Begou,O., Drabert,K., Theodoridis,G., Tsikas,D.
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
J.Pharm.Anal.,2020;10(1):49-59
http://dx.doi.org/10.1016/j.jpha.2019.11.006
Originalpublikation 

 

Bollenbach,A., Gambaryan,S., Mindukshev,I., Pich,A., Tsikas,D.
GC-MS and LC-MS/MS pilot studies on the guanidine (N(G))-dimethylation in native, asymmetrically and symmetrically N(G)-dimethylated arginine-vasopressin peptides and proteins in human red blood cells
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2020;1141():122024-
http://dx.doi.org/10.1016/j.jchromb.2020.122024
Originalpublikation

 

Bollenbach,A., Schutte,A. E., Kruger,R., Tsikas,D.
An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies 
J.Clin.Med.,2020;9(3):844.-
http://dx.doi.org/10.3390/jcm9030844
Originalpublikation 

 

Bollenbach,A., Tsikas,D.
Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry
Anal.Biochem.,2020;():-
http://dx.doi.org/10.1016/j.ab.2020.113841
Originalpublikation

 

Brinkmann,F., Hanusch,B., Ballmann,M., Mayorandan,S., Bollenbach,A., Chobanyan-Jürgens,K., Jansen,K., Schmidt-Choudhury,A., Derichs,N., Tsikas,D., Lücke,T.
Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results,
J.Clin.Med.,2020;9(6):E2012 [pii]-
http://dx.doi.org/10.3390/jcm9062012
Originalpublikation

 

Craig,A., Mels,C. M. C., Schutte,A. E., Bollenbach,A., Tsikas,D., Schwedhelm,E., Kruger,R.
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
Hypertens.Res.,2020;():-
http://dx.doi.org/10.1038/s41440-020-0514-1
Originalpublikation

 

Craig,A., Mels,C. M. C., Schutte,A. E., Tsikas,D., Kruger,R.
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
Amino Acids,2020;52(4):639-648
http://dx.doi.org/10.1007/s00726-020-02842-3
Originalpublikation

 

Cseko,K., Pecsi,D., Kajtar,B., Hegedus,I., Bollenbach,A., Tsikas,D., Szabo,I. L., Szabo,S., Helyes,Z.
Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target
Int.J.Mol.Sci.,2020;21(16):E5591 [pii]-
http://dx.doi.org/10.3390/ijms21165591
Originalpublikation

 

Jansen,K., Hanusch,B., Pross,S., Hanff,E., Drabert,K., Bollenbach,A., Dugave,I., Carmann,C., Siefen,R. G., Emons,B., Juckel,G., Legenbauer,T., Tsikas,D., Lücke,T. 
Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate 
J.Clin.Med.,2020;9(1):pii: E175-
http://dx.doi.org/10.3390/jcm9010175
Originalpublikation 

 

Jansing,J. C., Fiedler,J., Pich,A., Viereck,J., Thum,T., Mühlfeld,C., Brandenberger,C.
miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury
Int.J.Mol.Sci.,2020;21(3):E822-
http://dx.doi.org/10.3390/ijms21030822 
Originalpublikation 

 

Kedia,G. T., Ückert,S., Tsikas,D., Becker,A. J., Kuczyk,M. A., Bannowsky,A.
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts 
J.Clin.Med.,2020;9(9):E2987-
http://dx.doi.org/10.3390/jcm9092987
Übersicht 

 

Melzer,C., Jacobs,R., Dittmar,T., Pich,A., von der Ohe,J., Yang,Y., Hass,R.
Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line 
Int.J.Mol.Sci.,2020;21(13):E4752.-
http://dx.doi.org/10.3390/ijms21134752
Originalpublikation 

 

Neu,A., Hornig,S., Sasani,A., Isbrandt,D., Gerloff,C., Tsikas,D., Schwedhelm,E., Choe,C. U.
Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
Amino Acids,2020;52(6-7):1067-1069
http://dx.doi.org/10.1007/s00726-020-02865-w
Letter

 

Tsikas,D.
Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond ,Switzerland,J.Clin.Med.,2020;9(6):-
http://dx.doi.org/10.3390/jcm9061843
Übersicht 

 

Yepes-Calderon,M., Sotomayor,C. G., Gans,R. O. B., Berger,S. P., Leuvenink,H. G. D., Tsikas,D., Rodrigo,R., Navis,G. J., Bakker,S. J. L.
Post-transplantation plasma malondialdehyde is associated with cardiovascular mortality in renal transplant recipients: a prospective cohort study 
Nephrol.Dial.Transplant.,2020;35(3):512-519
http://dx.doi.org/10.1093/ndt/gfz288
Originalpublikation 

