Bai,Yiling ; Wu,Zhaojia ; Leary,Scot C. ; Fang,Chen ; Yu,Michelle ; Genth,Harald ; Xie,Yufeng ; Shi,Jinhui ; Xiang,Jim ;
Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways,
Switzerland,Int.J.Mol.Sci.,2025;26(4):1669- doi.org/10.3390/ijms26041669
Originalpublikation

Dastagir,Nadjib ; Liebsch,Christina ; Kutz,Jaqueline ; Wronski,Sabine ; Pich,Andreas ; Obed,Doha ; Vogt,Peter Maria ; Bucan,Vesna ; Strauß,Sarah ;
Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity,
United States,PLoS One,2025;20(3):-e0316257
doi.org/10.1371/journal.pone.0316257
Originalpublikation

Gand,Luis Vincens ; Lanzuolo,Chiara ; Li,Mugeng ; Rosti,Valentina ; Weber,Natalie ; Lu,Dongchao ; Bär,Christian ; Thum,Thomas ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ;
Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia,
Germany,J.Cachexia Sarcopenia Muscle,2025;16(2):-e13776  doi.org/10.1002/jcsm.13776
Originalpublikation

Gao,Linfeng ; Nowakowska,Maria Barbara ; Selby,Katja ; Przykopanski,Adina ; Chen,Baohua ; Krüger,Maren ; Douillard,François Paul ; Lam,Kwok-Ho ; Chen,Peng ; Huang,Ting ; Minton,Nigel Peter ; Dorner,Martin Bernhard ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Lindström,Miia ; Jin,Rongsheng ;
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47,
United States,Nat.Struct.Mol.Biol.,2025;():-
doi.org/10.1038/s41594-024-01479-0
Originalpublikation

Heimerl,Maren ; Erschow,Sergej ; Müller-Olling,Mirco ; Manstein,Dietmar J. ; Decher,Niels ; Kauferstein,Silke ; Jenewein,Tina ; Pich,Andreas ; Ricke-Hoch,Melanie ; Hilfiker-Kleiner,Denise ;
Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression,
England,Eur.Heart J.,2025;(): doi.org/10.1093/eurheartj/ehaf047
Originalpublikation

Horn,Vanessa ; Zarnovican,Patricia ; Tiemann,Birgit ; Pich,Andreas ; Bakker,Hans ; Routier,Françoise H. ;
N-Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii,
Germany,,2025;():-e202400239 doi.org/10.1002/pmic.202400239
Originalpublikation

Ibrahim,Nurul Khalida ; Schreek,Sabine ; Cinar,Buesra ; Stasche,Anna Sophie ; Lee,Su Hyun ; Zeug,Andre ; Dolgner,Tim ; Niessen,Julia ; Ponimaskin,Evgeni ; Shcherbata,Halyna ; Fehlhaber,Beate ; Bourquin,Jean-Pierre ; Bornhauser,Beat ; Stanulla,Martin ; Pich,Andreas ; Gutierrez,Alejandro ; Hinze,Laura ;
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response,
United States,Cell.Rep.,2025;44(4): doi.org/10.1016/j.celrep.2025.115434
Originalpublikation

Josuran,Roland ; Wenger,Andreas ; Worbs,Sylvia ; Kampa,Bettina ; Rummel,Andreas ; Dorner,Brigitte G. ; Gerber,Sabina ;
N-Glycosylation Profile of Abrin Certified EU Reference Material,
Switzerland,Toxins (Basel),2025;17(3):108 doi.org/10.3390/toxins17030108
Originalpublikation

Tammen,Harald ; Pich,Andreas ; Hess,Rüdiger ; Lechowicz,Urszula ; Janciauskiene,Sabina ; Chorostowska,Joanna ;
Quantitative mass spectrometric analysis of C-terminal 36 amino acid peptides of alpha-1 antitrypsin in plasma using survey spectra,
United States,Methods,2025;240():7-13 doi.org/10.1016/j.ymeth.2025.04.004
Originalpublikation

Tsikas,Dimitrios ;
Interpretation of negative-ion chemical ionization GC-MS and GC-MS/MS mass spectra of perfluorinated organic analyte derivatives: Consideration of reduction reactions in the gas phase,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1253():124487 doi.org/10.1016/j.jchromb.2025.124487
Originalpublikation

Tsikas,Dimitrios ;
Pentafluorobenzyl bromide - A versatile derivatization agent in chromatography and mass spectrometry: II. Analysis of organic acids and bases, and comparison with other perfluorinated reagents,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1257():124578 doi.org/10.1016/j.jchromb.2025.124578
Originalpublikation

Tsikas,Dimitrios ;
Underlying Mechanisms of Chromatographic H/D, H/F, cis/trans and Isomerism Effects in GC-MS,
Switzerland,,2025;15(1):43-
doi.org/10.3390/metabo15010043
Originalpublikation

Abbas,Naisam ; Bentele,Marco ; Waleczek,Florian J. G. ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Pich,Andreas ; Linke,Sophie ; Neumüller,Susanne ; Stucki-Koch,Angelika ; Jordan,Maria ; Perbellini,Filippo ; Werlein,Christopher ; Korte,Wilhelm ; Ius,Fabio ; Ruhparwar,Arjang ; Weber,Natalie ; Fiedler,Jan ; Thum,Thomas ;
Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine
J.Mol.Cell.Cardiol., 2024, 196(), 125- 140,
Originalpublikation

Abbas,Naisam ; Haas,Jonas A. ; Xiao,Ke ; Fuchs,Maximilian ; Just,Annette ; Pich,Andreas ; Perbellini,Filippo ; Werlein,Christopher ; Ius,Fabio ; Ruhparwar,Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ;
Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo
Eur.Heart J., 2024, 45(22), 2016- 2018,
Originalpublikation

Albers,Marco Darius ; Tiemann,Birgit ; Kaynert,Jonas Till ; Pich,Andreas ; Bakker, Hans ;
Konservierte Cysteine verhindern die C-Mannosylierung von Mucin-Cys-Domänen,
England, FEBS J., 2024; 291(15):3539-3552
Originalpublikation

Baskal,Svetlana ; Posma, Rene A. ; Bollenbach, Alexander ; Dieperink, Willem ; Bakker, Stephan J. L. ; Nijsten, Maarten W. ; Touw, Daan J. ; Tsikas, Dimitrios ;
GC-MS-Analyse von 4-Hydroxyprolin: erhöhte Prolinhydroxylierung bei Patienten mit Metformin-assoziierter Laktatazidose und mit Metformin behandelten Patienten mit Becker-Muskeldystrophie,
Österreich, Aminosäuren, 2024; 56(1):21-
Originalpublikation

Dimina,Laurianne Jolata ; Leray,Vincent ; Voute,Marion ; David,Jérémie ; Blavignac,Christelle ; Farges,Marie-Chantal ; Rossary,Adrien ; Tsikas,Dimitrios ; Rémond,Didier ; Pickering,Gisèle ; Mariotti,François ;
Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial Impairments in Vascular Endothelial Function in Healthy Older Adults with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial
J.Nutr., 2024, 154(12), 3664- 3680,
Originalpublikation

Hedlund,Petter ; Rahardjo,Harrina E. ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; Ückert,Stefan ;
Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET)
World J.Urol., 2024, 42(1), 654- ,
Originalpublikation

Hirsch,Merle S. ; Hildebrand, Christina B. ; Geltinger,Florian ; Pich,Andreas ; Mühlfeld,Christian ; Wedekind, Dirk ; Brandenberger, Christina ; Seneszenz in alveolären epithelialen Typ-II-Zellen fördert akute Lungenschäden und beeinträchtigt die Regeneration,Vereinigte Staaten,Am.J.Respir.Cell Mol.Biol.,2024; ():-
Originalpublikation

Hose, Leonie; Langenhagen, Alina Katharina; Kefalakes, Ekaterini; Schweitzer, Theresa; Kubinski, Sabrina; Barak, Segev; Pich, Andreas; Grothe, Claudia
A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice.
PMID: 38185886
Originalpublikation

Khan,Bushra ; Lanzuolo,Chiara ; Rosti,Valentina ; Santarelli,Philina ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ;
Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes,
United States,,2024;27(10):110913
Originalpublikation

Klawitter,Jost ; Weissenborn,Wiebke ; Gvon,Iuliia ; Walz,Mackenzie ; Klawitter,Jelena ; Jackson,Matthew ; Sempio,Cristina ; Joksimovic,Sonja L. ; Shokati,Touraj ; Just,Ingo ; Christians,Uwe ; Todorovic,Slobodan M. ;
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?
Mol.Pharmacol., 2024, 105(2), 75- 83,
Originalpublikation

Krueger,Jonas ; Preusse,Matthias ; Oswaldo Gomez,Nicolas ; Frommeyer,Yannick Noah ; Doberenz,Sebastian ; Lorenz,Anne ; Kordes,Adrian ; Grobe,Svenja ; Müsken,Mathias; Depledge,Daniel P. ; Svensson,Sarah L. ; Weiss,Siegfried ; Kaever,Volkhard ; Pich,Andreas ; Sharma,Cynthia M. ; Ignatova,Zoya ; Häussler,Susanne ;
tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa,
United States,Proc.Natl.Acad.Sci.U.S.A.,2024;121(11):-e2312874121
Originalpublikation

Kukoc-Modun, Lea; Kraljevic, Tomislav; Tsikas, Dimitrios; Spassov, Tony G; Kolev, Spas D
Determination of -Acetyl-L-cysteine Ethyl Ester (NACET) by Sequential Injection Analysis.
PMID: 38257405
Originalpublikation

Neufeldt,Dimyana ; Schmidt,Arne ; Mohr,Elisa ; Lu,Dongchao; Chatterjee,Shambhabi ; Fuchs,Maximilian; Xiao,Ke ; Pan,Wen; Cushman,Sarah; Jahn,Christopher; Juchem,Malte; Hunkler,Hannah Jill ; Cipriano,Giuseppe ; Jürgens,Bjarne ; Schmidt,Kevin ; Groß,Sonja ; Jung,Mira ; Hoepfner,Jeannine ; Weber,Natalie ; Foo,Roger ; Pich,Andreas ; Zweigerdt,Robert ; Kraft,Theresia ; Thum,Thomas ; Bär,Christian ;
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival,
Germany,Basic Res.Cardiol.,2024;119(4):613-632
Originalpublikation

Oms,Elisabeth ;
Untersuchung des RGD-Motivs in der Bindung und Aufnahme von C3bot in HT22 Zellen,
Hannover,,2024;():-4 ungezählte Blätter, 98 Blätter :
Dissertation

Posma,Rene A. ; Bakker,Stephan J. L. ; Nijsten,Maarten W. ; Touw,Daan J. ; Tsikas,Dimitrios ;
Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment,
Switzerland,J.Clin.Med.,2024;13(13):3692-
Originalpublikation

Post,Adrian ; Groothof,Dion ; Kremer,Daan ; Knobbe,Tim J. ; Abma,Willem ; Koops,Christa A. ; Tsikas,Dimitrios ; Wallimann,Theo ; Dullaart,Robin P. F. ; Franssen,Casper F. M. ; Kema,Ido P. ; Heiner-Fokkema,M. Rebecca ; Bakker,Stephan J. L. ;
Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls,
Austria,Amino Acids,2024;56(1):42-
Originalpublikation

Przykopanski,Adina ;
Untersuchung der Komplexbildung des proteinogenen Botulinum Neurotoxins mit dessen assoziierten Proteinen und deren Einfluss auf den transepithelialen Transport des Toxins
2023,
Dissertation

Sainz von Petzinger,Sylvana ;
Protektive Effekte von Chitosan Oligosacchariden gegen Clostridioides difficile Toxin A und Toxin B
2024,
Masterarbeit

Schmidt,Kevin ; Schmidt,Arne ; Groß,Sonja ; Just,Annette ; Pfanne,Angelika ; Fuchs,Maximilian ; Jordan,Maria ; Mohr,Elisa ; Pich,Andreas ; Fiedler,Jan ; Thum,Thomas ;
SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation,
England,Sci.Rep.,2024;14(1):16459-
Originalpublikation

Scholz,Jonas ; Stephan,Till ; Pérez,Aina Gallemí ; Csiszár,Agnes ; Hersch,Nils ; Fischer,Lisa S. ; Brühmann,Stefan ; Körber,Sarah ; Litschko,Christof ; Mijanovic,Lucija ; Kaufmann,Thomas ; Lange,Felix ; Springer,Ronald ; Pich,Andreas ; Jakobs,Stefan ; Peckham,Michelle ; Tarantola,Marco ; Grashoff,Carsten ; Merkel,Rudolf ; Faix,Jan ;
Decisive role of mDia-family formins in cell cortex function of highly adherent cells
Sci.Adv., 2024, 10(44), - eadp5929,
Originalpublikation

Tapken,Ines ; Schweitzer,Theresa ; Paganin,Martina ; Schüning,Tobias ; Detering,Nora T. ; Sharma,Gaurav ; Niesert,Moritz ; Saffari,Afshin ; Kuhn,Daniela ; Glynn,Amy ; Cieri,Federica ; Santonicola,Pamela ; Cannet,Claire ; Gerstner,Florian ; Faller,Kiterie M. E. ; Huang,Yu-Ting ; Kothary,Rashmi ; Gillingwater,Thomas H. ; Di Schiavi,Elia ; Simon,Christian M. ; Hensel,Niko ; Ziegler,Andreas ; Viero,Gabriella ; Pich,Andreas ; Claus,Peter ;
The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy
Brain, 2024, (), - ,
Originalpublikation

Tsap,Mariana I. ; Yatsenko,Andriy S. ; Hegermann,Jan ; Beckmann,Bibiana ; Tsikas,Dimitros ; Shcherbata,Halyna R. ;
Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier,
England,Elife,2024;13():-e98020
Originalpublikation

Tsikas, Dimitrios
Application of the Bland-Altman and Receiver Operating Characteristic (ROC) Approaches to Study Isotope Effects in Gas Chromatography-Mass Spectrometry Analysis of Human Plasma, Serum and Urine Samples
Molecules, 29(2):365, 2024 ISSN:1420-3049 (elektronisch)PMID:38257277 »DOI:10.3390/molecules29020365 »
Originalpublikation

Tsikas,Dimitrios ;
Perspektiven der quantitativen GC-MS, LC-MS und ICP-MS in der klinischen Medizin - Die Rolle der analytischen Chemie,
Schweiz, J.Clin.Med., 2024; 13(23):7276
Originalpublikation

Tsikas,Dimitrios ;
Zugrunde liegende Mechanismen von chromatographischen H/D-, H/F-, cis/trans- und Isomerie-Effekten bei GC-MS,
Schweiz, 2025; 15(1):43
Originalpublikation

Waleczek,Florian J. G. ; Cipriano,Giuseppe ; Haas,Jonas A. ; Garg,Ankita ; Pfanne,Angelika ; Just,Annette ; Neumüller,Susanne ; Hegermann,Jan ; Pich,Andreas ; Radocaj,Ante ; Xiao,Ke ; Weber,Natalie ; Thum,Thomas ;
Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure
Int.J.Mol.Sci., 2024, 26(1), 218- ,
Originalpublikation

Wu,Xuekun ; Zheng,Linqun ; Reboll,Marc R. ; Hyde,Lillian F. ; Mass,Elvira ; Niessen,Hans W. ; Kosanke,Maike ; Pich,Andreas ; Giannitsis,Evangelos ; Tillmanns,Jochen ; Bauersachs,Johann ; Heineke,Joerg ; Wang,Yong ; Korf-Klingebiel,Mortimer ; Polten,Felix ; Wollert,Kai C. ;
Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair,
England,Nat.Cardiovasc.Res.,2024;3(2):186-202
Originalpublikation

Zobl,Walter ;
Integration of in vitro methods into regulatory hazard assessment: two proof-of-concept case studies,
Hannover,,2024;():IX, 20, 17 Blätter, Blatt 38, 14 Blätter-77 : Illustrationen, Diagramme
Dissertation

Bousnaki,Maria; Bakopoulou,Athina; Grivas,Ioannis; Bekiari,Chrysa; Pich,Andreas; Rizk,Marta; Keklikoglou,Kleoniki; Papachristou,Eleni; Papadopoulos,Georgios C.; Kritis,Aristeidis; Mikos,Antonios G.; Koidis,Petros;
Behandlung von Kiefergelenksarthrose durch dentales Stammzellsekretom,
Vereinigte Staaten,Stammzell.Rev.Rep.,2023; 19(8):2957-2979
Originalpublikation

Deppe,Julian;
Untersuchung der Funktion der HCN-Domäne clostridieller Neurotoxine,
Hannover,,2022; ():V, 15, 22 Blätter, Blatt VI-XXII : Illustrationen, Diagramme
Dissertation

Eggenkemper,Lisa; Schlegtendal,Anne; Maier,Christoph; Lücke,Thomas; Brinkmann,Folke; Beckmann,Bibiana; Tsikas,Dimitrios; Koerner-Rettberg,Cordula;
Beeinträchtigte Stickstoffmonoxid-Synthetase-Aktivität bei primärer ziliärer Dyskinesie-datengesteuerter Hypothese,
Schweiz,J.Clin.Med.,2023; 12(18):6010
Originalpublikation

Emons,Barbara; Arning,Larissa; Makulla,Vera-Estelle; Suchy,Maria-Theresia; Tsikas,Dimitrios; Lücke,Thomas; Epplen,Jörg T.; Juckel,Georg; Roser,Patrik;
Endocannabinerge Modulation der zentralen serotonergen Aktivität bei gesunden menschlichen Freiwilligen,
England,Ann.Gen.Psychiatry.,2023; 22(1):11
Originalpublikation

Gao,Linfeng; Lam,Kwok-Ho; Liu,Shun; Przykopanski,Adina; Lübke,Johanna; Qi,Ruifeng; Krüger,Maren; Nowakowska,Maria B.; Selby,Katja; Douillard,François P.; Dorner,Martin B.; Perry,Kay; Lindström,Miia; Dorner,Brigitte G.; Rummel,Andreas; Jin,Rongsheng;
Kristallstrukturen von OrfX1, OrfX2 und dem OrfX1-OrfX3-Komplex aus dem orfX-Gencluster des Botulinum-Neurotoxins E1,
England, FEBS Lett.,2023;597(4):524-537 10.1002/1873-3468.14576,
Originalpublikation

Haukamp,Funmilola Josephine; Hartmann,Zoe Maria; Pich,Andreas; Kuhn,Joachim; Blasczyk,Rainer; Stieglitz,Florian; Bade-Döding,Christina;
HLA-B*57:01/Carbamazepin-10,11-Epoxid-Assoziation löst Hochregulierung der NFkappaB- und JAK/STAT-Signalwege aus,
Schweiz,Cells,2023;12(5):676-10.3390 /cells12050676 Berichtsjahr:2023 | ID: RefID:26161-haukamp2023hla-b*57:01/carbamazepine-1
Originalpublikation

Heils,Lucas; Schneemann,Martina; Gerhard,Ralf; Schulzke,Jörg-Dieter; Bücker,Roland;
CDT von Clostridioides difficile induziert MLC-abhängige intestinale Barrieredysfunktion in HT-29/B6-Epithelzellmonoschichten,
Schweiz,Toxine (Basel),2023;15(1):54-10.3390 /toxins15010054, Berichtsjahr:2023 | ID: RefID:26111-heils2023cdt
Originalpublikation

