Publikationen von Dr. Günter Bernhardt

Die vollständige Publikationsliste kann unter folgendem Link eingesehen werden:

Bernhardt, Günter - Web of Science Core Collection


Schneider J, Kuhlmann L, Xiao Y, Raha S, Bernhardt G, Stadler M, Thol F, Heuser M, Eder M, Ganser A, Ravens S, Förster R, Prinz I, Koenecke C, Schultze-Florey CR. Healthy-like CD4+ Regulatory and CD4+ Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion. Int J Mol Sci. 2022 Sep 18;23(18):10914. doi: 10.3390/ijms231810914. PMID: 36142824; PMCID: PMC9505302.

Behrens GMN, Barros-Martins J, Cossmann A, Ramos GM, Stankov MV, Odak I, Dopfer-Jablonka A, Hetzel L, Köhler M, Patzer G, Binz C, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Krähling V, Bernhardt G, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Hammerschmidt SI, Förster R. BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19. Nat Commun. 2022 Aug 18;13(1):4872. doi: 10.1038/s41467-022-32527-2. PMID: 35982040; PMCID: PMC9387891.

Odak I, Schultze-Florey CR, Hammerschmidt SI, Ritter C, Willenzon S, Friedrichsen M, Ravens I, Sikora R, Bayir LM, Gutierrez Jauregui R, Bernhardt G, Stankov MV, Cossmann A, Hansen G, Krey T, Cornberg M, Koenecke C, Behrens GMN, Bošnjak B, Förster R. Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of Concern. Front Immunol. 2022 Mar 14;13:863039. doi: 10.3389/fimmu.2022.863039. PMID: 35359969; PMCID: PMC8964088.

Hammerschmidt SI, Thurm C, Bošnjak B, Bernhardt G, Reinhold A, Willenzon S, Ritter C, Reinhold D, Schraven B, Förster R. Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination. Eur J Immunol. 2022 Feb;52(2):356-359. doi: 10.1002/eji.202149645. Epub 2022 Jan 7. PMID: 34870322.

Georgiev H, Papadogianni G, Bernhardt G. Identification of Follicular T Cells in the Gut. Methods Mol Biol. 2022;2380:85-95. doi: 10.1007/978-1-0716-1736-6_8. PMID: 34802124.


Papadogianni G, Ravens I, Hassan A, Dittrich-Breiholz O, Bernhardt G, Georgiev H. The impact of stress on the transcriptomic signature of iNKT1 cells. Biochem Biophys Rep. 2021 Oct 29;28:101163. doi: 10.1016/j.bbrep.2021.101163. PMID: 34765746; PMCID: PMC8570944.

Hammerschmidt SI, Bosnjak B, Bernhardt G, Friedrichsen M, Ravens I, Dopfer-Jablonka A, Hoffmann M, Pöhlmann S, Behrens GMN, Förster R. Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination. Cell Mol Immunol. 2021 Oct;18(10):2455-2456. doi: 10.1038/s41423-021-00755-z. Epub 2021 Aug 23. PMID: 34426672; PMCID: PMC8381713.

Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Förster R, Behrens GMN. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Nat Med. 2021 Jul 14. doi: 10.1038/s41591-021-01449-9. Epub ahead of print. PMID: 34262158.

Yu K, Hammerschmidt SI, Permanyer M, Galla M, Rothe M, Zheng X, Werth K, Martens R, Lueder Y, Janssen A, Friedrichsen M, Bernhardt G, Förster R. Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses. Cell Rep. 2021 Jun 22;35(12):109273. doi: 10.1016/j.celrep.2021.109273. PMID: 34161766.


Papadogianni G, Ravens I, Dittrich-Breiholz O, Bernhardt G, Georgiev H. Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. Front Immunol. 2020 Oct 30;11:575764. doi: 10.3389/fimmu.2020.575764. PMID: 33193368; PMCID: PMC7662090.

Bošnjak B, Stein SC, Willenzon S, Cordes AK, Puppe W, Bernhardt G, Ravens I, Ritter C, Schultze-Florey CR, Gödecke N, Martens J, Kleine-Weber H, Hoffmann M, Cossmann A, Yilmaz M, Pink I, Hoeper MM, Behrens GMN, Pöhlmann S, Blasczyk R, Schulz TF, Förster R. Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods. Cell Mol Immunol. 2020 Nov 2:1–9. doi: 10.1038/s41423-020-00573-9. Epub ahead of print. PMID: 33139905; PMCID: PMC7604543.

