Nadja ; Dorner,Martin B. ; Schaarschmidt,Sara ; Avondet,Marc A. ; Fulde,Marcus ; Rummel,Andreas ; Strommenger,Birgit ; Maurischat,Sven ; Dorner,Brigitte G. ; Highly Sensitive Suspension Immunoassay for Multiplex Detection, Differentiation, and Quantification of Eight Staphylococcus aureus Enterotoxins (SEA to SEI), Switzerland,Toxins (Basel),2025;17(6):265-http://doi.org/10.3390/toxins17060265 Originalpublikation Dietz-Ziegler,Stefanie ; Kewitz,Samantha ; Kaiser,Gabriele ; Rühle,Jessica ; Marmé,Alexander ; Dalpke,Alexander ; Cheaib,Bachar ; Pauluschke-Fröhlich,Jan ; Henes,Melanie ; Velic,Ana ; Pich,Andreas ; Vollert,Anneli ; Schaller,Martin ; Knab,Felix ; Lajqi,Trim ; Poets,Christian F. ; Gille,Christian ; Köstlin-Gille,Natascha Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro, Germany,Eur.J.Immunol.,2025;55(9):e70056 Originalpublikation Frommeyer,Yannick N. ; Gomez,Nicolas O. ; Preusse,Matthias ; Arce-Rodriguez,Alejandro ; Neubauer,Kerstin ; Kennepohl,Benedikt ; Witte,Julius ; Bouheraoua,Safaa ; Cetraro,Pierina ; Erdmann,Jelena ; Neumann-Schaal,Meina ; Müsken,Mathias ; Pich,Andreas ; Bähre,Heike ; Depledge,Daniel P. ; Häussler,Susanne ; tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity, England,Nucleic Acids Res.,2025;53(14):gkaf719 Originalpublikation Gand,Luis Vincens ; Lanzuolo,Chiara ; Li,Mugeng ; Rosti,Valentina ; Weber,Natalie ; Lu,Dongchao ; Bär,Christian ; Thum,Thomas ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ; Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia, Germany,J.Cachexia Sarcopenia Muscle,2025;16(2):-e13776 Originalpublikation Gao,Linfeng ; Nowakowska,Maria Barbara ; Selby,Katja ; Przykopanski,Adina ; Chen,Baohua ; Krüger,Maren ; Douillard,François Paul ; Lam,Kwok-Ho ; Chen,Peng ; Huang,Ting ; Minton,Nigel Peter ; Dorner,Martin Bernhard ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Lindström,Miia ; Jin,Rongsheng ; Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47, United States,Nat.Struct.Mol.Biol.,2025;():- Originalpublikation Hage,David S. ; Liu,Huwei ; Theodoridis,Georgios ; Tsikas,Dimitrios ; Virgilliou,Christina ; Wilson,Ian ; Chemical analysis-relating nomenclature issues in the Journal of Chromatography B, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1263():124703 Originalpublikation Hage,David S. ; Liu,Huwei ; Theodoridis,Georgios ; Tsikas,Dimitrios ; Virgilliou,Christina ; Wilson,Ian D. ; Refreshing the Aims and Scope of the Journal of Chromatography B J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci., 2026, 1269(), 124865- , Editorial Heimerl,Maren ; Erschow,Sergej ; Müller-Olling,Mirco ; Manstein,Dietmar J. ; Decher,Niels ; Kauferstein,Silke ; Jenewein,Tina ; Pich,Andreas ; Ricke-Hoch,Melanie ; Hilfiker-Kleiner,Denise ; Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression, England,Eur.Heart J.,2025;(): Originalpublikation Horn,Vanessa ; Zarnovican,Patricia ; Tiemann,Birgit ; Pich,Andreas ; Bakker,Hans ; Routier,Françoise H. ; N-Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii, Germany,,2025;():-e202400239 Originalpublikation Ibrahim,Nurul Khalida ; Schreek,Sabine ; Cinar,Buesra ; Stasche,Anna Sophie ; Lee,Su Hyun ; Zeug,Andre ; Dolgner,Tim ; Niessen,Julia ; Ponimaskin,Evgeni ; Shcherbata,Halyna ; Fehlhaber,Beate ; Bourquin,Jean-Pierre ; Bornhauser,Beat ; Stanulla,Martin ; Pich,Andreas ; Gutierrez,Alejandro ; Hinze,Laura ; SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response, United States,Cell.Rep.,2025;44(4): Originalpublikation Jordan,Maria ; Schmidt,Kevin ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Willmer,Lena ; Neubert,Lavinia ; Werlein,Christopher ; Zardo,Patrick ; Pich,Andreas ; Thum,Thomas ; Fiedler,Jan ; Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung, Switzerland,Front.Pharmacol.,2025;16():1534989 Originalpublikation Josuran,Roland ; Wenger,Andreas ; Worbs,Sylvia ; Kampa,Bettina ; Rummel,Andreas ; Dorner,Brigitte G. ; Gerber,Sabina ; N-Glycosylation Profile of Abrin Certified EU Reference Material, Switzerland,Toxins (Basel),2025;17(3):108 Originalpublikation Kaiser,Annette ; Agostinelli,Enzo ; Tsikas,Dimitrios The hypusine pathway in Ixodes ricinus: molecular cloning and validation of deoxyhypusine synthase as a novel target for drug discovery to treat and prevent vector borne diseases Switzerland,Front.Cell.Infect.Microbiol.,2025;15():1638906 Originalpublikation Kroh,Amelie ; Charakterisierung der nichttoxischen OrfX-Proteine 1-3 sowie P47 aus Clostridium botulinum Serotyp E Subtyp E1 Stamm Beluga, Hannover,,2024;():XII, 154 Blätter, Blatt XIII-XX : Illustrationen, Diagramme Dissertation Lam,Kwok-Ho ; Gao,Linfeng ; Przykopanski,Adina ; Chen,Baohua ; Huang,Ting ; Krüger,Maren ; Bartels,Anna-Magdalena ; Dorner,Martin Bernhard ; Perry,Kay ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Jin,Rongsheng ; A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex, United States,Sci.Adv.,2025;11(35):eadx5831 Originalpublikation Masuyer,Geoffrey ; Rummel,Andreas ; Stenmark,Pål ; Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity, England,Commun.Chem.,2025;8(1):171 Originalpublikation Ostermann,Lena ; Seeliger,Benjamin ; Peukert,Konrad ; Steinmetz,Lara-Kristin ; Flasche,Carolin ; Maus,Regina ; Stolper,Jennifer ; Vogl,Thomas ; Pich,Andreas ; Bode,Christian ; Neumann,Konstantin ; Brand,Korbinian ; Tessier,Philippe A. ; Roth,Johannes ; Maus,Ulrich A. ; Lack of S100A8 impairs lung protective immunity against Streptococcus pneumoniae, United States,J.Infect.Dis.,2025;() Originalpublikation Paulmann,Volker ; Mikuteit,Marie ; Just,Ingo ; Karmann,Naomi ; Steffens,Sandra ; The science module in the MHH's model curriculum - development, implementation, results, Germany,GMS J.Med.Educ.,2025;42(5):Doc59 Originalpublikation Ramachandran,Dhanya ; Dewender,Robin Tarek ; Schröder-Heurich,Bianca ; Froböse,Wiebke ; Avdulahu,Florian ; Richter,Katja ; Baker,Valerie L. ; Winn,Virginia D. ; Pich,Andreas ; von Versen-Höynck,Frauke Exploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum Netherlands,J.Assist.Reprod.Genet.,2025 Originalpublikation Schmidt,Arne ; Schmidt,Kevin ; Groß,Sonja ; Lu,Dongchao ; Xiao,Ke ; Neufeldt,Dimyana ; Cushman,Sarah ; Lehmann,Nele ; Thum,Sabrina ; Pfanne,Angelika ; Just,Annette ; Pich,Andreas ; Heinz,Alexander ; Hiller,Karsten ; Hunkler,Hannah Jill ; Tan,Wilson Lek Wen ; Foo,Roger ; Bär,Christian ; Thum,Thomas ; Jung,Mira ; Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism, England,Sci.Rep.,2025;15(1):20331 Originalpublikation Smandzich,Nadine J. ; Pich,Andreas ; Gschwendtberger,Thomas ; Greten,Stephan ; Ye,Lan ; Klietz,Martin ; Di Fonzo,Alessio ; Henkel,Lisa M. ; Wegner,Florian Proteomics of Patient-Derived Striatal Medium Spiny Neurons in Multiple System Atrophy Switzerland,,2025;14(17):1394 Originalpublikation Steinberg,Maximilian ; Wilk,Laura-Varenne ; Stern,Daniel ; Weisemann,Jasmin ; Messelhäußer,Ute ; Wittwer,Matthias ; Krüger,Maren ; Mages,Hans Werner ; Rummel,Andreas ; Dorner,Martin B. ; Dorner,Brigitte G. ; Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism, Germany,ALTEX,2025;(): Originalpublikation Tammen,Harald ; Pich,Andreas ; Hess,Rüdiger ; Lechowicz,Urszula ; Janciauskiene,Sabina ; Chorostowska,Joanna ; Quantitative mass spectrometric analysis of C-terminal 36 amino acid peptides of alpha-1 antitrypsin in plasma using survey spectra, United States,Methods,2025;240():7-13 Originalpublikation Tsikas,Dimitrios ; Analysis of eicosanoids by quadrupole gas chromatography-negative ion chemical ionization-tandem mass spectrometry as pentafluorobenzyl trimethylsilyl derivatives: Naming the Murphy rearrangement Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1267():124794 Übersicht Tsikas,Dimitrios ; Analysis, biology and significance of dimethylamine, trimethylamine and trimethylamine N-oxide in humans and in the marine ecosystem, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1258():124602 Originalpublikation Tsikas,Dimitrios ; Assessment of matrix effects in quantitative GC-MS by using isotopologs, United States,Anal.Biochem.,2025;705():115928 Originalpublikation Tsikas,Dimitrios ; Interpretation of negative-ion chemical ionization GC-MS and GC-MS/MS mass spectra of perfluorinated organic analyte derivatives: Consideration of reduction reactions in the gas phase, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1253():124487 Originalpublikation Tsikas,Dimitrios ; Pentafluorobenzyl bromide - A versatile derivatization agent in chromatography and mass spectrometry: II. Analysis of organic acids and bases, and comparison with other perfluorinated reagents, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1257():124578 Originalpublikation Tsikas,Dimitrios ; Proposal and application of nitrogen rules in interpreting gas chromatography negative-ion chemical ionization mass spectrometry spectra, United States,Anal.Biochem.,2025;705():115922 Originalpublikation Tsikas,Dimitrios ; Quantitative Gas Chromatography-Mass Spectrometry in the Life Sciences Principles and Bioanalytical Applications. In: . . Chantilly: , 2025, 735 Seiten- , Buchbeitrag, Monografie Tsikas,Dimitrios ; Quantitative GC-MS/MS in the clinical analysis of eicosanoids: A critical review and discussion, a 40-years historical retrospect, and possible implications for LC-MS/MS, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1270():124911 Originalpublikation Tsikas,Dimitrios ; Quantitative GC-NICI-MS and GC-NICI-MS/MS analysis by using isotopologs as internal standards: A tutorial review, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124648 Originalpublikation Tsikas,Dimitrios ; Underlying Mechanisms of Chromatographic H/D, H/F, cis/trans and Isomerism Effects in GC-MS, Switzerland,,2025;15(1):43- Originalpublikation Tsikas,Dimitrios ; A McLafferty-Type Rearrangement in the Pentafluorobenzyl Ester Derivatives of Dialkyl Phosphates in GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis Molecules, 2025, 31(1), 22- , Originalpublikation Tsikas,Dimitrios S . ; Tsikas,Stefanos A. ; Collision-Induced Gas-Phase Reactions of PFB-TMS Derivatives of F(2)-Prostaglandins in Quadrupole GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis, Switzerland,Molecules,2025;30(19):3846- Originalpublikation Ückert,Stefan ; Hedlund,Petter ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract, Germany,World J.Urol.,2025;44(1):26 Originalpublikation Wolter,Sabine ; Neumann,Martin ; Koenig,Theresa ; Hagedorn,Tina ; Schwede,Frank ; Pich,Andreas ; Seifert,Roland Identification of cCMP- and cUMP-binding proteins using cCMP and cUMP coupled to agarose and biotin matrices, United States,PLoS One,2025;20(10):e0333904- Originalpublikation 2024 Abbas,Naisam ; Bentele,Marco ; Waleczek,Florian J. G. ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Pich,Andreas ; Linke,Sophie ; Neumüller,Susanne ; Stucki-Koch,Angelika ; Jordan,Maria ; Perbellini,Filippo ; Werlein,Christopher ; Korte,Wilhelm ; Ius,Fabio ; Ruhparwar,Arjang ; Weber,Natalie ; Fiedler,Jan ; Thum,Thomas ; Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine J.Mol.Cell.Cardiol., 2024, 196(), 125- 140, Originalpublikation Abbas,Naisam ; Haas,Jonas A. ; Xiao,Ke ; Fuchs,Maximilian ; Just,Annette ; Pich,Andreas ; Perbellini,Filippo ; Werlein,Christopher ; Ius,Fabio ; Ruhparwar,Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ; Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo Eur.Heart J., 2024, 45(22), 2016- 2018, Originalpublikation Albers,Marco Darius ; Tiemann,Birgit ; Kaynert,Jonas Till ; Pich,Andreas ; Bakker, Hans ; Konservierte Cysteine verhindern die C-Mannosylierung von Mucin-Cys-Domänen, England, FEBS J., 2024; 291(15):3539-3552 Originalpublikation Baskal,Svetlana ; Posma, Rene A. ; Bollenbach, Alexander ; Dieperink, Willem ; Bakker, Stephan J. L. ; Nijsten, Maarten W. ; Touw, Daan J. ; Tsikas, Dimitrios ; GC-MS-Analyse von 4-Hydroxyprolin: erhöhte Prolinhydroxylierung bei Patienten mit Metformin-assoziierter Laktatazidose und mit Metformin behandelten Patienten mit Becker-Muskeldystrophie, Österreich, Aminosäuren, 2024; 56(1):21- Originalpublikation Dimina,Laurianne Jolata ; Leray,Vincent ; Voute,Marion ; David,Jérémie ; Blavignac,Christelle ; Farges,Marie-Chantal ; Rossary,Adrien ; Tsikas,Dimitrios ; Rémond,Didier ; Pickering,Gisèle ; Mariotti,François ; Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial Impairments in Vascular Endothelial Function in Healthy Older Adults with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial J.Nutr., 2024, 154(12), 3664- 3680, Originalpublikation Hedlund,Petter ; Rahardjo,Harrina E. ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; Ückert,Stefan ; Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET) World J.Urol., 2024, 42(1), 654- , Originalpublikation Hirsch,Merle S. ; Hildebrand, Christina B. ; Geltinger,Florian ; Pich,Andreas ; Mühlfeld,Christian ; Wedekind, Dirk ; Brandenberger, Christina ; Seneszenz in alveolären epithelialen Typ-II-Zellen fördert akute Lungenschäden und beeinträchtigt die Regeneration,Vereinigte Staaten,Am.J.Respir.Cell Mol.Biol.,2024; ():- Originalpublikation Hose, Leonie; Langenhagen, Alina Katharina; Kefalakes, Ekaterini; Schweitzer, Theresa ; Kubinski, Sabrina; Barak, Segev; Pich, Andreas ; Grothe, Claudia A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice. PMID: 38185886 Originalpublikation Khan,Bushra ; Lanzuolo,Chiara ; Rosti,Valentina ; Santarelli,Philina ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ; Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, United States,,2024;27(10):110913 Originalpublikation Klawitter,Jost ; Weissenborn,Wiebke ; Gvon,Iuliia ; Walz,Mackenzie ; Klawitter,Jelena ; Jackson,Matthew ; Sempio,Cristina ; Joksimovic,Sonja L. ; Shokati,Touraj ; Just,Ingo ; Christians,Uwe ; Todorovic,Slobodan M. ; β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia? Mol.Pharmacol., 2024, 105(2), 75- 83, Originalpublikation Krueger,Jonas ; Preusse,Matthias ; Oswaldo Gomez,Nicolas ; Frommeyer,Yannick Noah ; Doberenz,Sebastian ; Lorenz,Anne ; Kordes,Adrian ; Grobe,Svenja ; Müsken,Mathias; Depledge,Daniel P. ; Svensson,Sarah L. ; Weiss,Siegfried ; Kaever,Volkhard ; Pich,Andreas ; Sharma,Cynthia M. ; Ignatova,Zoya ; Häussler,Susanne ; tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa, United States,Proc.Natl.Acad.Sci.U.S.A.,2024;121(11):-e2312874121 Originalpublikation Kukoc-Modun, Lea; Kraljevic, Tomislav; Tsikas, Dimitrios ; Spassov, Tony G; Kolev, Spas D Determination of -Acetyl-L-cysteine Ethyl Ester (NACET) by Sequential Injection Analysis. PMID: 38257405 Originalpublikation Neufeldt,Dimyana ; Schmidt,Arne ; Mohr,Elisa ; Lu,Dongchao; Chatterjee,Shambhabi ; Fuchs,Maximilian; Xiao,Ke ; Pan,Wen; Cushman,Sarah; Jahn,Christopher; Juchem,Malte; Hunkler,Hannah Jill ; Cipriano,Giuseppe ; Jürgens,Bjarne ; Schmidt,Kevin ; Groß,Sonja ; Jung,Mira ; Hoepfner,Jeannine ; Weber,Natalie ; Foo,Roger ; Pich,Andreas ; Zweigerdt,Robert ; Kraft,Theresia ; Thum,Thomas ; Bär,Christian ; Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival, Germany,Basic Res.Cardiol.,2024;119(4):613-632 Originalpublikation Oms,Elisabeth ; Untersuchung des RGD-Motivs in der Bindung und Aufnahme von C3bot in HT22 Zellen, Hannover,,2024;():-4 ungezählte Blätter, 98 Blätter : Dissertation Posma,Rene A. ; Bakker,Stephan J. L. ; Nijsten,Maarten W. ; Touw,Daan J. ; Tsikas,Dimitrios ; Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment, Switzerland,J.Clin.Med.,2024;13(13):3692- Originalpublikation Post,Adrian ; Groothof,Dion ; Kremer,Daan ; Knobbe,Tim J. ; Abma,Willem ; Koops,Christa A. ; Tsikas,Dimitrios ; Wallimann,Theo ; Dullaart,Robin P. F. ; Franssen,Casper F. M. ; Kema,Ido P. ; Heiner-Fokkema,M. Rebecca ; Bakker,Stephan J. L. ; Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls, Austria,Amino Acids,2024;56(1):42- Originalpublikation Przykopanski,Adina ; Untersuchung der Komplexbildung des proteinogenen Botulinum Neurotoxins mit dessen assoziierten Proteinen und deren Einfluss auf den transepithelialen Transport des Toxins 2023, Dissertation Sainz von Petzinger,Sylvana ; Protektive Effekte von Chitosan Oligosacchariden gegen Clostridioides difficile Toxin A und Toxin B 2024, Masterarbeit Schmidt,Kevin ; Schmidt,Arne ; Groß,Sonja ; Just,Annette ; Pfanne,Angelika ; Fuchs,Maximilian ; Jordan,Maria ; Mohr,Elisa ; Pich,Andreas ; Fiedler,Jan ; Thum,Thomas ; SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation, England,Sci.Rep.,2024;14(1):16459- Originalpublikation Scholz,Jonas ; Stephan,Till ; Pérez,Aina Gallemí ; Csiszár,Agnes ; Hersch,Nils ; Fischer,Lisa S. ; Brühmann,Stefan ; Körber,Sarah ; Litschko,Christof ; Mijanovic,Lucija ; Kaufmann,Thomas ; Lange,Felix ; Springer,Ronald ; Pich,Andreas ; Jakobs,Stefan ; Peckham,Michelle ; Tarantola,Marco ; Grashoff,Carsten ; Merkel,Rudolf ; Faix,Jan ; Decisive role of mDia-family formins in cell cortex function of highly adherent cells Sci.Adv., 2024, 10(44), - eadp5929, Originalpublikation Tapken,Ines ; Schweitzer,Theresa ; Paganin,Martina ; Schüning,Tobias ; Detering,Nora T. ; Sharma,Gaurav ; Niesert,Moritz ; Saffari,Afshin ; Kuhn,Daniela ; Glynn,Amy ; Cieri,Federica ; Santonicola,Pamela ; Cannet,Claire ; Gerstner,Florian ; Faller,Kiterie M. E. ; Huang,Yu-Ting ; Kothary,Rashmi ; Gillingwater,Thomas H. ; Di Schiavi,Elia ; Simon,Christian M. ; Hensel,Niko ; Ziegler,Andreas ; Viero,Gabriella ; Pich,Andreas ; Claus,Peter ; The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy Brain, 2024, (), - , Originalpublikation Tsap,Mariana I. ; Yatsenko,Andriy S. ; Hegermann,Jan ; Beckmann,Bibiana ; Tsikas,Dimitros ; Shcherbata,Halyna R. ; Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier, England,Elife,2024;13():-e98020 Originalpublikation Tsikas, Dimitrios Application of the Bland-Altman and Receiver Operating Characteristic (ROC) Approaches to Study Isotope Effects in Gas Chromatography-Mass Spectrometry Analysis of Human Plasma, Serum and Urine Samples Molecules, 29(2):365, 2024 ISSN:1420-3049 (elektronisch)PMID:38257277 »DOI:10.3390/molecules29020365 » Originalpublikation Tsikas,Dimitrios ; Perspektiven der quantitativen GC-MS, LC-MS und ICP-MS in der klinischen Medizin - Die Rolle der analytischen Chemie, Schweiz, J.Clin.Med., 2024; 13(23):7276 Originalpublikation Tsikas,Dimitrios ; Zugrunde liegende Mechanismen von chromatographischen H/D-, H/F-, cis/trans- und Isomerie-Effekten bei GC-MS, Schweiz, 2025; 15(1):43 Originalpublikation Waleczek,Florian J. 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PMID: 38159068 Originalpublikation Joensuu,Merja; Syed,Parnayan; Saber,Saber H.; Lanoue,Vanessa; Wallis,Tristan P.; Rae,James; Blum,Ailisa; Gormal,Rachel S.; Small,Christopher; Sanders,Shanley; Jiang,Anmin; Mahrhold,Stefan ; Krez,Nadja; Cousin,Michael A.; Cooper-White,Ruby; Cooper-White,Justin J.; Collins,Brett M.; Parton,Robert G.; Balistreri,Giuseppe; Rummel,Andreas ; Meunier,Frederic A.; Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry, England,EMBO J.,2023;42(13):-e112095 10.15252/embj.2022112095 Berichtsjahr:2023 | ID: RefID:39384-joensuu2023presynaptic Originalpublikation Liu,Zheng; Lee,Pyung-Gang; Krez,Nadja; Lam,Kwok-Ho; Liu,Hao; Przykopanski,Adina ; Chen,Peng; Yao,Guorui; Zhang,Sicai; Tremblay,Jacqueline M.; Perry,Kay; Shoemaker,Charles B.; Rummel,Andreas ; Dong,Min; Jin,Rongsheng; Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, England,Nat.Commun.,2023;14(1):2338-10.1038/s41467-023-37860-8 Berichtsjahr:2023 | ID: RefID:26323-liu2023structural Originalpublikation Manion,John; Musser,Melissa A.; Kuziel,Gavin A.; Liu,Min; Schäfer,Amy; Wang,Siyu; Lee,Pyung-Gang; Zhao,Leo; Zhang,Jie; Marreddy,Ravi K. R.; Goldschmied,Jeffrey D.; Yuan,Ke; Hürde,Julian G.; Gerhard,Ralf ; Jin,Rongsheng; Rakoff-Nahoum,Seth; Rao,Meenakshi; Dong,Min; C. difficile vergiftet Neuronen und Perizyten, um neurogene Entzündungen voranzutreiben, England,,2023; 622(7983):611-618 Originalpublikation Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner 3rd, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich , Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet Die pharmakologische Hemmung von Bromodomänen und extraterminalen Proteinen induziert einen NRF-2-vermittelten antiviralen Zustand, der durch eine SARS-CoV-2-Infektion untergraben wird, Vereinigte Staaten, PLoS Pathog., 2023; ():- Originalpublikation Mikuteit,Marie; Baskal,Svetlana ; Klawitter,Sandra; Dopfer-Jablonka,Alexandra; Behrens,Georg M. N.; Müller,Frank; Schröder,Dominik; Klawonn,Frank; Steffens,Sandra; Tsikas,Dimitrios ; Aminosäuren, posttranslationale Modifikationen, Stickstoffmonoxid und oxidativer Stress in Serum und Urin von Long-COVID- und Ex-COVID-Probanden, Österreich,Aminosäuren,2023; 55(9):1173-1188 Originalpublikation Pankoke,Sophia; Schweitzer,Theresa ; Biker,Rolf; Pich,Andreas ; Pfarrer,Christiane; Mühlfeld,Christian; Schipke,Julia; Fettleibigkeit wirkt sich auf die Hypoxieanpassung der Lunge aus, Vereinigte Staaten,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023; 325(3):L352-L359 Originalpublikation Pokrant,Thomas; Hein,Jens Ingo; Körber,Sarah; Disanza,Andrea; Pich,Andreas ; Scita,Giorgio; Rottner,Klemens; Faix,Jan; Das Ena/VASP-Clustering an den Mikrospike-Spitzen umfasst Lamellipodin, aber keine I-BAR-Proteine und erfordert unbedingt unkonventionelle Myosin-X, United States,Proc.Natl.Acad.Sci.U.S.A.,2023;120(2):-e2217437120 10.1073/pnas.2217437120 Berichtsjahr:2023 | ID: RefID:26134-pokrant2023ena/vasp Originalpublikation Rahardjo,Harrina E.; Märker,Viktoria; Tsikas,Dimitrios ; Kuczyk,Markus A.; Ückert,Stefan; Bannowsky,Andreas; Fibrotische Erkrankungen der menschlichen Harn- und Genitalwege: aktuelles Verständnis und mögliche Behandlungsstrategien, Schweiz,J.Clin.Med.,2023; 12(14):4770 Originalpublikation Rahardjo,Harrina E. ; Ückert,Stefan ; Tsikas,Dimitrios ; Bannowsky,Andreas ; Kuczyk,Markus A. ; Becker,Armin J. ; Courses of Arginine-Vasopressin in the Systemic and Cavernous Blood through Different Stages of Sexual Arousal in Healthy Males and Patients with Erectile Dysfunction,,,2023;2023():7978734- Originalpublikation Rohrbeck,Astrid ; Bruhn,Vanessa Anna ; Hussein,Nali ; Hagemann,Sandra ; Just,Ingo ; Clostridium botulinum C3bot vermittelte Wirkungen auf den Zytokin-induzierten Psoriasis-ähnlichen Phänotyp im Hautmodell mit voller Dicke, Deutschland,Naunyn Schmiedebergs Arch.Pharmacol.,2023; ():- Originalpublikation Rosenstein,Christopher ; Identifizierung einer zweiten Rezeptorbindungstasche in Botulinum