Bogutzki,A., Naue,N., Litz,L., Pich,A., Curth,U.
E. coli primase and DNA polymerase III holoenzyme are able to bind concurrently to a primed template during DNA replication.
Sci.Rep.2019;9(1):14460-
http://dx.doi.org/10.1038/s41598-019-51031-0
Originalpublikation 

 

Bollenbach,A., Bakker,S. J. L., Tsikas,D.
GC-MS measurement of biological N(G)-hydroxy-L-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor
Amino Acids,2019;51(4):627-64
http://dx.doi.org/10.1007/s00726-018-02695-x
Originalpublikation 

 

Bollenbach,A., Cordts,K., Hanff,E., Atzler,D., Choe,C. U., Schwedhelm,E., Tsikas,D.
Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans 
Anal.Biochem.,2019;577():59-66
http://dx.doi.org/10.1016/j.ab.2019.04.019
Originalpublikation

 

Bollenbach,A., Hanff,E., Brunner,G., Tsikas,D.
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection
Amino Acids,2019;51(6):961-971
http://dx.doi.org/10.1007/s00726-019-02737-y
Originalpublikation

 

Bollenbach,A., Huneau,J. F., Mariotti,F., Tsikas,D.
Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men
Nutrients,2019;11(7):E1463-
http://dx.doi.org/10.3390/nu11071463
Originalpublikation

 

Bollenbach,A., Tsikas,D., Lenzen,S., Jörns,A.
Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-alpha antibody-based therapy
Amino Acids,2020;52(1):103-110
http://dx.doi.org/10.1007/s00726-019-02811-5
Originalpublikation

 

Erdmann,J., Thöming,J. G., Pohl,S., Pich,A., Lenz,C., Häussler,S.
The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates
Cells,2019;8(10):E1129 [pii]-
http://dx.doi.org/10.3390/cells8101129
Originalpublikation

 

Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M., Trogisch,F. A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M., Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A., Remedios,C. D., Riechert,E., Völkers,M., Doroudgar,S., Jungmann,A., Bauer,R., Yin,X., Mayr,M., Wollert,K. C., Pich,A., Xiao,H., Katus,H. A., Bauersachs,J., Müller,O. J., Heineke,J.
TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
EMBO Mol.Med.,2019;11(10):e10018-
http://dx.doi.org/10.15252/emmm.201810018
Originalpublikation

 

Hanff,E., Bollenbach,A., Beckmann,B., Brunner,G., Tsikas,D.
GC-MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine
Amino Acids,2020;52(2):225-234
http://dx.doi.org/10.1007/s00726-019-02786-3
Originalpublikation

 

Hanff,E., Ruben,S., Kreuzer,M., Bollenbach,A., Kayacelebi,A. A., Das,A. M., von Versen-Höynck,F., von Kaisenberg,C., Haffner,D., Ückert,S., Tsikas,D.
Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity
Amino Acids,2019;51(3):529-547
http://dx.doi.org/10.1007/s00726-018-02688-w
Originalpublikation 

 

Hanff,E., Said,M. Y., Kayacelebi,A. A., Post,A., Minovic,I., van den Berg,E., de Borst,M. H., van Goor,H., Bakker,S. J. L., Tsikas,D.
High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients
Amino Acids,2019;51(10-12):1485-1499
http://dx.doi.org/10.1007/s00726-019-02783-6
Originalpublikation

 

Ho,G. T., Heinen,F. J., Blasczyk,R., Pich,A., Bade-Doeding,C.
HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint
Int.J.Mol.Sci.,2019;20(22):E5572.-
http://dx.doi.org/10.3390/ijms20225572
Originalpublikation 

 

Kluge,A., Rangrez,A. Y., Kilian,L. S., Pott,J., Bernt,A., Frauen,R., Rohrbeck,A., Frey,N., Frank,D.
Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy
J.Mol.Cell.Cardiol.,2019;129():130-143
http://dx.doi.org/10.1016/j.yjmcc.2019.01.028
Originalpublikation 

 

