and subsequently controls neuronal excitability and gene expression. We aim at revealing the therapeutic potential of microglia depletion on inflammation-related network defects. On the other hand, the [...] circuits. By unraveling the underlying mechanisms, we aim at establishing novel perspectives for therapeutic approaches in virus-related neural deficits. Tissue cultures are suitable in vitro models of the [...] on neuronal transmission and plasticity, which ultimately aims at the implementation of novel therapeutic strategies in the treatment of inflammation-related network dysfunction, e.g. in neurodegeneration
functions and the development of new therapeutic strategies for cardiovascular diseases is a major focus of Professor Thum's Institute of Molecular and Translational Therapeutic Strategies (IMTTS) at Hannover [...] Thum entitled: “ CircRNAs as new therapeutic targets in HFpEF”, “MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes”, and “ncRNAs-based therapeutic approaches in HF”. IMTTS researchers: [...] about the function and potential therapeutic modulation using in vitro and ex vivo models of HFpEF, (2) to establish a new cell‑type specific circRNA-based therapeutic approach of HFpEF and (3) to test
of lesion-induced plasticity and network reorganization. These findings will help to identify therapeutic targets that improve post-lesion network reorganization. Sensory deprivation is a major trigger [...] ultrastructural reorganizations of synapses. Since retinoid metabolism represents a potential therapeutic target, the clinical potential of these signaling pathways will be evaluated. In conclusion, this [...] features in the adult human neocortex? Following this approach, we will investigate potential therapeutic strategies that efficiently target synaptic transmission and plasticity in the human brain. St
of lesion-induced plasticity and network reorganization. These findings will help to identify therapeutic targets that improve post-lesion network reorganization. Sensory deprivation is a major trigger [...] ultrastructural reorganizations of synapses. Since retinoid metabolism represents a potential therapeutic target, the clinical potential of these signaling pathways will be evaluated. In conclusion, this [...] features in the adult human neocortex? Following this approach, we will investigate potential therapeutic strategies that efficiently target synaptic transmission and plasticity in the human brain. St
Dr. med. Thomas Thum Address: Hannover Medical School Institute of Molecular and Translational Therapeutic Strategies OE 8886 Carl-Neuberg-Str. 1 D-30625 Hannover Building I3, entrance C, level 01 ( site
rapie des Hepatozellulären Karzinoms (HCC). In der aktuell in dem wissenschaftlichen Journal „Therapeutic Advances in Medical Oncology“ publizierten Artikel “ Atezolizumab and bevacizumab in patients with [...] prior therapies. "Studies under controlled conditions are important to ensure comparability of therapeutic options, and new treatment concepts are nowadays usually approved based on data from these trials [...] prior systemic therapy: a real-world experience" , recently published in the scientific journal "Therapeutic Advances in Medical Oncology", the group led by Arndt Vogel and Anna Saborowski addresses the question
mechanism of enzymes, the mode of action of small-molecule effectors, and support the development of therapeutic drugs. Hybrid approaches, which combine analysis by X-ray crystallography with cryo-electron microscopy [...] specific contractile proteins in supporting motile functions and the potential of small ligands as therapeutic drugs. To follow dynamic events in cells and externally triggered changes, we use fluorescence-based
Excellence Initiative as a Full Professor and Director of the Institute of Molecular and Translational Therapeutic Strategies (IMTTS; Hannover Medical School). In June 2013, he was appointed as a Visiting Professor [...] evaluation of patients (Circ Res, 2014). Thum also pioneered the use of lncRNAs and circRNAs as therapeutic targets (Science Trans Med. 2016, Eur Heart J. 2022). Academic Distinctions Awards and Prizes
künstliche Organe. Philippe Alexandre Vollmer Barbosa verteidigte seine Arbeit: „Lung models and therapeutic development for pulmonary antiviral RNAi" am 19.01.2023. Er fertigte diese am Institut für Exp
randomisierten, kontrollierten Pilotstudie, in welcher ein additiver Therapeutischer Plasmaaustausch (Therapeutic Plasma Exchange (TPE)) bei Patienten mit schwerem refraktärem septischem Schock untersucht wurde [...] doi: 10.1186/s13054-022-04003-2. PMID: 35551628 Free PMC article. Clinical Trial. 2. Adjuvant therapeutic plasma exchange in septic shock. David S, Bode C, Putensen C, Welte T, Stahl K; EXCHANGE study