Freise GERMANY supervisor: Prof. Dr. Zeidler, Dept. Rheumatology, OE 6850, project: Viability and gene expression of Chlamydia trachomatis during persistent infection. A study to establish new therapeutic [...] Feodor-Lynen-Str. 7, 30625 Hannover, project: Regulatory mechanism of mammalian circadian clock genes Final exam June 2006 Yijiang Li CHINA supervisor: Prof. Dr. Haverich/Dr. Simon, THG-Surgery, OE 6286 [...] TURKEY (Dr. med.) supervisor: Prof. Dr. Kreipe, Pathology, OE 5110, project: Quantitative analysis of gene expression in different mechanisms of early allograft damage after renal transplantation Final exam

receptor (TCR) gene transfer Final exam November 2010 Tobias Mätzig GERMANY supervisor: Prof. Dr. Baum, Experimental Hematology, OE 6960, project: Evaluation of retro- and lentiviral vectors for gene therapy [...] now University of Ulm project: Analysis of functional consequences of the deletion of candidate genes of the DNA damage pathway; analysis of a telomerase activating compound in improving liver regeneration [...] supervisor: Prof. Dr. Gaestel, Biochemistry, OE 4310, project: Characterisation of p38 MAPK regulated gene expression in MK2/3 deficient cells Final exam June 2010 Nidhi Narain INDIA supervisor: Prof. Dr.

internalization and regulates gene expression. Cellular Signalling 26 : 49-55. Hansen, B., Dittrich-Breiholz, O., Kracht, M., and Windheim, M. (2013) Regulation of the NF-kB-dependent gene expression by ligand-induced [...] endent mechanism. Journal of Immunology 201: 3373-3382. Windheim, M. (2016) Interleukin-1-induced gene expression requires the membrane-raft-dependent internalization of the interleukin-1 receptor. Cellular

past years, important advances have been achieved in the field (viral vector-mediated gene transfer, CRISPR cas9 gene editing etc) making these technologies rapid, efficient and more affordable. These methods [...] Ex vivo technologies Genetic engineering is the manipulation of an organism’s genes using biotech methodologies and it includes several applications that are widely adopted to study cardiac biology. In [...] sudden cardiac death or heart failure. Most patients with a confirmed mutation carry mutations in genes encoding sarcomeric proteins in β-myosin heavy chain ( MYH7 , β-MyHC), cardiac myosin-binding protein

en unter normalen und entzünd­li­chen Bedin­gun­gen und erarbeiten neuartige Isolierungs- und Kultivierungsstrategien. Inhaltliche Schwerpunkte lie­gen auf dem Verständnis von Stammzellfunk­tionen und [...] n und mehrfach gra­dierten Im­plantats für einen zu­künfti­gen Ein­satz am Seh­nen-Knochen-Übergang der Rota­toren­man­schette aufzu­zei­gen. Die FOR 2180 um­spannt Fach­gebiete aus den Ingenieur-, Na­tur- [...] dere auch immun­suppressive) Funk­tionen. Diese Eigenschaften beruhen im we­sentlichen auf Wirkun­gen von lösli­chen Faktoren, die von MSCs abgegeben werden. MSCs sind daher medi­zinisch hoch relevant:

rases and Related Genes 1035-1045. Bakker, H. and Ashikov, A. (2014). UDP-Xylose and UDP-N-Acetylglucosamine Transporter (SLC35B4). Handbook of Glycosyltransferases and Related Genes 1393-1402. Bakker [...] and Related Genes 1439-1448. Bakker, H. , Ashikov, A., Routier, F.H., and Gerardy-Schahn, R. (2014). GDP-Fucose Transporter 1 (SLC35C1). Handbook of Glycosyltransferases and Related Genes 1403-1411. Buettner [...] A.C., van Zandbergen,G., Wenzel,A., Gerardy-Schahn,R., Wiese,M., and Routier,F.H. (2007). Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J. Biol. Chem

Rivera-Pomar R., and Gossler A. (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes & Development , 18, 1725-36. Hofmann M., Schuster-Gossler [...] K., Alten, L., Ueffing, M., Blum, M., Gossler, A., 2018. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Sci [...] K., Kühnel, M.P., Hegermann, J., Ueffing, M., Gossler, A., 2017. 1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis. Dev Biol . doi:10

protein production (E. coli, D. discoideum, Sf9-cells); Fluorescence Labeling techniques; gene silencing; stable gene expression; polyclonal antibody production. Functional Assays: Determination and chara

and gene regulation Flow of genetic information The cytoskeleton Microscopic techniques Membrane transport of small molecules Receptors and signal transduction Cell cycle and oncogenesis Human Gene finding [...] lymphoid organs Gene therapy : Stem cells, regulations of transgenes in somatic cells, embryonic and somatic cloning in mammals, Safety and efficiency in the use of viral vectors for gene therapy Microbiology [...] Scientific English 2.5 Radiation protection 2.7 Gene technological security 2.8 Introduction to ethics Ethical cases in medicine Ethical aspects of gene technology Scientific ethics 3. Other Courses 3

Tic-Erkrankungen liegt wahrscheinlich ein komplexes Vererbungsmuster zugrunde, bei dem verschiedene Gene dazu beitragen, die Wahrscheinlichkeit für das Auftraten der Erkrankung zu erhöhen. Je nach verändertem [...] vermutlich ein anderes klinisches Bild der Erkrankung. Ein viel versprechendes Kandidatengen – d.h. ein Gen, das mit hoher Wahrscheinlichkeit mit dem Eintreten eines Tourette-Syndroms oder einer Tic-Störung