Kutschenko,A., Weisemann,J., Kollewe,K., Fiedler,T., Alvermann,S., Böselt,S., Escher,C., Garde,N., Gingele,S., Kaehler,S. B., Karatschai,R., Krüger,T. H. C., Sikorra,S., Tacik,P., Wegner,F., Wollmann,J., Bigalke,H., Wohlfarth,K., Rummel,A.
Botulinum neurotoxin serotype D - A potential treatment alternative for BoNT/A and B non-responding patients
Clin.Neurophysiol.,2019;130(6):1066-1073
http://dx.doi.org/10.1016/j.clinph.2019.02.007
Originalpublikation

 

Nebl,J., Drabert,K., Haufe,S., Wasserfurth,P., Eigendorf,J., Tegtbur,U., Hahn,A., Tsikas,D.
Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns
Nutrients,2019;11(8):E1875-
http://dx.doi.org/10.3390/nu11081875
Originalpublikation

 

Pich,A., Junemann,J., Stieglitz,F., Schweitzer,T.
Clostridioides difficile-Toxine verändern das Proteom von Darmzellen
BIOspektrum,2019;25(6):633-636
http://dx.doi.org/10.1007/s12268-019-0213-0
Originalpublikation

 

Post,A., Said,M. Y., Gomes-Neto,A. W., van der Krogt,J., de Blaauw,P., Berger,S. P., Geleijnse,J. M., Borgonjen,K., van den Berg,E., van Goor,H., Rimbach,G., Kema,I. P., Tsikas,D., Heiner-Fokkema,M. R., Bakker,S. J. L.
Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients
Nutrients,2019;11(9):E2212-
http://dx.doi.org/10.3390/nu11092212
Originalpublikation

 

Post,A., Tsikas,D., Bakker,S. J. L.
Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review
Nutrients,2019;11(5):E1044-
http://dx.doi.org/10.3390/nu11051044
Übersicht

 

Rahardjo,H. E., Ückert,S., Tsikas,D., Hedlund,P., Bannowsky,A., Kuczyk,M. A., Kedia,G. T.
Arginase enzymes in the human prostate: A molecular biological and immunohistochemical approach
Andrologia,2019;51(9):e13349-
http://dx.doi.org/10.1111/and.13349
Originalpublikation

 

Said,M. Y., Bollenbach,A., Minovic,I., van Londen,M., Frenay,A. R., de Borst,M. H., van den Berg,E., Kayacelebi,A. A., Tsikas,D., van Goor,H., Navis,G., Bakker,S. J. L.
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients
Amino Acids,2019;51(6):913-927
http://dx.doi.org/10.1007/s00726-019-02725-2
Originalpublikation

 

Said,M. Y., Douwes,R. M., van Londen,M., Minovic,I., Frenay,A. R., de Borst,M. H., van den Berg,E., Heiner-Fokkema,M. R., Kayacelebi,A. A., Bollenbach,A., van Goor,H., Navis,G., Tsikas,D., Bakker,S. J. L.
Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants
Amino Acids,2019;51(3):565-575
http://dx.doi.org/10.1007/s00726-018-02693-z
Originalpublikation 

 

Sasani,A., Hornig,S., Grzybowski,R., Cordts,K., Hanff,E., Tsikas,D., Böger,R., Gerloff,C., Isbrandt,D., Neu,A., Schwedhelm,E., Choe,C. U.
Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure
Amino Acids,2020;52(1):73-85
http://dx.doi.org/10.1007/s00726-019-02812-4
Originalpublikation

 

Schoenherr,C., Wohlan,K., Dallmann,I., Pich,A., Hegermann,J., Ganser,A., Hilfiker-Kleiner,D., Heidenreich,O., Scherr,M., Eder,M.
Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
PLoS One,2019;14(12):e0225977-
http://dx.doi.org/10.1371/journal.pone.0225977
Originalpublikation 

 

Simper,G. S., Gräser,L. S., Celik,A. A., Kuhn,J., Kunze-Schumacher,H., Ho,G. T., Blasczyk,R., Pich,A., Bade-Doeding,C.
The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
Pharmaceutics,2019;11(10):pii: E536-
http://dx.doi.org/10.3390/pharmaceutics11100536
Originalpublikation

 

Sonnenschein,K., Fiedler,J., Pfanne,A., Just,A., Mitzka,S., Geffers,R., Pich,A., Bauersachs,J., Thum,T.
Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury Cardiovasc.Res.,2019;115(12):1804-1810
http://dx.doi.org/10.1093/cvr/cvz063
Originalpublikation 

 