Luu TT, Wagner AK, Schmied L, Meinke S, Freund JE, Kambayashi T, Ravens I, Achour A, Bernhardt G, Chambers BJ, Höglund P, Kadri N. IL-15 and CD155 expression regulate LAT expression in murine DNAM1+ NK cells, enhancing their effectors functions. Eur J Immunol. 2020 Apr;50(4):494-504. doi: 10.1002/eji.201948233. Epub 2020 Feb 20. PMID: 31834938.


Ott M, Avendaño-Guzmán E, Ullrich E, Dreyer C, Strauss J, Harden M, Schön M, Schön MP, Bernhardt G, Stadelmann C, Wegner C, Brück W, Nessler S. Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity. J Neuroinflammation. 2019 Feb 26;16(1):49. doi: 10.1186/s12974-019-1437-0. PubMed PMID: 30808363


Georgiev H, Ravens I, Papadogianni G, Bernhardt G. Coming of Age: CD96 Emerges as Modulator of Immune Responses. Front Immunol. 2018 May 17;9:1072. doi: 10.3389/fimmu.2018.01072. eCollection 2018. Review. PubMed PMID: 29868026; PubMed Central PMCID: PMC5966540

Roman Aguilera A, Lutzky VP, Mittal D, Li XY, Stannard K, Takeda K, Bernhardt G, Teng MWL, Dougall WC, Smyth MJ. CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity. Oncoimmunology. 2018 Feb 1;7(5):e1424677. doi: 10.1080/2162402X.2018.1424677. eCollection 2018. PubMed PMID: 29721390; PubMed Central PMCID: PMC5927540

Georgiev, H., Ravens, I., Papadogianni, G., Halle, S., Malissen, B., Loots, G. G., Forster, R., and Bernhardt, G. (2018). Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol 9, 714

Georgiev H, Ravens I, Papadogianni G, Malissen B, Förster R, Bernhardt G. Blocking the ART2.2/P2 × 7-system is essential to avoid a detrimental bias in functional CD4 T cell studies. Eur J Immunol. 2018 Mar 5. doi: 10.1002/eji.201747420. [Epub ahead of print] PubMed PMID: 29508376

Brooks J, Fleischmann-Mundt B, Woller N, Niemann J, Ribback S, Peters K, Demir IE, Armbrecht N, Ceyhan GO, Manns MP, Wirth TC, Kubicka S, Bernhardt G, Smyth MJ, Calvisi DF, Gürlevik E, Kühnel F. Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer. Cancer Res. 2018 Jan 15;78(2):475-488. doi: 10.1158/0008-5472.CAN-17-2415. Epub 2017 Nov 27. PubMed PMID: 29180478


Wagner AK, Kadri N, Snäll J, Brodin P, Gilfillan S, Colonna M, Bernhardt G, Höglund P, Kärre K, Chambers BJ. Expression of CD226 is associated to but not required for NK cell education. Nat Commun. 2017 May 31;8:15627. doi: 10.1038/ncomms15627. PubMed PMID: 28561023; PubMed Central PMCID: PMC5460037


Georgiev H, Ravens I, Benarafa C, Förster R, Bernhardt G. Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets. Nat Commun. 2016 Oct 10;7:13116. doi: 10.1038/ncomms13116. PubMed PMID: 27721447.

Blake SJ, Stannard K, Liu J, Allen S, Yong MC, Mittal D, Aguilera AR, Miles JJ, Lutzky VP, de Andrade LF, Martinet L, Colonna M, Takeda K, Kühnel F, Gurlevik E, Bernhardt G, Teng MW, Smyth MJ. Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy. Cancer Discov. 2016 Apr;6(4):446-59. doi: 10.1158/2159-8290.CD-15-0944. Epub 2016 Jan 19. PubMed PMID: 26787820.

Georgiev H, Ravens I, Shibuya A, Förster R, Bernhardt G. CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation. Eur J Immunol. 2016 Apr;46(4):993-1003. doi: 10.1002/eji.201546073. Epub 2016 Jan 20. PubMed PMID: 26689152.

Kraus AK, Chen J, Edenhofer I, Ravens I, Gaspert A, Cippà PE, Mueller S, Wuthrich RP, Segerer S, Bernhardt G, Fehr T. The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation. PLoS One. 2016 Feb 3;11(2):e0147951. doi: 10.1371/journal.pone.0147951. eCollection 2016. PubMed PMID: 26840537; PubMed Central PMCID: PMC4739582.

Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC, Dominguez-Villar M, Garcia-Cozar F, Mueller S, Ravens I, Bernhardt G, Chambers BJ. Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions. J Leukoc Biol. 2016 Mar 31. pii: jlb.3A0615-271RR. [Epub ahead of print] PubMed PMID: 27034402.

Elhai M, Chiocchia G, Marchiol C, Lager F, Renault G, Colonna M, Bernhardt G, Allanore Y, Avouac J. Targeting CD226/DNAX accessory molecule-1 (DNAM-1) in collagen-induced arthritis mouse models. J Inflamm (Lond). 2015 Feb 8;12:9. doi: 10.1186/s12950-015-0056-5. eCollection 2015. PubMed PMID: 25685070; PubMed Central PMCID: PMC4327789.

Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C. Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver. Biol Blood Marrow Transplant. 2015 Dec;21(12):2069-78. doi: 10.1016/j.bbmt.2015.08.038. Epub 2015 Sep 5. PubMed PMID: 26348893.

Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K. CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation. J Immunol. 2015 Jun 15;194(12):5644-53. doi: 10.4049/jimmunol.1401942. Epub 2015 May 13. PubMed PMID: 25972481.

Khan S, Toyoda H, Linehan M, Iwasaki A, Nomoto A, Bernhardt G, Cello J, Wimmer E. Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation. J Gen Virol. 2014 Aug;95(Pt 8):1668-76. doi: 10.1099/vir.0.064535-0. Epub 2014 Apr 30. PubMed PMID: 24784416; PubMed Central PMCID: PMC4103066.

Nagumo Y, Iguchi-Manaka A, Yamashita-Kanemaru Y, Abe F, Bernhardt G, Shibuya A, Shibuya K. Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. PLoS One. 2014 Nov 10;9(11):e112415. doi: 10.1371/journal.pone.0112415. eCollection 2014. PubMed PMID: 25384044; PubMed Central PMCID: PMC4226556.

Bernhardt, G., TACTILE becomes tangible: CD96 discloses its inhibitory peculiarities, Nat Immunol, 2014, 15(5):406-408.

Georgiev, H., Danisch, S., Chambers, B. J., Shibuya, A., Forster, R. and Bernhardt, G., To the editor: TIGIT versus CD226: hegemony or coexistence?, Eur J Immunol, 2014, 44(1):307-308.


Van Laethem, F., Tikhonova, A. N., Pobezinsky, L. A., Tai, X., Kimura, M. Y., Le Saout, C., Guinter, T. I., Adams, A., Sharrow, S. O., Bernhardt, G., Feigenbaum, L. and Singer, A., Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire, Cell, 2013, 154(6):1326-1341.

Pabst, O. and Bernhardt, G., On the road to tolerance - Generation and migration of gut regulatory T cells, Eur J Immunol, 2013, 43(6):1422-1425.

Danisch, S., Qiu, Q., Seth, S., Ravens, I., Dorsch, M., Shibuya, A., Shibuya, K., Forster, R. and Bernhardt, G., CD226 interaction with CD155 impacts on retention and negative selection of CD8 positive thymocytes as well as T cell differentiation to follicular helper cells in Peyer's Patches, Immunobiology, 2013, 218(2):152-158.

Avouac, J., Elhai, M., Tomcik, M., Ruiz, B., Friese, M., Piedavent, M., Colonna, M., Bernhardt, G., Kahan, A., Chiocchia, G., Distler, J. H. and Allanore, Y., Critical role of the adhesion receptor DNAX accessory molecule-1 (DNAM-1) in the development of inflammation-driven dermal fibrosis in a mouse model of systemic sclerosis, Ann Rheum Dis, 2013, 72(6):1089-1098.


Tikhonova, A. N., Van Laethem, F., Hanada, K., Lu, J., Pobezinsky, L. A., Hong, C., Guinter, T. I., Jeurling, S. K., Bernhardt, G., Park, J. H., Yang, J. C., Sun, P. D. and Singer, A., alphabeta T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities, Immunity, 2012, 36(1):79-91.


Seth, S., Ravens, I., Lee, C. W., Glage, S., Bleich, A., Forster, R., Bernhardt, G. and Koenecke, C., Absence of CD155 aggravates acute graft-versus-host disease, Proc Natl Acad Sci U S A, 2011, 108(10):E32-33; author reply E34.

