Publikationen des Instituts seit 1997
Gao,Linfeng; Lam,Kwok-Ho; Liu,Shun; Przykopanski,Adina; Lübke,Johanna; Qi,Ruifeng; Krüger,Maren; Nowakowska,Maria B.; Selby,Katja; Douillard,François P.; Dorner,Martin B.; Perry,Kay; Lindström,Miia; Dorner,Brigitte G.; Rummel,Andreas; Jin,Rongsheng;
Kristallstrukturen von OrfX1, OrfX2 und dem OrfX1-OrfX3-Komplex aus dem orfX-Gencluster des Botulinum-Neurotoxins E1,
England, FEBS Lett.,2023;597(4):524-537 10.1002/1873-3468.14576,
Originalpublikation
Heils,Lucas; Schneemann,Martina; Gerhard,Ralf; Schulzke,Jörg-Dieter; Bücker,Roland;
CDT von Clostridioides difficile induziert MLC-abhängige intestinale Barrieredysfunktion in HT-29/B6-Epithelzellmonoschichten,
Schweiz,Toxine (Basel),2023;15(1):54-10.3390 /toxins15010054, Berichtsjahr:2023 | ID: RefID:26111-heils2023cdt
Originalpublikation
Hildebrand,Christina B.; Lichatz,Rita; Pich,Andreas; Mühlfeld,Christian; Woltemate,Sabrina; Vital,Marius; Brandenberger,Christina;
Kurzkettige Fettsäuren verbessern die Alterung und akute Lungenschädigung bei alten Mäusen,
Vereinigte Staaten,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023;():- 10.1152/ajplung.00296.2022 Berichtsjahr:2023 | ID: RefID:26113-hildebrand2023short
Originalpublikation
Pokrant,Thomas; Hein,Jens Ingo; Körber,Sarah; Disanza,Andrea; Pich,Andreas; Scita,Giorgio; Rottner,Klemens; Faix,Jan;
Das Ena/VASP-Clustering an den Mikrospike-Spitzen umfasst Lamellipodin, aber keine I-BAR-Proteine und erfordert unbedingt unkonventionelle Myosin-X,
United States,Proc.Natl.Acad.Sci.U.S.A.,2023;120(2):-e2217437120 10.1073/pnas.2217437120 Berichtsjahr:2023 | ID: RefID:26134-pokrant2023ena/vasp
Originalpublikation
Tsikas,Dimitrios; Büttner,Petra;
Sagen zirkulierende Konzentrationen von L-Arginin-Metaboliten den Status der koronaren Herzkrankheit und die Wahrscheinlichkeit kardiovaskulärer Ereignisse voraus?,
Poland,Pol.Arch.Intern.Med.,2023;133(2):16429-10.20452 /pamw.16429 Berichtsjahr:2023 | ID: RefID:26154-tsikas2023zirkulierend
Editorial
Haukamp,Funmilola Josephine; Hartmann,Zoe Maria; Pich,Andreas; Kuhn,Joachim; Blasczyk,Rainer; Stieglitz,Florian; Bade-Döding,Christina;
HLA-B*57:01/Carbamazepin-10,11-Epoxid-Assoziation löst Hochregulierung der NFkappaB- und JAK/STAT-Signalwege aus,
Schweiz,Cells,2023;12(5):676-10.3390 /cells12050676 Berichtsjahr:2023 | ID: RefID:26161-haukamp2023hla-b*57:01/carbamazepine-1
Originalpublikation
Rosenstein,Christopher; Identifizierung einer zweiten Rezeptorbindungstasche in Botulinum Neurotoxin F,
Hannover,,2022;():-2 ungezählte Blätter, 77 Blätter : 10.26068/mhhrpm/20230601-002 Berichtsjahr:2023 | ID: RefID:26365-rosenstein2022identifizierung
Dissertation
Tsikas,Dimitrios; Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2023;1221():123684-10.1016/j.jchromb.2023.123684 Berichtsjahr:2023 | ID: RefID:26250-tsikas2023measurement
Letter
Joensuu,Merja; Syed,Parnayan; Saber,Saber H.; Lanoue,Vanessa; Wallis,Tristan P.; Rae,James; Blum,Ailisa; Gormal,Rachel S.; Small,Christopher; Sanders,Shanley; Jiang,Anmin; Mahrhold,Stefan; Krez,Nadja; Cousin,Michael A.; Cooper-White,Ruby; Cooper-White,Justin J.; Collins,Brett M.; Parton,Robert G.; Balistreri,Giuseppe; Rummel,Andreas; Meunier,Frederic A.; Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry,
England,EMBO J.,2023;42(13):-e112095 10.15252/embj.2022112095 Berichtsjahr:2023 | ID: RefID:39384-joensuu2023presynaptic
Originalpublikation
Liu,Zheng; Lee,Pyung-Gang; Krez,Nadja; Lam,Kwok-Ho; Liu,Hao; Przykopanski,Adina; Chen,Peng; Yao,Guorui; Zhang,Sicai; Tremblay,Jacqueline M.; Perry,Kay; Shoemaker,Charles B.; Rummel,Andreas; Dong,Min; Jin,Rongsheng; Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2,
England,Nat.Commun.,2023;14(1):2338-10.1038/s41467-023-37860-8 Berichtsjahr:2023 | ID: RefID:26323-liu2023structural
Originalpublikation
Baskal,S.; Beckmann,B.; Stahmer,L.; Peter,C.; Bohnhorst,B.; Das,A. M.; Tsikas,D.;
Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period,
Austria,Amino Acids,2022;():- 10.1007/s00726-022-03197-7 Berichtsjahr:2022 | ID: RefID:25095-baskal2022role
Originalpublikation
Baskal,S.; Bollenbach,A.; Henzi,B.; Hafner,P.; Fischer,D.; Tsikas,D.;
Stable-Isotope Dilution GC-MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination,
Switzerland,Molecules,2022;27(12):3850-10.3390/molecules27123850 Berichtsjahr:2022 | ID: RefID:25096-baskal2022stable-isotope
Originalpublikation
Baskal,S.; Dimina,L.; Tsikas,S. A.; Mosoni,L.; Remond,D.; Mariotti,F. ; Tsikas,D.;
Lysine and homoarginine are closely interrelated metabolites in the rat,
Austria,Amino Acids,2022;54(6):967-976, 10.1007/s00726-022-03158-0 Berichtsjahr:2022 | ID: RefID:25097-baskal2022lysine
Originalpublikation
Baskal,S.; Kaiser,A.; Mels,C.; Kruger,R.; Tsikas,D.;
Specific and sensitive GC-MS analysis of hypusine, N(epsilon)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
Austria, Amino Acids, 2022, (), - , Berichtsjahr: 2022| ID: 11345 (35243537)
Originalpublikation
Baskal,S.; Tsikas,S. A.; Begou,O.; Bollenbach,A.; Lenzen,S.; Jörns,A.; Tsikas,D.;
Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-alpha Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes
Switzerland, Int.J.Mol.Sci., 2022, 23(3), 1541- , Berichtsjahr: 2022| ID: 11166 (35163462)
Originalpublikation
Baskal,Svetlana; Tsikas,Dimitrios;
Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nepsilon-Carboxymethyl-Lysine, Nepsilon-Carboxyethyl-Lysine and Nepsilon-Hydroxymethyl-Lysine.