Tao,L., Tian,S., Zhang,J., Liu,Z., Robinson-McCarthy,L., Miyashita,S. I., Breault,D. T., Gerhard,R., Oottamasathien,S., Whelan,S. P. J., Dong,M.
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Nat.Microbiol.,2019;4(10):1760-1769
http://dx.doi.org/10.1038/s41564-019-0464-z
Originalpublikation 

 

Tsikas,D., Bollenbach,A., Hanff,E., Beckmann,B., Redfors,B.
Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat
Amino Acids,2020;52(2):235-245
http://dx.doi.org/10.1007/s00726-019-02808-0
Originalpublikation

 

Ückert,S., Kedia,G. T., Tsikas,D., Simon,A., Bannowsky,A., Kuczyk,M. A.
Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate,Germany,World J.Urol.,2020;38(6):1423-1435
http://dx.doi.org/10.1007/s00345-019-02933-1
Übersicht

 

von Berg,L., Stern,D., Pauly,D., Mahrhold,S., Weisemann,J., Jentsch,L., Hansbauer,E. M., Müller,C., Avondet,M. A., Rummel,A., Dorner,M. B., Dorner,B. G.
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
Sci.Rep.,2019;9(1):5531-
http://dx.doi.org/10.1038/s41598-019-41722-z
Originalpublikation 

 

von Berg,L., Stern,D., Weisemann,J., Rummel,A., Dorner,M. B., Dorner,B. G.
Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments
Toxins (Basel),2019;11(10):E588-
http://dx.doi.org/10.3390/toxins11100588
Originalpublikation 

 

Welz,B., Bikker,R., Junemann,J., Christmann,M., Neumann,K., Weber,M., Hoffmeister,L., Preuss,K., Pich,A., Huber,R., Brand,K.
Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes
Int.J.Mol.Sci.,2019;20(5):E1241-
http://dx.doi.org/10.3390/ijms20051241
Originalpublikation

 

Wieczorek-Surdacka,E., Hanff,E., Chyrchel,B., Kuzniewski,M., Surdacki,A., Tsikas,D.
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease
Amino Acids,2019;51(6):977-982
http://dx.doi.org/10.1007/s00726-019-02738-x
Originalpublikation

 

Zeleny,R., Rummel,A., Jansson,D., Dorner,B. G.
Challenges in the Development of Reference Materials for Protein Toxins. In: Applications in Forensic Proteomics: Protein Identification and Profiling 2019; 1339: 185-202 
http://dx.doi.org/doi:10.1021/bk-2019-1339.ch012
Buchbeitrag, Monografie

Abere,B., Samarina,N., Gramolelli,S., Rückert,J., Gerold,G., Pich,A.,Schulz,T. F.
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2alpha To Activate Productive Viral Replication
J.Virol. 2018; 92(17):e00544-18-
Originalpublikation
http://dx.doi.org/10.1128/JVI.00544-18

 

Adolf,A., Rohrbeck,A., Münster-Wandowski,A., Johansson,M., Kuhn,H. G., Kopp,M. A., Brommer,B., Schwab,J. M., Just,I., Ahnert-Hilger,G., Höltje,M.,
Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons.
Glia 2019; 67(4):703-717
Originalpublikation
http://dx.doi.org/10.1002/glia.23566

 

Aye,R., Weldearegay,Y. B., Lutta,H. O., Chuma,F., Pich,A., Jores,J., Meens,J., Naessens,J. 
Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides.
Vet.Immunol.Immunopathol. 2018; 204(11-18)
Originalpublikation
http://dx.doi.org/10.1016/j.vetimm.2018.09.002

 

Beer,L. A., Tatge,H., Reich,N., Tenspolde,M., Olling,A., Goy,S., Rottner,K., Alekov,A. K., Gerhard,R. 
Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate.
Cell.Microbiol. 2018; 20(10):e12865-
Originalpublikation
http://dx.doi.org/10.1111/cmi.12865

 

Beer,L. A., Tatge,H., Schneider,C., Ruschig,M., Hust,M., Barton,J., Thiemann,S., Fühner,V., Russo,G., Gerhard,R. 
The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains.
Toxins (Basel) 2018; 10(6):E225-
Originalpublikation
http://dx.doi.org/10.3390/toxins10060225

 

Bollenbach,A., Hanff,E., Beckmann,B., Kruger,R., Tsikas,D.,
GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index.
Anal.Biochem. 2018; 556(40-44)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.06.021

 

