Final exam June 2022 Claudio Rodriguez Gonzalez SPAIN Supervisors: Dr. Antje Munder / PD. Dr. Nico Lachmann, Department of Pediatric Pneumology and Institute of Experimental Hematology Project: Pulmonary

Solovyeva A, Mardan J, Nasri M, Ritter M, Zahabi A, Arreba-Tutusaus P, Mir P, Stein F, Kandabarau S, Lachmann N, Moritz T, Morishima T, Konantz M, Lengerke C, Ripperger T, Steinemann D , Erlacher M, Niemeyer [...] F, Vollmer Barbosa P, Kuehle J, Steinemann D , Lenz D, Buchegger T, Morgan M, Falk CS, Klein C, Lachmann N, Schambach A. Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation [...] 101697. Epub 2020 Jan 9. PMID: 32062129. Hoffmann D, Kuehle J, Lenz D, Philipp F, Zychlinski D, Lachmann N, Moritz T, Steinemann D , Morgan M, Skokowa J, Klein C, Schambach A. Lentiviral gene therapy and

expansion after transplantation, generation of novel transplantation strategies (Dirk Hoffmann, Nico Lachmann). Our institute also uses designer nucleases, such as TALE nucleases (TALENs) or clustered regularly

eine Förderung in Höhe von einer Million Euro aus dem „Niedersächsischen Vorab“. Professor Dr. Nico Lachmann aus unserem Team erforscht hier bestimmte Immunzellen, die Bakterien und Viren beseitigen können

Pluripotent Stem Cell–derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis Happle, Christine, Lachmann, Nico, Ackermann, Mania, Mirenska, Anja, Göhring, Gudrun, Thomay, Kathrin, Mucci, Adele, Hetzel [...] H., Gaedcke, Svenja, Fenske, Arno, Jang, Mi-Sun, Jirmo, Adan C., Abeln, Markus, Hansen, Gesine; Lachmann, Nico. Stem Cell Research & Therapy. 2024. Publisher's page Preclinical toxicity analyses of lentiviral [...] Hetzel, Miriam, Abdin, Shifaa M., Wegner, Tim, Schwarzer, Adrian, Hansen, Gesine, Schambach, Axel, Lachmann, Nico; Ackermann, Mania. Journal of Immunology and Regenerative Medicine. 2022. Publisher's page

FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hematopoietic stem cell gene therapy for IFNgammaR1 deficiency protects mice from mycobacterial

neben der hocheffizienten Reprogrammierung in iPS-Zellen (Haase, A., Cell Stem Cell, 2009. 5: 434.; Lachmann, N., Am J Respir Crit Care Med, 2014. 189: 167) auch die effiziente genetische Modifikationen der

González-Motos V, Steinbrück L, Ritter B, Rodríguez-González C, Böning H, Nikolouli E, Kinchington PR, Lachmann N, Depledge DP, Krey T, Viejo-Borbolla A. 2024. Viral modulation of type II interferon increases

FC, Goethe R, Jonigk D , Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N: Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial [...] Blank P, Philipp F, Goethe R, Jonigk D , Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N: Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived M

TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C. T helper 1 immunity requires complement-driven NLRP3 in