Seth, S., Qiu, Q., Danisch, S., Maier, M. K., Braun, A., Ravens, I., Czeloth, N., Hyde, R., Dittrich-Breiholz, O., Forster, R. and Bernhardt, G., Intranodal Interaction with Dendritic Cells Dynamically Regulates Surface Expression of the Co-stimulatory Receptor CD226 Protein on Murine T Cells, J Biol Chem, 2011, 286(45):39153-39163.

Ksienzyk, A., Neumann, B., Nandakumar, R., Finsterbusch, K., Grashoff, M., Zawatzky, R., Bernhardt, G., Hauser, H. and Kroger, A., IRF-1 expression is essential for natural killer cells to suppress metastasis, Cancer Res, 2011, 71(20):6410-6418.


Rathinasamy, A., Czeloth, N., Pabst, O., Forster, R. and Bernhardt, G., The origin and maturity of dendritic cells determine the pattern of sphingosine 1-phosphate receptors expressed and required for efficient migration, J Immunol, 2010, 185(7):4072-4081.

Qiu, Q., Ravens, I., Seth, S., Rathinasamy, A., Maier, M. K., Davalos-Misslitz, A., Forster, R. and Bernhardt, G., CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus, J Immunol, 2010, 184(4):1681-1689.

Pabst, O. and Bernhardt, G., The puzzle of intestinal lamina propria dendritic cells and macrophages, Eur J Immunol, 2010, 40(8):2107-2111.

del Rio, M. L., Bernhardt, G., Rodriguez-Barbosa, J. I. and Forster, R., Development and functional specialization of CD103+ dendritic cells, Immunol Rev, 2010, 234(1):268-281.


Seth, S., Ravens, I., Kremmer, E., Maier, M. K., Hadis, U., Hardtke, S., Forster, R. and Bernhardt, G., Abundance of follicular helper T cells in Peyer's patches is modulated by CD155, Eur J Immunol, 2009, 39(11):3160-3170.

Seth, S., Georgoudaki, A. M., Chambers, B. J., Qiu, Q., Kremmer, E., Maier, M. K., Czeloth, N., Ravens, I., Foerster, R. and Bernhardt, G., Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells, J Leukoc Biol, 2009, 86(1):91-101.

Pabst, O., Wahl, B., Bernhardt, G. and Hammerschmidt, S. I., Mesenteric lymph node stroma cells in the generation of intestinal immune responses, J Mol Med, 2009, 87(10):945-951.

Meyer, D., Seth, S., Albrecht, J., Maier, M. K., Pasquier, L., Ravens, I., Dreyer, L., Burger, R., Gramatzki, M., Schwinzer, R., Kremmer, E., Foerster, R. and Bernhardt, G., CD96 Interaction with CD155 via Its First Ig-like Domain Is Modulated by Alternative Splicing or Mutations in Distal Ig-like Domains, J Biol Chem, 2009, 284(4):2235-2244.


Worbs, T., Bernhardt, G. and Forster, R., Factors governing the intranodal migration behavior of T lymphocytes, Immunol Rev, 2008, 221:44-63.

Herbrand, H., Bernhardt, G., Forster, R. and Pabst, O., Dynamics and function of solitary intestinal lymphoid tissue, Crit Rev Immunol, 2008, 28(1):1-13.


Seth, S., Maier, M. K., Qiu, Q., Ravens, I., Kremmer, E., Forster, R. and Bernhardt, G., The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1, Biochem Biophys Res Commun, 2007, 364(4):959-965.

Pabst, O., Bernhardt, G. and Forster, R., The impact of cell-bound antigen transport on mucosal tolerance induction, J Leukoc Biol, 2007, 82(4):795-800.

Maier, M. K., Seth, S., Czeloth, N., Qiu, Q., Ravens, I., Kremmer, E., Ebel, M., Muller, W., Pabst, O., Forster, R. and Bernhardt, G., The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens, Eur J Immunol, 2007, 37(8):2214-2225.

Davalos-Misslitz, A. C., Worbs, T., Willenzon, S., Bernhardt, G. and Forster, R., Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice, Blood, 2007, 110(13):4351-4359.

Davalos-Misslitz, A. C., Rieckenberg, J., Willenzon, S., Worbs, T., Kremmer, E., Bernhardt, G. and Forster, R., Generalized multi-organ autoimmunity in CCR7-deficient mice, Eur J Immunol, 2007, 37(3):613-622.

Czeloth, N., Schippers, A., Wagner, N., Muller, W., Kuster, B., Bernhardt, G. and Forster, R., Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen, J Immunol, 2007, 179(9):5855-5863.