Bollenbach,A., Hanff,E., Tsikas,D. 
Investigation of N(G)-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1100-1101(174-178)
Originalpublikation
http://dx.doi.org/10.1016/j.jchromb.2018.10.007

 

Bollenbach,A., Hanff,E., Tsikas,D. 
Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
Anal.Biochem. 2018; 563(67-70)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.10.012

 

Bollenbach,A., Tsikas,D. 
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N(G)-hydroxy-L-arginine, N(omega),N(omega)-dimethyl-L-citrulline and N(omega),N(omega)-dimethyl-N(delta)-hydroxy-L-citrulline: results and overview.
Amino Acids 2019; 51(3):483-494
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2684-6

 

Chung,S. Y., Schöttelndreier,D., Tatge,H., Fühner,V., Hust,M., Beer,L. A., Gerhard,R. 
The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
Front.Microbiol. 2018; 9(2314-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.02314

 

Erdmann,J., Preusse,M., Khaledi,A., Pich,A., Häussler,S. 
Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa.
Environ.Microbiol. 2018; 20(11):3952-3963
Originalpublikation
http://dx.doi.org/10.1111/1462-2920.14419

 

Finkel,A., Röhrich,M. A., Maassen,N., Lützow,M., Blau,L. S., Hanff,E., Tsikas,D., Maassen,M., Long-term effects of NO3(-) on the relationship between oxygen uptake and power after 3 weeks of supplemented HIHV training
J.Appl.Physiol.(1985) 2018; 125(6):1997-2007
Originalpublikation
http://dx.doi.org/10.1152/japplphysiol.00176.2018

 

Fischer,V., Dudzinska,A., Just,I. 
The impact of the program structure at Hannover Medical School on academic success in medical studies
GMS J.Med.Educ. 2018; 35(2):Doc22-
Originalpublikation
http://dx.doi.org/10.3205/zma001169

 

Genth,H., Junemann,J., Lämmerhirt,C. M., Lücke,A. C., Schelle,I., Just,I., Gerhard,R., Pich,A. 
Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
Front.Microbiol. 2018; 9(3078-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.03078

   

Hanff,E., Hafner,P., Bollenbach,A., Bonati,U., Kayacelebi,A. A., Fischer,D., Tsikas,D.
Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications
Amino Acids 2018; 50(10):1391-1406
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2614-7

 

Hanff,E., Zinke,M., Böhmer,A., Niebuhr,J., Maassen,M., Endeward,V., Maassen,N., Tsikas,D.
GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV
Anal.Biochem. 2018; 550(132-136)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.05.001

 

Junemann,J., Just,I., Gerhard,R., Pich,A.
Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells
Front.Microbiol. 2018; 9(3083-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.03083

 

Just,I., Fischer,V.
Prüfungen an der Medizinischen Hochschule Hannover - Wie kommt man vom Ist zum Soll?
Wien.Med.Wochenschr. 2019; 169(5-6):119-125
Originalpublikation
http://dx.doi.org/10.1007/s10354-018-0663-x

 

Lam,K. H., Sikorra,S., Weisemann,J., Maatsch,H., Perry,K., Rummel,A., Binz,T., Jin,R.
Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA
Pathog.Dis. 2018; 76(4):10.1093/femspd/fty044-
Originalpublikation
http://dx.doi.org/10.1093/femspd/fty044

 

Mehner-Breitfeld,D., Rathmann,C., Riedel,T., Just,I., Gerhard,R., Overmann,J., Brüser,T.
Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile
Front.Microbiol. 2018; 9(2446-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.02446

 

Montag,J., Kowalski,K., Makul,M., Ernstberger,P., Radocaj,A., Beck,J., Becker,E., Tripathi,S., Keyser,B., Mühlfeld,C., Wissel,K., Pich,A., van der Velden,J., Dos Remedios,C. G., Perrot,A., Francino,A., Navarro-Lopez,F., Brenner,B., Kraft,T.
Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
Front.Physiol. 2018; 9(359-
Originalpublikation
http://dx.doi.org/10.3389/fphys.2018.00359

 

Rahardjo,H. E., Ückert,S., Bannowsky,A., Tsikas,D., Becker,A. J., Kuczyk,M. A.
Course of transforming growth factor ss1 in the systemic and cavernous blood of healthy males through different penile conditions
Andrologia 2019; 51(1):e13150-
Originalpublikation
http://dx.doi.org/10.1111/and.13150

 