Hildebrand,Christina B.; Lichatz,Rita; Pich,Andreas; Mühlfeld,Christian; Woltemate,Sabrina; Vital,Marius; Brandenberger,Christina;
Kurzkettige Fettsäuren verbessern die Alterung und akute Lungenschädigung bei alten Mäusen,
Vereinigte Staaten,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023;():- 10.1152/ajplung.00296.2022 Berichtsjahr:2023 | ID: RefID:26113-hildebrand2023short
Originalpublikation 

Hollwedel, Femke D; Maus, Regina; Stolper, Jennifer; Iwai, Satoru; Kasai, Hayato; Holtfreter, Silva; Pich, Andreas; Neubert, Lavinia; Welte, Tobias; Yamasaki, Sho; Maus, Ulrich A
Ectopic expression of C-type lectin Mincle renders mice susceptible to staphylococcal pneumonia.
PMID: 38159068
Originalpublikation

Joensuu,Merja; Syed,Parnayan; Saber,Saber H.; Lanoue,Vanessa; Wallis,Tristan P.; Rae,James; Blum,Ailisa; Gormal,Rachel S.; Small,Christopher; Sanders,Shanley; Jiang,Anmin; Mahrhold,Stefan; Krez,Nadja; Cousin,Michael A.; Cooper-White,Ruby; Cooper-White,Justin J.; Collins,Brett M.; Parton,Robert G.; Balistreri,Giuseppe; Rummel,Andreas; Meunier,Frederic A.;
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry,
England,EMBO J.,2023;42(13):-e112095 10.15252/embj.2022112095 Berichtsjahr:2023 | ID: RefID:39384-joensuu2023presynaptic
Originalpublikation

Liu,Zheng; Lee,Pyung-Gang; Krez,Nadja; Lam,Kwok-Ho; Liu,Hao; Przykopanski,Adina; Chen,Peng; Yao,Guorui; Zhang,Sicai; Tremblay,Jacqueline M.; Perry,Kay; Shoemaker,Charles B.; Rummel,Andreas; Dong,Min; Jin,Rongsheng; Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2,
England,Nat.Commun.,2023;14(1):2338-10.1038/s41467-023-37860-8 Berichtsjahr:2023 | ID: RefID:26323-liu2023structural
Originalpublikation

Manion,John; Musser,Melissa A.; Kuziel,Gavin A.; Liu,Min; Schäfer,Amy; Wang,Siyu; Lee,Pyung-Gang; Zhao,Leo; Zhang,Jie; Marreddy,Ravi K. R.; Goldschmied,Jeffrey D.; Yuan,Ke; Hürde,Julian G.; Gerhard,Ralf; Jin,Rongsheng; Rakoff-Nahoum,Seth; Rao,Meenakshi; Dong,Min;
C. difficile vergiftet Neuronen und Perizyten, um neurogene Entzündungen voranzutreiben,
England,,2023; 622(7983):611-618
Originalpublikation

Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner 3rd, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet
Die pharmakologische Hemmung von Bromodomänen und extraterminalen Proteinen induziert einen NRF-2-vermittelten antiviralen Zustand, der durch eine SARS-CoV-2-Infektion untergraben wird,
Vereinigte Staaten, PLoS Pathog., 2023; ():-
Originalpublikation

Mikuteit,Marie; Baskal,Svetlana; Klawitter,Sandra; Dopfer-Jablonka,Alexandra; Behrens,Georg M. N.; Müller,Frank; Schröder,Dominik; Klawonn,Frank; Steffens,Sandra; Tsikas,Dimitrios;
Aminosäuren, posttranslationale Modifikationen, Stickstoffmonoxid und oxidativer Stress in Serum und Urin von Long-COVID- und Ex-COVID-Probanden,
Österreich,Aminosäuren,2023; 55(9):1173-1188
Originalpublikation

Pankoke,Sophia; Schweitzer,Theresa; Biker,Rolf; Pich,Andreas; Pfarrer,Christiane; Mühlfeld,Christian; Schipke,Julia;
Fettleibigkeit wirkt sich auf die Hypoxieanpassung der Lunge aus,
Vereinigte Staaten,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023; 325(3):L352-L359
Originalpublikation

Pokrant,Thomas; Hein,Jens Ingo; Körber,Sarah; Disanza,Andrea; Pich,Andreas; Scita,Giorgio; Rottner,Klemens; Faix,Jan;
Das Ena/VASP-Clustering an den Mikrospike-Spitzen umfasst Lamellipodin, aber keine I-BAR-Proteine und erfordert unbedingt unkonventionelle Myosin-X,
United States,Proc.Natl.Acad.Sci.U.S.A.,2023;120(2):-e2217437120 10.1073/pnas.2217437120 Berichtsjahr:2023 | ID: RefID:26134-pokrant2023ena/vasp
Originalpublikation

Rahardjo,Harrina E.; Märker,Viktoria; Tsikas,Dimitrios; Kuczyk,Markus A.; Ückert,Stefan; Bannowsky,Andreas;
Fibrotische Erkrankungen der menschlichen Harn- und Genitalwege: aktuelles Verständnis und mögliche Behandlungsstrategien,
Schweiz,J.Clin.Med.,2023; 12(14):4770
Originalpublikation

Rahardjo,Harrina E. ; Ückert,Stefan ; Tsikas,Dimitrios ; Bannowsky,Andreas ; Kuczyk,Markus A. ; Becker,Armin J. ;
Courses of Arginine-Vasopressin in the Systemic and Cavernous Blood through Different Stages of Sexual Arousal in Healthy Males and Patients with Erectile Dysfunction,,,2023;2023():7978734-
Originalpublikation

Rohrbeck,Astrid; Bruhn,Vanessa Anna; Hussein,Nali; Hagemann,Sandra; Just,Ingo;
Clostridium botulinum C3bot vermittelte Wirkungen auf den Zytokin-induzierten Psoriasis-ähnlichen Phänotyp im Hautmodell mit voller Dicke,
Deutschland,Naunyn Schmiedebergs Arch.Pharmacol.,2023; ():-
Originalpublikation

Rosenstein,Christopher;
Identifizierung einer zweiten Rezeptorbindungstasche in Botulinum Neurotoxin F,
Hannover,,2022;():-2 ungezählte Blätter, 77 Blätter : 10.26068/mhhrpm/20230601-002 Berichtsjahr:2023 | ID: RefID:26365-rosenstein2022identifizierung
Dissertation

Schneemann,Martina; Heils,Lucas; Moos,Verena; Weiß,Franziska; Krug,Susanne M.; Weiner,Januar; Beule,Dieter; Gerhard,Ralf; Schulzke,Jörg-Dieter; Bücker,Roland;
Ein Kolon-Organoid-Modell, das mit den großen Toxinen von Clostridioides difficile TcdA und TcdB konfrontiert ist, weist deregulierte Tight-Junction-Proteine auf,
Schweiz,Toxins (Basel),2023; 15(11):643
Originalpublikation

Schweitzer,Theresa;
Untersuchungen zu den Wirkungen clostridieller glukosylierender Toxine,Hannover,,2023; ():-VIII, 115 Seiten : Illustrationen, Diagramme
Dissertation

Sinningen,Kathrin; Emons,Barbara; Böhme,Pierre; Juckel,Georg; Hanusch,Beatrice; Beckmann,Bibiana; Tsikas,Dimitrios; Lücke,Thomas;
L-Arginin/Stickstoffmonoxid-Signalweg und oxidativer Stress bei Erwachsenen mit ADHS: Auswirkungen der Methylphenidat-Behandlung,
Vereinigte Staaten, Stickstoffmonoxid, 2023; 138-139():64-69
Originalpublikation

Tsikas,Dimitrios;
Acetazolamid und menschliche Carboanhydrasen: Rückblick, Rückblick und Diskussion einer intimen Beziehung,
England,J.Enzyme Inhib.Med.Chem.,2024; 39(1):2291336
sonstiges

Tsikas,Dimitrios; Beckmann,Bibiana; Baskal,Svetlana; Brunner,Görig;
Pentafluorpropionsäure-Anhydrid-Derivatisierung und GC-MS-Analyse von Histamin, Agmatin, Putrescin und Spermidin: Auswirkungen von Lösungsmitteln und Startsäulentemperatur,
Schweiz,Moleküle,2023; 28(3):939
Originalpublikation

Tsikas,Dimitrios; Beckmann,Bibiana;
Qualitätskontrolle in gezielter GC-MS für Aminosäure-OMICS,
Schweiz,,2023; 13(9):986
Originalpublikation

Tsikas,Dimitrios; Büttner,Petra;
Sagen zirkulierende Konzentrationen von L-Arginin-Metaboliten den Status der koronaren Herzkrankheit und die Wahrscheinlichkeit kardiovaskulärer Ereignisse voraus?,
Poland,Pol.Arch.Intern.Med.,2023;133(2):16429-10.20452 /pamw.16429 Berichtsjahr:2023 | ID: RefID:26154-tsikas2023zirkulierend
Editorial 

Tsikas,Dimitrios;
GC-MS- und GC-MS/MS-Messung von Malondialdehyd (MDA) in klinischen Studien: Präanalytische und klinische Überlegungen,
Niederlande,J.Mass.Spectrom.Adv.Clin.Lab.,2023; 30():10-24
Übersicht

Tsikas,Dimitrios;
GC-MS-Studien zur Stickstoffmonoxid-Autoxidation und S-Nitrosothiol-Hydrolyse zu Nitrit in pH-neutralen wässrigen Puffern: Definitive Ergebnisse unter Verwendung von (15)N- und (18)O-Isotopen,
Schweiz,Moleküle,2023; 28(11):4281-http://doi.org/10.3390/molecules28114281
Originalpublikation

Tsikas,Dimitrios;
Malondialdehyd-induzierte posttranslationale Modifikation des menschlichen Hämoglobins,
Vereinigte Staaten,J.Proteome Res.,2023; 22(6):2141-2143
Kommentar

Tsikas,Dimitrios;
Massenspektrometrie-basierte Bewertung des Bland-Altman-Ansatzes: Überprüfung, Diskussion und Vorschlag,
Schweiz,Moleküle,2023; 28(13):4905
Übersicht

Tsikas,Dimitrios;
Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2023;1221():123684-10.1016/j.jchromb.2023.123684 Berichtsjahr:2023 | ID: RefID:26250-tsikas2023measurement
Letter

Tsikas,Dimitrios; Tsikas,Stefanos A.; Mikuteit,Marie; Ückert,Stefan;
Zirkulierende und Urinkonzentrationen von Malondialdehyd bei alternden Menschen in Gesundheit und Krankheit: Überprüfung und Diskussion,
Schweiz,,2023; 11(10):2744
Übersicht

Weißenborn,Wiebke;
Pharmakologische Untersuchungen des Sesquiterpens BCP als potenzielle postoperative Opioidalternative,
Hannover,,2022; ():-4 ungezählte Blätter, 78 Blätter
Dissertation

Baskal,S.; Beckmann,B.; Stahmer,L.; Peter,C.; Bohnhorst,B.; Das,A. M.; Tsikas,D.;
Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period,
Austria,Amino Acids,2022;():- 10.1007/s00726-022-03197-7 Berichtsjahr:2022 | ID: RefID:25095-baskal2022role
Originalpublikation

Baskal,S.; Bollenbach,A.; Henzi,B.; Hafner,P.; Fischer,D.; Tsikas,D.;
Stable-Isotope Dilution GC-MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination,
Switzerland,Molecules,2022;27(12):3850-10.3390/molecules27123850 Berichtsjahr:2022 | ID: RefID:25096-baskal2022stable-isotope
Originalpublikation

Baskal,S.; Dimina,L.; Tsikas,S. A.; Mosoni,L.; Remond,D.; Mariotti,F. ; Tsikas,D.;
Lysine and homoarginine are closely interrelated metabolites in the rat,
Austria,Amino Acids,2022;54(6):967-976, 10.1007/s00726-022-03158-0 Berichtsjahr:2022 | ID: RefID:25097-baskal2022lysine
Originalpublikation

Baskal,S.; Kaiser,A.; Mels,C.; Kruger,R.; Tsikas,D.;
Specific and sensitive GC-MS analysis of hypusine, N(epsilon)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
Austria, Amino Acids, 2022, (), - , Berichtsjahr: 2022| ID: 11345 (35243537)
Originalpublikation

Baskal,S.; Tsikas,S. A.; Begou,O.; Bollenbach,A.; Lenzen,S.; Jörns,A.; Tsikas,D.;
Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-alpha Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes
Switzerland, Int.J.Mol.Sci., 2022, 23(3), 1541- , Berichtsjahr: 2022| ID: 11166 (35163462)
Originalpublikation

Baskal,Svetlana; Tsikas,Dimitrios;
Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nepsilon-Carboxymethyl-Lysine, Nepsilon-Carboxyethyl-Lysine and Nepsilon-Hydroxymethyl-Lysine.
,,Int J Mol Sci,2022;23(7):3446-10.3390/ijms23073446 Berichtsjahr:2022 | ID: RefID:25100-baskal2022free
Originalpublikation

Becker,E. ; Francino,A. ; Pich,A. ; Perrot,A. ; Kraft,T. ; Radocaj,A. ; ,
AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy
Switzerland, Front.Cardiovasc.Med., 2022, 9(), 816330- ,Berichtsjahr: 2022| ID: 11362 (35265683)
Originalpublikation

Bense,S. ; Witte,J. ; Preuße,M. ; Koska,M. ; Pezoldt,L. ; Dröge,A. ; Hartmann,O. ; Müsken,M. ; Schulze,J. ; Fiebig,T. ; Bähre,H. ; Felgner,S. ; Pich,A. ; Häussler,S. ;
Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels,
England,Mol.Microbiol.,2022;117(5):1213-1226, 10.1111/mmi.14902 Berichtsjahr:2022 | ID: RefID:25178-bense2022pseudomonas
Originalpublikation

Bollenbach,A. ; Baskal,S. ; Mels,C. ; Kruger,R. ; Tsikas,D. ;
Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine,
Switzerland,Molecules,2022;27(16):5202-10.3390/molecules27165202 Berichtsjahr:2022 | ID: RefID:25229-bollenbach2022unusual
Originalpublikation

Borgert,Sebastian Roman ; Henke,Steffi ; Witzgall,Florian ; Schmelz,Stefan ; Zur Lage,Susanne ; Hotop,Sven-Kevin ; Stephen,Steffi ; Lübken,Dennis ; Krüger,Jonas ; Gomez,Nicolas Oswaldo ; van Ham,Marco ; Jänsch,Lothar ; Kalesse,Markus ; Pich,Andreas ; Brönstrup,Mark ; Häussler,Susanne ; Blankenfeldt,Wulf ;
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa,
England,Nat.Commun.,2022;13(1):7402-10.1038/s41467-022-35030-w, Berichtsjahr:2022 | ID: RefID:25237-borgert2022moonlighting
Originalpublikation

Durisin,M. ; Krüger,C. ; Pich,A. ; Warnecke,A. ; Steffens,M. ; Zeilinger,C. ; Lenarz,T. ; Prenzler,N. ; Schmitt,H. ;
Proteomprofil von Patienten mit ausgezeichneter und schlechter Sprachverständlichkeit nach Cochlea-Implantation: Können Perilymphproteine die Leistung vorhersagen?,
United States,PLoS One,2022;17(3):-e0263765, 10.1371/journal.pone.0263765 Berichtsjahr:2022 | ID: RefID:25549-durisin2022proteome
Originalpublikation

Fan,C. ; Wu,Z. ; Cooper,D. M. L. ; Magnus,A. ; Harrison,K. ; Eames, B. F. ; Chibbar,R. ; Groot,G. ; Huang,J. ; Genth,H. ; Zhang,J. ; Tan,X. ; Deng,Y. ; Xiang,J. ;
Die Aktivierung der fokalen Adhäsionskinase stellt die simulierte Mikrogravitations-induzierte Hemmung der Osteoblastendifferenzierung über den Wnt/Beta-Catenin-Signalweg wieder her,
Schweiz,Int.J.Mol.Sci.,2022;23(10):5593-10.3390, /ijms23105593 Berichtsjahr:2022 | ID: RefID:25625-fan2022activation
Originalpublikation

Gall,E. ; Stieglitz,F. ; Pich,A. ; Behrens,G. M. N. ; Kuhn,J. ; Blasczyk,R. ; Haukamp,F. J. ; Bade-Döding,C. ;
Proteomic Profiling and T Cell Receptor Usage of Abacavir Susceptible Subjects,
Switzerland,,2022;10(3):693-10.3390, /biomedicines10030693 Berichtsjahr:2022 | ID: RefID:25735-gall2022proteomic
Originalpublikation

Hanusch,B. ; Sinningen,K. ; Brinkmann,F. ; Dillenhöfer,S. ; Frank,M. ; Jöckel,K. H. ; Koerner-Rettberg,C. ; Holtmann,M. ; Legenbauer,T. ; Langrock,C. ; Reinehr,T. ; Maasjosthusmann,P. ; Beckmann,B. ; Hamelmann,E. ; Tsikas,D. ; Lücke,T. ; 
Charakterisierung des L-Arginin/Stickstoffmonoxid-Signalwegs und des oxidativen Stresses bei pädiatrischen Patienten mit atopischen Erkrankungen,
Schweiz,Int.J.Mol.Sci.,2022;23(4):2136-10.3390, /ijms23042136 Berichtsjahr:2022 | ID: RefID:25936-hanusch2022Charakterisierung
Originalpublikation

Harre,Jennifer ; Heinkele,Laura ; Steffens,Melanie ; Warnecke,Athanasia ; Lenarz,Thomas ; Just, Ingo ; Rohrbeck,Astrid ;
Korrigendum: Potenzierung des aus dem Gehirn stammenden neurotrophen Faktor-induzierten Schutzes von Spiralganglienneuronen durch C3-Exoenzym/Rho-Inhibitor,
Schweiz,Front.Cell.Neurosci.,2022;16():1078962-10.3389
/fncel.2022.1078962 Berichtsjahr:2022 | ID: RefID:25948-harre2022 Korrigendum:
Korrigendum

Haukamp,F. J. ; Gall,E. ; Hò,G. T. ; Hiemisch,W. ; Stieglitz,F. ; Kuhn,J. ; Blasczyk,R. ; Pich,A. ; Bade-Döding,C. ;
Entschlüsselung der Proteomik von HLA-B*57:01(+) Antigen-präsentierenden Zellen während der Abacavir-Medikation,
Schweiz,J.Pers.Med.,2022;12(1):40-10.3390, /jpm12010040 Berichtsjahr:2022 | ID: RefID:25968-haukamp2022unravelling
Originalpublikation

Henkel,Daniel ;
Die Rezeptorinteraktion der Clostridioides difficile Toxine TcdA und TcdB,
Hannover,,2021;():-VII, 99 Seiten : Illustrationen, Diagramme, Berichtsjahr:2022 | ID: RefID:26012-henkel2021die
Dissertation