Neurotoxin F, Hannover,,2022;():-2 ungezählte Blätter, 77 Blätter : 10.26068/mhhrpm/20230601-002 Berichtsjahr:2023 | ID: RefID:26365-rosenstein2022identifizierung Dissertation Schneemann,Martina; Heils,Lucas; Moos,Verena; Weiß,Franziska; Krug,Susanne M.; Weiner,Januar; Beule,Dieter; Gerhard,Ralf ; Schulzke,Jörg-Dieter; Bücker,Roland; Ein Kolon-Organoid-Modell, das mit den großen Toxinen von Clostridioides difficile TcdA und TcdB konfrontiert ist, weist deregulierte Tight-Junction-Proteine auf, Schweiz,Toxins (Basel),2023; 15(11):643 Originalpublikation Schweitzer,Theresa ; Untersuchungen zu den Wirkungen clostridieller glukosylierender Toxine,Hannover,,2023; ():-VIII, 115 Seiten : Illustrationen, Diagramme Dissertation Sinningen,Kathrin; Emons,Barbara; Böhme,Pierre; Juckel,Georg; Hanusch,Beatrice; Beckmann,Bibiana ; Tsikas,Dimitrios ; Lücke,Thomas; L-Arginin/Stickstoffmonoxid-Signalweg und oxidativer Stress bei Erwachsenen mit ADHS: Auswirkungen der Methylphenidat-Behandlung, Vereinigte Staaten, Stickstoffmonoxid, 2023; 138-139():64-69 Originalpublikation Tsikas,Dimitrios ; Acetazolamid und menschliche Carboanhydrasen: Rückblick, Rückblick und Diskussion einer intimen Beziehung, England,J.Enzyme Inhib.Med.Chem.,2024; 39(1):2291336 sonstiges Tsikas,Dimitrios ; Beckmann,Bibiana ; Baskal,Svetlana ; Brunner,Görig ; Pentafluorpropionsäure-Anhydrid-Derivatisierung und GC-MS-Analyse von Histamin, Agmatin, Putrescin und Spermidin: Auswirkungen von Lösungsmitteln und Startsäulentemperatur, Schweiz,Moleküle,2023; 28(3):939 Originalpublikation Tsikas,Dimitrios ; Beckmann,Bibiana ; Qualitätskontrolle in gezielter GC-MS für Aminosäure-OMICS, Schweiz,,2023; 13(9):986 Originalpublikation Tsikas,Dimitrios ; Büttner,Petra; Sagen zirkulierende Konzentrationen von L-Arginin-Metaboliten den Status der koronaren Herzkrankheit und die Wahrscheinlichkeit kardiovaskulärer Ereignisse voraus?, Poland,Pol.Arch.Intern.Med.,2023;133(2):16429-10.20452 /pamw.16429 Berichtsjahr:2023 | ID: RefID:26154-tsikas2023zirkulierend Editorial Tsikas,Dimitrios ; GC-MS- und GC-MS/MS-Messung von Malondialdehyd (MDA) in klinischen Studien: Präanalytische und klinische Überlegungen, Niederlande,J.Mass.Spectrom.Adv.Clin.Lab.,2023; 30():10-24 Übersicht Tsikas,Dimitrios ; GC-MS-Studien zur Stickstoffmonoxid-Autoxidation und S-Nitrosothiol-Hydrolyse zu Nitrit in pH-neutralen wässrigen Puffern: Definitive Ergebnisse unter Verwendung von (15)N- und (18)O-Isotopen, Schweiz,Moleküle,2023; 28(11):4281-http://doi.org/10.3390/molecules28114281 Originalpublikation Tsikas,Dimitrios ; Malondialdehyd-induzierte posttranslationale Modifikation des menschlichen Hämoglobins, Vereinigte Staaten,J.Proteome Res.,2023; 22(6):2141-2143 Kommentar Tsikas,Dimitrios ; Massenspektrometrie-basierte Bewertung des Bland-Altman-Ansatzes: Überprüfung, Diskussion und Vorschlag, Schweiz,Moleküle,2023; 28(13):4905 Übersicht Tsikas,Dimitrios ; Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2023;1221():123684-10.1016/j.jchromb.2023.123684 Berichtsjahr:2023 | ID: RefID:26250-tsikas2023measurement Letter Tsikas,Dimitrios ; Tsikas,Stefanos A.; Mikuteit,Marie; Ückert,Stefan; Zirkulierende und Urinkonzentrationen von Malondialdehyd bei alternden Menschen in Gesundheit und Krankheit: Überprüfung und Diskussion, Schweiz,,2023; 11(10):2744 Übersicht Weißenborn,Wiebke ; Pharmakologische Untersuchungen des Sesquiterpens BCP als potenzielle postoperative Opioidalternative, Hannover,,2022; ():-4 ungezählte Blätter, 78 Blätter Dissertation 2022 Baskal,S. ; Beckmann,B. ; Stahmer,L.; Peter,C.; Bohnhorst,B.; Das,A. M.; Tsikas,D. ; Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period, Austria,Amino Acids,2022;():- 10.1007/s00726-022-03197-7 Berichtsjahr:2022 | ID: RefID:25095-baskal2022role Originalpublikation Baskal,S. ; Bollenbach,A. ; Henzi,B.; Hafner,P.; Fischer,D.; Tsikas,D. ; Stable-Isotope Dilution GC-MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination, Switzerland,Molecules,2022;27(12):3850-10.3390/molecules27123850 Berichtsjahr:2022 | ID: RefID:25096-baskal2022stable-isotope Originalpublikation Baskal,S. ; Dimina,L.; Tsikas,S. A.; Mosoni,L.; Remond,D.; Mariotti,F. ; Tsikas,D. ; Lysine and homoarginine are closely interrelated metabolites in the rat, Austria,Amino Acids,2022;54(6):967-976, 10.1007/s00726-022-03158-0 Berichtsjahr:2022 | ID: RefID:25097-baskal2022lysine Originalpublikation Baskal,S. ; Kaiser,A.; Mels,C.; Kruger,R.; Tsikas,D. ; Specific and sensitive GC-MS analysis of hypusine, N(epsilon)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study Austria, Amino Acids, 2022, (), - , Berichtsjahr: 2022| ID: 11345 (35243537) Originalpublikation Baskal,S. ; Tsikas,S. A.; Begou,O.; Bollenbach,A. ; Lenzen,S.; Jörns,A.; Tsikas,D. ; Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-alpha Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes Switzerland, Int.J.Mol.Sci., 2022, 23(3), 1541- , Berichtsjahr: 2022| ID: 11166 (35163462) Originalpublikation Baskal,Svetlana ; Tsikas,Dimitrios ; Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nepsilon-Carboxymethyl-Lysine, Nepsilon-Carboxyethyl-Lysine and Nepsilon-Hydroxymethyl-Lysine. ,,Int J Mol Sci,2022;23(7):3446-10.3390/ijms23073446 Berichtsjahr:2022 | ID: RefID:25100-baskal2022free Originalpublikation Becker,E. ; Francino,A. ; Pich,A. ; Perrot,A. ; Kraft,T. ; Radocaj,A. ; , AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy Switzerland, Front.Cardiovasc.Med., 2022, 9(), 816330- ,Berichtsjahr: 2022| ID: 11362 (35265683) Originalpublikation Bense,S. ; Witte,J. ; Preuße,M. ; Koska,M. ; Pezoldt,L. ; Dröge,A. ; Hartmann,O. ; Müsken,M. ; Schulze,J. ; Fiebig,T. ; Bähre,H. ; Felgner,S. ; Pich,A. ; Häussler,S. ; Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels, England,Mol.Microbiol.,2022;117(5):1213-1226, 10.1111/mmi.14902 Berichtsjahr:2022 | ID: RefID:25178-bense2022pseudomonas Originalpublikation Bollenbach,A. ; Baskal,S. ; Mels,C. ; Kruger,R. ; Tsikas,D. ; Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine, Switzerland,Molecules,2022;27(16):5202-10.3390/molecules27165202 Berichtsjahr:2022 | ID: RefID:25229-bollenbach2022unusual Originalpublikation Borgert,Sebastian Roman ; Henke,Steffi ; Witzgall,Florian ; Schmelz,Stefan ; Zur Lage,Susanne ; Hotop,Sven-Kevin ; Stephen,Steffi ; Lübken,Dennis ; Krüger,Jonas ; Gomez,Nicolas Oswaldo ; van Ham,Marco ; Jänsch,Lothar ; Kalesse,Markus ; Pich,Andreas ; Brönstrup,Mark ; Häussler,Susanne ; Blankenfeldt,Wulf ; Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa, England,Nat.Commun.,2022;13(1):7402-10.1038/s41467-022-35030-w, Berichtsjahr:2022 | ID: RefID:25237-borgert2022moonlighting Originalpublikation Durisin,M. ; Krüger,C. ; Pich,A. ; Warnecke,A. ; Steffens,M. ; Zeilinger,C. ; Lenarz,T. ; Prenzler,N. ; Schmitt,H. ; Proteomprofil von Patienten mit ausgezeichneter und schlechter Sprachverständlichkeit nach Cochlea-Implantation: Können Perilymphproteine die Leistung vorhersagen?, United States,PLoS One,2022;17(3):-e0263765, 10.1371/journal.pone.0263765 Berichtsjahr:2022 | ID: RefID:25549-durisin2022proteome Originalpublikation Fan,C. ; Wu,Z. ; Cooper,D. 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Amino Acids 2017; 49(4):783-794 Originalpublikation Volltext Debez A, Belghith I, Pich A, Taamalli W, Abdelly C, Braun H P High salinity impacts germination of the halophyte Cakile maritima but primes seeds for rapid germination upon stress release. Physiol. Plant. 2017, ppl.12679- Originalpublikation Volltext Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells. Proteomics 2017; 17(15-16):1600435- Originalpublikation Volltext Fischer V, Just I Qualitätssicherung in Prüfungen am Beispiel von 10 Jahren e-Prüfungen an der MHH. Qualität in der Wissenschaft (QiW) 2017; 11(2):60-64 Originalpublikation Volltext Günes D N, Kayacelebi A A, Hanff E, Lundgren J, Redfors B, Tsikas D Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat. Amino Acids 2017; 49(12):2033-2044 Originalpublikation Volltext Haghikia A, Yanchev G R, Kayacelebi A A, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients. Amino Acids 2017; 49(6):1111-1121 Originalpublikation Volltext Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Göhring G, Schmidt H, Sgodda M, Cantz T In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. Biol.Chem. 2017; 398(8):939-954 Originalpublikation Volltext Junemann J, Lämmerhirt C M, Polten F, Just I, Gerhard R, Genth H, Pich A Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis. Proteomics 2017; 17(9):1700016- Originalpublikation Volltext Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H, Feelisch M, van Goor H, Bakker S J L, Tsikas D Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients. Amino Acids 2017; 49(7):1193-1202 Originalpublikation Volltext Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells. Chembiochem 2017; 18(13):1317-1331 Originalpublikation Volltext Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms. J. Proteome Res. 2017; 16(3):1133-1149 Originalpublikation Volltext Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands. Croat. Chem. Acta 2017; 90(2):263-271 Originalpublikation Volltext Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012- Originalpublikation Volltext Nkuipou-Kenfack E, Schanstra J P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P The use of urinary proteomics in the assessment of suitability of mouse models for ageing. PLoS One 2017; 12(2):e0166875- Originalpublikation Volltext Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature. Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038- Übersicht Volltext Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation 2017; 136(19):1809-1823 Originalpublikation Volltext Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif. J. Biol. Chem. 2017; 292(43):17668-17680 Originalpublikation Volltext Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front. Cell. Infect. Microbiol. 2017; 7(67- Originalpublikation Volltext Rummel A Two Feet on the Membrane: Uptake of Clostridial Neurotoxins. Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48- Übersicht Volltext Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics. PLoS One 2017; 12(5):e0178182- Originalpublikation Volltext Tsikas D Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first. Atherosclerosis 2017; 264:79-82 Editorial Volltext Tsikas D The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a. J Controversies Biomed Res 2017; 3(1):11-15 Originalpublikation Volltext Tsikas D Does oxidative stress change during orthotopic liver transplantation? J Controversies Biomed Res 2017; 3(2):1-5 Originalpublikation Volltext Tsikas D Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox. J Controversies Biomed Res 2017; 3(1):16-22 Originalpublikation Volltext Tsikas D Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans". Anal.Bioanal Chem. 2017; 409(9):2495- Letter Volltext Tsikas D Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS? Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040- Letter Volltext Tsikas D Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid. JSM Biochem Mol Biol 2017; 4(2):1027- Originalpublikation Volltext Tsikas D What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72 Übersicht Volltext Tsikas D, Böhmer A S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature. Nitric Oxide 2017; 65:22-36 Originalpublikation Volltext Tsikas D, Bollenbach A, Savvidou M D Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction? Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2- Originalpublikation Volltext Tsikas D, Eigendorf J Diet and Exercise and Serum Markers of Oxidative Stress-Letter. Cancer.Prev.Res.(Phila) 2017; 10(8):485-486 Letter Volltext Tsikas D, Hanff E Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142 Übersicht Volltext Tsikas D, Hanff E, Becker T Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft? Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009- Letter Volltext Tsikas D, Hanff E, Bollenbach A S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics. World J.Gastroenterol. 2017; 23(40):7343-7346 Letter Volltext Tsikas D, Hanff E, Brunner G Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase. Trends Microbiol. 2017; 25(8):601-602 Letter Volltext Tsikas D, Hanff E, Brunner G Spermidine for a long, dementia-free life? Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576- Übersicht Volltext Tsikas D, Kinzel M Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men. Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004- Originalpublikation Volltext Tsikas D, Savvidou M Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile. JSM Biochem Mol Biol 2017; 4(2):1028- Originalpublikation Volltext Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview. 2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003- Originalpublikation Volltext von Elsner L, Hagemann S, Just I, Rohrbeck A Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation. J Mol Signal 2017; 12(1- Originalpublikation Volltext Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093- Originalpublikation Volltext Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. Sci.Rep. 2017; 7(1):7438- Originalpublikation Volltext Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567- Originalpublikation Volltext 2016 Frädrich C, Beer LA, Gerhard R Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B Toxins (Basel) 2016; 8 (1), 25 Übersicht Abstract Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82) Originalpublikation Abstract Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme Journal of Neurochemistry 2016; 139 (2): 234-244 Originalpublikation Volltext Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization Scientific Reports 2016; 6 (36598-) Originalpublikation Volltext Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A Biological toxins of potential bioterrorism risk: Current status of detection and identification technology TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102 Übersicht Abstract Gerhard R Receptors and Binding Structures for Clostridium difficile Toxins A and B Current Topics in Microbiology and Immunology 2016: 1-18 Originalpublikation Abstract Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa Environmental Microbiology 2016; 18 (10): 3583-3592 Originalpublikation Volltext Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1 Biochemical Journal 2016; 473 (17): 2645-2654 Originalpublikation Volltext Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody Toxins (Basel) 2016; 8(4):100 Originalpublikation Volltext Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M Frizzled proteins are colonic epithelial receptors for C. difficile toxin B Nature 2016; 538(7625): 350-355 Originalpublikation Volltext von Elsner L, Hagemann S, Just I, Rohrbeck A C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031 Originalpublikation Volltext Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin Toxins (Basel) 2016; 8(5), 154 Originalpublikation Volltext Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A Nature Structural & Molecular Biology 2016; 23 (7): 656-662 Originalpublikation Volltext Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043 Originalpublikation Volltext Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4) Originalpublikation Volltext Genth H, Schelle I, Just I Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B Toxins (Basel) 2016; 8 (4): 109 Originalpublikation Volltext Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry Analyst 2016; 141 (18): 5281 -5297 Originalpublikation Volltext Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8 Originalpublikation Abstract Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50 Originalpublikation Volltext Schelle I, Bruening J, Buetepage M, Genth H Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B Toxins (Basel) 2016; 9 (1), 2 Originalpublikation Volltext 2015 Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction Nature medicine 2015;2;2;140-149 Volltext Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype PLoS One 2015;10;2 Volltext Rohrbeck A, von Elsner L, Hagemann S, Just I Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells Toxins 2015;7;380-395 Volltext Bothe M, Dutow P, Pich A, Genth H, Klos A DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166 Toxins 2015;17;621-637 Volltext Haschemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients. Eur Addict Res 2016;22(2);59 -69 Volltext Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics. Toxicon 2015;107(Pt.A);43 -49 Abstract Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G UV radiation induces CXCL5 expression in human skin. Exp Dermatol 2015;24(4);309 -312 Volltext Rummel A The long journey of botulinum neurotoxins into the synapse. Toxicon 2015;107(Pt.A):9 -24 Abstract Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity Neurochem Int 2015; 90;232 -245 Abstract Schröder A, Rohrbeck A, Just I, Pich A Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme. J Proteome Res 2015;14(11);4721 -4733 Volltext Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH miR-139-5p controls translation in myeloid leukemia through EIF4G2. Oncogene 2015;DOI: 10.1038/onc.2015.247 Volltext Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117 Abstract Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta 2015;1853(1);136 -143 Volltext Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP). J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016 Volltext Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Microbiol 2015;17(8);1179 -1204 Volltext Dorner BG, Rummel A Preface biological Toxins ancient molecules posing a current threat. Toxins 2015;7(12);5320 -5321 Volltext 2014 Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F. Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca and GTPgammaS ,,Toxicology,2015;328():48-56 Originalpublikation Chatterji,B. ; Dickhut,C. ; Mielke,S. ; Krüger,J. ; Just,I. ; Glage,S. ; Meier,M. ; Wedekind,D. ; Pich,A. MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease , Germany,Proteomics,2014;14(13-14):1674-1687 Originalpublikation Dressler,D. ; Adib Saberi,F. ; Bigalke,H. IncobotulinumtoxinA (Xeomin((R))) can produce antibody-induced therapy failure in a patient pretreated with abobotulinumtoxinA (Dysport((R))) Austria,J.Neural Transm.,2014;121(7):769-771 Case report Dressler,D. ; Gessler,F. ; Tacik,P. ; Bigalke,H. An enzyme-linked immunosorbent assay for detection of botulinum toxin-antibodies United States,Mov.Disord.,2014;29(10):1322-1324 Originalpublikation Genth,H. ; Pauillac,S. ; Schelle,I. ; Bouvet,P. ; Bouchier,C. ; Varela-Chavez,C. ; Just,I. ; Popoff,M. R. Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins England,Cell.Microbiol.,2014;16(11):1706-1721 Originalpublikation Gonzalez-Escalona,N. ; Thirunavukkarasu,N. ; Singh,A. ; Toro,M. ; Brown,E. W. ; Zink,D. ; Rummel,A. ; Sharma,S. K. Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type United States,Genome Announc,2014;2(6):10.1128/genomeA.01275-14 Originalpublikation Goy,S. D. ; Olling,A. ; Neumann,D. ; Pich,A. ; Gerhard,R. Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor ,,Cell.Microbiol.,2015;17(6):893-909 Originalpublikation Hardtke-Wolenski,M. ; Taubert,R. ; Noyan,F. ; Sievers,M. ; Dywicki,J. ; Schlue,J. ; Falk,C. S. ; Lundgren,B. A. ; Scott,H. S. ; Pich,A. ; Anderson,M. S. ; Manns,M. P. ; Jaeckel,E. Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens ,,Hepatology,2015;61(4):1295-1305 Originalpublikation Jochim,N. ; Gerhard,R. ; Just,I. ; Pich,A. Time-resolved cellular effects induced by TcdA from Clostridium difficile England,Rapid Commun.Mass Spectrom.,2014;28(10):1089-1100 Originalpublikation Jünger,J. ; Just,I. Recommendations of the German Society for Medical Education and the German Association of Medical Faculties regarding university-specific assessments during the study of human, dental and veterinary medicine Germany,GMS Z.Med.Ausbild,2014;31(3):Doc34- Originalpublikation Konze,S. A. ; van Diepen,L. ; Schröder,A. ; Olmer,R. ; Moller,H. ; Pich,A. ; Weissmann,R. ; Kuss,A. W. ; Zweigerdt,R. ; Buettner,F. F. Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells United States,Mol.Cell.Proteomics,2014;13(4):990-1007 Originalpublikation Lee,K. ; Lam,K. H. ; Kruel,A. M. ; Perry,K. ; Rummel,A. ; Jin,R. High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex United States,Biochem.Biophys.Res.Commun.,2014;446(2):568-573 Originalpublikation Lee,K. ; Zhong,X. ; Gu,S. ; Kruel,A. M. ; Dorner,M. B. ; Perry,K. ; Rummel,A. ; Dong,M. ; Jin,R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex United States,Science,2014;344(6190):1405-1410 Originalpublikation Matsui,T. ; Gu,S. ; Lam,K. H. ; Carter,L. G. ; Rummel,A. ; Mathews,I. I. ; Jin,R. Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex England,J.Mol.Biol.,2014;426(22):3773-3782 Originalpublikation May,M. ; Schelle,I. ; Brakebusch,C. ; Rottner,K. ; Genth,H. Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry United States,Cell.Cycle,2014;13(14):2211-2221 Originalpublikation Nkuipou-Kenfack,E. ; Koeck,T. ; Mischak,H. ; Pich,A. ; Schanstra,J. P. ; Zürbig,P. ; Schumacher,B. Proteome analysis in the assessment of ageing ,,Ageing Res.Rev.,2014;18C():74-85 Übersicht Olling,A. ; Hüls,C. ; Goy,S. ; Müller,M. ; Krooss,S. ; Rudolf,I. ; Tatge,H. ; Gerhard,R. The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation Switzerland,Toxins (Basel),2014;6(7):2162-2176 Originalpublikation Rohrbeck,A. ; Schröder,A. ; Hagemann,S. ; Pich,A. ; Höltje,M. ; Ahnert-Hilger,G. ; Just,I. Vimentin mediates uptake of C3 exoenzyme United States,PLoS One,2014;9(6):e101071- Originalpublikation Rohrbeck,A. ; von Elsner,L. ; Hagemann,S. ; Just,I. Binding of Clostridium botulinum C3 exoenzyme to intact cells Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2014;387(6):523-532 Originalpublikation Rummel,A. ; The dual receptor recognition of botulinum neurotoxins New York, NY,,2014;4():129-150 Buchbeitrag, Monografie Saul,V. V. ; Niedenthal,R. ; Pich,A. ; Weber,F. ; Lienhard Schmitz,M. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity Netherlands,Biochim.Biophys.Acta,2015;1853(1):136-143 Originalpublikation Strotmeier,J. ; Mahrhold,S. ; Krez,N. ; Janzen,C. ; Lou,J. ; Marks,J. D. ; Binz,T. ; Rummel,A. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A Netherlands,FEBS Lett.,2014;588(7):1087-1093 Originalpublikation Wagner,S. ; Maibaum,D. ; Pich,A. ; Nolte,I. ; Murua Escobar,H. Verification of a Canine PSMA (FolH1) Antibody Greece,Anticancer Res.,2015;35(1):145-148 Originalpublikation Wohlan,K. ; Goy,S. ; Olling,A. ; Srivaratharajan,S. ; Tatge,H. ; Genth,H. ; Gerhard,R. Pyknotic cell death induced by Clostridium difficile TcdB: Chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity ,,Cell.Microbiol.,2014;76(11):1678-1692 Originalpublikation Boetzkes,Alexander Sekretomanalyse hypervirulenter Clostridium difficile-Stämme ,,,2014;():Getr. Zählung- Dissertation Brandes,Vanessa Die durch Tauroursodeoxycholsäure vermittelte Phosphorylierung von Rac1/Cdc42 bewirkt eine reduzierte Glucosylierung katalysiert durch C. difficile Toxin B ,,,2014;():Bl. 77 - 84, Bl. 11 - 43- Dissertation Goy,Sebastian David Clostridium difficile Toxin B activates formyl peptide receptor 1 of human neutrophil granulocytes via N-terminal glucosyltransferase domain ,,,2014;():138 Bl. Ill., graph. Darst.- Dissertation Rotsch,Jacqueline Zelluläre Auswirkungen des bakteriellen Exoenzyms C3 bot ,,,2011;():III, 72 Bl. Ill., graph. Darst.- Dissertation Beer,Lara-Antonia Die Rolle der niedermolekularen GTpase Rac1 und der NADPH Oxidase bei der Clostridium difficile TcdB-induzierten Pyknose ,,,2011;():- Masterarbeit Petersen,Lara Die Rolle von Rho-GTPasen in den zytopathischen und zytotoxischen Wirkungen von Clostridium difficile Toxinen ,,,2011;():62 S.- Masterarbeit Gangl,Anna-Katharina Effekte des marinen Toxins Latrunculin B auf die epitheliale Barrierefunktion des Kolon ,,,2011;():37 S.- Bachelorarbeit 2013 Bagramyan,K. ; Kaplan,B. E. ; Cheng,L. W. ; Strotmeier,J. ; Rummel,A. ; Kalkum,M. Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples United States,Anal.Chem.,2013;85(11):5569-5576 Originalpublikation Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F. Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPgammaS containing intracellular solution Netherlands,Eur.J.Pharmacol.,2013;720(1-3):227-236 Originalpublikation Barth,H. ; Bigalke,H. ; Gerhard,R. ; Bakterielle Toxine (Kap. 42) Stuttgart,,2013;():1157-1180 Buchbeitrag, Monografie Bigalke,H. Botulinum toxin: application, safety, and limitations Germany,Curr.Top.Microbiol.Immunol.,2013;364():307-317 Originalpublikation Chatterji,B. ; Pich,A. MALDI imaging mass spectrometry and analysis of endogenous peptides England,Expert Rev.Proteomics,2013;10(4):381-388 Originalpublikation Gerhard,R. ; Frenzel,E. ; Goy,S. ; Olling,A. Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain ,,J.Med.Microbiol.,2013;62(9):1414-1422 Originalpublikation Höltje,M. ; Schulze,S. ; Strotmeier,J. ; Mahrhold,S. ; Richter,K. ; Binz,T. ; Bigalke,H. ; Ahnert-Hilger,G. ; Rummel,A. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons ,,Toxicon,2013;75C():108-121 Originalpublikation Huelsenbeck,S. C. ; Roggenkamp,D. ; May,M. ; Huelsenbeck,J. ; Brakebusch,C. ; Rottner,K. ; Ladwein,M. ; Just,I. ; Fritz,G. ; Schmidt,G. ; Genth,H. Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1 Netherlands,Int.J.Biochem.Cell Biol.,2013;45(8):1767-1775 Originalpublikation Lee,K. ; Gu,S. ; Jin,L. ; Le,T. T. ; Cheng,L. W. ; Strotmeier,J. ; Kruel,A. M. ; Yao,G. ; Perry,K. ; Rummel,A. ; Jin,R. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity United States,PLoS Pathog.,2013;9(10):e1003690- Originalpublikation Mahrhold,S. ; Strotmeier,J. ; Garcia-Rodriguez,C. ; Lou,J. ; Marks,J. D. ; Rummel,A. ; Binz,T. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E England,Biochem.J.,2013;453(1):37-47 Originalpublikation May,M. ; Wang,T. ; Müller,M. ; Genth,H. Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470 Switzerland,Toxins (Basel),2013;5(1):106-119 Originalpublikation Pirazzini,M. ; Henke,T. ; Rossetto,O. ; Mahrhold,S. ; Krez,N. ; Rummel,A. ; Montecucco,C. ; Binz,T. Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain Netherlands,FEBS Lett.,2013;587(23):3831-3836 Originalpublikation Rangrez,A. Y. ; Bernt,A. ; Poyanmehr,R. ; Harazin,V. ; Boomgaarden,I. ; Kuhn,C. ; Rohrbeck,A. ; Frank,D. ; Frey,N. Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy United States,J.Cell Biol.,2013;203(4):643-656 Originalpublikation Rummel,A. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity Germany,Curr.Top.Microbiol.Immunol.,2013;364():61-90 Originalpublikation Scherr,M. ; Elder,A. ; Battmer,K. ; Barzan,D. ; Bomken,S. ; Ricke-Hoch,M. ; Schröder,A. ; Venturini,L. ; Blair,H. J. ; Vormoor,J. ; Ottmann,O. ; Ganser,A. ; Pich,A. ; Hilfiker-Kleiner,D. ; Heidenreich,O. ; Eder,M. ; Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia ,,Leukemia,2014;28(3):554-565 Originalpublikation Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P. The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases United States,PLoS Pathog.,2013;9(11):e1003746- Originalpublikation Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P. The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases United States,PLoS Pathog.,2013;9(11):e1003746- Originalpublikation Steffen,A. ; Ladwein,M. ; Dimchev,G. A. ; Hein,A. ; Schwenkmezger,L. ; Arens,S. ; Ladwein,K. I. ; Holleboom,J. M. ; Schur,F. ; Small,J. V. ; Schwarz,J. ; Gerhard,R. ; Faix,J. ; Stradal,T. E. ; Brakebusch,C. ; Rottner,K. Rac function is critical for cell migration but not required for spreading and focal adhesion formation ,,J.Cell.Sci.,2013;126(Pt.20):4572-4588 Originalpublikation Stevens,G. B. ; Silver,D. A. ; Zgaga-Griesz,A. ; Bessler,W. G. ; Vashist,S. K. ; Patel,P. ; Achazi,K. ; Strotmeier,J. ; Worbs,S. ; Dorner,M. B. ; Dorner,B. G. ; Pauly,D. ; Rummel,A. ; Urban,G. A. ; Krueger,M. Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity ,,Analyst,2013;138(20):6154-6162 Originalpublikation Willjes,G. ; Mahrhold,S. ; Strotmeier,J. ; Eichner,T. ; Rummel,A. ; Binz,T. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity United States,Biochemistry,2013;52(22):3930-3938 Originalpublikation Zeiser,J. ; Gerhard,R. ; Just,I. ; Pich,A. Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques ,,J.Proteome Res.,2013;12(4):1604-1618 Originalpublikation Völker,Anne Katrin Identifizierung und Charakterisierung der Rezeptorbindungstaschen von Botulinum Neurotoxin Serotyp D (BoNTD) ,,,2013;():Getr. Zählung Ill., graph. Darst.- Dissertation Benski,Anastasia ; Analysis of C3bot exoenzyme-dependent ADP-ribosylation of smal Rho-GTPases by Mass Spectrometry ,,,2013;():- Masterarbeit Hüls,Corinna Intrazelluläre Assoziation funtioneller Domänen von Clostridium difficile Toxin A ,,,2013;():- Masterarbeit Raasch,Sabine Hemmung clostridialer glucosylierender Toxine durch tauro- und glucokonjugierte Gallensäuren ,,,2013;():- Masterarbeit Ulfig,Anneli Untersuchung von endogenen Peptiden in Rattenhirnen mittels MALDI Imaging and LC-MS ,,,2013;():- Masterarbeit Völkening,Lea Neutralisierende Wirkung tauro- und glycokonjugierter Gallensäuren auf Clostridium difficile Toxin B ,,,2013;():- Masterarbeit Wohlan,Katharina Rho-abhängige und unabhängige Wirkung von Clostridium difficile Toxin B auf den Zellzyklus ,,,2013;():- Masterarbeit Bollenbach,Alexander Identifizierung der aktivitätsmindernden Aminosäuren der Botulinum Neurotoxin Subtypen A4 und A8 (Chemnitz Stamm) ,,,2012;():- Bachelorarbeit Weigt,David Die Wirkung der Zytotoxisch Nekrotisierenden Faktoren aus Yersinia pseudotuberculosis und Escherichia coli auf die epitheliale Barrierefunktion von kultivierten Nierenepithelzellen ,,,2012;():- Bachelorarbeit 2012 Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L. Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons. Front Cell Neurosci 2012;6;43 Originalpublikation Baron,J. ; Blex,C. ; Rohrbeck,A. ; Rachakonda,S. K. ; Birnbaumer,L. ; Ahnert-Hilger,G. ; Brunk,I. The alpha-subunit of the trimeric GTPase Go2 regulates axonal growth ,,J.Neurochem.,2013;124(6):782-794 Originalpublikation Bigalke H, Frevert J. Botulinum toxin A: dose and immune response. Int J Rehabil Res 2012;35(2);93 Originalpublikation Boetzkes,A. ; Felkel,K. W. ; Zeiser,J. ; Jochim,N. ; Just,I. ; Pich,A. Secretome analysis of Clostridium difficile strains Germany,Arch.Microbiol.,2012;194(8):675-687 Originalpublikation Brandes V, Schelle I, Brinkmann S, Schulz F, Schwarz J, Gerhard R, Genth H. Protection from C. difficile Toxin B-catalysed Rac/Cdc42 glucosylation by tauroursodeioxycholic acid-induced Rac/Cdc42 phosphorylation. Biol Chem 2012;1;393(1-2);77-84 Originalpublikation Chiaradia,E. ; Avellini,L. ; Tartaglia,M. ; Gaiti,A. ; Just,I. ; Scoppetta,F. ; Czentnar,Z. ; Pich,A. Proteomic evaluation of sheep serum proteins England,BMC Vet.Res.,2012;8():66- Originalpublikation Debez,A. ; Braun,H. P. ; Pich,A. ; Taamalli,W. ; Koyro,H. W. ; Abdelly,C. ; Huchzermeyer,B. Proteomic and physiological responses of the halophyte Cakile maritima to moderate salinity at the germinative and vegetative stages Netherlands,J.Proteomics,2012;75(18):5667-5694 Originalpublikation Gu,S. ; Rumpel,S. ; Zhou,J. ; Strotmeier,J. ; Bigalke,H. ; Perry,K. ; Shoemaker,C. B. ; Rummel,A. ; Jin,R. Botulinum neurotoxin is shielded by NTNHA in an interlocked complex United States,Science,2012;335(6071):977-981 Originalpublikation Hammerschmidt,A. ; Chatterji,B. ; Zeiser,J. ; Schröder,A. ; Genieser,H. G. ; Pich,A. ; Kaever,V. ; Schwede,F. ; Wolter,S. ; Seifert,R. Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose United States,PLoS One,2012;7(7):e39848- Originalpublikation Hefter,H. ; Hartmann,C. ; Kahlen,U. ; Moll,M. ; Bigalke,H. Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins--a single cohort 4-year follow-up study England,BMJ Open,2012;2(4):10.1136/bmjopen-2011-000646. Print 2012 Originalpublikation Huelsenbeck,J. ; May,M. ; Schulz,F. ; Schelle,I. ; Ronkina,N. ; Hohenegger,M. ; Fritz,G. ; Just,I. ; Gerhard,R. ; Genth,H. Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin Netherlands,FEBS Lett.,2012;586(20):3665-3673 Originalpublikation Hülsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Tallini K. C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury Neurotherapeutics 2012;9;185-198 Originalpublikation Katsch,K. ; de Jong,S. J. ; Albrecht,J. C. ; Steger,J. ; Genth,H. ; Posern,G. ; Biesinger,B. Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip England,Cell.Commun.Signal.,2012;10(1):5-811X-10-5 Originalpublikation May,M. ; Kolbe,T. ; Wang,T. ; Schmidt,G. ; Genth,H. Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis United States,J.Signal.Transduct,2012;2012():570183- Originalpublikation Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R. Release of TcdA and TcdB from Clostridium cdi 630 is not affected by functional inactivation of the tcdE gene. Microb Pathog 2012;52(1);92-100 Originalpublikation Rohrbeck,A. ; Kolbe,T. ; Hagemann,S. ; Genth,H. ; Just,I. Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q England,FEBS J.,2012;279(15):2657-2671 Originalpublikation Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC. Inhibition of macrophage migration by C. botulinum exoenzym C3 Naumyn-Schmiedebergs's Arch Pharmacol 2012;385(9);883-90. May29 [Epub ahead of print] Originalpublikation Schwarz,J. ; Proff,J. ; Hävemeier,A. ; Ladwein,M. ; Rottner,K. ; Barlag,B. ; Pich,A. ; Tatge,H. ; Just,I. ; Gerhard,R. Serine-71 phosphorylation of rac1 modulates downstream signaling United States,PLoS One,2012;7(9):e44358- Originalpublikation Strotmeier,J. ; Willjes,G. ; Binz,T. ; Rummel,A. Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity Netherlands,FEBS Lett.,2012;586(4):310-313 Originalpublikation Weigoldt,M. ; Meens,J. ; Bange,F. C. ; Pich,A. ; Gerlach,G. F. ; Goethe,R. Metabolic adaptation of Mycobacterium avium subsp. paratuberculosis to the gut environment ,,Microbiology,2013;159(Pt.2):380-391 Originalpublikation Wellhöner,H. ; Weiss,A. ; Schulz,A. ; Adermann,K. ; Braitbard,O. ; Bar-Sinai,A. ; Hochman,J. Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates England,J.Drug Target.,2012;20(5):445-452 Originalpublikation Euler,Friederike Christina Bedeutung der Autoproteolyse für die intrazelluläre Wirkung von Clostridium difficile Toxin A ,,,2011;():50 Bl.- Dissertation Fritsch,Cornelia Bindung und Aufnahme von Clostridium botulinum C3 Exoenzym in F98-Zellen ,,,2012;():97 Bl.- Dissertation Janzen,Constantin Identifizierung der SV2-Bindungstasche in der H CC -Domäne von Botulinum Neurotoxin Serotyp A ,,,2012;():[2], 73 Bl.- Dissertation Lica,Marta Anna Unterschiede in der biologischen Wirkung des Clostridium difficile Toxin B in proliferierenden und nicht-proliferierenden Zellen ,,,2011;():[1], 275-283, 10-25 Bl.- Dissertation Roggenkamp,Dennis Funktionelle Charakterisierung der Interaktion von Hautzellen und neuronalen Zellen in gesunder und gestresster Haut ,,,2011;():VI S., S. 7-94, IV S.- Dissertation Schröder,Anke Effekte des C3 Exoenzyms aus Clostridium botulinum auf das Proteom muriner Hippocampuszellen ,,,2012;():VI, 107 Bl. Ill., graph. Darst.- Dissertation Zeiser,Johannes Das Substratspektrum clostridialer glukosylierender Toxine und die Auswirkungen auf das Proteom von Colonozyten ,,,2012;():[7], 3 - 106, [20] Bl.- Dissertation Brinkmann,Sophie Cdk 1 abhängige Phosphorylierung des Rac GEF Proteins beta-Pix ,,,2012;():- Masterarbeit Doberenz,Sebastian ; Kinetische Analyse der Toxin A vermittelten Glukosylierung kleiner GTPasen ,,,2012;():- Masterarbeit Edeling,Maria Funktionelle Charakterisierung von Renalen Tubuluszellen in einem Modell für diabetische Nephropathie ,,,2012;():- Masterarbeit Findeisen,Katja Neutralisation von Clostridium difficile Toxin B durch Tauro-konjugierte-Gallensäuren ,,,2012;():- Masterarbeit Krüger,Jonas Ribosomale Proteomanalyse C3 Exoenzym behandelter Zellen ,,,2012;():- Masterarbeit Nolte,Annika Die Rac1-induzierte Hochregulation von Frizzled-Rezeptoren ,,,2012;():- Masterarbeit Rataj,Dennis Beteiligung von CIC-5 an der zellulären Aufnahme der clostridialen Toxine TcdA und TcdA1-1874 ,,,2012;():- Masterarbeit 2011 Boer U, Lohrenz A, Klingenberg M, Pich A, Haverich A, Wilhelmi M. The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts. Biomaterials 2011;32;9730-9737 Originalpublikation Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Federov PC. The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells.PLoS Pathog 2011;7(12) Originalpublikation Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I. Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B Naunyn Schmiedebergs Arch Pharmacol 2011;383;285-295 Originalpublikation Höltje M, Just I, Ahnert-Hilger G. Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration. Ann Anat 2011;193(4);314-320 Originalpublikation Jochim N, Gerhard R, Just I, Pich A. Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotype-coded protein labeling and LC-MALDI. Proteome Sci 2011;9;48 Originalpublikation Lica M, Schulz F, Schelle I, May M, Just I, Genth H. Difference in the biological effects of Clostridium difficile B in profilerating and non-proliferating cells. Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);275-283 Originalpublikation Mueller MQ, Zeiser JJ, Dreiocker F, Pich A, Schaefer M, Sinz A. An universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis. Rapid Commun Mass Spectrom 2011;25(1);155-161 Originalpublikation Nölle A, Zeug A, van Bergeijk, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, Omer J, Srivastrav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P. The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Human molecular genetics 2011;15;20(24);4865-4878 Originalpublikation Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R. The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A. PLoS One 2011;18;6(3) e17623 Originalpublikation Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, v. Neuhoff N. Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology. Lung Cancer 2011;72(1);136-138 Originalpublikation Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP. The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol 2011;13(8);1004-1009 Originalpublikation Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D. Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion. J Cell Science 2011;15;124(Pt18);3066-73 Originalpublikation Rummel A, Mahrhold S, Bigalke H, Binz T. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin. FEBS J 2011;278(23);4506-4515 Originalpublikation Rummel,A. Molecular biology of Clostridium botulinum organism and botulinum neurotoxins, insight into the molecular machinery involved in Clostridium botulinum neurotoxity ,Hauppauge, N.Y.,,2011;():37-70 Buchbeitrag, Monografie Rummel,A. ; Mahrhold,S. ; Bigalke,H. ; Binz,T. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin ,,FEBS J.,2011;278(23):4506-4515 10.1111/j.1742-4658.2011.08196.x Originalpublikation Schacht T, Unger C, Pich A, Wydra K. Endo- and exopolygalacturonases of Ralstonia solanacearum are inhibited by polygalacturonase-inhibiting protein (PGIP) activity in tomato stem extracts. Plant Physiol Biochem 2011;49(4);377-387 Originalpublikation Schulte-Baukloh H, Herholz J, Bigalke H, Miller K, Knispel HH. Results of a BoNT/A Antibody Study in Children and Adolescents after Onabotulinumtoxin A (Botox(R)) Detrusor Injection. Urol Int 2011;87(4);434-438 Originalpublikation Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T. The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol Microbiol 2011;81(1);143-156 Originalpublikation Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N. Proteomic Bronchiolitis Obliterans Syndrome Risk Monitoring in Lung Transplant Recipients. Transplantation 2011;92(4);477-485 Originalpublikation Zeiser J, Klodmann J, Braun HP, Gerhard R, Just I, Pich A. Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis. Journal of Proteomics 2011;75;469-479 Originalpublikation Felkel,Katharina-Wiebke LC-MS basierte Sekretomanalyse verschiedener Clostridium difficile Stämme ,,,2010;():104 Bl.- Dissertation Halabi Cabezon,Ismael Aufhebung des zytopathischen Effekts von Clostridium difficile Toxin B durch Rac1 Aktivierung ,,,2010;():3751-3756, 7-20 Bl.- Dissertation Jochim,Nelli LC-MS-basierte globale Proteomanalyse von Colonzellen nach Behandlung mit clostridialen glucosylierenden Toxinen ,,,2011;():XVII, 124 Bl.- Dissertation Kreimeyer,Isa Die autoproteolytische Spaltung beeinflusst den zytotoxischen Effekt von Clostridium difficile Toxin A ,,,2010;():36 Bl.- Dissertation Lücke,Nina Sekretomanalyse der hämatopoetischen Progenitorzelllinie DKmix ,,,2010;():46 Bl.- Dissertation May,Martin Role of Rac1 and PAK in the regulation of G2-M transition and mitotic cell rounding ,,,2011;():[7], 79 Bl.- Dissertation Schrader,Merle Korrelation der C. difficile Toxin A-induzierten Apoptose mit der Hochregulation des GTP-bindenden Proteins RhoB ,,,2011;():62 Bl.- Dissertation Werner,Stefan Charakterisierung der zellulären Aufnahme von C. botulinum C3-Exoenzym ,,,2010;():[3], 86 Bl.- Dissertation Dickhut,Clarissa Bildgebende Massenspektrometrie zur histologischen Analyse von Geweben ,,,2010;():- Masterarbeit Frenzel,Eileen Charakterisierung der zellulären Aufnahme der C. difficile Toxine TcdA und TcdA1-1874 ,,,2010;():- Masterarbeit Lentes,Jana Auswirkungen der GTP-Beladung auf die Glucosylierung von Rho Proteinen durch Clostridien Toxine ,,,2011;():- Bachelorarbeit 2010 Adler,S. ; Bicker,G. ; Bigalke,H. ; Bishop,C. ; Blumel,J. ; Dressler,D. ; Fitzgerald,J. ; Gessler,F. ; Heuschen,H. ; Kegel,B. ; Luch,A. ; Milne,C. ; Pickett,A. ; Ratsch,H. ; Ruhdel,I. ; Sesardic,D. ; Stephens,M. ; Stiens,G. ; Thornton,P. D. ; Thürmer,R. ; Vey,M. ; Spielmann,H. ; Grune,B. ; Liebsch,M. The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting England,Altern.Lab.Anim.,2010;38(4):315-330 Originalpublikation Backert S, Kenny B, Gerhard R, Tegtmeyer N, Bran S. PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function. Gut Microbes 2010;1(2);94-99 Originalpublikation Dahal,D. ; Pich,A. ; Braun,H. P. ; Wydra,K. Analysis of cell wall proteins regulated in stem of susceptible and resistant tomato species after inoculation with Ralstonia solanacearum: a proteomic approach Netherlands,Plant Mol.Biol.,2010;73(6):643-658 10.1007/s11103-010-9646-z Originalpublikation Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B. SNARE tagging allows stepwise assembly of a multimodular medicinal toxin. Proc Natl Acad Sci USA 2010;107(42);18197-18201 Originalpublikation Genth H, Just I. Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease. Eur J Cell Biol 2010;12(4);Epub ahead of print Originalpublikation Genth H, Schulz F, Just I. Gluscosylation of Rho/Ras Proteins by Lethal Toxin - Implication of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease. Open Toxinology 2010;3;13-18 Originalpublikation Just I, Hülsenbeck SC, Genth H. Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent. Open Toxinology 2010;3;19-23 Originalpublikation Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M. Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);247-52; Epub 2010 Übersicht Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R. Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A. Naunyn Schmiedebergs Arch Pharmacol 2010;11(3); Epub 2010 Originalpublikation Krückeberg J, Just I, Möbs D, Matthies H, Fischer V. Mehrwert erkannt, Defizite gebannt? - die quantitative Analyse elektronisch verfasster Klausuren an der Medizinischen Hochschule Hannover. GMA [Hrsg.]: Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA). Bochum, 23.-25.09.2010 Vortrag Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A. Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix. Rapid Commun Mass Spectrom 2010;24(5);561-570 Originalpublikation Naue N, Fedorov R, Pich A, Manstein DJ, Curth U. Site-directed mutagenesis of the {chi} subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction. Nucleic Acids Res 2010;23(10); Epub ahead of print Originalpublikation Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem J 2010;431(2):207-216 Originalpublikation Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, Genth H, Klos A. Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. PLoS One 2010;5(3) Originalpublikation Häfner,Kirstin Kompetitionsexperimente am Maus-Hemidiaphragma-Assay zur Identifizierung von Proteinrezeptoren der clostridiellen Neurotoxine: SV2 vermittelt die Aufnahme von BoNT/F in neuronale Zellen ,,,2010;():- Dissertation Lange,Oliver Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A : much ado about nothing? ,,,2010;():213 - 218, 16 Bl.- Dissertation Nottrott,Stefanie Die Clostridium difficile Toxin A-induzierte Apoptose ist unabhängig von p53, aber abhängig von der Glucosylierung von Rho-GTPasen ,,,2010;():[1], 33 Bl.