,,Int J Mol Sci,2022;23(7):3446-10.3390/ijms23073446 Berichtsjahr:2022 | ID: RefID:25100-baskal2022free
Originalpublikation
Becker,E. ; Francino,A. ; Pich,A. ; Perrot,A. ; Kraft,T. ; Radocaj,A. ; ,
AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy
Switzerland, Front.Cardiovasc.Med., 2022, 9(), 816330- ,Berichtsjahr: 2022| ID: 11362 (35265683)
Originalpublikation
Bense,S. ; Witte,J. ; Preuße,M. ; Koska,M. ; Pezoldt,L. ; Dröge,A. ; Hartmann,O. ; Müsken,M. ; Schulze,J. ; Fiebig,T. ; Bähre,H. ; Felgner,S. ; Pich,A. ; Häussler,S. ;
Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels,
England,Mol.Microbiol.,2022;117(5):1213-1226, 10.1111/mmi.14902 Berichtsjahr:2022 | ID: RefID:25178-bense2022pseudomonas
Originalpublikation
Bollenbach,A. ; Baskal,S. ; Mels,C. ; Kruger,R. ; Tsikas,D. ;
Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine,
Switzerland,Molecules,2022;27(16):5202-10.3390/molecules27165202 Berichtsjahr:2022 | ID: RefID:25229-bollenbach2022unusual
Originalpublikation
Borgert,Sebastian Roman ; Henke,Steffi ; Witzgall,Florian ; Schmelz,Stefan ; Zur Lage,Susanne ; Hotop,Sven-Kevin ; Stephen,Steffi ; Lübken,Dennis ; Krüger,Jonas ; Gomez,Nicolas Oswaldo ; van Ham,Marco ; Jänsch,Lothar ; Kalesse,Markus ; Pich,Andreas ; Brönstrup,Mark ; Häussler,Susanne ; Blankenfeldt,Wulf ;
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa,
England,Nat.Commun.,2022;13(1):7402-10.1038/s41467-022-35030-w, Berichtsjahr:2022 | ID: RefID:25237-borgert2022moonlighting
Originalpublikation
Durisin,M. ; Krüger,C. ; Pich,A. ; Warnecke,A. ; Steffens,M. ; Zeilinger,C. ; Lenarz,T. ; Prenzler,N. ; Schmitt,H. ;
Proteomprofil von Patienten mit ausgezeichneter und schlechter Sprachverständlichkeit nach Cochlea-Implantation: Können Perilymphproteine die Leistung vorhersagen?,
United States,PLoS One,2022;17(3):-e0263765, 10.1371/journal.pone.0263765 Berichtsjahr:2022 | ID: RefID:25549-durisin2022proteome
Originalpublikation
Fan,C. ; Wu,Z. ; Cooper,D. M. L. ; Magnus,A. ; Harrison,K. ; Eames, B. F. ; Chibbar,R. ; Groot,G. ; Huang,J. ; Genth,H. ; Zhang,J. ; Tan,X. ; Deng,Y. ; Xiang,J. ;
Die Aktivierung der fokalen Adhäsionskinase stellt die simulierte Mikrogravitations-induzierte Hemmung der Osteoblastendifferenzierung über den Wnt/Beta-Catenin-Signalweg wieder her,
Schweiz,Int.J.Mol.Sci.,2022;23(10):5593-10.3390, /ijms23105593 Berichtsjahr:2022 | ID: RefID:25625-fan2022activation
Originalpublikation
Gall,E. ; Stieglitz,F. ; Pich,A. ; Behrens,G. M. N. ; Kuhn,J. ; Blasczyk,R. ; Haukamp,F. J. ; Bade-Döding,C. ;
Proteomic Profiling and T Cell Receptor Usage of Abacavir Susceptible Subjects,
Switzerland,,2022;10(3):693-10.3390, /biomedicines10030693 Berichtsjahr:2022 | ID: RefID:25735-gall2022proteomic
Originalpublikation
Hanusch,B. ; Sinningen,K. ; Brinkmann,F. ; Dillenhöfer,S. ; Frank,M. ; Jöckel,K. H. ; Koerner-Rettberg,C. ; Holtmann,M. ; Legenbauer,T. ; Langrock,C. ; Reinehr,T. ; Maasjosthusmann,P. ; Beckmann,B. ; Hamelmann,E. ; Tsikas,D. ; Lücke,T. ;
Charakterisierung des L-Arginin/Stickstoffmonoxid-Signalwegs und des oxidativen Stresses bei pädiatrischen Patienten mit atopischen Erkrankungen,
Schweiz,Int.J.Mol.Sci.,2022;23(4):2136-10.3390, /ijms23042136 Berichtsjahr:2022 | ID: RefID:25936-hanusch2022Charakterisierung
Originalpublikation
Harre,Jennifer ; Heinkele,Laura ; Steffens,Melanie ; Warnecke,Athanasia ; Lenarz,Thomas ; Nur, Ingo ; Rohrbeck,Astrid ;
Korrigendum: Potenzierung des aus dem Gehirn stammenden neurotrophen Faktor-induzierten Schutzes von Spiralganglienneuronen durch C3-Exoenzym/Rho-Inhibitor,
Schweiz,Front.Cell.Neurosci.,2022;16():1078962-10.3389
/fncel.2022.1078962 Berichtsjahr:2022 | ID: RefID:25948-harre2022 Korrigendum:
Korrigendum
Haukamp,F. J. ; Gall,E. ; Hò,G. T. ; Hiemisch,W. ; Stieglitz,F. ; Kuhn,J. ; Blasczyk,R. ; Pich,A. ; Bade-Döding,C. ;
Entschlüsselung der Proteomik von HLA-B*57:01(+) Antigen-präsentierenden Zellen während der Abacavir-Medikation,
Schweiz,J.Pers.Med.,2022;12(1):40-10.3390, /jpm12010040 Berichtsjahr:2022 | ID: RefID:25968-haukamp2022unravelling
Originalpublikation
Henkel,Daniel ;
Die Rezeptorinteraktion der Clostridioides difficile Toxine TcdA und TcdB,
Hannover,,2021;():-VII, 99 Seiten : Illustrationen, Diagramme, Berichtsjahr:2022 | ID: RefID:26012-henkel2021die
Dissertation
Maassen,H. ; Said,M. Y. ; Frenay,A. S. ; Koning,A. ; Post,A. ; Riphagen,I. J. ; Heiner-Fokkema,M. R. ; Drabert,K. ; Fernandez,B. O. ; Gans,R. O. B. ; van den Berg,E. ; Navis,G. ; Tsikas,D. ; Feelisch,M. ; Bakker,S. J. L. ; van Goor,H. ;
Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study,
United States,Nitric Oxide,2022;125-126():1-11 10.1016/j.niox.2022.05.005 Berichtsjahr:2022 | ID: 11666
Originalpublikation
Malfeld,Kathrin ; Armbrecht,Nina ; Pich,Andreas ; Volk,Holger A. ; Lenarz,Thomas ; Scheper,Verena ;
Prävention von lärmbedingtem Hörverlust in vivo: Kontinuierliche Anwendung des insulinähnlichen Wachstumsfaktors 1 und seine Wirkung auf Innenohrsynapsen, Hörfunktion und Perilymphproteine,
Schweiz,Int.J.Mol.Sci.,2022;24(1):291-10.3390 /ijms24010291 Berichtsjahr:2022 | ID: RefID:23508-malfeld2022prevention
Originalpublikation
Mangan,Matthew S. J. ; Gorki,Friederike ; Krause,Karoline ; Heinz,Alexander ; Pankow,Anne ; Ebert,Thomas ; Jahn,Dieter ; Hiller,Karsten ; Hornung,Veit ; Maurer,Marcus ; Schmidt,Florian I. ; Gerhard,Ralf ; Latz,Eicke ;
Für die Aktivierung von Pyrin inflammasom in menschlichen Makrophagen ist eine Transkriptionslizenzierung erforderlich, die durch Mutationen umgangen wird, die das familiäre Mittelmeerfieber verursachen,
United States,PLoS Biol.,2022;20(11):-e3001351 10.1371/journal.pbio.3001351 Berichtsjahr:2022 | ID: RefID:23516-mangan2022transcriptional
Originalpublikation
Neumann-Schaal,M; Groß,U; Just,I; Jahn,D
The Deadly Secrets of C. difficile—Insights Into Host-Pathogen Interaction.
Front. Microbiol. 13:897612. doi: 10.3389/fmicb.2022.897612 (2022)
Editorial
Neumann-Schaal,Meina ; Groß,Uwe ; Nur, Ingo ; Jahn,Dieter ;
The Deadly Secrets of C. difficile-Insights into Host-Pathogen Interaction, Volume II,
Switzerland,Front.Microbiol.,2022;13():896979-10.3389 /fmicb.2022.896979 Berichtsjahr:2022 | ID: RefID:23740-neumann-schaal2022editorial:
Editorial
Nowakowska,M. B. ; Selby,K. ; Przykopanski,A. ; Krüger,M. ; Krez,N. ; Dorner,B. G. ; Dorner,M. B. ; Jin,R. ; Minton, N. P. ; Rummel,A. ; Lindström,M. ;
Konstruktion und Validierung eines sicheren Clostridium botulinum Gruppe II Surrogatstamms, der inaktives Botulinum-Neurotoxin Typ E produziert, Toxoid,
England, Sci.Rep.,2022;12(1):1790-10.1038/s41598-022-05008-1 Berichtsjahr:2022 | ID: RefID:23775-nowakowska2022construction
Originalpublikation
Petersen,Lara ; Stroh,Svenja ; Schöttelndreier,Dennis ; Grassl,Guntram A. ; Rottner,Klemens ; Brakebusch,Cord ; Fahrer,Jörg ; Genth,Harald ;
Die wesentliche Rolle der Rac1-Glucosylierung bei der B-induzierten Verhaftung des G1-S-Übergangs durch Clostridioides difficile Toxin.,,
Front Microbiol,2022;13():846215-10.3389 /fmicb.2022.846215 Berichtsjahr:2022 | ID: RefID:23897-petersen2022essential
Originalpublikation
Piepgras,J. ; Rohrbeck,A. ; Nur,ich. ; Bittner,S. ; Ahnert-Hilger,G. ; Höltje,M. ;
Verstärkung der Phosphorylierungs- und Transportaktivität des neuronalen Glutamattransporters exzitatorischen Aminosäuretransporters 3 durch C3bot und ein 26mer-C3bot-Peptid,
Schweiz,Front.Cell.Neurosci.,2022;16():860823-10.3389 /fncel.2022.860823 Berichtsjahr:2022 | ID: RefID:23925-piepgras2022enhancement
Originalpublikation
Reboll,M. R. ; Klede,S. ; Taft,M. H. ; Cai,C. L. ; Feld,L. J. ; Lavine,K. J. ; Koenig,A. L. ; Fleischauer,J. ; Meyer,J. ; Schambach,A. ; Niessen,H. W. ; Kosanke,M. ; van den Heuvel,J. ; Pich,A. ; Bauersachs,J. ; Wu,X. ; Zheng,L. ; Wang,Y. ; Korf-Klingebiel,M. ; Pölten,F. ; Wollert,K. C. ;
Meteorin-like fördert die Herzreparatur durch endotheliale KIT-Rezeptor-Tyrosinkinase,
Vereinigte Staaten,Science,2022;376(6599):1343-1347 10.1126/science.abn3027 Berichtsjahr:2022 | ID: RefID:24037-reboll2022meteorin-like
Originalpublikation
Schweitzer,T. ; Genth,H. ; Pich,A. ;
Das Alpha-Toxin von Clostridium novyi verändert das Proteom und das Phosphoproteom von HEp-2-Zellen,
Schweiz,Int.J.Mol.Sci.,2022;23(17):9939-10.3390 /ijms23179939 Berichtsjahr:2022 | ID: RefID:24343-schweitzer2022clostridium
Originalpublikation
Stieglitz,F. ; Gerhard,R. ; Hönig,R. ; Giehl,K. ; Pich,A. ;
TcdB von Clostridioides difficile vermittelt RAS-abhängige Nekrose in Epithelzellen,
Schweiz,Int.J.Mol.Sci.,2022;23(8):4258-10.3390 /ijms23084258 Berichtsjahr:2022 | ID: RefID:24479-stieglitz2022tcdb
Originalpublikation
Stieglitz,Florian ;
LC-MS-basierte Charakterisierung von Effekten auf Signalmoleküle, die durch Clostridioides difficile-Toxine induziert werden,
Hannover,,2022;():iv, 90 Blätter, Blatt v-viii : Illustrationen, Diagramme, Berichtsjahr:2022 | ID: RefID:24480-stieglitz2022lc-ms-basiert
Dissertation
Tian,Songhai ; Xiong,Xiaozhe ; Zeng,Ji ; Wang,Siyu ; Tremblay,Benjamin Jean-Marie ; Chen,Peng ; Chen,Baohua ; Liu,Min ; Chen,Pengsheng ; Sheng,Kuanwei ; Zeve,Daniel ; Qi,Wanshu ; Breault,David T. ; Rodríguez,César ; Gerhard,Ralf ; Jin,Rongsheng ; Doxey,Andrew C. ; Dong,Min ;
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants,
England,Nat.Commun.,2022;13(1):6786-10.1038/s41467-022-33964-9 Berichtsjahr:2022 | ID: RefID:24582-tian2022identification
Originalpublikation
Tsikas,D. ; Redfors,B. ;
Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy,
Switzerland,Int.J.Mol.Sci.,2022;23(9):4734-10.3390/ijms23094734 Berichtsjahr:2022 | ID: RefID:24608-tsikas2022pilot
Originalpublikation
Tsikas,Dimitrios ;
Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids,
Austria,Amino Acids,2022;():- 10.1007/s00726-022-03218-5, Berichtsjahr:2022 | ID: RefID:24610-tsikas2022determination
Originalpublikation
Tsikas,Dimitrios ;
Homoarginine in health and disease,
England,Curr.Opin.Clin.Nutr.Metab.Care,2023;26(1):42-49, 10.1097/MCO.0000000000000889 Berichtsjahr:2022 | ID: RefID:24609-tsikas2023homoarginine
Übersicht
Tsikas,Dimitrios ; Editorial.,,
Amino Acids,2022;54():481-484 10.1007/s00726-022-03164-2 Berichtsjahr:2022 | ID: 11513
Editorial
Tsikas,Dimitrios ; Mikuteit,Marie ;
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
,,Amino Acids,2022;54(9):1251-1260, 10.1007/s00726-022-03185-x
Übersicht
van Dieken,A. ; Staecker,H. ; Schmitt,H. ; Harre,J. ; Pich,A. ; Roßberg,W. ; Lenarz,T. ; Durisin,M. ; Warnecke,A. ;
Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas,
Switzerland,Front.Cell.Dev.Biol.,2022;10():847157-10.3389/fcell.2022.847157 Berichtsjahr:2022 | ID: RefID:24649-van2022bioinformatic
Originalpublikation
von Hanstein,Anna-Sophie ; Tsikas,Dimitrios ; Lenzen,Sigurd ; Jörns,Anne ; Plötz,Thomas ;
Potentiation of Lipotoxicity in Human EndoC-betaH1 Beta-cells by Glucose is Dependent on the Structure of Free Fatty Acids,
Germany,Mol.Nutr.Food Res.,2023;():-e2200582, 10.1002/mnfr.202200582 Berichtsjahr:2022 | ID: RefID:24703-von2023potentiation
Originalpublikation
Wessig,A. K. ; Hoffmeister,L. ; Klingberg,A. ; Alberts,A. ; Pich,A. ; Brand,K. ; Witte,T. ; Neumann,K. ;
Natural antibodies and CRP drive anaphylatoxin production by urate crystals,
England,Sci.Rep.,2022;12(1):4483-10.1038/s41598-022-08311-z Berichtsjahr:2022 | ID: RefID:24815-wessig2022natural
Originalpublikation
Baskal,S. ; Bollenbach,A. ; Mels,C. ; Kruger,R. ; Tsikas,D.