Maassen,H. ; Said,M. Y. ; Frenay,A. S. ; Koning,A. ; Post,A. ; Riphagen,I. J. ; Heiner-Fokkema,M. R. ; Drabert,K. ; Fernandez,B. O. ; Gans,R. O. B. ; van den Berg,E. ; Navis,G. ; Tsikas,D. ; Feelisch,M. ; Bakker,S. J. L. ; van Goor,H. ;
Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study,
United States,Nitric Oxide,2022;125-126():1-11 10.1016/j.niox.2022.05.005 Berichtsjahr:2022 | ID: 11666
Originalpublikation 

Malfeld,Kathrin ; Armbrecht,Nina ; Pich,Andreas ; Volk,Holger A. ; Lenarz,Thomas ; Scheper,Verena ;
Prävention von lärmbedingtem Hörverlust in vivo: Kontinuierliche Anwendung des insulinähnlichen Wachstumsfaktors 1 und seine Wirkung auf Innenohrsynapsen, Hörfunktion und Perilymphproteine,
Schweiz,Int.J.Mol.Sci.,2022;24(1):291-10.3390 /ijms24010291 Berichtsjahr:2022 | ID: RefID:23508-malfeld2022prevention
Originalpublikation

Mangan,Matthew S. J. ; Gorki,Friederike ; Krause,Karoline ; Heinz,Alexander ; Pankow,Anne ; Ebert,Thomas ; Jahn,Dieter ; Hiller,Karsten ; Hornung,Veit ; Maurer,Marcus ; Schmidt,Florian I. ; Gerhard,Ralf ; Latz,Eicke ;
Für die Aktivierung von Pyrin inflammasom in menschlichen Makrophagen ist eine Transkriptionslizenzierung erforderlich, die durch Mutationen umgangen wird, die das familiäre Mittelmeerfieber verursachen,
United States,PLoS Biol.,2022;20(11):-e3001351 10.1371/journal.pbio.3001351 Berichtsjahr:2022 | ID: RefID:23516-mangan2022transcriptional
Originalpublikation

Neumann-Schaal,M; Groß,U; Just,I; Jahn,D
The Deadly Secrets of C. difficile—Insights Into Host-Pathogen Interaction.
Front. Microbiol. 13:897612. doi: 10.3389/fmicb.2022.897612 (2022)
Editorial

Neumann-Schaal,Meina ; Groß,Uwe ; Just, Ingo ; Jahn,Dieter ;
The Deadly Secrets of C. difficile-Insights into Host-Pathogen Interaction, Volume II,
Switzerland,Front.Microbiol.,2022;13():896979-10.3389 /fmicb.2022.896979 Berichtsjahr:2022 | ID: RefID:23740-neumann-schaal2022editorial:
Editorial

Nowakowska,M. B. ; Selby,K. ; Przykopanski,A. ; Krüger,M. ; Krez,N. ; Dorner,B. G. ; Dorner,M. B. ; Jin,R. ; Minton, N. P. ; Rummel,A. ; Lindström,M. ;
Konstruktion und Validierung eines sicheren Clostridium botulinum Gruppe II Surrogatstamms, der inaktives Botulinum-Neurotoxin Typ E produziert, Toxoid,
England, Sci.Rep.,2022;12(1):1790-10.1038/s41598-022-05008-1 Berichtsjahr:2022 | ID: RefID:23775-nowakowska2022construction
Originalpublikation

Petersen,Lara ; Stroh,Svenja ; Schöttelndreier,Dennis ; Grassl,Guntram A. ; Rottner,Klemens ; Brakebusch,Cord ; Fahrer,Jörg ; Genth,Harald ;
Die wesentliche Rolle der Rac1-Glucosylierung bei der B-induzierten Verhaftung des G1-S-Übergangs durch Clostridioides difficile Toxin.,,
Front Microbiol,2022;13():846215-10.3389 /fmicb.2022.846215 Berichtsjahr:2022 | ID: RefID:23897-petersen2022essential
Originalpublikation

Piepgras,J. ; Rohrbeck,A. ; Just, Ingo ; Bittner,S. ; Ahnert-Hilger,G. ; Höltje,M. ;
Verstärkung der Phosphorylierungs- und Transportaktivität des neuronalen Glutamattransporters exzitatorischen Aminosäuretransporters 3 durch C3bot und ein 26mer-C3bot-Peptid,
Schweiz,Front.Cell.Neurosci.,2022;16():860823-10.3389 /fncel.2022.860823 Berichtsjahr:2022 | ID: RefID:23925-piepgras2022enhancement
Originalpublikation

Reboll,M. R. ; Klede,S. ; Taft,M. H. ; Cai,C. L. ; Feld,L. J. ; Lavine,K. J. ; Koenig,A. L. ; Fleischauer,J. ; Meyer,J. ; Schambach,A. ; Niessen,H. W. ; Kosanke,M. ; van den Heuvel,J. ; Pich,A. ; Bauersachs,J. ; Wu,X. ; Zheng,L. ; Wang,Y. ; Korf-Klingebiel,M. ; Pölten,F. ; Wollert,K. C. ;
Meteorin-like fördert die Herzreparatur durch endotheliale KIT-Rezeptor-Tyrosinkinase,
Vereinigte Staaten,Science,2022;376(6599):1343-1347 10.1126/science.abn3027 Berichtsjahr:2022 | ID: RefID:24037-reboll2022meteorin-like
Originalpublikation

Schweitzer,T. ; Genth,H. ; Pich,A. ;
Das Alpha-Toxin von Clostridium novyi verändert das Proteom und das Phosphoproteom von HEp-2-Zellen,
Schweiz,Int.J.Mol.Sci.,2022;23(17):9939-10.3390 /ijms23179939 Berichtsjahr:2022 | ID: RefID:24343-schweitzer2022clostridium
Originalpublikation

Stieglitz,F. ; Gerhard,R. ; Hönig,R. ; Giehl,K. ; Pich,A. ;
TcdB von Clostridioides difficile vermittelt RAS-abhängige Nekrose in Epithelzellen,
Schweiz,Int.J.Mol.Sci.,2022;23(8):4258-10.3390 /ijms23084258 Berichtsjahr:2022 | ID: RefID:24479-stieglitz2022tcdb
Originalpublikation

Stieglitz,Florian ;
LC-MS-basierte Charakterisierung von Effekten auf Signalmoleküle, die durch Clostridioides difficile-Toxine induziert werden,
Hannover,,2022;():iv, 90 Blätter, Blatt v-viii : Illustrationen, Diagramme, Berichtsjahr:2022 | ID: RefID:24480-stieglitz2022lc-ms-basiert
Dissertation

Tian,Songhai ; Xiong,Xiaozhe ; Zeng,Ji ; Wang,Siyu ; Tremblay,Benjamin Jean-Marie ; Chen,Peng ; Chen,Baohua ; Liu,Min ; Chen,Pengsheng ; Sheng,Kuanwei ; Zeve,Daniel ; Qi,Wanshu ; Breault,David T. ; Rodríguez,César ; Gerhard,Ralf ; Jin,Rongsheng ; Doxey,Andrew C. ; Dong,Min ;
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants,
England,Nat.Commun.,2022;13(1):6786-10.1038/s41467-022-33964-9 Berichtsjahr:2022 | ID: RefID:24582-tian2022identification
Originalpublikation

Tsikas,D. ; Redfors,B. ;
Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy,
Switzerland,Int.J.Mol.Sci.,2022;23(9):4734-10.3390/ijms23094734 Berichtsjahr:2022 | ID: RefID:24608-tsikas2022pilot
Originalpublikation

Tsikas,Dimitrios ;
Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids,
Austria,Amino Acids,2022;():- 10.1007/s00726-022-03218-5, Berichtsjahr:2022 | ID: RefID:24610-tsikas2022determination
Originalpublikation

Tsikas,Dimitrios ;
Homoarginine in health and disease,
England,Curr.Opin.Clin.Nutr.Metab.Care,2023;26(1):42-49, 10.1097/MCO.0000000000000889 Berichtsjahr:2022 | ID: RefID:24609-tsikas2023homoarginine
Übersicht

Tsikas,Dimitrios ; Editorial.,,
Amino Acids,2022;54():481-484 10.1007/s00726-022-03164-2  Berichtsjahr:2022 | ID: 11513
Editorial

Tsikas,Dimitrios ; Mikuteit,Marie ;
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
,,Amino Acids,2022;54(9):1251-1260, 10.1007/s00726-022-03185-x
Übersicht

van Dieken,A. ; Staecker,H. ; Schmitt,H. ; Harre,J. ; Pich,A. ; Roßberg,W. ; Lenarz,T. ; Durisin,M. ; Warnecke,A. ;
Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas,
Switzerland,Front.Cell.Dev.Biol.,2022;10():847157-10.3389/fcell.2022.847157 Berichtsjahr:2022 | ID: RefID:24649-van2022bioinformatic
Originalpublikation

von Hanstein,Anna-Sophie ; Tsikas,Dimitrios ; Lenzen,Sigurd ; Jörns,Anne ; Plötz,Thomas ;
Potentiation of Lipotoxicity in Human EndoC-betaH1 Beta-cells by Glucose is Dependent on the Structure of Free Fatty Acids,
Germany,Mol.Nutr.Food Res.,2023;():-e2200582, 10.1002/mnfr.202200582 Berichtsjahr:2022 | ID: RefID:24703-von2023potentiation
Originalpublikation

Wessig,A. K. ; Hoffmeister,L. ; Klingberg,A. ; Alberts,A. ; Pich,A. ; Brand,K. ; Witte,T. ; Neumann,K. ;
Natural antibodies and CRP drive anaphylatoxin production by urate crystals,
England,Sci.Rep.,2022;12(1):4483-10.1038/s41598-022-08311-z Berichtsjahr:2022 | ID: RefID:24815-wessig2022natural
Originalpublikation

Baskal,S. ; Bollenbach,A. ; Mels,C. ; Kruger,R. ; Tsikas,D.
Development, validation of a GC-MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine,
Austria,Amino Acids,2021;():-
Originalpublikation

Baskal,S. ; Bollenbach,A. ; Tsikas,D.
Two-Step Derivatization of Amino Acids for Stable-Isotope Dilution GC-MS Analysis: Long-Term Stability of Methyl Ester-Pentafluoropropionic Derivatives in Toluene Extracts
Switzerland,Molecules,2021;26(6):1726-
Originalpublikation

Baskal,S. ; Bollenbach,A. ; Tsikas,D.
GC-MS Discrimination of Citrulline from Ornithine and Homocitrulline from Lysine by Chemical Derivatization: Evidence of Formation of N(5)-Carboxy-ornithine and N(6)-Carboxy-lysine
Switzerland,Molecules,2021;26(8):2301-
Originalpublikation

Baskal,S. ; Büttner,P. ; Werner,S. ; Besler,C. ; Lurz,P. ; Thiele,H. ; Tsikas,D.
Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats,
Austria, Amino Acids,2021;():-
Originalpublikation

Baskal,S. ; Post,A. ; Kremer,D. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D.
Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality,
Austria,Amino Acids,2021;():-
Originalpublikation

Begou,O. ; Pavlaki,A. ; Deda,O. ; Bollenbach,A. ; Drabert,K. ; Gika,H. ; Farmaki,E. ; Dotis,J. ; Printza,N. ; Theodoridis,G. ; Tsikas,D.
Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery,
Switzerland, J.Clin.Med.,2021;10(7):1467-
Originalpublikation

Begou,O. ; Weber,K. ; Beckmann,B. ; Tsikas,D.
GC-MS Studies on Derivatization of Creatinine and Creatine by BSTFA and Their Measurement in Human Urine,
Switzerland, Molecules,2021;26(11):3206 [pii]-
Originalpublikation

Bousnaki,M. ; Bakopoulou,A. ; Pich,A. ; Papachristou,E. ; Kritis,A. ; Koidis,P.
Mapping the Secretome of Dental Pulp Stem Cells Under Variable Microenvironmental Conditions
United States,Stem Cell.Rev.Rep.,2021;():-
Originalpublikation

Büttner,P. ; Werner,S. ; Baskal,S. ; Tsikas,D. ; Adams,V. ; Lurz,P. ; Besler,C. ; Knauth,S. ; Bahls,M. ; Schwedhelm,E. ; Thiele,H.
Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction,
England,Sci.Rep.,2021;11(1):20684-
Originalpublikation

Chen,P. ; Zeng,J. ; Liu,Z. ; Thaker,H. ; Wang,S. ; Tian,S. ; Zhang,J. ; Tao,L. ; Gutierrez,C. B. ; Xing,L. ; Gerhard,R. ; Huang,L. ; Dong,M. ; Jin,R.
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection,
England,Nat.Commun.,2021;12(1):3748-
Originalpublikation

Fischer, V., Just, I. (2021)
An integrated formula for determining the admission capacity in medical studies in reference to patients.
Beiträge zur Hochschulforschung, 43(4), 52-65.
Originalpublikation

Harre,J. ; Heinkele,L. ; Steffens,M. ; Warnecke,A. ; Lenarz,T. ; Just,I. ; Rohrbeck,A.
Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor
Switzerland,Front.Cell.Neurosci.,2021;15():602897-
Originalpublikation

Kendre,G. ; Marhenke,S. ; Lorz,G. ; Becker,D. ; Reineke-Plaass,T. ; Poth,T. ; Murugesan,K. ; Kühnel,F. ; Woller,N. ; Wirtz,R. M. ; Pich,A. ; Marquardt,J. U. ; Saborowski,M. ; Vogel,A. ; Saborowski,A.
The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma,
United States,Hepatology,2021;74(3):1357-1370
Originalpublikation

Klepka,C. ; Sandmann,M. ; Tatge,H. ; Mangan,M. ; Arens,A. ; Henkel,D. ; Gerhard,R.
Impairment of lysosomal function by Clostridioides difficile TcdB
England,Mol.Microbiol.,2021;():-
Originalpublikation

Korf-Klingebiel,M. ; Reboll,M. R. ; Polten,F. ; Weber,N. ; Jäckle,F. ; Wu,X. ; Kallikourdis,M. ; Kunderfranco,P. ; Condorelli,G. ; Giannitsis,E. ; Kustikova,O. S. ; Schambach,A. ; Pich,A. ; Widder,J. D. ; Bauersachs,J. ; van den Heuvel,J. ; Kraft,T. ; Wang,Y. ; Wollert,K. C.
Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Expression in Cardiomyocytes,
United States,Circulation,2021;144(15):1227-1240
Originalpublikation

Kukoc-Modun,L. ; Kraljević,T. ; Tsikas,D. ; Radić,N. ; Modun,D.
Determination of N-Acetyl-l-cysteine Ethyl Ester (NACET) by Flow Injection Analysis and Spectrophotometric Detection Using Different Thiol-Sensitive Ligands
Switzerland,Molecules,2021;26(22):6826-
Originalpublikation

Marquardt,I. ; Jakob,J. ; Scheibel,J. ; Hofmann,J. D. ; Klawonn,F. ; Neumann-Schaal,M. ; Gerhard,R. ; Bruder,D. ; Jänsch,L.
Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells,
Switzerland,Front.Microbiol.,2021;12():752549-
Originalpublikation

Mhlekude,B. ; Lenman,A. ; Sidoyi,P. ; Joseph,J. ; Kruppa,J. ; Businge,C. B. ; Mdaka,M. L. ; Konietschke,F. ; Pich,A. ; Gerold,G. ; Goffinet,C. ; Mall,A. S.
The barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission,
England,AIDS,2021;35(3):2105-2117
Originalpublikation

Neumann,T. ; Krüger,M. ; Weisemann,J. ; Mahrhold,S. ; Stern,D. ; Dorner,M. B. ; Feraudet-Tarisse,C. ; Pöhlmann,C. ; Schulz,K. ; Messelhäusser,U. ; Rimek,D. ; Gessler,F. ; Elßner,T. ; Simon,S. ; Rummel,A. ; Dorner,B. G.
Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies,
Switzerland,Toxins (Basel),2021;13(4):266-
Originalpublikation

Nickel,K. ; Wensorra,U. ; Wenck,H. ; Peters,N. ; Genth,H. 
Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors,
Switzerland,Cells,2021;10(11):2931-
Originalpublikation

Ostermann,L. ; Maus,R. ; Stolper,J. ; Schütte,L. ; Katsarou,K. ; Tumpara,S. ; Pich,A. ; Mueller,C. ; Janciauskiene,S. ; Welte,T. ; Maus,U. A.
Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice,
United States,JCI Insight,2021;6(3):-
Originalpublikation

Post,A. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D. ;
Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients,
Austria, Amino Acids,2021;53(4):541-554
Originalpublikation

Schenke,M. ; Prause,H. C. ; Bergforth,W. ; Przykopanski,A. ; Rummel,A. ; Klawonn,F. ; Seeger,B.
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1,
Switzerland,Toxins (Basel),2021;13(8):585-
Originalpublikation

Schmitt,H. A. ; Pich,A. ; Prenzler,N. K. ; Lenarz,T. ; Harre,J. ; Staecker,H. ; Durisin,M. ; Warnecke,A. 
Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry,
United States,ACS Omega,2021;6(33):21241-21254
Originalpublikation

Stieglitz,F. ; Gerhard,R. ; Pich,A. ;
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells,
Switzerland,Front.Microbiol.,2021;12():725612-
Originalpublikation

Stojanovic,S. D. ; Fuchs,M. ; Liang,C. ; Schmidt,K. ; Xiao,K. ; Just,A. ; Pfanne,A. ; Pich,A. ; Warnecke,G. ; Braubach,P. ; Petzold,C. ; Jonigk,D. ; Distler,J. H. W. ; Fiedler,J. ; Thum,T. ; Kunz,M.
Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics,
England,Sci.Rep.,2021;11(1):12456-
Originalpublikation

Tsikas,D.
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology-part I
Austria, Amino Acids,2021;53(4):485-487
Editorial

Tsikas,D. ;
Comment on the article Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase,
England,IUCrJ,2021;8(Pt 2):327-328
Comment

Tsikas,D. ;
Extra-platelet low-molecular-mass thiols mediate the inhibitory action of S-nitrosoalbumin on human platelet aggregation via S-transnitrosylation of the platelet surface,
Austria, Amino Acids,2021;53(4):563-573
Originalpublikation 

Tsikas,D. ;
GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization,
Switzerland,Molecules,2021;26(22):7003-
Originalpublikation

Tsikas,D. ;
Homocysteine and copper ions: is their interaction responsible for cardiovascular-related damage?
Austria, Amino Acids,2021;53(8):1297-1298
Letter

Tsikas,D. ; Gambaryan,S. ;
Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets
England,J.Enzyme Inhib.Med.Chem.,2021;36(1):525-534
Originalpublikation

Ückert,S. ; Richter,K. ; Fischer,K. D. ; Tsikas,D. ; Kuczyk,M. A.
Re-evaluation of the immunohistochemical distribution of isoforms of nitric oxide synthase in the human prostate: A light and electron microscopical study
Germany,Andrologia,2021;53(7):e14098-
Originalpublikation

Walter,L. M. ; Rademacher,S. ; Pich,A. ; Claus,P. 
Profilin2 regulates actin rod assembly in neuronal cells,
England,Sci.Rep.,2021;11(1):10287-
Originalpublikation

Wang,Y. ; Polten,F. ; Jäckle,F. ; Korf-Klingebiel,M. ; Kempf,T. ; Bauersachs,J. ; Freitag-Wolf,S. ; Lichtinghagen,R. ; Pich,A. ; Wollert,K. C.
A mouse model of cardiogenic shock,
England,Cardiovasc.Res.,2021;117(12):2414-2415
Letter