Schöttelndreier,D., Seeger,K., Grassl,G. A., Winny,M. R., Lindner,R., Genth,H.
Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
Front.Microbiol. 2018; 9(1483-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.01483

 

Schröder,A., Benski,A., Oltmanns,A., Just,I., Rohrbeck,A., Pich,A.
MS-based quantification of RhoA/B and RhoC ADP-ribosylation
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1092(268-271)
Originalpublikation 
http://dx.doi.org/S1570-0232(18)30604-4

 

Shahin,P., Rahardjo,H. E., Bannowsky,A., Tsikas,D., Sohn,M., Kuczyk,M. A., Ückert,S.
Endopeptidase inhibition attenuates the contraction induced by big endothelin-1 of isolated human penile erectile tissue
Andrologia 2018; 50(5):e13008-
Originalpublikation
http://dx.doi.org/10.1111/and.13008

 

Sikorra,S., Skiba,M., Dorner,M. B., Weisemann,J., Weil,M., Valdezate,S., Davletov,B., Rummel,A., Dorner,B. G., Binz,T.
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)(-)K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
Toxins (Basel) 2018; 10(8):E311-
Originalpublikation
http://dx.doi.org/10.3390/toxins10080311

 

Stern,D., Weisemann,J., Le Blanc,A., von Berg,L., Mahrhold,S., Piesker,J., Laue,M., Luppa,P. B., Dorner,M. B., Dorner,B. G., Rummel,A.
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
PLoS Pathog. 2018; 14(5):e1007048-
Originalpublikation
http://dx.doi.org/10.1371/journal.ppat.1007048

 

Tan,X., Xu,A., Zhao,T., Zhao,Q., Zhang,J., Fan,C., Deng,Y., Freywald,A., Genth,H., Xiang,J.,
Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
Sci.Rep. 2018; 8(1):3769-
Originalpublikation
http://dx.doi.org/10.1038/s41598-018-20459-1

 

Tsikas,D.,
Bioanalytical method validation of endogenous substances according to guidelines by the FDA and other organizations: Basic need to specify concentration ranges
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1093-1094(80-81)
Letter
http://dx.doi.org/10.1016/j.jchromb.2018.07.005

 

Tsikas,D., Bollenbach,A., Hanff,E., Kayacelebi,A. A.
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes
Cardiovasc.Diabetol. 2018; 17(1):1-
Comment
http://dx.doi.org/10.1186/s12933-017-0656-x

 

Tsikas,D., Hanff,E.
Measurement of S -Nitrosoglutathione in Plasma by Liquid Chromatography-Tandem Mass Spectrometry Methods
Mol.Biol. 2018; 1747(113-129
Originalpublikation
http://dx.doi.org/10.1007/978-1-4939-7695-9_10

 

Tsikas,D., Hanff,E., Bollenbach,A., Kruger,R., Pham,V. V., Chobanyan-Jürgens,K., Wedekind,D., Arndt,T., Jörns,A., Berbee,J. F. P., Princen,H. M. G., Lücke,T., Mariotti,F., Huneau,J. F., Ückert,S., Frölich,J. C., Lenzen,S.,
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
Amino Acids 2018; 50(7):799-821
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2573-z

 

Wolling,H., Konze,S. A., Höfer,A., Erdmann,J., Pich,A., Zweigerdt,R., Buettner,F. F. R.,
Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis
Proteomics 2018; 18(14):e1800102-
Originalpublikation
http://dx.doi.org/10.1002/pmic.201800102

Zhao,T., Li,R., Tan,X., Zhang,J., Fan,C., Zhao,Q., Deng,Y., Xu,A., Lukong,K. E., Genth,H., Xiang,J.,
Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-kappaB and ERK1/2 Pathways
Int.J.Mol.Sci. 2018; 19(7):E1994-
Originalpublikation
http://dx.doi.org/10.3390/ijms19071994

Buck A, Kayacelebi A A, Chobanyan-Jürgens K, Illsinger S, Bohnhorst B, Beckmann B, Hanff E, Das A M, Tsikas D, Lücke T

Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth.

Amino Acids 2017; 49(4):783-794
Originalpublikation
Volltext
 
Debez A, Belghith I, Pich A, Taamalli W, Abdelly C, Braun H P

High salinity impacts germination of the halophyte Cakile maritima but primes seeds for rapid germination upon stress release.

Physiol. Plant. 2017, ppl.12679-
Originalpublikation
Volltext
  
Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A

Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.