Development, validation of a GC-MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine,
Austria,Amino Acids,2021;():-
Originalpublikation
Baskal,S. ; Bollenbach,A. ; Tsikas,D.
Two-Step Derivatization of Amino Acids for Stable-Isotope Dilution GC-MS Analysis: Long-Term Stability of Methyl Ester-Pentafluoropropionic Derivatives in Toluene Extracts
Switzerland,Molecules,2021;26(6):1726-
Originalpublikation
Baskal,S. ; Bollenbach,A. ; Tsikas,D.
GC-MS Discrimination of Citrulline from Ornithine and Homocitrulline from Lysine by Chemical Derivatization: Evidence of Formation of N(5)-Carboxy-ornithine and N(6)-Carboxy-lysine
Switzerland,Molecules,2021;26(8):2301-
Originalpublikation
Baskal,S. ; Büttner,P. ; Werner,S. ; Besler,C. ; Lurz,P. ; Thiele,H. ; Tsikas,D.
Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats,
Austria, Amino Acids,2021;():-
Originalpublikation
Baskal,S. ; Post,A. ; Kremer,D. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D.
Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality,
Austria,Amino Acids,2021;():-
Originalpublikation
Begou,O. ; Pavlaki,A. ; Deda,O. ; Bollenbach,A. ; Drabert,K. ; Gika,H. ; Farmaki,E. ; Dotis,J. ; Printza,N. ; Theodoridis,G. ; Tsikas,D.
Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery,
Switzerland, J.Clin.Med.,2021;10(7):1467-
Originalpublikation
Begou,O. ; Weber,K. ; Beckmann,B. ; Tsikas,D.
GC-MS Studies on Derivatization of Creatinine and Creatine by BSTFA and Their Measurement in Human Urine,
Switzerland, Molecules,2021;26(11):3206 [pii]-
Originalpublikation
Bousnaki,M. ; Bakopoulou,A. ; Pich,A. ; Papachristou,E. ; Kritis,A. ; Koidis,P.
Mapping the Secretome of Dental Pulp Stem Cells Under Variable Microenvironmental Conditions
United States,Stem Cell.Rev.Rep.,2021;():-
Originalpublikation
Büttner,P. ; Werner,S. ; Baskal,S. ; Tsikas,D. ; Adams,V. ; Lurz,P. ; Besler,C. ; Knauth,S. ; Bahls,M. ; Schwedhelm,E. ; Thiele,H.
Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction,
England,Sci.Rep.,2021;11(1):20684-
Originalpublikation
Chen,P. ; Zeng,J. ; Liu,Z. ; Thaker,H. ; Wang,S. ; Tian,S. ; Zhang,J. ; Tao,L. ; Gutierrez,C. B. ; Xing,L. ; Gerhard,R. ; Huang,L. ; Dong,M. ; Jin,R.
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection,
England,Nat.Commun.,2021;12(1):3748-
Originalpublikation
Fischer, V., Just, I. (2021)
An integrated formula for determining the admission capacity in medical studies in reference to patients.
Beiträge zur Hochschulforschung, 43(4), 52-65.
Originalpublikation
Harre,J. ; Heinkele,L. ; Steffens,M. ; Warnecke,A. ; Lenarz,T. ; Just,I. ; Rohrbeck,A.
Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor
Switzerland,Front.Cell.Neurosci.,2021;15():602897-
Originalpublikation
Kendre,G. ; Marhenke,S. ; Lorz,G. ; Becker,D. ; Reineke-Plaass,T. ; Poth,T. ; Murugesan,K. ; Kühnel,F. ; Woller,N. ; Wirtz,R. M. ; Pich,A. ; Marquardt,J. U. ; Saborowski,M. ; Vogel,A. ; Saborowski,A.
The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma,
United States,Hepatology,2021;74(3):1357-1370
Originalpublikation
Klepka,C. ; Sandmann,M. ; Tatge,H. ; Mangan,M. ; Arens,A. ; Henkel,D. ; Gerhard,R.
Impairment of lysosomal function by Clostridioides difficile TcdB
England,Mol.Microbiol.,2021;():-
Originalpublikation
Korf-Klingebiel,M. ; Reboll,M. R. ; Polten,F. ; Weber,N. ; Jäckle,F. ; Wu,X. ; Kallikourdis,M. ; Kunderfranco,P. ; Condorelli,G. ; Giannitsis,E. ; Kustikova,O. S. ; Schambach,A. ; Pich,A. ; Widder,J. D. ; Bauersachs,J. ; van den Heuvel,J. ; Kraft,T. ; Wang,Y. ; Wollert,K. C.
Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Expression in Cardiomyocytes,
United States,Circulation,2021;144(15):1227-1240
Originalpublikation
Kukoc-Modun,L. ; Kraljević,T. ; Tsikas,D. ; Radić,N. ; Modun,D.
Determination of N-Acetyl-l-cysteine Ethyl Ester (NACET) by Flow Injection Analysis and Spectrophotometric Detection Using Different Thiol-Sensitive Ligands
Switzerland,Molecules,2021;26(22):6826-
Originalpublikation
Marquardt,I. ; Jakob,J. ; Scheibel,J. ; Hofmann,J. D. ; Klawonn,F. ; Neumann-Schaal,M. ; Gerhard,R. ; Bruder,D. ; Jänsch,L.
Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells,
Switzerland,Front.Microbiol.,2021;12():752549-
Originalpublikation
Mhlekude,B. ; Lenman,A. ; Sidoyi,P. ; Joseph,J. ; Kruppa,J. ; Businge,C. B. ; Mdaka,M. L. ; Konietschke,F. ; Pich,A. ; Gerold,G. ; Goffinet,C. ; Mall,A. S.
The barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission,
England,AIDS,2021;35(3):2105-2117
Originalpublikation
Neumann,T. ; Krüger,M. ; Weisemann,J. ; Mahrhold,S. ; Stern,D. ; Dorner,M. B. ; Feraudet-Tarisse,C. ; Pöhlmann,C. ; Schulz,K. ; Messelhäusser,U. ; Rimek,D. ; Gessler,F. ; Elßner,T. ; Simon,S. ; Rummel,A. ; Dorner,B. G.
Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies,
Switzerland,Toxins (Basel),2021;13(4):266-
Originalpublikation
Nickel,K. ; Wensorra,U. ; Wenck,H. ; Peters,N. ; Genth,H.
Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors,
Switzerland,Cells,2021;10(11):2931-
Originalpublikation
Ostermann,L. ; Maus,R. ; Stolper,J. ; Schütte,L. ; Katsarou,K. ; Tumpara,S. ; Pich,A. ; Mueller,C. ; Janciauskiene,S. ; Welte,T. ; Maus,U. A.
Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice,
United States,JCI Insight,2021;6(3):-
Originalpublikation
Post,A. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D. ;
Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients,
Austria, Amino Acids,2021;53(4):541-554
Originalpublikation
Schenke,M. ; Prause,H. C. ; Bergforth,W. ; Przykopanski,A. ; Rummel,A. ; Klawonn,F. ; Seeger,B.
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1,
Switzerland,Toxins (Basel),2021;13(8):585-
Originalpublikation
Schmitt,H. A. ; Pich,A. ; Prenzler,N. K. ; Lenarz,T. ; Harre,J. ; Staecker,H. ; Durisin,M. ; Warnecke,A.
Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry,
United States,ACS Omega,2021;6(33):21241-21254
Originalpublikation
Stieglitz,F. ; Gerhard,R. ; Pich,A. ;
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells,
Switzerland,Front.Microbiol.,2021;12():725612-
Originalpublikation
Stojanovic,S. D. ; Fuchs,M. ; Liang,C. ; Schmidt,K. ; Xiao,K. ; Just,A. ; Pfanne,A. ; Pich,A. ; Warnecke,G. ; Braubach,P. ; Petzold,C. ; Jonigk,D. ; Distler,J. H. W. ; Fiedler,J. ; Thum,T. ; Kunz,M.
Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics,
England,Sci.Rep.,2021;11(1):12456-
Originalpublikation
Tsikas,D.
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology-part I
Austria, Amino Acids,2021;53(4):485-487
Editorial
Tsikas,D. ;
Comment on the article Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase,
England,IUCrJ,2021;8(Pt 2):327-328
Comment
Tsikas,D. ;
Extra-platelet low-molecular-mass thiols mediate the inhibitory action of S-nitrosoalbumin on human platelet aggregation via S-transnitrosylation of the platelet surface,
Austria, Amino Acids,2021;53(4):563-573
Originalpublikation
Tsikas,D. ;
GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization,
Switzerland,Molecules,2021;26(22):7003-
Originalpublikation
Tsikas,D. ;
Homocysteine and copper ions: is their interaction responsible for cardiovascular-related damage?
Austria, Amino Acids,2021;53(8):1297-1298
Letter
Tsikas,D. ; Gambaryan,S. ;
Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets
England,J.Enzyme Inhib.Med.Chem.,2021;36(1):525-534
Originalpublikation
Ückert,S. ; Richter,K. ; Fischer,K. D. ; Tsikas,D. ; Kuczyk,M. A.
Re-evaluation of the immunohistochemical distribution of isoforms of nitric oxide synthase in the human prostate: A light and electron microscopical study
Germany,Andrologia,2021;53(7):e14098-
Originalpublikation
Walter,L. M. ; Rademacher,S. ; Pich,A. ; Claus,P.
Profilin2 regulates actin rod assembly in neuronal cells,
England,Sci.Rep.,2021;11(1):10287-
Originalpublikation
Wang,Y. ; Polten,F. ; Jäckle,F. ; Korf-Klingebiel,M. ; Kempf,T. ; Bauersachs,J. ; Freitag-Wolf,S. ; Lichtinghagen,R. ; Pich,A. ; Wollert,K. C.
A mouse model of cardiogenic shock,
England,Cardiovasc.Res.,2021;117(12):2414-2415
Letter
Ahmadpour,Jamshid
Untersuchung zur Antikörperbildung gegen Botulinum Neurotoxin A im Rahmen der Therapie von Bewegungsstörungen
Hannover,,2018;():4 ungezählte Seiten, 76 Seiten : Illustrationen, -
Dissertation
Schneider,Carmen
Intrazelluläre Aktivität der pathogenen Domäne großer clostridialer Glucosyltransferasen
Hannover,,2021;():VII, 135 Blätter : Illustrationen, Diagramme-
Dissertation
Weber,Kathrin
GC-MS-basierte Untersuchungen zur Bedeutung der renalen Carboanhydrasen für die Rückresorption von Nitrit und den oxidativen Stress am Menschen
Hannover,,2020;():5 ungezählte Blätter, VI Blätter, 102 Blätter -
Dissertation
Hussein,Nali
C3-vermittelte Effekte bei Psoriasis am Phenion 3D-Vollhautmodell,
Hannover,,;():78 Seiten-
Masterarbeit
Langejürgen,Anna
Die Rolle der Makropinozytose in der zellulären Aufnahme von C. difficile Toxin
Hannover,,;():74 Seiten-
Masterarbeit
von der Kammer,Urs
Darstellung der Interaktion der Botulinum Neurotoxine Serotyp A und E mit ihren Proteinrezeptoren Synaptisches Vesikelglykoprotein C und A,
Hannover,,;():106 Seiten-
Masterarbeit
Adolf,A. ; Turko,P. ; Rohrbeck,A. ; Just,I. ; Vida,I. ; Ahnert-Hilger,G. ; Höltje,M.
The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin
Switzerland,Front.Cell.Neurosci.,2020;14():596072-
Originalpublikation
Alberts,A. ; Klingberg,A. ; Hoffmeister,L. ; Wessig,A. K. ; Brand,K. ; Pich,A. ; Neumann,K.
Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures
Switzerland,Front.Immunol.,2020;11():596103-
Originalpublikation
Alberts,A. ; Klingberg,A. ; Wessig,A. K. ; Combes,C. ; Witte,T. ; Brand,K. ; Pich,A. ; Neumann,K.
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1
England,Sci.Rep.,2020;10(1):6391-
Originalpublikation
Becker,T. ; Pich,A. ; Tamm,S. ; Hedtfeld,S. ; Ibrahim,M. ; Altmüller,J. ; Dalibor,N. ; Toliat,M. R. ; Janciauskiene,S. ; Tümmler,B. ; Stanke,F.
Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B
England,Sci.Rep.,2020;10(1):22447-
Originalpublikation
Begou,O. ; Drabert,K. ; Theodoridis,G. ; Tsikas,D.
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
China,J.Pharm.Anal.,2020;10(1):49-59
Originalpublikation
Bollenbach,A. ; Gambaryan,S. ; Mindukshev,I. ; Pich,A. ; Tsikas,D.
GC-MS and LC-MS/MS pilot studies on the guanidine (N(G))-dimethylation in native, asymmetrically and symmetrically N(G)-dimethylated arginine-vasopressin peptides and proteins in human red blood cells
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2020;1141():122024-
Originalpublikation
Bollenbach,A. ; Schutte,A. E. ; Kruger,R. ; Tsikas,D.
An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies Switzerland,J.Clin.Med.,2020;9(3):844.-
Originalpublikation
Bollenbach,A. ; Tsikas,D.
Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry
United States,Anal.Biochem.,2020;():-
Originalpublikation
Brinkmann,F. ; Hanusch,B. ; Ballmann,M. ; Mayorandan,S. ; Bollenbach,A. ; Chobanyan-Jürgens,K. ; Jansen,K. ; Schmidt-Choudhury,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T.
Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results
Switzerland,J.Clin.Med.,2020;9(6):E2012 [pii]-
Originalpublikation
Craig,A. ; M C Mels,C. ; Tsikas,D. ; Boeger,R. H. ; Schwedhelm,E. ; Schutte,A. E. ; Kruger,R.
Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study
England,J.Hum.Hypertens.,2021;35(11):985-993
Originalpublikation
Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Bollenbach,A. ; Tsikas,D. ; Schwedhelm,E. ; Kruger,R. ;
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
England,Hypertens.Res.,2021;44(1):71-79
Originalpublikation
Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Tsikas,D. ; Kruger,R. ;
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
Austria,Amino Acids,2020;52(4):639-648
Originalpublikation
Cseko,K. ; Pecsi,D. ; Kajtar,B. ; Hegedus,I. ; Bollenbach,A. ; Tsikas,D. ; Szabo,I. L. ; Szabo,S. ; Helyes,Z.
Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target
Switzerland,Int.J.Mol.Sci.,2020;21(16):E5591 [pii]-
Originalpublikation
Deppe,J. ; Weisemann,J. ; Mahrhold,S. ; Rummel,A.
The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity
Switzerland,Toxins (Basel),2020;12(12):-
Originalpublikation
Hanusch,B. ; Brinkmann,F. ; Mayorandan,S. ; Chobanyan-Jürgens,K. ; Wiemers,A. ; Jansen,K. ; Ballmann,M. ; Schmidt-Choudhury,A. ; Bollenbach,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T.
Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment Switzerland,J.Clin.Med.,2020;9(12)::E3802-
Originalpublikation
Henkel,D. ; Tatge,H. ; Schöttelndreier,D. ; Tao,L. ; Dong,M. ; Gerhard,R.
Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
Switzerland,Toxins (Basel),2020;12(12):-
Originalpublikation
Hensel,N. ; Raker,V. ; Förthmann,B. ; Buch,A. ; Sodeik,B. ; Pich,A. ; Claus,P.
The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus
Switzerland,Front.Neurol.,2020;11():844-
Originalpublikation
Herkt,M. ; Foinquinos,A. ; Batkai,S. ; Thum,T. ; Pich,A.
Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry
Switzerland,Front.Pharmacol.,2020;11():220-
Originalpublikation
Ho,G. T. ; Hiemisch,W. ; Pich,A. ; Behrens,G. M. N. ; Blasczyk,R. ; Bade-Doeding,C.
The Loss of HLA-F/KIR3DS1 Ligation Is Mediated by Hemoglobin Peptides
Switzerland,Int.J.Mol.Sci.,2020;21(21):8012-
Originalpublikation
Hobuss,L. ; Foinquinos,A. ; Jung,M. ; Kenneweg,F. ; Xiao,K. ; Wang,Y. ; Zimmer,K. ; Remke,J. ; Just,A. ; Nowak,J. ; Schmidt,A. ; Pich,A. ; Mazlan,S. ; Reamon-Buettner,S. M. ; Ramos,G. C. ; Frantz,S. ; Viereck,J. ; Loyer,X. ; Boulanger,C. ; Wollert,K. C. ; Fiedler,J. ; Thum,T.
Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19 England,J.Mol.Cell.Cardiol.,2020;146():43-59
Originalpublikation
Hollwedel,F. D. ; Maus,R. ; Stolper,J. ; Khan,A. ; Stocker,B. L. ; Timmer,M. S. M. ; Lu,X. ; Pich,A. ; Welte,T. ; Yamasaki,S. ; Maus,U. A.
Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice
United States,J.Immunol.,2020;205(12):3390-3399
Originalpublikation
Jansen,K. ; Hanusch,B. ; Pross,S. ; Hanff,E. ; Drabert,K. ; Bollenbach,A. ; Dugave,I. ; Carmann,C. ; Siefen,R. G. ; Emons,B. ; Juckel,G. ; Legenbauer,T. ; Tsikas,D. ; Lücke,T.
Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate
Switzerland,J.Clin.Med.,2020;9(1):pii: E175-
Originalpublikation
Jansing,J. C. ; Fiedler,J. ; Pich,A. ; Viereck,J. ; Thum,T. ; Mühlfeld,C. ; Brandenberger,C.
miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury
Switzerland,Int.J.Mol.Sci.,2020;21(3):E822-
Originalpublikation
Kedia,G. T. ; Ückert,S. ; Tsikas,D. ; Becker,A. J. ; Kuczyk,M. A. ; Bannowsky,A.