Ahmadpour,Jamshid
Untersuchung zur Antikörperbildung gegen Botulinum Neurotoxin A im Rahmen der Therapie von Bewegungsstörungen
Hannover,,2018;():4 ungezählte Seiten, 76 Seiten : Illustrationen, -
Dissertation

Schneider,Carmen
Intrazelluläre Aktivität der pathogenen Domäne großer clostridialer Glucosyltransferasen
Hannover,,2021;():VII, 135 Blätter : Illustrationen, Diagramme-
Dissertation

Weber,Kathrin
GC-MS-basierte Untersuchungen zur Bedeutung der renalen Carboanhydrasen für die Rückresorption von Nitrit und den oxidativen Stress am Menschen
Hannover,,2020;():5 ungezählte Blätter, VI Blätter, 102 Blätter -
Dissertation

Hussein,Nali
C3-vermittelte Effekte bei Psoriasis am Phenion 3D-Vollhautmodell,
Hannover,,;():78 Seiten-
Masterarbeit

Langejürgen,Anna
Die Rolle der Makropinozytose in der zellulären Aufnahme von C. difficile Toxin
Hannover,,;():74 Seiten-
Masterarbeit

von der Kammer,Urs
Darstellung der Interaktion der Botulinum Neurotoxine Serotyp A und E mit ihren Proteinrezeptoren Synaptisches Vesikelglykoprotein C und A,
Hannover,,;():106 Seiten-
Masterarbeit

Adolf,A. ; Turko,P. ; Rohrbeck,A. ; Just,I. ; Vida,I. ; Ahnert-Hilger,G. ; Höltje,M.
The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin
Switzerland,Front.Cell.Neurosci.,2020;14():596072-
Originalpublikation

Alberts,A. ; Klingberg,A. ; Hoffmeister,L. ; Wessig,A. K. ; Brand,K. ; Pich,A. ; Neumann,K.
Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures
Switzerland,Front.Immunol.,2020;11():596103-
Originalpublikation

Alberts,A. ; Klingberg,A. ; Wessig,A. K. ; Combes,C. ; Witte,T. ; Brand,K. ; Pich,A. ; Neumann,K.
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1
England,Sci.Rep.,2020;10(1):6391-
Originalpublikation

Becker,T. ; Pich,A. ; Tamm,S. ; Hedtfeld,S. ; Ibrahim,M. ; Altmüller,J. ; Dalibor,N. ; Toliat,M. R. ; Janciauskiene,S. ; Tümmler,B. ; Stanke,F.
Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B
England,Sci.Rep.,2020;10(1):22447-
Originalpublikation

Begou,O. ; Drabert,K. ; Theodoridis,G. ; Tsikas,D.
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
China,J.Pharm.Anal.,2020;10(1):49-59
Originalpublikation

Bollenbach,A. ; Gambaryan,S. ; Mindukshev,I. ; Pich,A. ; Tsikas,D.
GC-MS and LC-MS/MS pilot studies on the guanidine (N(G))-dimethylation in native, asymmetrically and symmetrically N(G)-dimethylated arginine-vasopressin peptides and proteins in human red blood cells
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2020;1141():122024-
Originalpublikation

Bollenbach,A. ; Schutte,A. E. ; Kruger,R. ; Tsikas,D.
An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies Switzerland,J.Clin.Med.,2020;9(3):844.-
Originalpublikation

Bollenbach,A. ; Tsikas,D.
Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry
United States,Anal.Biochem.,2020;():-
Originalpublikation

Brinkmann,F. ; Hanusch,B. ; Ballmann,M. ; Mayorandan,S. ; Bollenbach,A. ; Chobanyan-Jürgens,K. ; Jansen,K. ; Schmidt-Choudhury,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T.
Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results
Switzerland,J.Clin.Med.,2020;9(6):E2012 [pii]-
Originalpublikation

Craig,A. ; M C Mels,C. ; Tsikas,D. ; Boeger,R. H. ; Schwedhelm,E. ; Schutte,A. E. ; Kruger,R.
Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study
England,J.Hum.Hypertens.,2021;35(11):985-993
Originalpublikation

Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Bollenbach,A. ; Tsikas,D. ; Schwedhelm,E. ; Kruger,R. ;
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
England,Hypertens.Res.,2021;44(1):71-79
Originalpublikation

Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Tsikas,D. ; Kruger,R. ;
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
Austria,Amino Acids,2020;52(4):639-648
Originalpublikation

Cseko,K. ; Pecsi,D. ; Kajtar,B. ; Hegedus,I. ; Bollenbach,A. ; Tsikas,D. ; Szabo,I. L. ; Szabo,S. ; Helyes,Z.
Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target
Switzerland,Int.J.Mol.Sci.,2020;21(16):E5591 [pii]-
Originalpublikation

Deppe,J. ; Weisemann,J. ; Mahrhold,S. ; Rummel,A.
The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity
Switzerland,Toxins (Basel),2020;12(12):-
Originalpublikation

Hanusch,B. ; Brinkmann,F. ; Mayorandan,S. ; Chobanyan-Jürgens,K. ; Wiemers,A. ; Jansen,K. ; Ballmann,M. ; Schmidt-Choudhury,A. ; Bollenbach,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T.
Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment Switzerland,J.Clin.Med.,2020;9(12)::E3802-
Originalpublikation

Henkel,D. ; Tatge,H. ; Schöttelndreier,D. ; Tao,L. ; Dong,M. ; Gerhard,R.
Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
Switzerland,Toxins (Basel),2020;12(12):-
Originalpublikation

Hensel,N. ; Raker,V. ; Förthmann,B. ; Buch,A. ; Sodeik,B. ; Pich,A. ; Claus,P.
The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus
Switzerland,Front.Neurol.,2020;11():844-
Originalpublikation

Herkt,M. ; Foinquinos,A. ; Batkai,S. ; Thum,T. ; Pich,A.
Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry
Switzerland,Front.Pharmacol.,2020;11():220-
Originalpublikation

Ho,G. T. ; Hiemisch,W. ; Pich,A. ; Behrens,G. M. N. ; Blasczyk,R. ; Bade-Doeding,C.
The Loss of HLA-F/KIR3DS1 Ligation Is Mediated by Hemoglobin Peptides
Switzerland,Int.J.Mol.Sci.,2020;21(21):8012-
Originalpublikation

Hobuss,L. ; Foinquinos,A. ; Jung,M. ; Kenneweg,F. ; Xiao,K. ; Wang,Y. ; Zimmer,K. ; Remke,J. ; Just,A. ; Nowak,J. ; Schmidt,A. ; Pich,A. ; Mazlan,S. ; Reamon-Buettner,S. M. ; Ramos,G. C. ; Frantz,S. ; Viereck,J. ; Loyer,X. ; Boulanger,C. ; Wollert,K. C. ; Fiedler,J. ; Thum,T.
Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19 England,J.Mol.Cell.Cardiol.,2020;146():43-59
Originalpublikation

Hollwedel,F. D. ; Maus,R. ; Stolper,J. ; Khan,A. ; Stocker,B. L. ; Timmer,M. S. M. ; Lu,X. ; Pich,A. ; Welte,T. ; Yamasaki,S. ; Maus,U. A.
Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice
United States,J.Immunol.,2020;205(12):3390-3399
Originalpublikation

Jansen,K. ; Hanusch,B. ; Pross,S. ; Hanff,E. ; Drabert,K. ; Bollenbach,A. ; Dugave,I. ; Carmann,C. ; Siefen,R. G. ; Emons,B. ; Juckel,G. ; Legenbauer,T. ; Tsikas,D. ; Lücke,T.
Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate
Switzerland,J.Clin.Med.,2020;9(1):pii: E175-
Originalpublikation

Jansing,J. C. ; Fiedler,J. ; Pich,A. ; Viereck,J. ; Thum,T. ; Mühlfeld,C. ; Brandenberger,C.
miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury
Switzerland,Int.J.Mol.Sci.,2020;21(3):E822-
Originalpublikation

Kedia,G. T. ; Ückert,S. ; Tsikas,D. ; Becker,A. J. ; Kuczyk,M. A. ; Bannowsky,A.
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts
Switzerland,J.Clin.Med.,2020;9(9):E2987-
Übersicht

Kropp,K. A. ; Srivaratharajan,S. ; Ritter,B. ; Yu,P. ; Krooss,S. ; Polten,F. ; Pich,A. ; Alcami,A. ; Viejo-Borbolla,A.
Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2
Switzerland,Viruses,2020;12(12):E1428 [pii]-
Originalpublikation

Melzer,C. ; Jacobs,R. ; Dittmar,T. ; Pich,A. ; von der Ohe,J. ; Yang,Y. ; Hass,R.
Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line
Switzerland,Int.J.Mol.Sci.,2020;21(13):E4752.-
Originalpublikation

Neu,A. ; Hornig,S. ; Sasani,A. ; Isbrandt,D. ; Gerloff,C. ; Tsikas,D. ; Schwedhelm,E. ; Choe,C. U.
Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
Austria,Amino Acids,2020;52(6-7):1067-1069
Letter

Schöttelndreier,D. ; Langejürgen,A. ; Lindner,R. ; Genth,H.
Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor Switzerland,Front.Cell.Infect.Microbiol.,2020;10():565465-
Originalpublikation

Stojanovic,S. D. ; Fuchs,M. ; Fiedler,J. ; Xiao,K. ; Meinecke,A. ; Just,A. ; Pich,A. ; Thum,T. ; Kunz,M.
Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts
Switzerland,Int.J.Mol.Sci.,2020;21(11):-
Originalpublikation

Stojanovic,S. D. ; Fuchs,M. ; Kunz,M. ; Xiao,K. ; Just,A. ; Pich,A. ; Bauersachs,J. ; Fiedler,J. ; Sedding,D. ; Thum,T.
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells
Switzerland,Front.Physiol.,2020;11():520-
Originalpublikation

Tian,S. ; Liu,Y. ; Wu,H. ; Liu,H. ; Zeng,J. ; Choi,M. Y. ; Chen,H. ; Gerhard,R. ; Dong,M.
Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL
United States,Cell.Host Microbe,2020;27(5):782-792.e7
Originalpublikation

Tsikas,D.
GC-MS approach revealing hidden nitrite reactions in hemolysate using (18)O-labelled nitrite and cysteine-based thiols
United States,Anal.Biochem.,2020;():114025-
Originalpublikation

Tsikas,D.
Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol
United States,Anal.Biochem.,2020;():113994-
Originalpublikation

Tsikas,D.
Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond
Switzerland,J.Clin.Med.,2020;9(6):-
Übersicht

Tsikas,D. ; Surdacki,A.
Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. Jakoby
United States,Anal.Biochem.,2020;():113993-
Übersicht

Yepes-Calderon,M. ; Sotomayor,C. G. ; Gans,R. O. B. ; Berger,S. P. ; Leuvenink,H. G. D. ; Tsikas,D. ; Rodrigo,R. ; Navis,G. J. ; Bakker,S. J. L.
Post-transplantation plasma malondialdehyde is associated with cardiovascular mortality in renal transplant recipients: a prospective cohort study
England,Nephrol.Dial.Transplant.,2020;35(3):512-519
Originalpublikation

Schöttelndreier,Dennis
Expression und zelluläre Internalisierung der Rezeptoren von Clostridium difficile Toxin A und Toxin B
Hannover,,2020;():VI, 75 Blätter : Illustrationen, Diagramme-
Dissertation

Kriedemann,Nils
LC-MS based proteomic analysis of human endomyocardial heart biopsies of heart failure patients
Hannover,,2020;():-
Masterarbeit

Scheele,Marven
Integration des SpyCatcher-SpyTag Systems in Clostridioides difficile Toxin B
Hannover,,2020;():68 Seiten-
Masterarbeit

Bogutzki,A., Naue,N., Litz,L., Pich,A., Curth,U.
E. coli primase and DNA polymerase III holoenzyme are able to bind concurrently to a primed template during DNA replication.
Sci.Rep.2019;9(1):14460-
http://dx.doi.org/10.1038/s41598-019-51031-0
Originalpublikation 

 

Bollenbach,A., Bakker,S. J. L., Tsikas,D.
GC-MS measurement of biological N(G)-hydroxy-L-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor
Amino Acids,2019;51(4):627-64
http://dx.doi.org/10.1007/s00726-018-02695-x
Originalpublikation 

 

Bollenbach,A., Cordts,K., Hanff,E., Atzler,D., Choe,C. U., Schwedhelm,E., Tsikas,D.
Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans 
Anal.Biochem.,2019;577():59-66
http://dx.doi.org/10.1016/j.ab.2019.04.019
Originalpublikation

 

Bollenbach,A., Hanff,E., Brunner,G., Tsikas,D.
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection
Amino Acids,2019;51(6):961-971
http://dx.doi.org/10.1007/s00726-019-02737-y
Originalpublikation

 

Bollenbach,A., Huneau,J. F., Mariotti,F., Tsikas,D.
Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men
Nutrients,2019;11(7):E1463-
http://dx.doi.org/10.3390/nu11071463
Originalpublikation

 

Bollenbach,A., Tsikas,D., Lenzen,S., Jörns,A.
Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-alpha antibody-based therapy
Amino Acids,2020;52(1):103-110
http://dx.doi.org/10.1007/s00726-019-02811-5
Originalpublikation

 

Erdmann,J., Thöming,J. G., Pohl,S., Pich,A., Lenz,C., Häussler,S.
The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates
Cells,2019;8(10):E1129 [pii]-
http://dx.doi.org/10.3390/cells8101129
Originalpublikation

 

Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M., Trogisch,F. A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M., Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A., Remedios,C. D., Riechert,E., Völkers,M., Doroudgar,S., Jungmann,A., Bauer,R., Yin,X., Mayr,M., Wollert,K. C., Pich,A., Xiao,H., Katus,H. A., Bauersachs,J., Müller,O. J., Heineke,J.
TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
EMBO Mol.Med.,2019;11(10):e10018-
http://dx.doi.org/10.15252/emmm.201810018
Originalpublikation

 

Hanff,E., Bollenbach,A., Beckmann,B., Brunner,G., Tsikas,D.
GC-MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine
Amino Acids,2020;52(2):225-234
http://dx.doi.org/10.1007/s00726-019-02786-3
Originalpublikation

 

Hanff,E., Ruben,S., Kreuzer,M., Bollenbach,A., Kayacelebi,A. A., Das,A. M., von Versen-Höynck,F., von Kaisenberg,C., Haffner,D., Ückert,S., Tsikas,D.
Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity
Amino Acids,2019;51(3):529-547
http://dx.doi.org/10.1007/s00726-018-02688-w
Originalpublikation 

 

Hanff,E., Said,M. Y., Kayacelebi,A. A., Post,A., Minovic,I., van den Berg,E., de Borst,M. H., van Goor,H., Bakker,S. J. L., Tsikas,D.
High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients
Amino Acids,2019;51(10-12):1485-1499
http://dx.doi.org/10.1007/s00726-019-02783-6
Originalpublikation

 

Ho,G. T., Heinen,F. J., Blasczyk,R., Pich,A., Bade-Doeding,C.
HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint
Int.J.Mol.Sci.,2019;20(22):E5572.-
http://dx.doi.org/10.3390/ijms20225572
Originalpublikation 

 

Kluge,A., Rangrez,A. Y., Kilian,L. S., Pott,J., Bernt,A., Frauen,R., Rohrbeck,A., Frey,N., Frank,D.
Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy
J.Mol.Cell.Cardiol.,2019;129():130-143
http://dx.doi.org/10.1016/j.yjmcc.2019.01.028
Originalpublikation 

 

Kutschenko,A., Weisemann,J., Kollewe,K., Fiedler,T., Alvermann,S., Böselt,S., Escher,C., Garde,N., Gingele,S., Kaehler,S. B., Karatschai,R., Krüger,T. H. C., Sikorra,S., Tacik,P., Wegner,F., Wollmann,J., Bigalke,H., Wohlfarth,K., Rummel,A.
Botulinum neurotoxin serotype D - A potential treatment alternative for BoNT/A and B non-responding patients
Clin.Neurophysiol.,2019;130(6):1066-1073
http://dx.doi.org/10.1016/j.clinph.2019.02.007
Originalpublikation

 

Nebl,J., Drabert,K., Haufe,S., Wasserfurth,P., Eigendorf,J., Tegtbur,U., Hahn,A., Tsikas,D.
Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns
Nutrients,2019;11(8):E1875-
http://dx.doi.org/10.3390/nu11081875
Originalpublikation

 

Pich,A., Junemann,J., Stieglitz,F., Schweitzer,T.
Clostridioides difficile-Toxine verändern das Proteom von Darmzellen
BIOspektrum,2019;25(6):633-636
http://dx.doi.org/10.1007/s12268-019-0213-0
Originalpublikation

 

Post,A., Said,M. Y., Gomes-Neto,A. W., van der Krogt,J., de Blaauw,P., Berger,S. P., Geleijnse,J. M., Borgonjen,K., van den Berg,E., van Goor,H., Rimbach,G., Kema,I. P., Tsikas,D., Heiner-Fokkema,M. R., Bakker,S. J. L.
Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients
Nutrients,2019;11(9):E2212-
http://dx.doi.org/10.3390/nu11092212
Originalpublikation

 

Post,A., Tsikas,D., Bakker,S. J. L.
Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review
Nutrients,2019;11(5):E1044-
http://dx.doi.org/10.3390/nu11051044
Übersicht

 

Rahardjo,H. E., Ückert,S., Tsikas,D., Hedlund,P., Bannowsky,A., Kuczyk,M. A., Kedia,G. T.
Arginase enzymes in the human prostate: A molecular biological and immunohistochemical approach
Andrologia,2019;51(9):e13349-
http://dx.doi.org/10.1111/and.13349
Originalpublikation

 

Said,M. Y., Bollenbach,A., Minovic,I., van Londen,M., Frenay,A. R., de Borst,M. H., van den Berg,E., Kayacelebi,A. A., Tsikas,D., van Goor,H., Navis,G., Bakker,S. J. L.
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients
Amino Acids,2019;51(6):913-927
http://dx.doi.org/10.1007/s00726-019-02725-2
Originalpublikation

 

Said,M. Y., Douwes,R. M., van Londen,M., Minovic,I., Frenay,A. R., de Borst,M. H., van den Berg,E., Heiner-Fokkema,M. R., Kayacelebi,A. A., Bollenbach,A., van Goor,H., Navis,G., Tsikas,D., Bakker,S. J. L.
Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants
Amino Acids,2019;51(3):565-575
http://dx.doi.org/10.1007/s00726-018-02693-z
Originalpublikation 

 

Sasani,A., Hornig,S., Grzybowski,R., Cordts,K., Hanff,E., Tsikas,D., Böger,R., Gerloff,C., Isbrandt,D., Neu,A., Schwedhelm,E., Choe,C. U.
Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure
Amino Acids,2020;52(1):73-85
http://dx.doi.org/10.1007/s00726-019-02812-4
Originalpublikation

 

Schoenherr,C., Wohlan,K., Dallmann,I., Pich,A., Hegermann,J., Ganser,A., Hilfiker-Kleiner,D., Heidenreich,O., Scherr,M., Eder,M.
Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
PLoS One,2019;14(12):e0225977-
http://dx.doi.org/10.1371/journal.pone.0225977
Originalpublikation 