- Dissertation Supthut,Hauke Intra- und extrazelluläre Faktoren, die die Sensitivität von CHO-Zellen gegenüber Clostridium difficile Toxin B bestimmen ,,,2009;():89 Bl.- Dissertation Barlag,Britta Beteiligung von IQGAP und MRCK an der Phospho-Rac1-vermittelten Filopodienbildung ,,,2010;():- Masterarbeit Goy,Sebastian Bedeutung der Rezeptorbindedomäne von Clostridium difficile Toxin A für die Funktionalität ,,,2010;():- Masterarbeit Kolbe,Tanja Wirkung Rho-modifizierter bakterieller Toxine in einem in vitro Modell der Wundheilung ,,,2010;():- Diplomarbeit Wang,Tianbang F-Aktin Depolymerisation durch clostridiale Toxine ,,,2010;():- Diplomarbeit 2009 Andresen,H. ; Bingel,U. ; Streichert,T. ; Schmoldt,A. ; Zoerner,A. A. ; Tsikas,D. ; Just,I. Severe glycerol intoxication after Meniere's disease diagnostic--case report and overview of kinetic data England,Clin.Toxicol.(Phila),2009;47(4):312-316 10.1080/15563650902849123 Originalpublikation Binz,T. ; Rummel,A. Cell entry strategy of clostridial neurotoxins England,J.Neurochem.,2009;109(6):1584-1595 10.1111/j.1471-4159.2009.06093.x Originalpublikation Brunger,A. T. ; Rummel,A. Receptor and substrate interactions of clostridial neurotoxins England,Toxicon,2009;54(5):550-560 10.1016/j.toxicon.2008.12.027 Originalpublikation Deplazes,J. ; Fuchs,M. ; Rauser,S. ; Genth,H. ; Lengyel,E. ; Busch,R. ; Luber,B. ; Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation England,Hum.Mol.Genet.,2009;18(19):3632-3644 10.1093/hmg/ddp312 Originalpublikation Dreger,S. C. ; Schulz,F. ; Huelsenbeck,J. ; Gerhard,R. ; Hofmann,F. ; Just,I. ; Genth,H. Killing of Rat Basophilic Leukemia Cells by Lethal Toxin from Clostridium sordellii: Critical Role of Phosphatidylinositide 3'-OH Kinase/Akt Signaling (dagger) ,,Biochemistry,2009;():- 10.1021/bi800708b Originalpublikation Genth H, Schulz F, Just I. Glucosylation of Rho/Ras Proteins by Lethal Toxin - Implications of Actin-Re-Organization and Apoptosis in C. Sordellii-Associated Disease. The Open Toxinology Journal 2009;2 Abstract Huelsenbeck,S. C. ; Klose,I. ; Reichenbach,M. ; Huelsenbeck,J. ; Genth,H. Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin Netherlands,FEBS Lett.,2009;583(19):3133-3139 10.1016/j.febslet.2009.09.006 Originalpublikation Huelsenbeck,S. C. ; May,M. ; Schmidt,G. ; Genth,H. Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis United States,Cell Motil.Cytoskeleton,2009;66(11):967-975 10.1002/cm.20390 Originalpublikation Just I, Hülsenbeck SC, Genth H. Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and an Neurothrophic Agent. The Open Toxinology Journal 2009;2 Abstract Kotz,A. ; Wagener,J. ; Engel,J. ; Routier,F. ; Echtenacher,B. ; Pich,A. ; Rohde,M. ; Hoffmann,P. ; Heesemann,J. ; Ebel,F. The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity ,,Fungal Genet.Biol.,2010;47(2):169-178 10.1016/j.fgb.2009.10.001 Originalpublikation Lange,O. ; Bigalke,H. ; Dengler,R. ; Wegner,F. ; deGroot,M. ; Wohlfarth,K. Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing? United States,Clin.Neuropharmacol.,2009;32(4):213-218 10.1097/WNF.0b013e3181914d0a Originalpublikation Mohammadi,B. ; Buhr,N. ; Bigalke,H. ; Krampfl,K. ; Dengler,R. ; Kollewe,K. A long-term follow-up of botulinum toxin A in cervical dystonia ,,Neurol.Res.,2009;31(5):463-466 10.1179/174313209X405137 Originalpublikation Mohammadi,B. ; Kollewe,K. ; Wegener,M. ; Bigalke,H. ; Dengler,R. Experience with long-term treatment with albumin-supplemented botulinum toxin type A Austria,J.Neural Transm.,2009;116(4):437-441 10.1007/s00702-009-0200-6 Originalpublikation Nerlich,A. ; Rohde,M. ; Talay,S. R. ; Genth,H. ; Just,I. ; Chhatwal,G. S. Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism United States,J.Biol.Chem.,2009;284(30):20319-20328 10.1074/jbc.M109.016501 Originalpublikation Rummel,A. ; Häfner,K. ; Mahrhold,S. ; Darashchonak,N. ; Holt,M. ; Jahn,R. ; Beermann,S. ; Karnath,T. ; Bigalke,H. ; Binz,T. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor England,J.Neurochem.,2009;110(6):1942-1954 10.1111/j.1471-4159.2009.06298.x Originalpublikation Schoentaube,J. ; Olling,A. ; Tatge,H. ; Just,I. ; Gerhard,R. Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A ,,Cell.Microbiol.,2009;11(12):1816-1826 10.1111/j.1462-5822.2009.01373.x Originalpublikation Schulz,F. ; Just,I. ; Genth,H. Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid United States,Biochemistry,2009;48(38):9002-9010 10.1021/bi900964c Originalpublikation Sun,X. ; He,X. ; Tzipori,S. ; Gerhard,R. ; Feng,H. Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages England,Microb.Pathog.,2009;46(6):298-305 10.1016/j.micpath.2009.03.002 Originalpublikation von Witzendorff,D. ; Maass,K. ; Pich,A. ; Ebeling,S. ; Kölle,S. ; Kochel,C. ; Ekhlasi-Hundrieser,M. ; Geyer,H. ; Geyer,R. ; Töpfer-Petersen,E. Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach Netherlands,Carbohydr.Res.,2009;344(12):1541-1549 10.1016/j.carres.2009.05.002 Originalpublikation Goltz,Björn Tetanustoxin und Botulinumtoxin A : Interaktion mit Mastzellen aus der Bauchfellhöhle der Ratte ,,,2008;():IV, 140 S.- Dissertation Teichert,Matthias Charakterisierung von mutiertem Clostridium difficile Toxin A zur Bestimmung von Glucosyltransferase-abhängigen Effekten ,,,2007;():11 Bl.- Dissertation 2008 Busche,S. ; Descot,A. ; Julien,S. ; Genth,H. ; Posern,G. Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling England,J.Cell.Sci.,2008;121(Pt 7):1025-1035 10.1242/jcs.014456 Originalpublikation Genth,H. ; Dreger,S. C. ; Huelsenbeck,J. ; Just,I. Clostridium difficile toxins: More than mere inhibitors of Rho proteins England,Int.J.Biochem.Cell Biol.,2008;40(4):592-597 10.1016/j.biocel.2007.12.014 Originalpublikation Gerhard,R. ; Nottrott,S. ; Schoentaube,J. ; Tatge,H. ; Olling,A. ; Just,I. Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells England,J.Med.Microbiol.,2008;57(Pt 6):765-770 10.1099/jmm.0.47769-0 Originalpublikation Halabi-Cabezon,I. ; Huelsenbeck,J. ; May,M. ; Ladwein,M. ; Rottner,K. ; Just,I. ; Genth,H. Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1 Netherlands,FEBS Lett.,2008;582(27):3751-3756 10.1016/j.febslet.2008.10.003 Originalpublikation Hoffmann,A. ; Hofmann,F. ; Just,I. ; Lehnardt,S. ; Hanisch,U. K. ; Brück,W. ; Kettenmann,H. ; Ahnert-Hilger,G. ; Höltje,M. Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia United States,Glia,2008;56(11):1162-1175 10.1002/glia.20687 Originalpublikation Höltje,M. ; Djalali,S. ; Hofmann,F. ; Münster-Wandowski,A. ; Hendrix,S. ; Boato,F. ; Dreger,S. C. ; Grosse,G. ; Henneberger,C. ; Grantyn,R. ; Just,I. ; Ahnert-Hilger,G. A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation ,,FASEB J.,2009;23(4):1115-1126/10.1096/fj.08-116855 Originalpublikation Höltje,M. ; Hofmann,F. ; Lux,R. ; Veh,R. W. ; Just,I. ; Ahnert-Hilger,G. Glutamate uptake and release by astrocytes are enhanced by Clostridium botulinum C3 protein United States,J.Biol.Chem.,2008;283(14):9289-9299 10.1074/jbc.M706499200 Originalpublikation Kamanova,J. ; Kofronova,O. ; Masin,J. ; Genth,H. ; Vojtova,J. ; Linhartova,I. ; Benada,O. ; Just,I. ; Sebo,P. Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling United States,J.Immunol.,2008;181(8):5587-5597 Originalpublikation Klisch,K. ; Jeanrond,E. ; Pang,P. C. ; Pich,A. ; Schuler,G. ; Dantzer,V. ; Kowalewski,M. P. ; Dell,A. A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins England,Glycobiology,2008;18(1):42-52 10.1093/glycob/cwm113 Originalpublikation Kühnel,T. S. ; Schulte-Mattler,W. ; Bigalke,H. ; Wohlfarth,K. Treatment of habitual snoring with botulinum toxin: a pilot study ,,Sleep Breath,2008;12(1):63-68 10.1007/s11325-007-0136-8 Originalpublikation Muetzelburg,M. V. ; Hofmann,F. ; Just,I. ; Pich,A. Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis ,,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2009;877(13):1344-1351 10.1016/j.jchromb.2008.12.005 Originalpublikation Neumann,D. ; Kollewe,C. ; Pich,A. ; Cao,P. ; Resch,K. ; Martin,M. U. Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation United States,J.Leukoc.Biol.,2008;84(3):807-813 10.1189/jlb.0507290 Originalpublikation Sander,L. E. ; Frank,S. P. ; Bolat,S. ; Blank,U. ; Galli,T. ; Bigalke,H. ; Bischoff,S. C. ; Lorentz,A. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells Germany,Eur.J.Immunol.,2008;38(3):855-863 10.1002/eji.200737634 Originalpublikation Schulte-Baukloh,H. ; Bigalke,H. ; Miller,K. ; Heine,G. ; Pape,D. ; Lehmann,J. ; Knispel,H. H. Botulinum neurotoxin type A in urology: antibodies as a cause of therapy failure Australia,Int.J.Urol.,2008;15(5):407-15; discussion 415 10.1111/j.1442-2042.2008.02016.x Originalpublikation Stolz,A. ; Haines,N. ; Pich,A. ; Irvine,K. D. ; Hokke,C. H. ; Deelder,A. M. ; Gerardy-Schahn,R. ; Wuhrer,M. ; Bakker,H. Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis United States,Glycoconj.J.,2008;25(2):167-175 10.1007/s10719-007-9069-5 Originalpublikation Tschernig,T. ; Neumann,D. ; Pich,A. ; Dorsch,M. ; Pabst,R. Experimental bronchial asthma - the strength of the species rat Netherlands,Curr.Drug Targets,2008;9(6):466-469 Originalpublikation 2007 Conrad S, Genth H, Hofmann F, Just I, Skutella T. Neogenin-RGMa signaling at the growth cone Is BMP-independent and involves RhoA, rock and PKC. J Biol Chem 2007;282(22);16423-33 Abstract Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS. Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood 2007;109(3);1248-1256 Abstract Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,Schmitt-Kopplin P, Schiffer E. Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry. Proteomics 2007;1(7);650-60 Abstract Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H. Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470. Inf Immun 2007;75(2);801-809 Abstract Huelsenbeck J, Dreger S, Gerhard R, Fritz G, Just I, Genth H. Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile. Biochemistry 2007;24;46(16);4923-31 Abstract Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT. Neurotoxin serotype C1 light chain protease: implications for dual substrate specificity. Biochemistry 2007;46;10685-93 Abstract Klisch K, Jeanrond E, Pang PC, Pich A, Schuller G, Dantzer V, Kowalewski MP, Dell A. A tetraantennary glycan with bisecting N-Acetylglucosamine and Sda antigen is the predominant N-glycan on bovine Pregnancy-associated glycoproteins. Glycobiology 2008;18(1);42-52; Epub 2007 Abstract Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R. Clostridium difficile Toxin A and B directly stimulate human mast cells. Inf Immun 2007;21(5) Abstract Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R. Apoptosis induced by Clostridium difficile Toxin A is p53-independent and tiggered by glucosylation of Rho GTPases. Apoptosis 2007;12(8);1443-53 Abstract Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T. Identification of the receptor binding site of botulinum neurotoxins B and G proves the double receptor concept. PNAS 2007;104;359-364 Abstract Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H. Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycospingolipid biosynthesis. Glycoconj J 2008;25(2);167-75; Epub 2007 Abstract 2006 Foster K, Bigalke H, Aoki R. Botulinum Neurotoxin - From Laboratory to Bedside Neurotoxicity Research 2006;9;133-140 Abstract Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R. Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B. FEBS Lett 2006;580;3565-3569 Abstract Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K. Cholesterol-dependent pore formation of Clostridium difficile toxin A. J Biol Chem 2006;281;10808-10815 Abstract Jin R, Rummel A, Binz T, Brunger AT. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity Nature 2006;444;1092-1095 Abstract Lee SH, Bigalke H. Botulinumtoxin – Pharmakologie, Sicherheit und sekundäre Non-Response durch Antikörper Neuropädiatrie in Klinik und Praxis 2006;5;52-56 Übersicht Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T. The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Lett 2006;Apr3;580(8);2011-4 Abstract Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal G.S. Localization of the C3-like ADP-ribosyltransferase from Staphylococcus aureus during baterial invasion of mammalian cells. Inf Immun 2006;74;3673-3677 Abstract Rosales RL, Bigalke H, Dressler D. Pharmacology of botulinum toxin: differences between type A preparations. Eur J Neurol; 2006;13;2-10 Abstract Schröder O, Gerhard R, Stein J. Antibiotic-associated diarrhea Diarrhö Z Gastroenterol 2006;44(2);193-204 Abstract Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter, P. High resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. Clin Cancer Res 2006;12;345-52 Abstract Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R. Application of mutated Clostridium difficile toxin A for determination of Glucosyltransferase-dependent effects. Inf Immun 2006;74(10);6006-6010 Abstract Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol 2006;7(3);230-40 Abstract Traub F, Jost M, Hess R, Schorn K, Menzel C, Budde P, Schulz-Knappe P, Lamping N, Pich A, Kreipe H, Tammen H. Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas. Lab Invest 2006;86;246-253 Abstract Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzig M, Neusüß C, Theodorescu D, Root KE, Ross MM, Mischak H. Biomarker discovery by CE.MS enables sequences analysis via MS/MS with platform-independent separation. Electrophoresis 2006;27(11);2111-21125 Abstract 2001 Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K. Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells. J Biol Chem. 2001 Apr 6; 276(14): 10670-6. Abstract Bigalke H, Wohlfarth K, Irmer A, Dengler R. Botulinum A toxin: Dysport improvement of biological availability. Exp Neurol. 2001 Mar;168(1):162-70. Abstract Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M. Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression. Eur J Immunol. 2001 May; 31(5): 1610-9. Abstract Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H. Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile. Infect Immun. 2001 Oct;69(10):6004-11. Abstract Just I, Hofmann F, Genth H, Gerhard R. Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins. Int J Med Microbiol. 2001 Sep;291(4):243-50. Abstract Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W. An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem. 2001 Jun 8; 276(23): 20451-7. Abstract Rollnik JD, Wohlfarth K, Dengler R, Bigalke H. Neutralizing botulinum toxin type a antibodies: clinical observations in patients with cervical dystonia. Neurol Clin Neurophysiol. 2001;2001(3):2-4. Abstract Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K. Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress. Pflugers Arch. 2001 Aug;442(5):675-87. Abstract Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S. Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3185-90. Abstract Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I. A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3. J Biol Chem 2001 Mar 23;276(12):9537-42 Abstract Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO. Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase. FASEB J. 2001 Aug;15(10):1753-63. Abstract 2000 Bigalke H. Neuromuskuläre Verbindung – Präsynaptisches Terminal. Klin. Neurophysiol 2000;31;115-121 Busch C, Hofmann F, Gerhard R, Aktories K. Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases. J Biol Chem. 2000 May 5;275(18):13228-34. Abstract Busch C, Schömig K, Hofmann F, Aktories K. Characterization of the catalytic domain of Clostridium novyi alpha-toxin. Infect Immun. 2000 Nov;68(11):6378-83. Abstract Dressler D, Bigalke H, Rothwell JC. The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans. J Neurol. 2000 Aug;247(8):630-2. Abstract Dressler D, Dirnberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD. Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay. Mov Disord. 2000 Sep;15(5):973-6. Abstract Dressler D, Zettl U, Benecke R, Bigalke H. Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure? Mov Disord. 2000 Nov;15(6):1279-81. Abstract Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J. 2000 Dec 1;19(23):6361-70. Abstract Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I. New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization. Infect Immun. 2000 Mar;68(3):1094-101. Abstract Just I, Boquet P Large clostridial cytotoxins as tools in cell biology. Curr Top Microbiol Immunol 2000;250;97-107 Review Just I, Hofmann F, Aktories K Molecular mode of action of the large clostridial cytotoxins. Curr Top Microbiol Immunol 2000;250;55-83 Review Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T. Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin Histochem Cell Biol. 2000 Nov;114(5):387-91. Abstract Linseman DA, Hofmann F, Fisher SK. A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase. J Neurochem. 2000 May;74(5):2010-20. Abstract Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W. Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1. J Neurosci. 2000 Sep 15;20(18):6743-51. Abstract Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M. Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C. Blood. 2000 Oct 1;96(7):2592-8. Abstract Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H. Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study. Abstract Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I. Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin. J Mol Biol. 2000 Sep 1;301(5):1091-5. Abstract Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9. Abstract Wilde C, Genth H, Aktories K, Just I. Recognition of RhoA by Clostridium botulinum C3 exoenzyme. J Biol Chem. 2000 Jun 2;275(22):16478-83. Abstract 1999 Feick P, Gilhaus S, Blum R, Hofmann F, Just I, Schulz I. Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity. FEBS Lett. 1999 May 28;451(3):269-74. Abstract Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer. 1999 May 31;81(5):682-7. Abstract Genth H, Aktories K, Just I. Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. J Biol Chem. 1999 Oct 8;274(41):29050-6. Abstract Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G. SNARE proteins and rab3A contribute to canalicular formation in parietal cells. Eur J Cell Biol. 1999 Nov;78(11):779-86. Abstract Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK. Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA. Br J Pharmacol. 1999 Jul;127(5):1060-3. Abstract 1998 Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, Hochman J, Wellhoner H. Isolation, characterization and synthesis of a novel paradaxin isoform. FEBS Lett. 1998 Sep 18;435(2-3):173-7. Abstract Barth H, Hofmann F, Olenik C, Just I, Aktories K. The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin. Infect Immun. 1998 Apr;66(4):1364-9. Abstract Barth H, Preiss JC, Hofmann F, Aktories K. Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis. J Biol Chem. 1998 Nov 6;273(45):29506-11. Abstract Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I. Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun. 1998 Apr;66(4):1755-8. Abstract Boquet P, Munro P, Fiorentini C, Just I. Toxins from anaerobic bacteria: speficity and molecular mechanism of action. Curr Opinion Microbiol 1998;1;66-74 Abstract Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K. A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem. 1998 Jul 31;273(31):19566-72. Abstract Gerhard R, Schmidt G, Hofmann F, Aktories K. Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infect Immun. 1998 Nov;66(11):5125-31. Abstract Herrmann C, Ahmadian MR, Hofmann F, Just I. Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35. J Biol Chem. 1998 Jun 26;273(26):16134-9. Abstract Hofmann F, Busch C, Aktories K. Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition. Infect Immun. 1998 Mar;66(3):1076-81. Abstract Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G. Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins. J Physiol. 1998 Jan 1;506 ( Pt 1):83-93. Abstract Naumann M, Toyka KV, Mansouri Taleghani B, Ahmadpour J, Reiners K, Bigalke H. Depletion of neutralising antibodies resensitises a secondary non-responder to botulinum A neurotoxin. J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):924-7. Abstract Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, Hochman J, Wellhoner H. Translocation of acylated pardaxin into cells. FEBS Lett. 1998 Nov 27;440(1-2):131-4. Abstract Reiser CO, Lanz T, Hofmann F, Hofer G, Rupprecht HD, Goppelt-Struebe M. Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins. Biochem J. 1998 Mar 15;330 ( Pt 3):1107-14. Abstract Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG. Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin. Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):385-92. Abstract Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K. Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. Biochemistry. 1998 Apr 14;37(15):5296-304. Abstract Wohlfarth K, Goeschel H, Frevert J, Dengler R, Bigalke H. Dose standardisation of botulinum toxin: Reply. Mov Disord. 1998, 13, 750-751. Abstract 1997 Goschel, H., Wohlfarth, K., Frevert, J., Dengler, R., Bigalke, H. Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies - therapeutic consequences. Exp. Neurol. 147, 1997, 96-102. Abstract Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krüll, M., Just, I., Aktories, K., von Eichel-Streiber, C., Suttorp, N. Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function. Am. J. Physiol. 1997, 272, L38-L43. Abstract Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K. Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin. J. Biol. Chem. 1997, 272, 11074-11078. Abstract Olenik, C., Barth, H., Just, I., Aktories, K., Meyer, D.K. Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain. Mol. Brain Res. 1997, 52, 272-279. Abstract Otto, B., Steusloff, A., Just, I., Aktories, K., Pfitzer, G. Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle. J. Physiol. (Lond.), 1997, 496, 317-329. Abstract Verschueren, H., de Baetselier, P., de Braekeleer, J., Dewitt, J., Aktories, K., Just, I. ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells. Eur. J. Cell Biol. 1997, 73, 182-187. Abstract Wohlfarth, K., Goschel, H., Frevert, J., Dengler, R., Bigalke, H. Botulinum A toxins: units versus units. Naunyn Schmiedebergs Arch. Pharmacol. 1997, 355, 335-40. Abstract