already many research results on the effects and therapeutic factors of psychotherapy, comparatively little is known about this for certain therapeutic services. These include, for example, body-oriented [...] Our research group aims to develop suitable instruments with which the effect and therapeutic factors of these therapeutic offers, which have so far been too little considered by research, can be tested [...] questions about its effect and therapeutic factors are still unanswered. A questionnaire has therefore been developed to help patients evaluate the effects and therapeutic factors of CBT in group setting

Figueiredo (Transfusion Medicine) Project: Correction of monogenetic kidney diseases using a gene therapeutic approach Aavani Biju Sindhu INDIA; Sindhu.Aavani @ mh-hannover.de Supervisor: Prof. Dr. Anke Bergmann [...] Supervisors: Dr. Natalie Weber/ Prof. Dr. Thomas Thum (Institute of Molecular and Translational Therapeutic Strategies IMTTS and Fraunhofer ITEM) Project: Integration and maturation of human stem cell-derived [...] Thum (Fraunhofer ITEM) Project: Cardiac fibrosis fingerprints and pre-clinical development of therapeutic approaches Maria is class speaker! Isabel Klefenz GERMANY; Klefenz.Isabel @ mh-hannover.de Supervisor:

Dr. Christian Bär (Institute of Molecular and Translational Therapeutic Strategies, IMTTS) Project: Investigating circular RNA as therapeutic targets in ischemic heart disease [...] Dr. Natalie Weber, PhD / Prof. Dr. Dr. Thomas Thum (Institute of Molecular and Translational Therapeutic Strategies IMTTS and Fraunhofer ITEM) Project: Investigation of novel therapies in hypertrophic [...] @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär (Institute of Molecular and Translational Therapeutic Strategies, IMTTS) Project: Elucidating the role of circRNAs in cardiomyocyte proliferation and

Molecular and Translational Therapeutic Strategies (IMTTS) Director: Prof. Dr. Dr. Thomas Thum Address: Hannover Medical School Institute of Molecular and Translational Therapeutic Strategies OE 8886 Carl

in a mouse model of myocardial infarction (MI). Therapeutic miR-24 antagonism counteracted loss of vascular structures and highlights novel therapeutic potential after MI. In addition miR-24 has been shown [...] Identification of druggable non-coding RNAs (ncRNAs) and novel therapeutic entities in the cardiopulmonary system The role of small non-coding microRNAs (miRs) in ischemic cardiac injury has been studied [...] molecules regulating fibroblast biology which is part of our research. Conclusively, miR-based therapeutic strategies are of great importance for basic translational research and novel non-coding RNA key

worldwide. Development of therapeutic approaches depends on suitable small and large animal models that replicate pathogenesis in humans. Non-coding RNAs are novel therapeutic targets as master regulators

inhibitors (siRNAs, GapmeRs, locked nucleic acids) or RNA mimics can also be utilized in a non-viral therapeutic approach. These synthesized molecules can be given through various routes of administration. Several [...] groups are optimizing organ-specific RNA delivery approaches. The development of novel RNA-based therapeutic strategies targeting disease is a multistep process combining various screening and validation [...] in vivo and in human patient material. In our laboratory, we have identified several promising therapeutic strategies for the treatment of cardiovascular diseases. These strategies are currently undergoing

develop and test new therapeutic strategies. Ongoing research projects Investigating of microRNA and non-coding RNAs in Hypertrophic Cardiomyopathy for development of novel therapeutic approaches HCM is the [...] regeneration and the evaluation of both structural and functional parameters which are affected by the therapeutic treatments. The group uses several in vitro and ex vivo models, with a particular focus on living [...] which are linked to cardiomyocyte dysfunction, hypertrophy and fibrosis. We aim to develop novel therapeutic strategies to prevent HCM initiation and progression. Investigating the regenerative potential

results in insufficient oxygen uptake and is often leading to death. Currently, there are limited therapeutic options to treat fibrotic diseases, highlighting the urgent need for innovative therapies. To address [...] fibrotic processes in the heart and lung using various model systems. We screen for potential therapeutic candidates involved in these processes by utilizing human cardiac cell types, living human myocardial [...] IMTTS, we are dedicated to advancing our understanding of cardiac fibrosis and developing novel therapeutic strategies to combat cardiopulmonary and related diseases. Key references: Piccoli, MT, Gupta,

divided into a non-obstructive (HNCM) and obstructive form (HOCM) therefore requiring personalized therapeutic therapies. HOCM differs from HNCM clinically by the presence of a pathological increased gradient [...] RNAs (ncRNAs) and cardiometabolic proteins as potential biomarkers for HCM identifying novel therapeutic targets in HCM is an important part of our translational research and a vision of our group. Fabry [...] relevance of ncRNAs to control endothelial function in adults with congenital heart disease. 4. Therapeutic targeting of ncRNAs in endothelial dysfunction in patients with heart failure.