 

Simper,G. S., Gräser,L. S., Celik,A. A., Kuhn,J., Kunze-Schumacher,H., Ho,G. T., Blasczyk,R., Pich,A., Bade-Doeding,C.
The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
Pharmaceutics,2019;11(10):pii: E536-
http://dx.doi.org/10.3390/pharmaceutics11100536
Originalpublikation

 

Sonnenschein,K., Fiedler,J., Pfanne,A., Just,A., Mitzka,S., Geffers,R., Pich,A., Bauersachs,J., Thum,T.
Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury Cardiovasc.Res.,2019;115(12):1804-1810
http://dx.doi.org/10.1093/cvr/cvz063
Originalpublikation 

 

Tao,L., Tian,S., Zhang,J., Liu,Z., Robinson-McCarthy,L., Miyashita,S. I., Breault,D. T., Gerhard,R., Oottamasathien,S., Whelan,S. P. J., Dong,M.
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Nat.Microbiol.,2019;4(10):1760-1769
http://dx.doi.org/10.1038/s41564-019-0464-z
Originalpublikation 

 

Tsikas,D., Bollenbach,A., Hanff,E., Beckmann,B., Redfors,B.
Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat
Amino Acids,2020;52(2):235-245
http://dx.doi.org/10.1007/s00726-019-02808-0
Originalpublikation

 

Ückert,S., Kedia,G. T., Tsikas,D., Simon,A., Bannowsky,A., Kuczyk,M. A.
Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate,Germany,World J.Urol.,2020;38(6):1423-1435
http://dx.doi.org/10.1007/s00345-019-02933-1
Übersicht

 

von Berg,L., Stern,D., Pauly,D., Mahrhold,S., Weisemann,J., Jentsch,L., Hansbauer,E. M., Müller,C., Avondet,M. A., Rummel,A., Dorner,M. B., Dorner,B. G.
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
Sci.Rep.,2019;9(1):5531-
http://dx.doi.org/10.1038/s41598-019-41722-z
Originalpublikation 

 

von Berg,L., Stern,D., Weisemann,J., Rummel,A., Dorner,M. B., Dorner,B. G.
Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments
Toxins (Basel),2019;11(10):E588-
http://dx.doi.org/10.3390/toxins11100588
Originalpublikation 

 

Welz,B., Bikker,R., Junemann,J., Christmann,M., Neumann,K., Weber,M., Hoffmeister,L., Preuss,K., Pich,A., Huber,R., Brand,K.
Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes
Int.J.Mol.Sci.,2019;20(5):E1241-
http://dx.doi.org/10.3390/ijms20051241
Originalpublikation

 

Wieczorek-Surdacka,E., Hanff,E., Chyrchel,B., Kuzniewski,M., Surdacki,A., Tsikas,D.
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease
Amino Acids,2019;51(6):977-982
http://dx.doi.org/10.1007/s00726-019-02738-x
Originalpublikation

 

Zeleny,R., Rummel,A., Jansson,D., Dorner,B. G.
Challenges in the Development of Reference Materials for Protein Toxins. In: Applications in Forensic Proteomics: Protein Identification and Profiling 2019; 1339: 185-202 
http://dx.doi.org/doi:10.1021/bk-2019-1339.ch012
Buchbeitrag, Monografie

Abere,B., Samarina,N., Gramolelli,S., Rückert,J., Gerold,G., Pich,A.,Schulz,T. F.
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2alpha To Activate Productive Viral Replication
J.Virol. 2018; 92(17):e00544-18-
Originalpublikation
http://dx.doi.org/10.1128/JVI.00544-18

 

Adolf,A., Rohrbeck,A., Münster-Wandowski,A., Johansson,M., Kuhn,H. G., Kopp,M. A., Brommer,B., Schwab,J. M., Just,I., Ahnert-Hilger,G., Höltje,M.,
Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons.
Glia 2019; 67(4):703-717
Originalpublikation
http://dx.doi.org/10.1002/glia.23566

 

Aye,R., Weldearegay,Y. B., Lutta,H. O., Chuma,F., Pich,A., Jores,J., Meens,J., Naessens,J. 
Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides.
Vet.Immunol.Immunopathol. 2018; 204(11-18)
Originalpublikation
http://dx.doi.org/10.1016/j.vetimm.2018.09.002

 

Beer,L. A., Tatge,H., Reich,N., Tenspolde,M., Olling,A., Goy,S., Rottner,K., Alekov,A. K., Gerhard,R. 
Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate.
Cell.Microbiol. 2018; 20(10):e12865-
Originalpublikation
http://dx.doi.org/10.1111/cmi.12865

 

Beer,L. A., Tatge,H., Schneider,C., Ruschig,M., Hust,M., Barton,J., Thiemann,S., Fühner,V., Russo,G., Gerhard,R. 
The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains.
Toxins (Basel) 2018; 10(6):E225-
Originalpublikation
http://dx.doi.org/10.3390/toxins10060225

 

Bollenbach,A., Hanff,E., Beckmann,B., Kruger,R., Tsikas,D.,
GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index.
Anal.Biochem. 2018; 556(40-44)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.06.021

 

Bollenbach,A., Hanff,E., Tsikas,D. 
Investigation of N(G)-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1100-1101(174-178)
Originalpublikation
http://dx.doi.org/10.1016/j.jchromb.2018.10.007

 

Bollenbach,A., Hanff,E., Tsikas,D. 
Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
Anal.Biochem. 2018; 563(67-70)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.10.012

 

Bollenbach,A., Tsikas,D. 
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N(G)-hydroxy-L-arginine, N(omega),N(omega)-dimethyl-L-citrulline and N(omega),N(omega)-dimethyl-N(delta)-hydroxy-L-citrulline: results and overview.
Amino Acids 2019; 51(3):483-494
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2684-6

 

Chung,S. Y., Schöttelndreier,D., Tatge,H., Fühner,V., Hust,M., Beer,L. A., Gerhard,R. 
The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
Front.Microbiol. 2018; 9(2314-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.02314

 

Erdmann,J., Preusse,M., Khaledi,A., Pich,A., Häussler,S. 
Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa.
Environ.Microbiol. 2018; 20(11):3952-3963
Originalpublikation
http://dx.doi.org/10.1111/1462-2920.14419

 

Finkel,A., Röhrich,M. A., Maassen,N., Lützow,M., Blau,L. S., Hanff,E., Tsikas,D., Maassen,M., Long-term effects of NO3(-) on the relationship between oxygen uptake and power after 3 weeks of supplemented HIHV training
J.Appl.Physiol.(1985) 2018; 125(6):1997-2007
Originalpublikation
http://dx.doi.org/10.1152/japplphysiol.00176.2018

 

Fischer,V., Dudzinska,A., Just,I. 
The impact of the program structure at Hannover Medical School on academic success in medical studies
GMS J.Med.Educ. 2018; 35(2):Doc22-
Originalpublikation
http://dx.doi.org/10.3205/zma001169

 

Genth,H., Junemann,J., Lämmerhirt,C. M., Lücke,A. C., Schelle,I., Just,I., Gerhard,R., Pich,A. 
Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
Front.Microbiol. 2018; 9(3078-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.03078

   

Hanff,E., Hafner,P., Bollenbach,A., Bonati,U., Kayacelebi,A. A., Fischer,D., Tsikas,D.
Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications
Amino Acids 2018; 50(10):1391-1406
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2614-7

 

Hanff,E., Zinke,M., Böhmer,A., Niebuhr,J., Maassen,M., Endeward,V., Maassen,N., Tsikas,D.
GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV
Anal.Biochem. 2018; 550(132-136)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.05.001

 

Junemann,J., Just,I., Gerhard,R., Pich,A.
Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells
Front.Microbiol. 2018; 9(3083-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.03083

 

Just,I., Fischer,V.
Prüfungen an der Medizinischen Hochschule Hannover - Wie kommt man vom Ist zum Soll?
Wien.Med.Wochenschr. 2019; 169(5-6):119-125
Originalpublikation
http://dx.doi.org/10.1007/s10354-018-0663-x

 

Lam,K. H., Sikorra,S., Weisemann,J., Maatsch,H., Perry,K., Rummel,A., Binz,T., Jin,R.
Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA
Pathog.Dis. 2018; 76(4):10.1093/femspd/fty044-
Originalpublikation
http://dx.doi.org/10.1093/femspd/fty044

 

Mehner-Breitfeld,D., Rathmann,C., Riedel,T., Just,I., Gerhard,R., Overmann,J., Brüser,T.
Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile
Front.Microbiol. 2018; 9(2446-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.02446

 

Montag,J., Kowalski,K., Makul,M., Ernstberger,P., Radocaj,A., Beck,J., Becker,E., Tripathi,S., Keyser,B., Mühlfeld,C., Wissel,K., Pich,A., van der Velden,J., Dos Remedios,C. G., Perrot,A., Francino,A., Navarro-Lopez,F., Brenner,B., Kraft,T.
Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
Front.Physiol. 2018; 9(359-
Originalpublikation
http://dx.doi.org/10.3389/fphys.2018.00359

 

Rahardjo,H. E., Ückert,S., Bannowsky,A., Tsikas,D., Becker,A. J., Kuczyk,M. A.
Course of transforming growth factor ss1 in the systemic and cavernous blood of healthy males through different penile conditions
Andrologia 2019; 51(1):e13150-
Originalpublikation
http://dx.doi.org/10.1111/and.13150

 

Schöttelndreier,D., Seeger,K., Grassl,G. A., Winny,M. R., Lindner,R., Genth,H.
Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
Front.Microbiol. 2018; 9(1483-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.01483

 

Schröder,A., Benski,A., Oltmanns,A., Just,I., Rohrbeck,A., Pich,A.
MS-based quantification of RhoA/B and RhoC ADP-ribosylation
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1092(268-271)
Originalpublikation 
http://dx.doi.org/S1570-0232(18)30604-4

 

Shahin,P., Rahardjo,H. E., Bannowsky,A., Tsikas,D., Sohn,M., Kuczyk,M. A., Ückert,S.
Endopeptidase inhibition attenuates the contraction induced by big endothelin-1 of isolated human penile erectile tissue
Andrologia 2018; 50(5):e13008-
Originalpublikation
http://dx.doi.org/10.1111/and.13008

 

Sikorra,S., Skiba,M., Dorner,M. B., Weisemann,J., Weil,M., Valdezate,S., Davletov,B., Rummel,A., Dorner,B. G., Binz,T.
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)(-)K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
Toxins (Basel) 2018; 10(8):E311-
Originalpublikation
http://dx.doi.org/10.3390/toxins10080311

 

Stern,D., Weisemann,J., Le Blanc,A., von Berg,L., Mahrhold,S., Piesker,J., Laue,M., Luppa,P. B., Dorner,M. B., Dorner,B. G., Rummel,A.
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
PLoS Pathog. 2018; 14(5):e1007048-
Originalpublikation
http://dx.doi.org/10.1371/journal.ppat.1007048

 

Tan,X., Xu,A., Zhao,T., Zhao,Q., Zhang,J., Fan,C., Deng,Y., Freywald,A., Genth,H., Xiang,J.,
Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
Sci.Rep. 2018; 8(1):3769-
Originalpublikation
http://dx.doi.org/10.1038/s41598-018-20459-1

 

Tsikas,D.,
Bioanalytical method validation of endogenous substances according to guidelines by the FDA and other organizations: Basic need to specify concentration ranges
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1093-1094(80-81)
Letter
http://dx.doi.org/10.1016/j.jchromb.2018.07.005

 

Tsikas,D., Bollenbach,A., Hanff,E., Kayacelebi,A. A.
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes
Cardiovasc.Diabetol. 2018; 17(1):1-
Comment
http://dx.doi.org/10.1186/s12933-017-0656-x

 

Tsikas,D., Hanff,E.
Measurement of S -Nitrosoglutathione in Plasma by Liquid Chromatography-Tandem Mass Spectrometry Methods
Mol.Biol. 2018; 1747(113-129
Originalpublikation
http://dx.doi.org/10.1007/978-1-4939-7695-9_10

 

Tsikas,D., Hanff,E., Bollenbach,A., Kruger,R., Pham,V. V., Chobanyan-Jürgens,K., Wedekind,D., Arndt,T., Jörns,A., Berbee,J. F. P., Princen,H. M. G., Lücke,T., Mariotti,F., Huneau,J. F., Ückert,S., Frölich,J. C., Lenzen,S.,
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
Amino Acids 2018; 50(7):799-821
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2573-z

 

Wolling,H., Konze,S. A., Höfer,A., Erdmann,J., Pich,A., Zweigerdt,R., Buettner,F. F. R.,
Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis
Proteomics 2018; 18(14):e1800102-
Originalpublikation
http://dx.doi.org/10.1002/pmic.201800102

Zhao,T., Li,R., Tan,X., Zhang,J., Fan,C., Zhao,Q., Deng,Y., Xu,A., Lukong,K. E., Genth,H., Xiang,J.,
Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-kappaB and ERK1/2 Pathways
Int.J.Mol.Sci. 2018; 19(7):E1994-
Originalpublikation
http://dx.doi.org/10.3390/ijms19071994

Buck A, Kayacelebi A A, Chobanyan-Jürgens K, Illsinger S, Bohnhorst B, Beckmann B, Hanff E, Das A M, Tsikas D, Lücke T

Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth.

Amino Acids 2017; 49(4):783-794
Originalpublikation
Volltext
 
Debez A, Belghith I, Pich A, Taamalli W, Abdelly C, Braun H P

High salinity impacts germination of the halophyte Cakile maritima but primes seeds for rapid germination upon stress release.

Physiol. Plant. 2017, ppl.12679-
Originalpublikation
Volltext
  
Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A

Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.

Proteomics 2017; 17(15-16):1600435-

Originalpublikation
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Fischer V, Just I

Qualitätssicherung in Prüfungen am Beispiel von 10 Jahren e-Prüfungen an der MHH.

Qualität in der Wissenschaft (QiW) 2017; 11(2):60-64
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Günes D N, Kayacelebi A A, Hanff E, Lundgren J, Redfors B, Tsikas D

Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.

Amino Acids 2017; 49(12):2033-2044
Originalpublikation
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Haghikia A, Yanchev G R, Kayacelebi A A, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D

The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.

Amino Acids 2017; 49(6):1111-1121
Originalpublikation
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Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Göhring G, Schmidt H, Sgodda M, Cantz T

In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells.

Biol.Chem. 2017; 398(8):939-954
Originalpublikation
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Junemann J, Lämmerhirt C M, Polten F, Just I, Gerhard R, Genth H, Pich A

Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis.

Proteomics 2017; 17(9):1700016-
Originalpublikation
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Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H,  Feelisch M, van Goor H, Bakker S J L, Tsikas D

Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.

Amino Acids 2017; 49(7):1193-1202
Originalpublikation
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Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R

Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells.

Chembiochem 2017; 18(13):1317-1331
Originalpublikation
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Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F

Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.

J. Proteome Res. 2017; 16(3):1133-1149
Originalpublikation
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Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N

Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands.

Croat. Chem. Acta 2017; 90(2):263-271
Originalpublikation
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Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R

The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.

Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012-
Originalpublikation
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Nkuipou-Kenfack E, Schanstra J  P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J  L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P

The use of urinary proteomics in the assessment of suitability of mouse models for ageing.

PLoS One 2017; 12(2):e0166875-
Originalpublikation
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Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038-
Übersicht
Volltext
  
Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C

EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.

Circulation 2017; 136(19):1809-1823
Originalpublikation
Volltext
  
Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I

The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif.

J. Biol. Chem. 2017; 292(43):17668-17680
Originalpublikation
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Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A

Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB.

Front. Cell. Infect. Microbiol. 2017; 7(67-
Originalpublikation
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Rummel A

Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.

Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48-
Übersicht
Volltext
  
Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A

Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics.

PLoS One 2017; 12(5):e0178182-
Originalpublikation
Volltext
  
Tsikas D

Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first.

Atherosclerosis 2017; 264:79-82
Editorial
Volltext
  
Tsikas D

The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a.

J Controversies Biomed Res 2017; 3(1):11-15
Originalpublikation
Volltext
  
Tsikas D

Does oxidative stress change during orthotopic liver transplantation?

J Controversies Biomed Res 2017; 3(2):1-5
Originalpublikation
Volltext
  
Tsikas D

Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox.

J Controversies Biomed Res 2017; 3(1):16-22
Originalpublikation
Volltext
  
Tsikas D

Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans&quot.

Anal.Bioanal Chem. 2017; 409(9):2495-
Letter
Volltext
  
Tsikas D

Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS?

Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040-
Letter
Volltext
  
Tsikas D

Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid.

JSM Biochem Mol Biol 2017; 4(2):1027-
Originalpublikation
Volltext
  
Tsikas D

What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine.

J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72
Übersicht
Volltext
  
Tsikas D, Böhmer A

S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature.

Nitric Oxide 2017; 65:22-36
Originalpublikation
Volltext

Tsikas D, Bollenbach A, Savvidou M D

Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?

Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2-
Originalpublikation
Volltext
  
Tsikas D, Eigendorf J

Diet and Exercise and Serum Markers of Oxidative Stress-Letter.

Cancer.Prev.Res.(Phila) 2017; 10(8):485-486
Letter
Volltext
  
Tsikas D, Hanff E

Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy.

J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142
Übersicht
Volltext
  
Tsikas D, Hanff E, Becker T

Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?

Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009-
Letter
Volltext
  
Tsikas D, Hanff E, Bollenbach A

S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics.

World J.Gastroenterol. 2017; 23(40):7343-7346
Letter
Volltext
  
Tsikas D, Hanff E, Brunner G

Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase.

Trends Microbiol. 2017; 25(8):601-602
Letter
Volltext
  
Tsikas D, Hanff E, Brunner G

Spermidine for a long, dementia-free life?

Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576-
Übersicht
Volltext

 

Tsikas D, Kinzel M

Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men.

Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004-
Originalpublikation
Volltext

  
Tsikas D, Savvidou M

Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile.

JSM Biochem Mol Biol 2017; 4(2):1028-
Originalpublikation
Volltext
  
Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S

S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) � Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview.

2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003-
Originalpublikation
Volltext

von Elsner L, Hagemann S, Just I, Rohrbeck A

Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation.