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts
Switzerland,J.Clin.Med.,2020;9(9):E2987-
Übersicht
Kropp,K. A. ; Srivaratharajan,S. ; Ritter,B. ; Yu,P. ; Krooss,S. ; Polten,F. ; Pich,A. ; Alcami,A. ; Viejo-Borbolla,A.
Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2
Switzerland,Viruses,2020;12(12):E1428 [pii]-
Originalpublikation
Melzer,C. ; Jacobs,R. ; Dittmar,T. ; Pich,A. ; von der Ohe,J. ; Yang,Y. ; Hass,R.
Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line
Switzerland,Int.J.Mol.Sci.,2020;21(13):E4752.-
Originalpublikation
Neu,A. ; Hornig,S. ; Sasani,A. ; Isbrandt,D. ; Gerloff,C. ; Tsikas,D. ; Schwedhelm,E. ; Choe,C. U.
Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
Austria,Amino Acids,2020;52(6-7):1067-1069
Letter
Schöttelndreier,D. ; Langejürgen,A. ; Lindner,R. ; Genth,H.
Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor Switzerland,Front.Cell.Infect.Microbiol.,2020;10():565465-
Originalpublikation
Stojanovic,S. D. ; Fuchs,M. ; Fiedler,J. ; Xiao,K. ; Meinecke,A. ; Just,A. ; Pich,A. ; Thum,T. ; Kunz,M.
Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts
Switzerland,Int.J.Mol.Sci.,2020;21(11):-
Originalpublikation
Stojanovic,S. D. ; Fuchs,M. ; Kunz,M. ; Xiao,K. ; Just,A. ; Pich,A. ; Bauersachs,J. ; Fiedler,J. ; Sedding,D. ; Thum,T.
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells
Switzerland,Front.Physiol.,2020;11():520-
Originalpublikation
Tian,S. ; Liu,Y. ; Wu,H. ; Liu,H. ; Zeng,J. ; Choi,M. Y. ; Chen,H. ; Gerhard,R. ; Dong,M.
Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL
United States,Cell.Host Microbe,2020;27(5):782-792.e7
Originalpublikation
Tsikas,D.
GC-MS approach revealing hidden nitrite reactions in hemolysate using (18)O-labelled nitrite and cysteine-based thiols
United States,Anal.Biochem.,2020;():114025-
Originalpublikation
Tsikas,D.
Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol
United States,Anal.Biochem.,2020;():113994-
Originalpublikation
Tsikas,D.
Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond
Switzerland,J.Clin.Med.,2020;9(6):-
Übersicht
Tsikas,D. ; Surdacki,A.
Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. Jakoby
United States,Anal.Biochem.,2020;():113993-
Übersicht
Yepes-Calderon,M. ; Sotomayor,C. G. ; Gans,R. O. B. ; Berger,S. P. ; Leuvenink,H. G. D. ; Tsikas,D. ; Rodrigo,R. ; Navis,G. J. ; Bakker,S. J. L.
Post-transplantation plasma malondialdehyde is associated with cardiovascular mortality in renal transplant recipients: a prospective cohort study
England,Nephrol.Dial.Transplant.,2020;35(3):512-519
Originalpublikation
Schöttelndreier,Dennis
Expression und zelluläre Internalisierung der Rezeptoren von Clostridium difficile Toxin A und Toxin B
Hannover,,2020;():VI, 75 Blätter : Illustrationen, Diagramme-
Dissertation
Kriedemann,Nils
LC-MS based proteomic analysis of human endomyocardial heart biopsies of heart failure patients
Hannover,,2020;():-
Masterarbeit
Scheele,Marven
Integration des SpyCatcher-SpyTag Systems in Clostridioides difficile Toxin B
Hannover,,2020;():68 Seiten-
Masterarbeit
Bogutzki,A., Naue,N., Litz,L., Pich,A., Curth,U.
E. coli primase and DNA polymerase III holoenzyme are able to bind concurrently to a primed template during DNA replication.
Sci.Rep.2019;9(1):14460-
http://dx.doi.org/10.1038/s41598-019-51031-0
Originalpublikation
Bollenbach,A., Bakker,S. J. L., Tsikas,D.
GC-MS measurement of biological N(G)-hydroxy-L-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor
Amino Acids,2019;51(4):627-64
http://dx.doi.org/10.1007/s00726-018-02695-x
Originalpublikation
Bollenbach,A., Cordts,K., Hanff,E., Atzler,D., Choe,C. U., Schwedhelm,E., Tsikas,D.
Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans
Anal.Biochem.,2019;577():59-66
http://dx.doi.org/10.1016/j.ab.2019.04.019
Originalpublikation
Bollenbach,A., Hanff,E., Brunner,G., Tsikas,D.
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection
Amino Acids,2019;51(6):961-971
http://dx.doi.org/10.1007/s00726-019-02737-y
Originalpublikation
Bollenbach,A., Huneau,J. F., Mariotti,F., Tsikas,D.
Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men
Nutrients,2019;11(7):E1463-
http://dx.doi.org/10.3390/nu11071463
Originalpublikation
Bollenbach,A., Tsikas,D., Lenzen,S., Jörns,A.
Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-alpha antibody-based therapy
Amino Acids,2020;52(1):103-110
http://dx.doi.org/10.1007/s00726-019-02811-5
Originalpublikation
Erdmann,J., Thöming,J. G., Pohl,S., Pich,A., Lenz,C., Häussler,S.
The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates
Cells,2019;8(10):E1129 [pii]-
http://dx.doi.org/10.3390/cells8101129
Originalpublikation
Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M., Trogisch,F. A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M., Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A., Remedios,C. D., Riechert,E., Völkers,M., Doroudgar,S., Jungmann,A., Bauer,R., Yin,X., Mayr,M., Wollert,K. C., Pich,A., Xiao,H., Katus,H. A., Bauersachs,J., Müller,O. J., Heineke,J.
TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
EMBO Mol.Med.,2019;11(10):e10018-
http://dx.doi.org/10.15252/emmm.201810018
Originalpublikation
Hanff,E., Bollenbach,A., Beckmann,B., Brunner,G., Tsikas,D.
GC-MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine
Amino Acids,2020;52(2):225-234
http://dx.doi.org/10.1007/s00726-019-02786-3
Originalpublikation
Hanff,E., Ruben,S., Kreuzer,M., Bollenbach,A., Kayacelebi,A. A., Das,A. M., von Versen-Höynck,F., von Kaisenberg,C., Haffner,D., Ückert,S., Tsikas,D.
Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity
Amino Acids,2019;51(3):529-547
http://dx.doi.org/10.1007/s00726-018-02688-w
Originalpublikation
Hanff,E., Said,M. Y., Kayacelebi,A. A., Post,A., Minovic,I., van den Berg,E., de Borst,M. H., van Goor,H., Bakker,S. J. L., Tsikas,D.
High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients
Amino Acids,2019;51(10-12):1485-1499
http://dx.doi.org/10.1007/s00726-019-02783-6
Originalpublikation
Ho,G. T., Heinen,F. J., Blasczyk,R., Pich,A., Bade-Doeding,C.
HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint
Int.J.Mol.Sci.,2019;20(22):E5572.-
http://dx.doi.org/10.3390/ijms20225572
Originalpublikation
Kluge,A., Rangrez,A. Y., Kilian,L. S., Pott,J., Bernt,A., Frauen,R., Rohrbeck,A., Frey,N., Frank,D.
Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy
J.Mol.Cell.Cardiol.,2019;129():130-143
http://dx.doi.org/10.1016/j.yjmcc.2019.01.028
Originalpublikation
Kutschenko,A., Weisemann,J., Kollewe,K., Fiedler,T., Alvermann,S., Böselt,S., Escher,C., Garde,N., Gingele,S., Kaehler,S. B., Karatschai,R., Krüger,T. H. C., Sikorra,S., Tacik,P., Wegner,F., Wollmann,J., Bigalke,H., Wohlfarth,K., Rummel,A.
Botulinum neurotoxin serotype D - A potential treatment alternative for BoNT/A and B non-responding patients
Clin.Neurophysiol.,2019;130(6):1066-1073
http://dx.doi.org/10.1016/j.clinph.2019.02.007
Originalpublikation
Nebl,J., Drabert,K., Haufe,S., Wasserfurth,P., Eigendorf,J., Tegtbur,U., Hahn,A., Tsikas,D.
Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns
Nutrients,2019;11(8):E1875-
http://dx.doi.org/10.3390/nu11081875
Originalpublikation
Pich,A., Junemann,J., Stieglitz,F., Schweitzer,T.
Clostridioides difficile-Toxine verändern das Proteom von Darmzellen
BIOspektrum,2019;25(6):633-636
http://dx.doi.org/10.1007/s12268-019-0213-0
Originalpublikation
Post,A., Said,M. Y., Gomes-Neto,A. W., van der Krogt,J., de Blaauw,P., Berger,S. P., Geleijnse,J. M., Borgonjen,K., van den Berg,E., van Goor,H., Rimbach,G., Kema,I. P., Tsikas,D., Heiner-Fokkema,M. R., Bakker,S. J. L.
Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients
Nutrients,2019;11(9):E2212-
http://dx.doi.org/10.3390/nu11092212
Originalpublikation
Post,A., Tsikas,D., Bakker,S. J. L.
Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review
Nutrients,2019;11(5):E1044-
http://dx.doi.org/10.3390/nu11051044
Übersicht
Rahardjo,H. E., Ückert,S., Tsikas,D., Hedlund,P., Bannowsky,A., Kuczyk,M. A., Kedia,G. T.
Arginase enzymes in the human prostate: A molecular biological and immunohistochemical approach
Andrologia,2019;51(9):e13349-
http://dx.doi.org/10.1111/and.13349
Originalpublikation
Said,M. Y., Bollenbach,A., Minovic,I., van Londen,M., Frenay,A. R., de Borst,M. H., van den Berg,E., Kayacelebi,A. A., Tsikas,D., van Goor,H., Navis,G., Bakker,S. J. L.
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients
Amino Acids,2019;51(6):913-927
http://dx.doi.org/10.1007/s00726-019-02725-2
Originalpublikation
Said,M. Y., Douwes,R. M., van Londen,M., Minovic,I., Frenay,A. R., de Borst,M. H., van den Berg,E., Heiner-Fokkema,M. R., Kayacelebi,A. A., Bollenbach,A., van Goor,H., Navis,G., Tsikas,D., Bakker,S. J. L.
Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants
Amino Acids,2019;51(3):565-575
http://dx.doi.org/10.1007/s00726-018-02693-z
Originalpublikation
Sasani,A., Hornig,S., Grzybowski,R., Cordts,K., Hanff,E., Tsikas,D., Böger,R., Gerloff,C., Isbrandt,D., Neu,A., Schwedhelm,E., Choe,C. U.
Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure
Amino Acids,2020;52(1):73-85
http://dx.doi.org/10.1007/s00726-019-02812-4
Originalpublikation
Schoenherr,C., Wohlan,K., Dallmann,I., Pich,A., Hegermann,J., Ganser,A., Hilfiker-Kleiner,D., Heidenreich,O., Scherr,M., Eder,M.
Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
PLoS One,2019;14(12):e0225977-
http://dx.doi.org/10.1371/journal.pone.0225977
Originalpublikation
Simper,G. S., Gräser,L. S., Celik,A. A., Kuhn,J., Kunze-Schumacher,H., Ho,G. T., Blasczyk,R., Pich,A., Bade-Doeding,C.
The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
Pharmaceutics,2019;11(10):pii: E536-
http://dx.doi.org/10.3390/pharmaceutics11100536
Originalpublikation
Sonnenschein,K., Fiedler,J., Pfanne,A., Just,A., Mitzka,S., Geffers,R., Pich,A., Bauersachs,J., Thum,T.
Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury Cardiovasc.Res.,2019;115(12):1804-1810
http://dx.doi.org/10.1093/cvr/cvz063
Originalpublikation
Tao,L., Tian,S., Zhang,J., Liu,Z., Robinson-McCarthy,L., Miyashita,S. I., Breault,D. T., Gerhard,R., Oottamasathien,S., Whelan,S. P. J., Dong,M.
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Nat.Microbiol.,2019;4(10):1760-1769
http://dx.doi.org/10.1038/s41564-019-0464-z
Originalpublikation
Tsikas,D., Bollenbach,A., Hanff,E., Beckmann,B., Redfors,B.
Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat
Amino Acids,2020;52(2):235-245
http://dx.doi.org/10.1007/s00726-019-02808-0
Originalpublikation
Ückert,S., Kedia,G. T., Tsikas,D., Simon,A., Bannowsky,A., Kuczyk,M. A.
Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate,Germany,World J.Urol.,2020;38(6):1423-1435
http://dx.doi.org/10.1007/s00345-019-02933-1
Übersicht
von Berg,L., Stern,D., Pauly,D., Mahrhold,S., Weisemann,J., Jentsch,L., Hansbauer,E. M., Müller,C., Avondet,M. A., Rummel,A., Dorner,M. B., Dorner,B. G.
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
Sci.Rep.,2019;9(1):5531-
http://dx.doi.org/10.1038/s41598-019-41722-z
Originalpublikation
von Berg,L., Stern,D., Weisemann,J., Rummel,A., Dorner,M. B., Dorner,B. G.
Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments
Toxins (Basel),2019;11(10):E588-
http://dx.doi.org/10.3390/toxins11100588
Originalpublikation
Welz,B., Bikker,R., Junemann,J., Christmann,M., Neumann,K., Weber,M., Hoffmeister,L., Preuss,K., Pich,A., Huber,R., Brand,K.
Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes
Int.J.Mol.Sci.,2019;20(5):E1241-
http://dx.doi.org/10.3390/ijms20051241
Originalpublikation
Wieczorek-Surdacka,E., Hanff,E., Chyrchel,B., Kuzniewski,M., Surdacki,A., Tsikas,D.
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease
Amino Acids,2019;51(6):977-982
http://dx.doi.org/10.1007/s00726-019-02738-x
Originalpublikation
Zeleny,R., Rummel,A., Jansson,D., Dorner,B. G.
Challenges in the Development of Reference Materials for Protein Toxins. In: Applications in Forensic Proteomics: Protein Identification and Profiling 2019; 1339: 185-202
http://dx.doi.org/doi:10.1021/bk-2019-1339.ch012
Buchbeitrag, Monografie
Abere,B., Samarina,N., Gramolelli,S., Rückert,J., Gerold,G., Pich,A.,Schulz,T. F.
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2alpha To Activate Productive Viral Replication
J.Virol. 2018; 92(17):e00544-18-
Originalpublikation
http://dx.doi.org/10.1128/JVI.00544-18
Adolf,A., Rohrbeck,A., Münster-Wandowski,A., Johansson,M., Kuhn,H. G., Kopp,M. A., Brommer,B., Schwab,J. M., Just,I., Ahnert-Hilger,G., Höltje,M.,
Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons.
Glia 2019; 67(4):703-717
Originalpublikation
http://dx.doi.org/10.1002/glia.23566
Aye,R., Weldearegay,Y. B., Lutta,H. O., Chuma,F., Pich,A., Jores,J., Meens,J., Naessens,J.
Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides.
Vet.Immunol.Immunopathol. 2018; 204(11-18)
Originalpublikation
http://dx.doi.org/10.1016/j.vetimm.2018.09.002
Beer,L. A., Tatge,H., Reich,N., Tenspolde,M., Olling,A., Goy,S., Rottner,K., Alekov,A. K., Gerhard,R.
Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate.
Cell.Microbiol. 2018; 20(10):e12865-
Originalpublikation
http://dx.doi.org/10.1111/cmi.12865
Beer,L. A., Tatge,H., Schneider,C., Ruschig,M., Hust,M., Barton,J., Thiemann,S., Fühner,V., Russo,G., Gerhard,R.
The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains.
Toxins (Basel) 2018; 10(6):E225-
Originalpublikation
http://dx.doi.org/10.3390/toxins10060225
Bollenbach,A., Hanff,E., Beckmann,B., Kruger,R., Tsikas,D.,
GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index.
Anal.Biochem. 2018; 556(40-44)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.06.021
Bollenbach,A., Hanff,E., Tsikas,D.
Investigation of N(G)-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1100-1101(174-178)
Originalpublikation
http://dx.doi.org/10.1016/j.jchromb.2018.10.007
Bollenbach,A., Hanff,E., Tsikas,D.
Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
Anal.Biochem. 2018; 563(67-70)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.10.012
Bollenbach,A., Tsikas,D.
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N(G)-hydroxy-L-arginine, N(omega),N(omega)-dimethyl-L-citrulline and N(omega),N(omega)-dimethyl-N(delta)-hydroxy-L-citrulline: results and overview.
Amino Acids 2019; 51(3):483-494
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2684-6
Chung,S. Y., Schöttelndreier,D., Tatge,H., Fühner,V., Hust,M., Beer,L. A., Gerhard,R.
The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
Front.Microbiol. 2018; 9(2314-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.02314
Erdmann,J., Preusse,M., Khaledi,A., Pich,A., Häussler,S.
Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa.
Environ.Microbiol. 2018; 20(11):3952-3963
Originalpublikation
http://dx.doi.org/10.1111/1462-2920.14419
Finkel,A., Röhrich,M. A., Maassen,N., Lützow,M., Blau,L. S., Hanff,E., Tsikas,D., Maassen,M., Long-term effects of NO3(-) on the relationship between oxygen uptake and power after 3 weeks of supplemented HIHV training
J.Appl.Physiol.(1985) 2018; 125(6):1997-2007
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http://dx.doi.org/10.1152/japplphysiol.00176.2018
Fischer,V., Dudzinska,A., Just,I.
The impact of the program structure at Hannover Medical School on academic success in medical studies
GMS J.Med.Educ. 2018; 35(2):Doc22-
Originalpublikation
http://dx.doi.org/10.3205/zma001169
Genth,H., Junemann,J., Lämmerhirt,C. M., Lücke,A. C., Schelle,I., Just,I., Gerhard,R., Pich,A.
Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
Front.Microbiol. 2018; 9(3078-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.03078
Hanff,E., Hafner,P., Bollenbach,A., Bonati,U., Kayacelebi,A. A., Fischer,D., Tsikas,D.
Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications
Amino Acids 2018; 50(10):1391-1406
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2614-7
Hanff,E., Zinke,M., Böhmer,A., Niebuhr,J., Maassen,M., Endeward,V., Maassen,N., Tsikas,D.
GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV
Anal.Biochem. 2018; 550(132-136)
Originalpublikation
http://dx.doi.org/10.1016/j.ab.2018.05.001
Junemann,J., Just,I., Gerhard,R., Pich,A.
Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells
Front.Microbiol. 2018; 9(3083-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.03083
Just,I., Fischer,V.
Prüfungen an der Medizinischen Hochschule Hannover - Wie kommt man vom Ist zum Soll?
Wien.Med.Wochenschr. 2019; 169(5-6):119-125
Originalpublikation
http://dx.doi.org/10.1007/s10354-018-0663-x
Lam,K. H., Sikorra,S., Weisemann,J., Maatsch,H., Perry,K., Rummel,A., Binz,T., Jin,R.
Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA
Pathog.Dis. 2018; 76(4):10.1093/femspd/fty044-
Originalpublikation
http://dx.doi.org/10.1093/femspd/fty044
Mehner-Breitfeld,D., Rathmann,C., Riedel,T., Just,I., Gerhard,R., Overmann,J., Brüser,T.
Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile
Front.Microbiol. 2018; 9(2446-
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http://dx.doi.org/10.3389/fmicb.2018.02446
Montag,J., Kowalski,K., Makul,M., Ernstberger,P., Radocaj,A., Beck,J., Becker,E., Tripathi,S., Keyser,B., Mühlfeld,C., Wissel,K., Pich,A., van der Velden,J., Dos Remedios,C. G., Perrot,A., Francino,A., Navarro-Lopez,F., Brenner,B., Kraft,T.
Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
Front.Physiol. 2018; 9(359-
Originalpublikation
http://dx.doi.org/10.3389/fphys.2018.00359
Rahardjo,H. E., Ückert,S., Bannowsky,A., Tsikas,D., Becker,A. J., Kuczyk,M. A.
Course of transforming growth factor ss1 in the systemic and cavernous blood of healthy males through different penile conditions
Andrologia 2019; 51(1):e13150-
Originalpublikation
http://dx.doi.org/10.1111/and.13150
Schöttelndreier,D., Seeger,K., Grassl,G. A., Winny,M. R., Lindner,R., Genth,H.
Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
Front.Microbiol. 2018; 9(1483-
Originalpublikation
http://dx.doi.org/10.3389/fmicb.2018.01483
Schröder,A., Benski,A., Oltmanns,A., Just,I., Rohrbeck,A., Pich,A.
MS-based quantification of RhoA/B and RhoC ADP-ribosylation
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1092(268-271)
Originalpublikation
http://dx.doi.org/S1570-0232(18)30604-4
Shahin,P., Rahardjo,H. E., Bannowsky,A., Tsikas,D., Sohn,M., Kuczyk,M. A., Ückert,S.
Endopeptidase inhibition attenuates the contraction induced by big endothelin-1 of isolated human penile erectile tissue
Andrologia 2018; 50(5):e13008-
Originalpublikation
http://dx.doi.org/10.1111/and.13008
Sikorra,S., Skiba,M., Dorner,M. B., Weisemann,J., Weil,M., Valdezate,S., Davletov,B., Rummel,A., Dorner,B. G., Binz,T.
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)(-)K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
Toxins (Basel) 2018; 10(8):E311-
Originalpublikation
http://dx.doi.org/10.3390/toxins10080311
Stern,D., Weisemann,J., Le Blanc,A., von Berg,L., Mahrhold,S., Piesker,J., Laue,M., Luppa,P. B., Dorner,M. B., Dorner,B. G., Rummel,A.
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
PLoS Pathog. 2018; 14(5):e1007048-
Originalpublikation
http://dx.doi.org/10.1371/journal.ppat.1007048
Tan,X., Xu,A., Zhao,T., Zhao,Q., Zhang,J., Fan,C., Deng,Y., Freywald,A., Genth,H., Xiang,J.,
Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
Sci.Rep. 2018; 8(1):3769-
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http://dx.doi.org/10.1038/s41598-018-20459-1
Tsikas,D.,
Bioanalytical method validation of endogenous substances according to guidelines by the FDA and other organizations: Basic need to specify concentration ranges
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1093-1094(80-81)
Letter
http://dx.doi.org/10.1016/j.jchromb.2018.07.005
Tsikas,D., Bollenbach,A., Hanff,E., Kayacelebi,A. A.
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes
Cardiovasc.Diabetol. 2018; 17(1):1-
Comment
http://dx.doi.org/10.1186/s12933-017-0656-x
Tsikas,D., Hanff,E.
Measurement of S -Nitrosoglutathione in Plasma by Liquid Chromatography-Tandem Mass Spectrometry Methods
Mol.Biol. 2018; 1747(113-129
Originalpublikation
http://dx.doi.org/10.1007/978-1-4939-7695-9_10
Tsikas,D., Hanff,E., Bollenbach,A., Kruger,R., Pham,V. V., Chobanyan-Jürgens,K., Wedekind,D., Arndt,T., Jörns,A., Berbee,J. F. P., Princen,H. M. G., Lücke,T., Mariotti,F., Huneau,J. F., Ückert,S., Frölich,J. C., Lenzen,S.,
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
Amino Acids 2018; 50(7):799-821
Originalpublikation
http://dx.doi.org/10.1007/s00726-018-2573-z
Wolling,H., Konze,S. A., Höfer,A., Erdmann,J., Pich,A., Zweigerdt,R., Buettner,F. F. R.,
Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis
Proteomics 2018; 18(14):e1800102-
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http://dx.doi.org/10.1002/pmic.201800102
Zhao,T., Li,R., Tan,X., Zhang,J., Fan,C., Zhao,Q., Deng,Y., Xu,A., Lukong,K. E., Genth,H., Xiang,J.,
Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-kappaB and ERK1/2 Pathways
Int.J.Mol.Sci. 2018; 19(7):E1994-
Originalpublikation
http://dx.doi.org/10.3390/ijms19071994
Buck A, Kayacelebi A A, Chobanyan-Jürgens K, Illsinger S, Bohnhorst B, Beckmann B, Hanff E, Das A M, Tsikas D, Lücke T
Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth.
Amino Acids 2017; 49(4):783-794
Originalpublikation
Volltext
Debez A, Belghith I, Pich A, Taamalli W, Abdelly C, Braun H P
High salinity impacts germination of the halophyte Cakile maritima but primes seeds for rapid germination upon stress release.
Physiol. Plant. 2017, ppl.12679-
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Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A
Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.
Proteomics 2017; 17(15-16):1600435-
Originalpublikation
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Fischer V, Just I
Qualitätssicherung in Prüfungen am Beispiel von 10 Jahren e-Prüfungen an der MHH.
Qualität in der Wissenschaft (QiW) 2017; 11(2):60-64
Originalpublikation
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Günes D N, Kayacelebi A A, Hanff E, Lundgren J, Redfors B, Tsikas D
Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.
Amino Acids 2017; 49(12):2033-2044
Originalpublikation
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Haghikia A, Yanchev G R, Kayacelebi A A, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D
The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.
Amino Acids 2017; 49(6):1111-1121
Originalpublikation
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Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Göhring G, Schmidt H, Sgodda M, Cantz T
In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells.
Biol.Chem. 2017; 398(8):939-954
Originalpublikation
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Junemann J, Lämmerhirt C M, Polten F, Just I, Gerhard R, Genth H, Pich A
Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis.
Proteomics 2017; 17(9):1700016-
Originalpublikation
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Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H, Feelisch M, van Goor H, Bakker S J L, Tsikas D
Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.
Amino Acids 2017; 49(7):1193-1202
Originalpublikation
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Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R
Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells.
Chembiochem 2017; 18(13):1317-1331
Originalpublikation
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Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F
Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.
J. Proteome Res. 2017; 16(3):1133-1149
Originalpublikation
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Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N
Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands.
Croat. Chem. Acta 2017; 90(2):263-271
Originalpublikation
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Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R
The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.
Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012-
Originalpublikation
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Nkuipou-Kenfack E, Schanstra J P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P
The use of urinary proteomics in the assessment of suitability of mouse models for ageing.
PLoS One 2017; 12(2):e0166875-
Originalpublikation
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Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.
Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038-
Übersicht
Volltext
Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C
EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.
Circulation 2017; 136(19):1809-1823
Originalpublikation
Volltext
Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I
The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif.
J. Biol. Chem. 2017; 292(43):17668-17680
Originalpublikation
Volltext
Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A
Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB.
Front. Cell. Infect. Microbiol. 2017; 7(67-
Originalpublikation
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Rummel A
Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.
Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48-
Übersicht
Volltext
Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A
Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics.
PLoS One 2017; 12(5):e0178182-
Originalpublikation
Volltext
Tsikas D
Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first.
Atherosclerosis 2017; 264:79-82
Editorial
Volltext
Tsikas D
The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a.
J Controversies Biomed Res 2017; 3(1):11-15
Originalpublikation
Volltext
Tsikas D
Does oxidative stress change during orthotopic liver transplantation?
J Controversies Biomed Res 2017; 3(2):1-5
Originalpublikation
Volltext
Tsikas D
Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox.
J Controversies Biomed Res 2017; 3(1):16-22
Originalpublikation
Volltext
Tsikas D
Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans".
Anal.Bioanal Chem. 2017; 409(9):2495-
Letter
Volltext
Tsikas D
Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS?
Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040-
Letter
Volltext
Tsikas D
Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid.
JSM Biochem Mol Biol 2017; 4(2):1027-
Originalpublikation
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Tsikas D
What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine.
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72
Übersicht
Volltext
Tsikas D, Böhmer A
S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature.
Nitric Oxide 2017; 65:22-36
Originalpublikation
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Tsikas D, Bollenbach A, Savvidou M D
Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?
Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2-
Originalpublikation
Volltext
Tsikas D, Eigendorf J
Diet and Exercise and Serum Markers of Oxidative Stress-Letter.
Cancer.Prev.Res.(Phila) 2017; 10(8):485-486
Letter
Volltext
Tsikas D, Hanff E
Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy.
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142
Übersicht
Volltext
Tsikas D, Hanff E, Becker T
Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?
Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009-
Letter
Volltext
Tsikas D, Hanff E, Bollenbach A
S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics.
World J.Gastroenterol. 2017; 23(40):7343-7346
Letter
Volltext
Tsikas D, Hanff E, Brunner G
Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase.
Trends Microbiol. 2017; 25(8):601-602
Letter
Volltext
Tsikas D, Hanff E, Brunner G
Spermidine for a long, dementia-free life?
Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576-
Übersicht
Volltext
Tsikas D, Kinzel M
Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men.
Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004-
Originalpublikation
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Tsikas D, Savvidou M
Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile.
JSM Biochem Mol Biol 2017; 4(2):1028-
Originalpublikation
Volltext
Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S
S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) � Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview.
2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003-
Originalpublikation
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von Elsner L, Hagemann S, Just I, Rohrbeck A
Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation.
J Mol Signal 2017; 12(1-
Originalpublikation
Volltext
Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.
Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093-
Originalpublikation
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Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R
A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.
Sci.Rep. 2017; 7(1):7438-
Originalpublikation
Volltext
Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M
Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.
PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567-
Originalpublikation
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Frädrich C, Beer LA, Gerhard R
Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B
Toxins (Basel) 2016; 8 (1), 25
Übersicht
Abstract
Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D
Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells
Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82)
Originalpublikation
Abstract
Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M
The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme
Journal of Neurochemistry 2016; 139 (2): 234-244
Originalpublikation
Volltext
Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S
Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization
Scientific Reports 2016; 6 (36598-)
Originalpublikation
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Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A
Biological toxins of potential bioterrorism risk: Current status of detection and identification technology
TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102
Übersicht
Abstract
Gerhard R
Receptors and Binding Structures for Clostridium difficile Toxins A and B
Current Topics in Microbiology and Immunology 2016: 1-18
Originalpublikation
Abstract
Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S
Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa
Environmental Microbiology 2016; 18 (10): 3583-3592
Originalpublikation
Volltext
Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A
Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1
Biochemical Journal 2016; 473 (17): 2645-2654
Originalpublikation
Volltext
Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I
Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody
Toxins (Basel) 2016; 8(4):100
Originalpublikation
Volltext
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Nature 2016; 538(7625): 350-355
Originalpublikation
Volltext
von Elsner L, Hagemann S, Just I, Rohrbeck A
C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors
Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031
Originalpublikation
Volltext
Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A
Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
Toxins (Basel) 2016; 8(5), 154
Originalpublikation
Volltext
Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
Nature Structural & Molecular Biology 2016; 23 (7): 656-662
Originalpublikation
Volltext
Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043
Originalpublikation
Volltext
Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A
Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells
Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4)
Originalpublikation
Volltext
Genth H, Schelle I, Just I
Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
Toxins (Basel) 2016; 8 (4): 109
Originalpublikation
Volltext
Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG
Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry
Analyst 2016; 141 (18): 5281 -5297
Originalpublikation
Volltext
Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A
BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay
Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8
Originalpublikation
Abstract
Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells
Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50
Originalpublikation
Volltext
Schelle I, Bruening J, Buetepage M, Genth H
Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
Toxins (Basel) 2016; 9 (1), 2
Originalpublikation
Volltext
Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC
Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
Nature medicine 2015;2;2;140-149
Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG
Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype
PLoS One 2015;10;2
Rohrbeck A, von Elsner L, Hagemann S, Just I
Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells
Toxins 2015;7;380-395
Bothe M, Dutow P, Pich A, Genth H, Klos A
DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166
Toxins 2015;17;621-637
Haschemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T
Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.
