understanding the molecular mechanisms driving neurodegenerative diseases, with a central focus on Spinal Muscular Atrophy (SMA). SMA is a severe neuromuscular disorder caused by the loss or functional deficiencies [...] for RNA metabolism, motor neuron maintenance, and regulation of the actin cytoskeleton. By utilizing a combination of state-of-the-art biophysical and biochemical techniques, including TIRF-Microscopy, Confocal [...] degeneration and progressive muscular atrophy in SMA patients. Our interdisciplinary approach provides a quantitative and mechanistic framework to guide the development of novel therapeutics that stabilize

available in a pre-edited version (see below). The REIGN framework consists mainly of the Discussion Paper of the same name, and of the “REIGN Toolkit”. The Discussion Paper identifies a concrete framework [...] (Use of Research Evidence to Inform Guidance regarding Normative-ethical Topics) project to develop a framework explicating the role of evidence in the development of ethics guidelines. The resulting “REIGN [...] addresses theoretical background assumptions about the use of evidence in ethics. The “Toolkit” is a brief summary of this framework with, among other things, checklists that can be used when developing

zur Zirrhose bis hin zum Leberkrebs fortschreiten lassen, sind nur unzureichend bekannt und hängen u.a. mit ernährungsbedingten und genetischen Risikofaktoren zusammen. In den letzten Jahren wurden mehrere [...] domain-containing protein 3“ (PNPLA3-I148M), welche mit der fortgeschrittenen NAFLD assoziiert ist u.a. unabhängig von BMI und/oder Diabetes Status. Die genauen Pathomechanismen, die auf die 148M-Variante [...] (einer Art Fastfood Diät) zeigen, dass die 148M-Variante zu einer besonders aggressiven NAFLD führt, u.a. auch mit der Entstehung einer mikrovesikulären Steatose. Besonders interessant war jedoch die Beobachtung

Be a Doc Professionalisierung im Medizinstudium Hintergrund Aufgrund eines sich kontinuierlich und rasch wandelnden beruflichen Umfeldes, immer komplexer werdenden Anforderungen an die ärztliche Tätigkeit [...] Kompetenzen, d.h. in dem konkreten ärztlichen Handeln in einer besonderen Qualität. Ziel Das Projekt „Be a Doc“ zielt darauf ab, die professionelle Entwicklung von Medizinstudierenden frühzeitig zu fördern, [...] , die den nicht-medizinischen Herausforderungen des ärztlichen Berufs optimal begegnen können. „Be a Doc“ stellt das Thema Professionalisierung in den Mittelpunkt und fokussiert die gezielte Entwicklung

Verantwortliche Person (SP, §14 & VP, §20c AMG) Stufenplanbeauftragter (SPB, nach §63a AMG) Informationsbeauftragter (IB, nach §74a AMG) Curriculum vitae

Results of a Delphi study in Germany. Support Care Cancer. 2021; DOI: 10.1007/s00520-021-06452-x (PubMed) Herbst FA, Gawinski L, Schneider N, Stiel S. ‘Mums are sacred, and mums don’t die’: A mixed-methods [...] Schneider N, Herbst FA. Exploring end-of-life interaction in dyads of parents and adult children: a protocol for a mixed-methods study. BMC Palliat Care 2018, 17: 68 (PubMed) Auszeichnungen Das Projektteam Dy@EoL [...] of life with their parents and parents at the end of life with their adult children: Findings from a mixed‐methods study. Psycho‐Oncol 2021; DOI: 10.1002/pon.5728 (PubMed) Herbst FA, Gawinski L, Schneider

my studies at Hannover Medical School I have completed and provided evidence of a suitable previous Bachelor's degree or a comparable degree programme at Leibniz Universität Hannover or another German or [...] language proficiency). I confirm that, in deviation from the above paragraph, I am unable to present a degree, but have proven at least 150 credit points by the application deadline. I will submit the c [...] lieu of an oath that the prerequisites have been fulfilled I confirm that I have acquired and proven a previous (German or foreign) university degree suitable for the subject at the beginning of my doctoral

endocytosis The pro-inflammatory cytokine IL-1 is a critical regulator of the innate immune response and the interleukin-1 (IL-1)-mediated signal transduction is a paradigm of immune signalling. IL-1 binding [...] binding, but the function of the IL-1RI internalization remained elusive. Recently, we demonstrated a critical role for the internalization of IL-1RI in the IL-1-mediated signal transduction. We also showed

patients with definite Meniere's disease. Prenzler NK*, Bültmann E*, Giourgas A, Steffens M, Salcher RB, Stolle S, Lesinski-Schiedat A, Lenarz T, Durisin M. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):751-756 [...] Kommunikation, sprechen Sie uns gerne an! Publikationen 2017: Age-related T2 relaxation times at 3 Tesla as a biomarker of infratentorial brain maturation. Bültmann E, Spineli LM, Göhner F, Hartmann H, Lanfermann [...] microstructure during infancy and childhood using clinical feasible ADC-maps. Bültmann E, Mußgnug HJ, Zapf A, Hartmann H, Nägele T, Lanfermann H. Childs Nerv Syst. 2017 May;33(5):735-745. doi: 10.1007/s00381-

peripheral tissues through a massive increase of their insulin secretion capacity. Nevertheless, in most affected patients a progressive loss of beta cell function and also a loss of beta cell mass can [...] increased luminal hydrogen peroxide generation. Furthermore, this ROS accumulation has been associated with a reduction of protein folding efficacy, initiation of oxidative ER stress, and loss of beta cell function