J Mol Signal 2017; 12(1-
Originalpublikation
Volltext
  
Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093-
Originalpublikation
Volltext
  

Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Sci.Rep. 2017; 7(1):7438-
Originalpublikation
Volltext

 

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567-
Originalpublikation
Volltext

Frädrich C, Beer LA, Gerhard R

Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B

Toxins (Basel) 2016; 8 (1), 25
Übersicht
Abstract

  

Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D

Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells

Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82)
Originalpublikation
Abstract
 

Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M

The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme

Journal of Neurochemistry 2016; 139 (2): 234-244
Originalpublikation
Volltext

  

Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S

Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization

Scientific Reports 2016; 6 (36598-)
Originalpublikation
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Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology 

TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102
Übersicht
Abstract

  

Gerhard R

Receptors and Binding Structures for Clostridium difficile Toxins A and B

Current Topics in Microbiology and Immunology 2016: 1-18
Originalpublikation
Abstract

 

Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S

Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa

Environmental Microbiology 2016; 18 (10): 3583-3592
Originalpublikation
Volltext

 

Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1

Biochemical Journal 2016; 473 (17): 2645-2654
Originalpublikation
Volltext
 

Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I

Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody

Toxins (Basel) 2016; 8(4):100
Originalpublikation
Volltext
 

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Nature 2016; 538(7625): 350-355
Originalpublikation
Volltext
 

von Elsner L, Hagemann S, Just I, Rohrbeck A

C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors

Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031
Originalpublikation
Volltext

 

Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

Toxins (Basel) 2016; 8(5), 154
Originalpublikation
Volltext

 

Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

Nature Structural & Molecular Biology 2016; 23 (7): 656-662
Originalpublikation
Volltext
 

Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043
Originalpublikation
Volltext

 

Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A

Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells

Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4) 
Originalpublikation 
Volltext

 
Genth H, Schelle I, Just I

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Toxins (Basel) 2016; 8 (4): 109
Originalpublikation
Volltext


 
Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry

Analyst 2016; 141 (18): 5281 -5297
Originalpublikation
Volltext

 
 
Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A

BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay

Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8
Originalpublikation
Abstract


 
Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D

Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells

Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50
Originalpublikation
Volltext


 
Schelle I, Bruening J, Buetepage M, Genth H

Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Toxins (Basel) 2016; 9 (1), 2
Originalpublikation
Volltext

Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T,  Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC

Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction

Nature medicine 2015;2;2;140-149

Volltext

 

Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG

Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype

PLoS One 2015;10;2

Volltext

 

Rohrbeck A, von Elsner L, Hagemann S, Just I

Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells

Toxins 2015;7;380-395

Volltext

 

Bothe M, Dutow P, Pich A, Genth H, Klos A

DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166

Toxins 2015;17;621-637

Volltext

 

Haschemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T

Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.

Eur Addict Res 2016;22(2);59 -69 
Volltext

 

Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

Toxicon 2015;107(Pt.A);43 -49 
Abstract

  

Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G

UV radiation induces CXCL5 expression in human skin. 

Exp Dermatol 2015;24(4);309 -312 
Volltext 
 
Rummel A

The long journey of botulinum neurotoxins into the synapse. 

Toxicon 2015;107(Pt.A):9 -24
Abstract

    
Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K

C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity

Neurochem Int 2015; 90;232 -245 
Abstract
 
Schröder A, Rohrbeck A, Just I, Pich A

Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.

J Proteome Res 2015;14(11);4721 -4733
Volltext 
 

Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH

miR-139-5p controls translation in myeloid leukemia through EIF4G2.

Oncogene 2015;DOI: 10.1038/onc.2015.247 
Volltext

   
Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T,  Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A,  Mischak H

Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117  
Abstract 
 
Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML

SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity.

Biochim Biophys Acta 2015;1853(1);136 -143
Volltext
 

Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J

Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP).

J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016
Volltext

 
Keller B, Mühlenkamp M, Deuschle E,  Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E

Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.

Cell Microbiol 2015;17(8);1179 -1204  
Volltext 

Dorner BG, Rummel A

Preface biological Toxins ancient molecules posing a current threat.

Toxins 2015;7(12);5320 -5321 
Volltext

Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F.
Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca and GTPgammaS ,,Toxicology,2015;328():48-56
Originalpublikation

Chatterji,B. ; Dickhut,C. ; Mielke,S. ; Krüger,J. ; Just,I. ; Glage,S. ; Meier,M. ; Wedekind,D. ; Pich,A.
MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease ,
Germany,Proteomics,2014;14(13-14):1674-1687
Originalpublikation

Dressler,D. ; Adib Saberi,F. ; Bigalke,H.
IncobotulinumtoxinA (Xeomin((R))) can produce antibody-induced therapy failure in a patient pretreated with abobotulinumtoxinA (Dysport((R)))
Austria,J.Neural Transm.,2014;121(7):769-771
Case report

Dressler,D. ; Gessler,F. ; Tacik,P. ; Bigalke,H.
An enzyme-linked immunosorbent assay for detection of botulinum toxin-antibodies
United States,Mov.Disord.,2014;29(10):1322-1324
Originalpublikation

Genth,H. ; Pauillac,S. ; Schelle,I. ; Bouvet,P. ; Bouchier,C. ; Varela-Chavez,C. ; Just,I. ; Popoff,M. R.
Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins
England,Cell.Microbiol.,2014;16(11):1706-1721
Originalpublikation

Gonzalez-Escalona,N. ; Thirunavukkarasu,N. ; Singh,A. ; Toro,M. ; Brown,E. W. ; Zink,D. ; Rummel,A. ; Sharma,S. K.
Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type
United States,Genome Announc,2014;2(6):10.1128/genomeA.01275-14
Originalpublikation

Goy,S. D. ; Olling,A. ; Neumann,D. ; Pich,A. ; Gerhard,R.
Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor ,,Cell.Microbiol.,2015;17(6):893-909
Originalpublikation

Hardtke-Wolenski,M. ; Taubert,R. ; Noyan,F. ; Sievers,M. ; Dywicki,J. ; Schlue,J. ; Falk,C. S. ; Lundgren,B. A. ; Scott,H. S. ; Pich,A. ; Anderson,M. S. ; Manns,M. P. ; Jaeckel,E.
Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens ,,Hepatology,2015;61(4):1295-1305
Originalpublikation

Jochim,N. ; Gerhard,R. ; Just,I. ; Pich,A.
Time-resolved cellular effects induced by TcdA from Clostridium difficile
England,Rapid Commun.Mass Spectrom.,2014;28(10):1089-1100
Originalpublikation

Jünger,J. ; Just,I.
Recommendations of the German Society for Medical Education and the German Association of Medical Faculties regarding university-specific assessments during the study of human, dental and veterinary medicine
Germany,GMS Z.Med.Ausbild,2014;31(3):Doc34-
Originalpublikation

Konze,S. A. ; van Diepen,L. ; Schröder,A. ; Olmer,R. ; Moller,H. ; Pich,A. ; Weissmann,R. ; Kuss,A. W. ; Zweigerdt,R. ; Buettner,F. F.
Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells
United States,Mol.Cell.Proteomics,2014;13(4):990-1007
Originalpublikation

Lee,K. ; Lam,K. H. ; Kruel,A. M. ; Perry,K. ; Rummel,A. ; Jin,R.
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex
United States,Biochem.Biophys.Res.Commun.,2014;446(2):568-573
Originalpublikation

Lee,K. ; Zhong,X. ; Gu,S. ; Kruel,A. M. ; Dorner,M. B. ; Perry,K. ; Rummel,A. ; Dong,M. ; Jin,R.
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex
United States,Science,2014;344(6190):1405-1410
Originalpublikation

Matsui,T. ; Gu,S. ; Lam,K. H. ; Carter,L. G. ; Rummel,A. ; Mathews,I. I. ; Jin,R.
Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex
England,J.Mol.Biol.,2014;426(22):3773-3782
Originalpublikation

May,M. ; Schelle,I. ; Brakebusch,C. ; Rottner,K. ; Genth,H.
Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry
United States,Cell.Cycle,2014;13(14):2211-2221
Originalpublikation

Nkuipou-Kenfack,E. ; Koeck,T. ; Mischak,H. ; Pich,A. ; Schanstra,J. P. ; Zürbig,P. ; Schumacher,B.
Proteome analysis in the assessment of ageing ,,Ageing Res.Rev.,2014;18C():74-85
Übersicht

Olling,A. ; Hüls,C. ; Goy,S. ; Müller,M. ; Krooss,S. ; Rudolf,I. ; Tatge,H. ; Gerhard,R.
The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation
Switzerland,Toxins (Basel),2014;6(7):2162-2176
Originalpublikation

Rohrbeck,A. ; Schröder,A. ; Hagemann,S. ; Pich,A. ; Höltje,M. ; Ahnert-Hilger,G. ; Just,I.
Vimentin mediates uptake of C3 exoenzyme
United States,PLoS One,2014;9(6):e101071-
Originalpublikation

Rohrbeck,A. ; von Elsner,L. ; Hagemann,S. ; Just,I.
Binding of Clostridium botulinum C3 exoenzyme to intact cells
Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2014;387(6):523-532
Originalpublikation

Rummel,A. ;
The dual receptor recognition of botulinum neurotoxins
New York, NY,,2014;4():129-150
Buchbeitrag, Monografie

Saul,V. V. ; Niedenthal,R. ; Pich,A. ; Weber,F. ; Lienhard Schmitz,M.
SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity
Netherlands,Biochim.Biophys.Acta,2015;1853(1):136-143
Originalpublikation

Strotmeier,J. ; Mahrhold,S. ; Krez,N. ; Janzen,C. ; Lou,J. ; Marks,J. D. ; Binz,T. ; Rummel,A.
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
Netherlands,FEBS Lett.,2014;588(7):1087-1093
Originalpublikation

Wagner,S. ; Maibaum,D. ; Pich,A. ; Nolte,I. ; Murua Escobar,H.
Verification of a Canine PSMA (FolH1) Antibody
Greece,Anticancer Res.,2015;35(1):145-148
Originalpublikation

Wohlan,K. ; Goy,S. ; Olling,A. ; Srivaratharajan,S. ; Tatge,H. ; Genth,H. ; Gerhard,R.
Pyknotic cell death induced by Clostridium difficile TcdB: Chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity ,,Cell.Microbiol.,2014;76(11):1678-1692
Originalpublikation

Boetzkes,Alexander
Sekretomanalyse hypervirulenter Clostridium difficile-Stämme ,,,2014;():Getr. Zählung-
Dissertation

Brandes,Vanessa
Die durch Tauroursodeoxycholsäure vermittelte Phosphorylierung von Rac1/Cdc42 bewirkt eine reduzierte Glucosylierung katalysiert durch C. difficile Toxin B ,,,2014;():Bl. 77 - 84, Bl. 11 - 43-
Dissertation

Goy,Sebastian David
Clostridium difficile Toxin B activates formyl peptide receptor 1 of human neutrophil granulocytes via N-terminal glucosyltransferase domain ,,,2014;():138 Bl. Ill., graph. Darst.-
Dissertation

Rotsch,Jacqueline
Zelluläre Auswirkungen des bakteriellen Exoenzyms C3 bot ,,,2011;():III, 72 Bl. Ill., graph. Darst.-
Dissertation

Beer,Lara-Antonia
Die Rolle der niedermolekularen GTpase Rac1 und der NADPH Oxidase bei der Clostridium difficile TcdB-induzierten Pyknose ,,,2011;():-
Masterarbeit

Petersen,Lara
Die Rolle von Rho-GTPasen in den zytopathischen und zytotoxischen Wirkungen von Clostridium difficile Toxinen ,,,2011;():62 S.-
Masterarbeit

Gangl,Anna-Katharina
Effekte des marinen Toxins Latrunculin B auf die epitheliale Barrierefunktion des Kolon ,,,2011;():37 S.-
Bachelorarbeit

Bagramyan,K. ; Kaplan,B. E. ; Cheng,L. W. ; Strotmeier,J. ; Rummel,A. ; Kalkum,M.
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples
United States,Anal.Chem.,2013;85(11):5569-5576
Originalpublikation 

Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F.
Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPgammaS containing intracellular solution
Netherlands,Eur.J.Pharmacol.,2013;720(1-3):227-236
Originalpublikation 

Barth,H. ; Bigalke,H. ; Gerhard,R. ;
Bakterielle Toxine (Kap. 42)
Stuttgart,,2013;():1157-1180
Buchbeitrag, Monografie 

Bigalke,H.
Botulinum toxin: application, safety, and limitations
Germany,Curr.Top.Microbiol.Immunol.,2013;364():307-317
Originalpublikation 

Chatterji,B. ; Pich,A.
MALDI imaging mass spectrometry and analysis of endogenous peptides
England,Expert Rev.Proteomics,2013;10(4):381-388
Originalpublikation 

Gerhard,R. ; Frenzel,E. ; Goy,S. ; Olling,A.
Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain ,,J.Med.Microbiol.,2013;62(9):1414-1422
Originalpublikation 

Höltje,M. ; Schulze,S. ; Strotmeier,J. ; Mahrhold,S. ; Richter,K. ; Binz,T. ; Bigalke,H. ; Ahnert-Hilger,G. ; Rummel,A.
Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons ,,Toxicon,2013;75C():108-121
Originalpublikation 

Huelsenbeck,S. C. ; Roggenkamp,D. ; May,M. ; Huelsenbeck,J. ; Brakebusch,C. ; Rottner,K. ; Ladwein,M. ; Just,I. ; Fritz,G. ; Schmidt,G. ; Genth,H.
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Netherlands,Int.J.Biochem.Cell Biol.,2013;45(8):1767-1775
Originalpublikation

Lee,K. ; Gu,S. ; Jin,L. ; Le,T. T. ; Cheng,L. W. ; Strotmeier,J. ; Kruel,A. M. ; Yao,G. ; Perry,K. ; Rummel,A. ; Jin,R.
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity
United States,PLoS Pathog.,2013;9(10):e1003690-
Originalpublikation 

Mahrhold,S. ; Strotmeier,J. ; Garcia-Rodriguez,C. ; Lou,J. ; Marks,J. D. ; Rummel,A. ; Binz,T.
Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E
England,Biochem.J.,2013;453(1):37-47
Originalpublikation 

May,M. ; Wang,T. ; Müller,M. ; Genth,H.
Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470
Switzerland,Toxins (Basel),2013;5(1):106-119
Originalpublikation 

Pirazzini,M. ; Henke,T. ; Rossetto,O. ; Mahrhold,S. ; Krez,N. ; Rummel,A. ; Montecucco,C. ; Binz,T.
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
Netherlands,FEBS Lett.,2013;587(23):3831-3836
Originalpublikation 

Rangrez,A. Y. ; Bernt,A. ; Poyanmehr,R. ; Harazin,V. ; Boomgaarden,I. ; Kuhn,C. ; Rohrbeck,A. ; Frank,D. ; Frey,N.
Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy
United States,J.Cell Biol.,2013;203(4):643-656
Originalpublikation 

Rummel,A.
Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity
Germany,Curr.Top.Microbiol.Immunol.,2013;364():61-90
Originalpublikation 

Scherr,M. ; Elder,A. ; Battmer,K. ; Barzan,D. ; Bomken,S. ; Ricke-Hoch,M. ; Schröder,A. ; Venturini,L. ; Blair,H. J. ; Vormoor,J. ; Ottmann,O. ; Ganser,A. ; Pich,A. ; Hilfiker-Kleiner,D. ; Heidenreich,O. ; Eder,M. ;
Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia ,,Leukemia,2014;28(3):554-565
Originalpublikation 

Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P.
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
United States,PLoS Pathog.,2013;9(11):e1003746-
Originalpublikation 

Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P.
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
United States,PLoS Pathog.,2013;9(11):e1003746-
Originalpublikation 

Steffen,A. ; Ladwein,M. ; Dimchev,G. A. ; Hein,A. ; Schwenkmezger,L. ; Arens,S. ; Ladwein,K. I. ; Holleboom,J. M. ; Schur,F. ; Small,J. V. ; Schwarz,J. ; Gerhard,R. ; Faix,J. ; Stradal,T. E. ; Brakebusch,C. ; Rottner,K.
Rac function is critical for cell migration but not required for spreading and focal adhesion formation ,,J.Cell.Sci.,2013;126(Pt.20):4572-4588
Originalpublikation 

Stevens,G. B. ; Silver,D. A. ; Zgaga-Griesz,A. ; Bessler,W. G. ; Vashist,S. K. ; Patel,P. ; Achazi,K. ; Strotmeier,J. ; Worbs,S. ; Dorner,M. B. ; Dorner,B. G. ; Pauly,D. ; Rummel,A. ; Urban,G. A. ; Krueger,M.
Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity ,,Analyst,2013;138(20):6154-6162
Originalpublikation

Willjes,G. ; Mahrhold,S. ; Strotmeier,J. ; Eichner,T. ; Rummel,A. ; Binz,T.
Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity
United States,Biochemistry,2013;52(22):3930-3938
Originalpublikation

Zeiser,J. ; Gerhard,R. ; Just,I. ; Pich,A.
Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques ,,J.Proteome Res.,2013;12(4):1604-1618
Originalpublikation 

Völker,Anne Katrin
Identifizierung und Charakterisierung der Rezeptorbindungstaschen von Botulinum Neurotoxin Serotyp D (BoNTD) ,,,2013;():Getr. Zählung Ill., graph. Darst.-
Dissertation 

Benski,Anastasia ;
Analysis of C3bot exoenzyme-dependent ADP-ribosylation of smal Rho-GTPases by Mass Spectrometry ,,,2013;():-
Masterarbeit 

Hüls,Corinna
Intrazelluläre Assoziation funtioneller Domänen von Clostridium difficile Toxin A ,,,2013;():-
Masterarbeit 

Raasch,Sabine
Hemmung clostridialer glucosylierender Toxine durch tauro- und glucokonjugierte Gallensäuren ,,,2013;():-
Masterarbeit 

Ulfig,Anneli
Untersuchung von endogenen Peptiden in Rattenhirnen mittels MALDI Imaging and LC-MS ,,,2013;():-
Masterarbeit 

Völkening,Lea
Neutralisierende Wirkung tauro- und glycokonjugierter Gallensäuren auf Clostridium difficile Toxin B ,,,2013;():-
Masterarbeit 

Wohlan,Katharina
Rho-abhängige und unabhängige Wirkung von Clostridium difficile Toxin B auf den Zellzyklus ,,,2013;():-
Masterarbeit 

Bollenbach,Alexander
Identifizierung der aktivitätsmindernden Aminosäuren der Botulinum Neurotoxin Subtypen A4 und A8 (Chemnitz Stamm) ,,,2012;():-
Bachelorarbeit 

Weigt,David
Die Wirkung der Zytotoxisch Nekrotisierenden Faktoren aus Yersinia pseudotuberculosis und Escherichia coli auf die epitheliale Barrierefunktion von kultivierten Nierenepithelzellen ,,,2012;():-
Bachelorarbeit 

Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L.
Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons.
Front Cell Neurosci 2012;6;43
Originalpublikation

Baron,J. ; Blex,C. ; Rohrbeck,A. ; Rachakonda,S. K. ; Birnbaumer,L. ; Ahnert-Hilger,G. ; Brunk,I.
The alpha-subunit of the trimeric GTPase Go2 regulates axonal growth ,,J.Neurochem.,2013;124(6):782-794
Originalpublikation 

Bigalke H, Frevert J.
Botulinum toxin A: dose and immune response.
Int J Rehabil Res 2012;35(2);93
Originalpublikation

Boetzkes,A. ; Felkel,K. W. ; Zeiser,J. ; Jochim,N. ; Just,I. ; Pich,A.
Secretome analysis of Clostridium difficile strains
Germany,Arch.Microbiol.,2012;194(8):675-687
Originalpublikation 

Brandes V, Schelle I, Brinkmann S, Schulz F, Schwarz J, Gerhard R, Genth H.
Protection from C. difficile Toxin B-catalysed Rac/Cdc42 glucosylation by tauroursodeioxycholic acid-induced Rac/Cdc42 phosphorylation.
Biol Chem 2012;1;393(1-2);77-84
Originalpublikation

Chiaradia,E. ; Avellini,L. ; Tartaglia,M. ; Gaiti,A. ; Just,I. ; Scoppetta,F. ; Czentnar,Z. ; Pich,A.
Proteomic evaluation of sheep serum proteins
England,BMC Vet.Res.,2012;8():66-
Originalpublikation