Proteomics 2017; 17(15-16):1600435-

Originalpublikation
Volltext
  
Fischer V, Just I

Qualitätssicherung in Prüfungen am Beispiel von 10 Jahren e-Prüfungen an der MHH.

Qualität in der Wissenschaft (QiW) 2017; 11(2):60-64
Originalpublikation
Volltext
 
Günes D N, Kayacelebi A A, Hanff E, Lundgren J, Redfors B, Tsikas D

Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.

Amino Acids 2017; 49(12):2033-2044
Originalpublikation
Volltext
  
Haghikia A, Yanchev G R, Kayacelebi A A, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D

The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.

Amino Acids 2017; 49(6):1111-1121
Originalpublikation
Volltext

Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Göhring G, Schmidt H, Sgodda M, Cantz T

In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells.

Biol.Chem. 2017; 398(8):939-954
Originalpublikation
Volltext

Junemann J, Lämmerhirt C M, Polten F, Just I, Gerhard R, Genth H, Pich A

Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis.

Proteomics 2017; 17(9):1700016-
Originalpublikation
Volltext
  
Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H,  Feelisch M, van Goor H, Bakker S J L, Tsikas D

Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.

Amino Acids 2017; 49(7):1193-1202
Originalpublikation
Volltext
  
Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R

Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells.

Chembiochem 2017; 18(13):1317-1331
Originalpublikation
Volltext
  
Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F

Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.

J. Proteome Res. 2017; 16(3):1133-1149
Originalpublikation
Volltext
  
Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N

Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands.

Croat. Chem. Acta 2017; 90(2):263-271
Originalpublikation
Volltext
  
Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R

The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.

Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012-
Originalpublikation
Volltext
  
Nkuipou-Kenfack E, Schanstra J  P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J  L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P

The use of urinary proteomics in the assessment of suitability of mouse models for ageing.

PLoS One 2017; 12(2):e0166875-
Originalpublikation
Volltext
  
Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038-
Übersicht
Volltext
  
Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C

EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.

Circulation 2017; 136(19):1809-1823
Originalpublikation
Volltext
  
Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I

The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif.

J. Biol. Chem. 2017; 292(43):17668-17680
Originalpublikation
Volltext
  
Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A

Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB.

Front. Cell. Infect. Microbiol. 2017; 7(67-
Originalpublikation
Volltext
  
Rummel A

Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.

Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48-
Übersicht
Volltext
  
Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A

Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics.

PLoS One 2017; 12(5):e0178182-
Originalpublikation
Volltext
  
Tsikas D

Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first.

Atherosclerosis 2017; 264:79-82
Editorial
Volltext
  
Tsikas D

The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a.

J Controversies Biomed Res 2017; 3(1):11-15
Originalpublikation
Volltext
  
Tsikas D

Does oxidative stress change during orthotopic liver transplantation?

J Controversies Biomed Res 2017; 3(2):1-5
Originalpublikation
Volltext
  
Tsikas D

Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox.

J Controversies Biomed Res 2017; 3(1):16-22
Originalpublikation
Volltext
  
Tsikas D

Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans&quot.

Anal.Bioanal Chem. 2017; 409(9):2495-
Letter
Volltext
  
Tsikas D

Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS?

Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040-
Letter
Volltext
  
Tsikas D

Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid.

JSM Biochem Mol Biol 2017; 4(2):1027-
Originalpublikation
Volltext
  
Tsikas D

What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine.

J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72
Übersicht
Volltext
  
Tsikas D, Böhmer A

S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature.

Nitric Oxide 2017; 65:22-36
Originalpublikation
Volltext

Tsikas D, Bollenbach A, Savvidou M D

Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?

Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2-
Originalpublikation
Volltext
  
Tsikas D, Eigendorf J

Diet and Exercise and Serum Markers of Oxidative Stress-Letter.

Cancer.Prev.Res.(Phila) 2017; 10(8):485-486
Letter
Volltext
  
Tsikas D, Hanff E

Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy.

J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142
Übersicht
Volltext
  
Tsikas D, Hanff E, Becker T

Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?

Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009-
Letter
Volltext
  
Tsikas D, Hanff E, Bollenbach A

S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics.

World J.Gastroenterol. 2017; 23(40):7343-7346
Letter
Volltext
  
Tsikas D, Hanff E, Brunner G

Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase.

Trends Microbiol. 2017; 25(8):601-602
Letter
Volltext
  
Tsikas D, Hanff E, Brunner G

Spermidine for a long, dementia-free life?

Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576-
Übersicht
Volltext

 

Tsikas D, Kinzel M

Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men.

Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004-
Originalpublikation
Volltext

  
Tsikas D, Savvidou M

Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile.

JSM Biochem Mol Biol 2017; 4(2):1028-
Originalpublikation
Volltext
  
Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S

S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) � Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview.

2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003-
Originalpublikation
Volltext

von Elsner L, Hagemann S, Just I, Rohrbeck A

Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation.

J Mol Signal 2017; 12(1-
Originalpublikation
Volltext
  
Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093-
Originalpublikation
Volltext
  

Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

Sci.Rep. 2017; 7(1):7438-
Originalpublikation
Volltext

 

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567-
Originalpublikation
Volltext

Frädrich C, Beer LA, Gerhard R

Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B

Toxins (Basel) 2016; 8 (1), 25
Übersicht
Abstract

  

Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D

Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells

Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82)
Originalpublikation
Abstract
 

Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M

The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme

Journal of Neurochemistry 2016; 139 (2): 234-244
Originalpublikation
Volltext

  

Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S

Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization

Scientific Reports 2016; 6 (36598-)
Originalpublikation
Volltext

  

Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A

Biological toxins of potential bioterrorism risk: Current status of detection and identification technology 

TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102
Übersicht
Abstract

  

Gerhard R

Receptors and Binding Structures for Clostridium difficile Toxins A and B

Current Topics in Microbiology and Immunology 2016: 1-18
Originalpublikation
Abstract

 

Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S

Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa

Environmental Microbiology 2016; 18 (10): 3583-3592
Originalpublikation
Volltext

 

Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1

Biochemical Journal 2016; 473 (17): 2645-2654
Originalpublikation
Volltext
 

Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I

Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody

Toxins (Basel) 2016; 8(4):100
Originalpublikation
Volltext
 

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Nature 2016; 538(7625): 350-355
Originalpublikation
Volltext
 

von Elsner L, Hagemann S, Just I, Rohrbeck A

C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors

Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031
Originalpublikation
Volltext

 

Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

Toxins (Basel) 2016; 8(5), 154
Originalpublikation
Volltext

 

Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

Nature Structural & Molecular Biology 2016; 23 (7): 656-662
Originalpublikation
Volltext
 

Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043
Originalpublikation
Volltext

 

Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A

Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells

Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4) 
Originalpublikation 
Volltext

 
Genth H, Schelle I, Just I

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Toxins (Basel) 2016; 8 (4): 109
Originalpublikation
Volltext


 
Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry

Analyst 2016; 141 (18): 5281 -5297
Originalpublikation
Volltext

 
 
Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A

BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay

Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8
Originalpublikation
Abstract


 
Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D

Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells

Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50
Originalpublikation
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Schelle I, Bruening J, Buetepage M, Genth H

Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Toxins (Basel) 2016; 9 (1), 2
Originalpublikation
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Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T,  Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC

Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction

Nature medicine 2015;2;2;140-149

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Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG

Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype

PLoS One 2015;10;2

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Rohrbeck A, von Elsner L, Hagemann S, Just I

Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells

Toxins 2015;7;380-395

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Bothe M, Dutow P, Pich A, Genth H, Klos A

DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166

Toxins 2015;17;621-637

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Haschemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T

Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.

Eur Addict Res 2016;22(2);59 -69 
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Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

Toxicon 2015;107(Pt.A);43 -49 
Abstract

  

Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G

UV radiation induces CXCL5 expression in human skin. 

Exp Dermatol 2015;24(4);309 -312 
Volltext 
 
Rummel A

The long journey of botulinum neurotoxins into the synapse. 

Toxicon 2015;107(Pt.A):9 -24
Abstract

    
Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K

C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity

Neurochem Int 2015; 90;232 -245 
Abstract
 
Schröder A, Rohrbeck A, Just I, Pich A

Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.

J Proteome Res 2015;14(11);4721 -4733
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Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH

miR-139-5p controls translation in myeloid leukemia through EIF4G2.

Oncogene 2015;DOI: 10.1038/onc.2015.247 
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Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T,  Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A,  Mischak H

Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117  
Abstract 
 
Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML

SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity.

Biochim Biophys Acta 2015;1853(1);136 -143
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Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J

Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP).

J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016
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Keller B, Mühlenkamp M, Deuschle E,  Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E

Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.

Cell Microbiol 2015;17(8);1179 -1204  
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Dorner BG, Rummel A

Preface biological Toxins ancient molecules posing a current threat.

Toxins 2015;7(12);5320 -5321 
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