Debez,A. ; Braun,H. P. ; Pich,A. ; Taamalli,W. ; Koyro,H. W. ; Abdelly,C. ; Huchzermeyer,B.
Proteomic and physiological responses of the halophyte Cakile maritima to moderate salinity at the germinative and vegetative stages
Netherlands,J.Proteomics,2012;75(18):5667-5694
Originalpublikation 

Gu,S. ; Rumpel,S. ; Zhou,J. ; Strotmeier,J. ; Bigalke,H. ; Perry,K. ; Shoemaker,C. B. ; Rummel,A. ; Jin,R.
Botulinum neurotoxin is shielded by NTNHA in an interlocked complex
United States,Science,2012;335(6071):977-981
Originalpublikation 

Hammerschmidt,A. ; Chatterji,B. ; Zeiser,J. ; Schröder,A. ; Genieser,H. G. ; Pich,A. ; Kaever,V. ; Schwede,F. ; Wolter,S. ; Seifert,R.
Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose
United States,PLoS One,2012;7(7):e39848-
Originalpublikation

Hefter,H. ; Hartmann,C. ; Kahlen,U. ; Moll,M. ; Bigalke,H.
Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins--a single cohort 4-year follow-up study
England,BMJ Open,2012;2(4):10.1136/bmjopen-2011-000646. Print 2012
Originalpublikation 

Huelsenbeck,J. ; May,M. ; Schulz,F. ; Schelle,I. ; Ronkina,N. ; Hohenegger,M. ; Fritz,G. ; Just,I. ; Gerhard,R. ; Genth,H.
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin
Netherlands,FEBS Lett.,2012;586(20):3665-3673
Originalpublikation 

Hülsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Tallini K.
C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury
Neurotherapeutics 2012;9;185-198
Originalpublikation

Katsch,K. ; de Jong,S. J. ; Albrecht,J. C. ; Steger,J. ; Genth,H. ; Posern,G. ; Biesinger,B.
Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
England,Cell.Commun.Signal.,2012;10(1):5-811X-10-5
Originalpublikation 

May,M. ; Kolbe,T. ; Wang,T. ; Schmidt,G. ; Genth,H.
Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis
United States,J.Signal.Transduct,2012;2012():570183-
Originalpublikation 

Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R.
Release of TcdA and TcdB from Clostridium cdi 630 is not affected by functional inactivation of the tcdE gene.
Microb Pathog 2012;52(1);92-100
Originalpublikation

Rohrbeck,A. ; Kolbe,T. ; Hagemann,S. ; Genth,H. ; Just,I.
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q
England,FEBS J.,2012;279(15):2657-2671
Originalpublikation 

Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC.
Inhibition of macrophage migration by C. botulinum exoenzym C3
Naumyn-Schmiedebergs's Arch Pharmacol 2012;385(9);883-90. May29 [Epub ahead of print]
Originalpublikation

Schwarz,J. ; Proff,J. ; Hävemeier,A. ; Ladwein,M. ; Rottner,K. ; Barlag,B. ; Pich,A. ; Tatge,H. ; Just,I. ; Gerhard,R.
Serine-71 phosphorylation of rac1 modulates downstream signaling
United States,PLoS One,2012;7(9):e44358-
Originalpublikation 

Strotmeier,J. ; Willjes,G. ; Binz,T. ; Rummel,A.
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity
Netherlands,FEBS Lett.,2012;586(4):310-313
Originalpublikation 

Weigoldt,M. ; Meens,J. ; Bange,F. C. ; Pich,A. ; Gerlach,G. F. ; Goethe,R.
Metabolic adaptation of Mycobacterium avium subsp. paratuberculosis to the gut environment ,,Microbiology,2013;159(Pt.2):380-391
Originalpublikation 

Wellhöner,H. ; Weiss,A. ; Schulz,A. ; Adermann,K. ; Braitbard,O. ; Bar-Sinai,A. ; Hochman,J.
Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates
England,J.Drug Target.,2012;20(5):445-452
Originalpublikation 

Euler,Friederike Christina
Bedeutung der Autoproteolyse für die intrazelluläre Wirkung von Clostridium difficile Toxin A ,,,2011;():50 Bl.-
Dissertation 

Fritsch,Cornelia
Bindung und Aufnahme von Clostridium botulinum C3 Exoenzym in F98-Zellen ,,,2012;():97 Bl.-
Dissertation 

Janzen,Constantin
Identifizierung der SV2-Bindungstasche in der H CC -Domäne von Botulinum Neurotoxin Serotyp A ,,,2012;():[2], 73 Bl.-
Dissertation 

Lica,Marta Anna
Unterschiede in der biologischen Wirkung des Clostridium difficile Toxin B in proliferierenden und nicht-proliferierenden Zellen ,,,2011;():[1], 275-283, 10-25 Bl.-
Dissertation 

Roggenkamp,Dennis 
Funktionelle Charakterisierung der Interaktion von Hautzellen und neuronalen Zellen in gesunder und gestresster Haut ,,,2011;():VI S., S. 7-94, IV S.-
Dissertation 

Schröder,Anke
Effekte des C3 Exoenzyms aus Clostridium botulinum auf das Proteom muriner Hippocampuszellen ,,,2012;():VI, 107 Bl. Ill., graph. Darst.-
Dissertation 

Zeiser,Johannes
Das Substratspektrum clostridialer glukosylierender Toxine und die Auswirkungen auf das Proteom von Colonozyten ,,,2012;():[7], 3 - 106, [20] Bl.-
Dissertation 

Brinkmann,Sophie
Cdk 1 abhängige Phosphorylierung des Rac GEF Proteins beta-Pix ,,,2012;():-
Masterarbeit 

Doberenz,Sebastian ;
Kinetische Analyse der Toxin A vermittelten Glukosylierung kleiner GTPasen ,,,2012;():-
Masterarbeit 

Edeling,Maria
Funktionelle Charakterisierung von Renalen Tubuluszellen in einem Modell für diabetische Nephropathie ,,,2012;():-
Masterarbeit 

Findeisen,Katja
Neutralisation von Clostridium difficile Toxin B durch Tauro-konjugierte-Gallensäuren ,,,2012;():-
Masterarbeit 

Krüger,Jonas
Ribosomale Proteomanalyse C3 Exoenzym behandelter Zellen ,,,2012;():-
Masterarbeit 

Nolte,Annika
Die Rac1-induzierte Hochregulation von Frizzled-Rezeptoren ,,,2012;():-
Masterarbeit 

Rataj,Dennis
Beteiligung von CIC-5 an der zellulären Aufnahme der clostridialen Toxine TcdA und TcdA1-1874 ,,,2012;():-
Masterarbeit

Boer U, Lohrenz A, Klingenberg M, Pich A, Haverich A, Wilhelmi M.
The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts. 
Biomaterials 2011;32;9730-9737
Originalpublikation

Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Federov PC.
The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells.PLoS Pathog 2011;7(12)
Originalpublikation

Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.
Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B
Naunyn Schmiedebergs Arch Pharmacol 2011;383;285-295
Originalpublikation

Höltje M, Just I, Ahnert-Hilger G.
Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration.
Ann Anat 2011;193(4);314-320
Originalpublikation

Jochim N, Gerhard R, Just I, Pich A.
Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotype-coded protein labeling and LC-MALDI.
Proteome Sci 2011;9;48
Originalpublikation

Lica M, Schulz F, Schelle I, May M, Just I, Genth H.
Difference in the biological effects of Clostridium difficile B in profilerating and non-proliferating cells.
Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);275-283
Originalpublikation

Mueller MQ, Zeiser JJ, Dreiocker F, Pich A, Schaefer M, Sinz A.
An universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis.
Rapid Commun Mass Spectrom 2011;25(1);155-161
Originalpublikation

Nölle A, Zeug A, van Bergeijk, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, Omer J, Srivastrav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P.
The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.
Human molecular genetics 2011;15;20(24);4865-4878
Originalpublikation

Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R.
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A.
PLoS One 2011;18;6(3) e17623
Originalpublikation

Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, v. Neuhoff N.
Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology.
Lung Cancer 2011;72(1);136-138
Originalpublikation

Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP.
The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication.
Nat Cell Biol 2011;13(8);1004-1009
Originalpublikation

Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D.
Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion.
J Cell Science 2011;15;124(Pt18);3066-73
Originalpublikation

Rummel A, Mahrhold S, Bigalke H, Binz T.
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
FEBS J 2011;278(23);4506-4515
Originalpublikation

Rummel,A.
Molecular biology of Clostridium botulinum organism and botulinum neurotoxins, insight into the molecular machinery involved in Clostridium botulinum neurotoxity ,Hauppauge, N.Y.,,2011;():37-70
Buchbeitrag, Monografie 

Rummel,A. ; Mahrhold,S. ; Bigalke,H. ; Binz,T.
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin ,,FEBS J.,2011;278(23):4506-4515 10.1111/j.1742-4658.2011.08196.x
Originalpublikation

Schacht T, Unger C, Pich A, Wydra K.
Endo- and exopolygalacturonases of Ralstonia solanacearum are inhibited by polygalacturonase-inhibiting protein (PGIP) activity in tomato stem extracts.
Plant Physiol Biochem 2011;49(4);377-387
Originalpublikation

Schulte-Baukloh H, Herholz J, Bigalke H, Miller K, Knispel HH.
Results of a BoNT/A Antibody Study in Children and Adolescents after Onabotulinumtoxin A (Botox(R)) Detrusor Injection.
Urol Int 2011;87(4);434-438
Originalpublikation

Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol Microbiol 2011;81(1);143-156
Originalpublikation

Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N.
Proteomic Bronchiolitis Obliterans Syndrome Risk Monitoring in Lung Transplant Recipients.
Transplantation 2011;92(4);477-485
Originalpublikation

Zeiser J, Klodmann J, Braun HP, Gerhard R, Just I, Pich A.
Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis.
Journal of Proteomics 2011;75;469-479
Originalpublikation

Felkel,Katharina-Wiebke
LC-MS basierte Sekretomanalyse verschiedener Clostridium difficile Stämme ,,,2010;():104 Bl.-
Dissertation 

Halabi Cabezon,Ismael
Aufhebung des zytopathischen Effekts von Clostridium difficile Toxin B durch Rac1 Aktivierung ,,,2010;():3751-3756, 7-20 Bl.-
Dissertation 

Jochim,Nelli
LC-MS-basierte globale Proteomanalyse von Colonzellen nach Behandlung mit clostridialen glucosylierenden Toxinen ,,,2011;():XVII, 124 Bl.-
Dissertation 

Kreimeyer,Isa
Die autoproteolytische Spaltung beeinflusst den zytotoxischen Effekt von Clostridium difficile Toxin A ,,,2010;():36 Bl.-
Dissertation 

Lücke,Nina
Sekretomanalyse der hämatopoetischen Progenitorzelllinie DKmix ,,,2010;():46 Bl.-
Dissertation 

May,Martin
Role of Rac1 and PAK in the regulation of G2-M transition and mitotic cell rounding ,,,2011;():[7], 79 Bl.-
Dissertation 

Schrader,Merle
Korrelation der C. difficile Toxin A-induzierten Apoptose mit der Hochregulation des GTP-bindenden Proteins RhoB ,,,2011;():62 Bl.-
Dissertation 

Werner,Stefan
Charakterisierung der zellulären Aufnahme von C. botulinum C3-Exoenzym ,,,2010;():[3], 86 Bl.-
Dissertation 

Dickhut,Clarissa
Bildgebende Massenspektrometrie zur histologischen Analyse von Geweben ,,,2010;():-
Masterarbeit 

Frenzel,Eileen
Charakterisierung der zellulären Aufnahme der C. difficile Toxine TcdA und TcdA1-1874 ,,,2010;():-
Masterarbeit 

Lentes,Jana
Auswirkungen der GTP-Beladung auf die Glucosylierung von Rho Proteinen durch Clostridien Toxine ,,,2011;():-
Bachelorarbeit 

Adler,S. ; Bicker,G. ; Bigalke,H. ; Bishop,C. ; Blumel,J. ; Dressler,D. ; Fitzgerald,J. ; Gessler,F. ; Heuschen,H. ; Kegel,B. ; Luch,A. ; Milne,C. ; Pickett,A. ; Ratsch,H. ; Ruhdel,I. ; Sesardic,D. ; Stephens,M. ; Stiens,G. ; Thornton,P. D. ; Thürmer,R. ; Vey,M. ; Spielmann,H. ; Grune,B. ; Liebsch,M.
The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting
England,Altern.Lab.Anim.,2010;38(4):315-330
Originalpublikation 

Backert S, Kenny B, Gerhard R, Tegtmeyer N, Bran S.
PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function.
Gut Microbes 2010;1(2);94-99
Originalpublikation

Dahal,D. ; Pich,A. ; Braun,H. P. ; Wydra,K.
Analysis of cell wall proteins regulated in stem of susceptible and resistant tomato species after inoculation with Ralstonia solanacearum: a proteomic approach
Netherlands,Plant Mol.Biol.,2010;73(6):643-658
10.1007/s11103-010-9646-z
Originalpublikation

Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B.
SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.
Proc Natl Acad Sci USA 2010;107(42);18197-18201
Originalpublikation

Genth H, Just I.
Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease.
Eur J Cell Biol 2010;12(4);Epub ahead of print
Originalpublikation

Genth H, Schulz F, Just I.
Gluscosylation of Rho/Ras Proteins by Lethal Toxin - Implication of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease.
Open Toxinology 2010;3;13-18
Originalpublikation

Just I, Hülsenbeck SC, Genth H.
Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent.
Open Toxinology 2010;3;19-23
Originalpublikation

Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M.
Therapeutic effects of Clostridium botulinum C3 exoenzyme.
Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);247-52; Epub 2010
Übersicht

Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R.
Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A.
Naunyn Schmiedebergs Arch Pharmacol 2010;11(3); Epub 2010
Originalpublikation

Krückeberg J, Just I, Möbs D, Matthies H, Fischer V.
Mehrwert erkannt, Defizite gebannt? - die quantitative Analyse elektronisch verfasster Klausuren an der Medizinischen Hochschule Hannover.
GMA [Hrsg.]: Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA). Bochum, 23.-25.09.2010
Vortrag

Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A.
Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix.
Rapid Commun Mass Spectrom 2010;24(5);561-570
Originalpublikation

Naue N, Fedorov R, Pich A, Manstein DJ, Curth U.
Site-directed mutagenesis of the {chi} subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.
Nucleic Acids Res 2010;23(10); Epub ahead of print
Originalpublikation

Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem J 2010;431(2):207-216
Originalpublikation

Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, Genth H, Klos A.
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac.
PLoS One 2010;5(3)
Originalpublikation

Häfner,Kirstin
Kompetitionsexperimente am Maus-Hemidiaphragma-Assay zur Identifizierung von Proteinrezeptoren der clostridiellen Neurotoxine: SV2 vermittelt die Aufnahme von BoNT/F in neuronale Zellen ,,,2010;():-
Dissertation 

Lange,Oliver
Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A : much ado about nothing? ,,,2010;():213 - 218, 16 Bl.-
Dissertation

Nottrott,Stefanie
Die Clostridium difficile Toxin A-induzierte Apoptose ist unabhängig von p53, aber abhängig von der Glucosylierung von Rho-GTPasen ,,,2010;():[1], 33 Bl.-
Dissertation 

Supthut,Hauke
Intra- und extrazelluläre Faktoren, die die Sensitivität von CHO-Zellen gegenüber Clostridium difficile Toxin B bestimmen ,,,2009;():89 Bl.-
Dissertation 

Barlag,Britta
Beteiligung von IQGAP und MRCK an der Phospho-Rac1-vermittelten Filopodienbildung ,,,2010;():-
Masterarbeit 

Goy,Sebastian
Bedeutung der Rezeptorbindedomäne von Clostridium difficile Toxin A für die Funktionalität ,,,2010;():-
Masterarbeit 

Kolbe,Tanja
Wirkung Rho-modifizierter bakterieller Toxine in einem in vitro Modell der Wundheilung ,,,2010;():-
Diplomarbeit 

Wang,Tianbang
F-Aktin Depolymerisation durch clostridiale Toxine ,,,2010;():-
Diplomarbeit 

Andresen,H. ; Bingel,U. ; Streichert,T. ; Schmoldt,A. ; Zoerner,A. A. ; Tsikas,D. ; Just,I.
Severe glycerol intoxication after Meniere's disease diagnostic--case report and overview of kinetic data
England,Clin.Toxicol.(Phila),2009;47(4):312-316
10.1080/15563650902849123
Originalpublikation 

Binz,T. ; Rummel,A.
Cell entry strategy of clostridial neurotoxins
England,J.Neurochem.,2009;109(6):1584-1595
10.1111/j.1471-4159.2009.06093.x
Originalpublikation

Brunger,A. T. ; Rummel,A.
Receptor and substrate interactions of clostridial neurotoxins
England,Toxicon,2009;54(5):550-560
10.1016/j.toxicon.2008.12.027
Originalpublikation 

Deplazes,J. ; Fuchs,M. ; Rauser,S. ; Genth,H. ; Lengyel,E. ; Busch,R. ; Luber,B. ;
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation
England,Hum.Mol.Genet.,2009;18(19):3632-3644
10.1093/hmg/ddp312
Originalpublikation

Dreger,S. C. ; Schulz,F. ; Huelsenbeck,J. ; Gerhard,R. ; Hofmann,F. ; Just,I. ; Genth,H.
Killing of Rat Basophilic Leukemia Cells by Lethal Toxin from Clostridium sordellii: Critical Role of Phosphatidylinositide 3'-OH Kinase/Akt Signaling (dagger) ,,Biochemistry,2009;():-
10.1021/bi800708b
Originalpublikation 

Genth H, Schulz F, Just I.
Glucosylation of Rho/Ras Proteins by Lethal Toxin - Implications of Actin-Re-Organization and Apoptosis in C. Sordellii-Associated Disease.
The Open Toxinology Journal 2009;2
Abstract

Huelsenbeck,S. C. ; Klose,I. ; Reichenbach,M. ; Huelsenbeck,J. ; Genth,H.
Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin
Netherlands,FEBS Lett.,2009;583(19):3133-3139
10.1016/j.febslet.2009.09.006
Originalpublikation 

Huelsenbeck,S. C. ; May,M. ; Schmidt,G. ; Genth,H.
Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis
United States,Cell Motil.Cytoskeleton,2009;66(11):967-975
10.1002/cm.20390
Originalpublikation 

Just I, Hülsenbeck SC, Genth H.
Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and an Neurothrophic Agent.
The Open Toxinology Journal 2009;2
Abstract

Kotz,A. ; Wagener,J. ; Engel,J. ; Routier,F. ; Echtenacher,B. ; Pich,A. ; Rohde,M. ; Hoffmann,P. ; Heesemann,J. ; Ebel,F.
The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity ,,Fungal Genet.Biol.,2010;47(2):169-178
10.1016/j.fgb.2009.10.001
Originalpublikation 

Lange,O. ; Bigalke,H. ; Dengler,R. ; Wegner,F. ; deGroot,M. ; Wohlfarth,K.
Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing?
United States,Clin.Neuropharmacol.,2009;32(4):213-218
10.1097/WNF.0b013e3181914d0a
Originalpublikation 

Mohammadi,B. ; Buhr,N. ; Bigalke,H. ; Krampfl,K. ; Dengler,R. ; Kollewe,K.
A long-term follow-up of botulinum toxin A in cervical dystonia ,,Neurol.Res.,2009;31(5):463-466
10.1179/174313209X405137
Originalpublikation

Mohammadi,B. ; Kollewe,K. ; Wegener,M. ; Bigalke,H. ; Dengler,R.
Experience with long-term treatment with albumin-supplemented botulinum toxin type A
Austria,J.Neural Transm.,2009;116(4):437-441
10.1007/s00702-009-0200-6
Originalpublikation

Nerlich,A. ; Rohde,M. ; Talay,S. R. ; Genth,H. ; Just,I. ; Chhatwal,G. S.
Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism
United States,J.Biol.Chem.,2009;284(30):20319-20328
10.1074/jbc.M109.016501
Originalpublikation

Rummel,A. ; Häfner,K. ; Mahrhold,S. ; Darashchonak,N. ; Holt,M. ; Jahn,R. ; Beermann,S. ; Karnath,T. ; Bigalke,H. ; Binz,T.
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
England,J.Neurochem.,2009;110(6):1942-1954
10.1111/j.1471-4159.2009.06298.x
Originalpublikation

Schoentaube,J. ; Olling,A. ; Tatge,H. ; Just,I. ; Gerhard,R.
Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A ,,Cell.Microbiol.,2009;11(12):1816-1826
10.1111/j.1462-5822.2009.01373.x
Originalpublikation

Schulz,F. ; Just,I. ; Genth,H.
Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid
United States,Biochemistry,2009;48(38):9002-9010
10.1021/bi900964c
Originalpublikation 

Sun,X. ; He,X. ; Tzipori,S. ; Gerhard,R. ; Feng,H.
Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages
England,Microb.Pathog.,2009;46(6):298-305
10.1016/j.micpath.2009.03.002
Originalpublikation

von Witzendorff,D. ; Maass,K. ; Pich,A. ; Ebeling,S. ; Kölle,S. ; Kochel,C. ; Ekhlasi-Hundrieser,M. ; Geyer,H. ; Geyer,R. ; Töpfer-Petersen,E.
Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach
Netherlands,Carbohydr.Res.,2009;344(12):1541-1549
10.1016/j.carres.2009.05.002
Originalpublikation

Goltz,Björn
Tetanustoxin und Botulinumtoxin A : Interaktion mit Mastzellen aus der Bauchfellhöhle der Ratte ,,,2008;():IV, 140 S.-
Dissertation 

Teichert,Matthias
Charakterisierung von mutiertem Clostridium difficile Toxin A zur Bestimmung von Glucosyltransferase-abhängigen Effekten ,,,2007;():11 Bl.-
Dissertation

Busche,S. ; Descot,A. ; Julien,S. ; Genth,H. ; Posern,G.
Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling
England,J.Cell.Sci.,2008;121(Pt 7):1025-1035
10.1242/jcs.014456
Originalpublikation 

Genth,H. ; Dreger,S. C. ; Huelsenbeck,J. ; Just,I.
Clostridium difficile toxins: More than mere inhibitors of Rho proteins
England,Int.J.Biochem.Cell Biol.,2008;40(4):592-597
10.1016/j.biocel.2007.12.014
Originalpublikation 

Gerhard,R. ; Nottrott,S. ; Schoentaube,J. ; Tatge,H. ; Olling,A. ; Just,I.
Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells
England,J.Med.Microbiol.,2008;57(Pt 6):765-770
10.1099/jmm.0.47769-0
Originalpublikation 

Halabi-Cabezon,I. ; Huelsenbeck,J. ; May,M. ; Ladwein,M. ; Rottner,K. ; Just,I. ; Genth,H.
Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1
Netherlands,FEBS Lett.,2008;582(27):3751-3756
10.1016/j.febslet.2008.10.003
Originalpublikation 

Hoffmann,A. ; Hofmann,F. ; Just,I. ; Lehnardt,S. ; Hanisch,U. K. ; Brück,W. ; Kettenmann,H. ; Ahnert-Hilger,G. ; Höltje,M.
Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia
United States,Glia,2008;56(11):1162-1175
10.1002/glia.20687
Originalpublikation

Höltje,M. ; Djalali,S. ; Hofmann,F. ; Münster-Wandowski,A. ; Hendrix,S. ; Boato,F. ; Dreger,S. C. ; Grosse,G. ; Henneberger,C. ; Grantyn,R. ; Just,I. ; Ahnert-Hilger,G.
A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation ,,FASEB J.,2009;23(4):1115-1126/10.1096/fj.08-116855
Originalpublikation

Höltje,M. ; Hofmann,F. ; Lux,R. ; Veh,R. W. ; Just,I. ; Ahnert-Hilger,G.
Glutamate uptake and release by astrocytes are enhanced by Clostridium botulinum C3 protein
United States,J.Biol.Chem.,2008;283(14):9289-9299
10.1074/jbc.M706499200
Originalpublikation

Kamanova,J. ; Kofronova,O. ; Masin,J. ; Genth,H. ; Vojtova,J. ; Linhartova,I. ; Benada,O. ; Just,I. ; Sebo,P.
Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
United States,J.Immunol.,2008;181(8):5587-5597
Originalpublikation

Klisch,K. ; Jeanrond,E. ; Pang,P. C. ; Pich,A. ; Schuler,G. ; Dantzer,V. ; Kowalewski,M. P. ; Dell,A.
A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins
England,Glycobiology,2008;18(1):42-52
10.1093/glycob/cwm113
Originalpublikation

Kühnel,T. S. ; Schulte-Mattler,W. ; Bigalke,H. ; Wohlfarth,K.
Treatment of habitual snoring with botulinum toxin: a pilot study ,,Sleep Breath,2008;12(1):63-68
10.1007/s11325-007-0136-8
Originalpublikation

Muetzelburg,M. V. ; Hofmann,F. ; Just,I. ; Pich,A.
Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis ,,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2009;877(13):1344-1351
10.1016/j.jchromb.2008.12.005
Originalpublikation 

Neumann,D. ; Kollewe,C. ; Pich,A. ; Cao,P. ; Resch,K. ; Martin,M. U.
Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation
United States,J.Leukoc.Biol.,2008;84(3):807-813
10.1189/jlb.0507290
Originalpublikation

Sander,L. E. ; Frank,S. P. ; Bolat,S. ; Blank,U. ; Galli,T. ; Bigalke,H. ; Bischoff,S. C. ; Lorentz,A.
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells
Germany,Eur.J.Immunol.,2008;38(3):855-863
10.1002/eji.200737634
Originalpublikation

Schulte-Baukloh,H. ; Bigalke,H. ; Miller,K. ; Heine,G. ; Pape,D. ; Lehmann,J. ; Knispel,H. H.
Botulinum neurotoxin type A in urology: antibodies as a cause of therapy failure
Australia,Int.J.Urol.,2008;15(5):407-15; discussion 415
10.1111/j.1442-2042.2008.02016.x
Originalpublikation

Stolz,A. ; Haines,N. ; Pich,A. ; Irvine,K. D. ; Hokke,C. H. ; Deelder,A. M. ; Gerardy-Schahn,R. ; Wuhrer,M. ; Bakker,H.
Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis
United States,Glycoconj.J.,2008;25(2):167-175
10.1007/s10719-007-9069-5
Originalpublikation

Tschernig,T. ; Neumann,D. ; Pich,A. ; Dorsch,M. ; Pabst,R.
Experimental bronchial asthma - the strength of the species rat
Netherlands,Curr.Drug Targets,2008;9(6):466-469
Originalpublikation

Conrad S, Genth H, Hofmann F, Just I, Skutella T.
Neogenin-RGMa signaling at the growth cone Is BMP-independent and involves RhoA, rock and PKC.
J Biol Chem 2007;282(22);16423-33
Abstract

Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS.
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.
Blood 2007;109(3);1248-1256
Abstract

Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,Schmitt-Kopplin P, Schiffer E.
Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry.
Proteomics 2007;1(7);650-60
Abstract

Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H.
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470.
Inf Immun 2007;75(2);801-809
Abstract

Huelsenbeck J, Dreger S, Gerhard R, Fritz G, Just I, Genth H.
Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile.
Biochemistry 2007;24;46(16);4923-31
Abstract

Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT.
Neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
Biochemistry 2007;46;10685-93
Abstract

Klisch K, Jeanrond E, Pang PC, Pich A, Schuller G, Dantzer V, Kowalewski MP, Dell A.
A tetraantennary glycan with bisecting N-Acetylglucosamine and Sda antigen is the predominant N-glycan on bovine Pregnancy-associated glycoproteins.
Glycobiology 2008;18(1);42-52; Epub 2007
Abstract

Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R.
Clostridium difficile Toxin A and B directly stimulate human mast cells.
Inf Immun 2007;21(5)
Abstract

Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R.
Apoptosis induced by Clostridium difficile Toxin A is p53-independent and tiggered by glucosylation of Rho GTPases.
Apoptosis 2007;12(8);1443-53
Abstract

Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
Identification of the receptor binding site of botulinum neurotoxins B and G proves the double receptor concept.
PNAS 2007;104;359-364
Abstract

Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H.
Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycospingolipid biosynthesis.
Glycoconj J 2008;25(2);167-75; Epub 2007
Abstract

Foster K, Bigalke H, Aoki R.
Botulinum Neurotoxin - From Laboratory to Bedside
Neurotoxicity Research 2006;9;133-140
Abstract

Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R.
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.
FEBS Lett 2006;580;3565-3569
Abstract

Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K.
Cholesterol-dependent pore formation of Clostridium difficile toxin A.
J Biol Chem 2006;281;10808-10815
Abstract

Jin R, Rummel A, Binz T, Brunger AT.
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Nature 2006;444;1092-1095
Abstract

Lee SH, Bigalke H.
Botulinumtoxin – Pharmakologie, Sicherheit und sekundäre Non-Response durch Antikörper
Neuropädiatrie in Klinik und Praxis 2006;5;52-56
Übersicht

Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T.
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
FEBS Lett 2006;Apr3;580(8);2011-4
Abstract

Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal G.S.
Localization of the C3-like ADP-ribosyltransferase from Staphylococcus aureus during baterial invasion of mammalian cells.
Inf Immun 2006;74;3673-3677
Abstract

Rosales RL, Bigalke H, Dressler D.
Pharmacology of botulinum toxin: differences between type A preparations.
Eur J Neurol; 2006;13;2-10
Abstract

Schröder O, Gerhard R, Stein J.
Antibiotic-associated diarrhea
Diarrhö Z Gastroenterol 2006;44(2);193-204
Abstract

Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter, P.
High resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer.
Clin Cancer Res 2006;12;345-52
Abstract

Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R.
Application of mutated Clostridium difficile toxin A for determination of Glucosyltransferase-dependent effects.
Inf Immun 2006;74(10);6006-6010
Abstract

Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF.
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.
Lancet Oncol 2006;7(3);230-40
Abstract

Traub F, Jost M, Hess R, Schorn K, Menzel C, Budde P, Schulz-Knappe P, Lamping N, Pich A, Kreipe H, Tammen H.
Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas.
Lab Invest 2006;86;246-253
Abstract

Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzig M, Neusüß C, Theodorescu D, Root KE, Ross MM, Mischak H.
Biomarker discovery by CE.MS enables sequences analysis via MS/MS with platform-independent separation.
Electrophoresis 2006;27(11);2111-21125
Abstract

Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K.
Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells.
J Biol Chem. 2001 Apr 6; 276(14): 10670-6.
Abstract 

Bigalke H, Wohlfarth K, Irmer A, Dengler R.
Botulinum A toxin: Dysport improvement of biological availability.
Exp Neurol. 2001 Mar;168(1):162-70.
Abstract

Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M.
Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression.
Eur J Immunol. 2001 May; 31(5): 1610-9.
Abstract 

Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H.
Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
Infect Immun. 2001 Oct;69(10):6004-11.
Abstract

Just I, Hofmann F, Genth H, Gerhard R.
Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins.
Int J Med Microbiol. 2001 Sep;291(4):243-50.
Abstract

Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W.
An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
J Biol Chem. 2001 Jun 8; 276(23): 20451-7.
Abstract 

Rollnik JD, Wohlfarth K, Dengler R, Bigalke H.
Neutralizing botulinum toxin type a antibodies: clinical observations in patients with cervical dystonia.
Neurol Clin Neurophysiol. 2001;2001(3):2-4.
Abstract

Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K.
Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress.
Pflugers Arch. 2001 Aug;442(5):675-87.
Abstract

Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S.
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O.
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3185-90.
Abstract 

Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I.
A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.
J Biol Chem 2001 Mar 23;276(12):9537-42
Abstract 

Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO.
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
FASEB J. 2001 Aug;15(10):1753-63.
Abstract 

Bigalke H.
Neuromuskuläre Verbindung – Präsynaptisches Terminal.
Klin. Neurophysiol 2000;31;115-121

Busch C, Hofmann F, Gerhard R, Aktories K.
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.
J Biol Chem. 2000 May 5;275(18):13228-34.
Abstract 

Busch C, Schömig K, Hofmann F, Aktories K.
Characterization of the catalytic domain of Clostridium novyi alpha-toxin.
Infect Immun. 2000 Nov;68(11):6378-83.
Abstract 

Dressler D, Bigalke H, Rothwell JC.
The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans.
J Neurol. 2000 Aug;247(8):630-2.
Abstract

Dressler D, Dirnberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD.
Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay.
Mov Disord. 2000 Sep;15(5):973-6.
Abstract 

Dressler D, Zettl U, Benecke R, Bigalke H.
Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure?
Mov Disord. 2000 Nov;15(6):1279-81.
Abstract 

Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P.
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.
EMBO J. 2000 Dec 1;19(23):6361-70.
Abstract 

Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I.
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.
Infect Immun. 2000 Mar;68(3):1094-101.
Abstract 

Just I, Boquet P
Large clostridial cytotoxins as tools in cell biology.
Curr Top Microbiol Immunol 2000;250;97-107
Review

Just I, Hofmann F, Aktories K 
Molecular mode of action of the large clostridial cytotoxins.
Curr Top Microbiol Immunol 2000;250;55-83
Review

Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T.
Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin
Histochem Cell Biol. 2000 Nov;114(5):387-91.
Abstract 

Linseman DA, Hofmann F, Fisher SK.
A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase.
J Neurochem. 2000 May;74(5):2010-20.
Abstract 

Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W.
Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.
J Neurosci. 2000 Sep 15;20(18):6743-51.
Abstract 

Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M.
Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C.
Blood. 2000 Oct 1;96(7):2592-8.
Abstract 

Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H.
Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study.
Abstract 

Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I.
Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin.
J Mol Biol. 2000 Sep 1;301(5):1091-5.
Abstract 

Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M.
Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.
Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9.
Abstract 

Wilde C, Genth H, Aktories K, Just I.
Recognition of RhoA by Clostridium botulinum C3 exoenzyme.
J Biol Chem. 2000 Jun 2;275(22):16478-83.
Abstract

Feick P, Gilhaus S, Blum R, Hofmann F, Just I, Schulz I.
Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity.
FEBS Lett. 1999 May 28;451(3):269-74.
Abstract 

Fritz G, Just I, Kaina B.
Rho GTPases are over-expressed in human tumors.
Int J Cancer. 1999 May 31;81(5):682-7.
Abstract 

Genth H, Aktories K, Just I.
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling.
J Biol Chem. 1999 Oct 8;274(41):29050-6.
Abstract 

Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G.
SNARE proteins and rab3A contribute to canalicular formation in parietal cells.
Eur J Cell Biol. 1999 Nov;78(11):779-86.
Abstract 

Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK.
Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA.
Br J Pharmacol. 1999 Jul;127(5):1060-3.
Abstract 

Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, Hochman J, Wellhoner H.
Isolation, characterization and synthesis of a novel paradaxin isoform.
FEBS Lett. 1998 Sep 18;435(2-3):173-7.
Abstract 

Barth H, Hofmann F, Olenik C, Just I, Aktories K.
The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin.
Infect Immun. 1998 Apr;66(4):1364-9.
Abstract 

Barth H, Preiss JC, Hofmann F, Aktories K.
Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis.
J Biol Chem. 1998 Nov 6;273(45):29506-11.
Abstract 

Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I.
Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli.
Infect Immun. 1998 Apr;66(4):1755-8.
Abstract 

Boquet P, Munro P, Fiorentini C, Just I.
Toxins from anaerobic bacteria: speficity and molecular mechanism of action.
Curr Opinion Microbiol 1998;1;66-74
Abstract

Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K.
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins.
J Biol Chem. 1998 Jul 31;273(31):19566-72.
Abstract 

Gerhard R, Schmidt G, Hofmann F, Aktories K.
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells.
Infect Immun. 1998 Nov;66(11):5125-31.
Abstract 

Herrmann C, Ahmadian MR, Hofmann F, Just I.
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.
J Biol Chem. 1998 Jun 26;273(26):16134-9.
Abstract 

Hofmann F, Busch C, Aktories K.
Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition.
Infect Immun. 1998 Mar;66(3):1076-81.
Abstract 

Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G.
Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins.
J Physiol. 1998 Jan 1;506 ( Pt 1):83-93.
Abstract 

Naumann M, Toyka KV, Mansouri Taleghani B, Ahmadpour J, Reiners K, Bigalke H.
Depletion of neutralising antibodies resensitises a secondary non-responder to botulinum A neurotoxin.
J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):924-7.
Abstract 

Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, Hochman J, Wellhoner H.
Translocation of acylated pardaxin into cells.
FEBS Lett. 1998 Nov 27;440(1-2):131-4.
Abstract 

Reiser CO, Lanz T, Hofmann F, Hofer G, Rupprecht HD, Goppelt-Struebe M.
Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins.
Biochem J. 1998 Mar 15;330 ( Pt 3):1107-14.
Abstract 

Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG.
Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin.
Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):385-92.
Abstract 

Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K.
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.
Biochemistry. 1998 Apr 14;37(15):5296-304.
Abstract 

Wohlfarth K, Goeschel H, Frevert J, Dengler R, Bigalke H.
Dose standardisation of botulinum toxin: Reply.
Mov Disord. 1998, 13, 750-751.
Abstract

Goschel, H., Wohlfarth, K., Frevert, J., Dengler, R., Bigalke, H.
Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies - therapeutic consequences.
Exp. Neurol. 147, 1997, 96-102.
Abstract

Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krüll, M., Just, I., Aktories, K., von Eichel-Streiber, C., Suttorp, N.
Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function.
Am. J. Physiol. 1997, 272, L38-L43.
Abstract

Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K.
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin.
J. Biol. Chem. 1997, 272, 11074-11078.
Abstract

Olenik, C., Barth, H., Just, I., Aktories, K., Meyer, D.K.
Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain.
Mol. Brain Res. 1997, 52, 272-279.
Abstract

Otto, B., Steusloff, A., Just, I., Aktories, K., Pfitzer, G.
Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle.
J. Physiol. (Lond.), 1997, 496, 317-329.
Abstract

Verschueren, H., de Baetselier, P., de Braekeleer, J., Dewitt, J., Aktories, K., Just, I.
ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells.
Eur. J. Cell Biol. 1997, 73, 182-187.
Abstract

Wohlfarth, K., Goschel, H., Frevert, J., Dengler, R., Bigalke, H.
Botulinum A toxins: units versus units.
Naunyn Schmiedebergs Arch. Pharmacol. 1997, 355, 335-40.
Abstract