Eur Addict Res 2016;22(2);59 -69
Volltext
Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R
Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.
Toxicon 2015;107(Pt.A);43 -49
Abstract
Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G
UV radiation induces CXCL5 expression in human skin.
Exp Dermatol 2015;24(4);309 -312
Volltext
Rummel A
The long journey of botulinum neurotoxins into the synapse.
Toxicon 2015;107(Pt.A):9 -24
Abstract
Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K
C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity
Neurochem Int 2015; 90;232 -245
Abstract
Schröder A, Rohrbeck A, Just I, Pich A
Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.
J Proteome Res 2015;14(11);4721 -4733
Volltext
Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH
miR-139-5p controls translation in myeloid leukemia through EIF4G2.
Oncogene 2015;DOI: 10.1038/onc.2015.247
Volltext
Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H
Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117
Abstract
Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML
SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity.
Biochim Biophys Acta 2015;1853(1);136 -143
Volltext
Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J
Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP).
J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016
Volltext
Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E
Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.
Cell Microbiol 2015;17(8);1179 -1204
Volltext
Dorner BG, Rummel A
Preface biological Toxins ancient molecules posing a current threat.
Toxins 2015;7(12);5320 -5321
Volltext
Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F.
Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca and GTPgammaS ,,Toxicology,2015;328():48-56
Originalpublikation
Chatterji,B. ; Dickhut,C. ; Mielke,S. ; Krüger,J. ; Just,I. ; Glage,S. ; Meier,M. ; Wedekind,D. ; Pich,A.
MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease ,
Germany,Proteomics,2014;14(13-14):1674-1687
Originalpublikation
Dressler,D. ; Adib Saberi,F. ; Bigalke,H.
IncobotulinumtoxinA (Xeomin((R))) can produce antibody-induced therapy failure in a patient pretreated with abobotulinumtoxinA (Dysport((R)))
Austria,J.Neural Transm.,2014;121(7):769-771
Case report
Dressler,D. ; Gessler,F. ; Tacik,P. ; Bigalke,H.
An enzyme-linked immunosorbent assay for detection of botulinum toxin-antibodies
United States,Mov.Disord.,2014;29(10):1322-1324
Originalpublikation
Genth,H. ; Pauillac,S. ; Schelle,I. ; Bouvet,P. ; Bouchier,C. ; Varela-Chavez,C. ; Just,I. ; Popoff,M. R.
Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins
England,Cell.Microbiol.,2014;16(11):1706-1721
Originalpublikation
Gonzalez-Escalona,N. ; Thirunavukkarasu,N. ; Singh,A. ; Toro,M. ; Brown,E. W. ; Zink,D. ; Rummel,A. ; Sharma,S. K.
Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type
United States,Genome Announc,2014;2(6):10.1128/genomeA.01275-14
Originalpublikation
Goy,S. D. ; Olling,A. ; Neumann,D. ; Pich,A. ; Gerhard,R.
Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor ,,Cell.Microbiol.,2015;17(6):893-909
Originalpublikation
Hardtke-Wolenski,M. ; Taubert,R. ; Noyan,F. ; Sievers,M. ; Dywicki,J. ; Schlue,J. ; Falk,C. S. ; Lundgren,B. A. ; Scott,H. S. ; Pich,A. ; Anderson,M. S. ; Manns,M. P. ; Jaeckel,E.
Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens ,,Hepatology,2015;61(4):1295-1305
Originalpublikation
Jochim,N. ; Gerhard,R. ; Just,I. ; Pich,A.
Time-resolved cellular effects induced by TcdA from Clostridium difficile
England,Rapid Commun.Mass Spectrom.,2014;28(10):1089-1100
Originalpublikation
Jünger,J. ; Just,I.
Recommendations of the German Society for Medical Education and the German Association of Medical Faculties regarding university-specific assessments during the study of human, dental and veterinary medicine
Germany,GMS Z.Med.Ausbild,2014;31(3):Doc34-
Originalpublikation
Konze,S. A. ; van Diepen,L. ; Schröder,A. ; Olmer,R. ; Moller,H. ; Pich,A. ; Weissmann,R. ; Kuss,A. W. ; Zweigerdt,R. ; Buettner,F. F.
Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells
United States,Mol.Cell.Proteomics,2014;13(4):990-1007
Originalpublikation
Lee,K. ; Lam,K. H. ; Kruel,A. M. ; Perry,K. ; Rummel,A. ; Jin,R.
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex
United States,Biochem.Biophys.Res.Commun.,2014;446(2):568-573
Originalpublikation
Lee,K. ; Zhong,X. ; Gu,S. ; Kruel,A. M. ; Dorner,M. B. ; Perry,K. ; Rummel,A. ; Dong,M. ; Jin,R.
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex
United States,Science,2014;344(6190):1405-1410
Originalpublikation
Matsui,T. ; Gu,S. ; Lam,K. H. ; Carter,L. G. ; Rummel,A. ; Mathews,I. I. ; Jin,R.
Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex
England,J.Mol.Biol.,2014;426(22):3773-3782
Originalpublikation
May,M. ; Schelle,I. ; Brakebusch,C. ; Rottner,K. ; Genth,H.
Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry
United States,Cell.Cycle,2014;13(14):2211-2221
Originalpublikation
Nkuipou-Kenfack,E. ; Koeck,T. ; Mischak,H. ; Pich,A. ; Schanstra,J. P. ; Zürbig,P. ; Schumacher,B.
Proteome analysis in the assessment of ageing ,,Ageing Res.Rev.,2014;18C():74-85
Übersicht
Olling,A. ; Hüls,C. ; Goy,S. ; Müller,M. ; Krooss,S. ; Rudolf,I. ; Tatge,H. ; Gerhard,R.
The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation
Switzerland,Toxins (Basel),2014;6(7):2162-2176
Originalpublikation
Rohrbeck,A. ; Schröder,A. ; Hagemann,S. ; Pich,A. ; Höltje,M. ; Ahnert-Hilger,G. ; Just,I.
Vimentin mediates uptake of C3 exoenzyme
United States,PLoS One,2014;9(6):e101071-
Originalpublikation
Rohrbeck,A. ; von Elsner,L. ; Hagemann,S. ; Just,I.
Binding of Clostridium botulinum C3 exoenzyme to intact cells
Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2014;387(6):523-532
Originalpublikation
Rummel,A. ;
The dual receptor recognition of botulinum neurotoxins
New York, NY,,2014;4():129-150
Buchbeitrag, Monografie
Saul,V. V. ; Niedenthal,R. ; Pich,A. ; Weber,F. ; Lienhard Schmitz,M.
SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity
Netherlands,Biochim.Biophys.Acta,2015;1853(1):136-143
Originalpublikation
Strotmeier,J. ; Mahrhold,S. ; Krez,N. ; Janzen,C. ; Lou,J. ; Marks,J. D. ; Binz,T. ; Rummel,A.
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
Netherlands,FEBS Lett.,2014;588(7):1087-1093
Originalpublikation
Wagner,S. ; Maibaum,D. ; Pich,A. ; Nolte,I. ; Murua Escobar,H.
Verification of a Canine PSMA (FolH1) Antibody
Greece,Anticancer Res.,2015;35(1):145-148
Originalpublikation
Wohlan,K. ; Goy,S. ; Olling,A. ; Srivaratharajan,S. ; Tatge,H. ; Genth,H. ; Gerhard,R.
Pyknotic cell death induced by Clostridium difficile TcdB: Chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity ,,Cell.Microbiol.,2014;76(11):1678-1692
Originalpublikation
Boetzkes,Alexander
Sekretomanalyse hypervirulenter Clostridium difficile-Stämme ,,,2014;():Getr. Zählung-
Dissertation
Brandes,Vanessa
Die durch Tauroursodeoxycholsäure vermittelte Phosphorylierung von Rac1/Cdc42 bewirkt eine reduzierte Glucosylierung katalysiert durch C. difficile Toxin B ,,,2014;():Bl. 77 - 84, Bl. 11 - 43-
Dissertation
Goy,Sebastian David
Clostridium difficile Toxin B activates formyl peptide receptor 1 of human neutrophil granulocytes via N-terminal glucosyltransferase domain ,,,2014;():138 Bl. Ill., graph. Darst.-
Dissertation
Rotsch,Jacqueline
Zelluläre Auswirkungen des bakteriellen Exoenzyms C3 bot ,,,2011;():III, 72 Bl. Ill., graph. Darst.-
Dissertation
Beer,Lara-Antonia
Die Rolle der niedermolekularen GTpase Rac1 und der NADPH Oxidase bei der Clostridium difficile TcdB-induzierten Pyknose ,,,2011;():-
Masterarbeit
Petersen,Lara
Die Rolle von Rho-GTPasen in den zytopathischen und zytotoxischen Wirkungen von Clostridium difficile Toxinen ,,,2011;():62 S.-
Masterarbeit
Gangl,Anna-Katharina
Effekte des marinen Toxins Latrunculin B auf die epitheliale Barrierefunktion des Kolon ,,,2011;():37 S.-
Bachelorarbeit
Bagramyan,K. ; Kaplan,B. E. ; Cheng,L. W. ; Strotmeier,J. ; Rummel,A. ; Kalkum,M.
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples
United States,Anal.Chem.,2013;85(11):5569-5576
Originalpublikation
Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F.
Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPgammaS containing intracellular solution
Netherlands,Eur.J.Pharmacol.,2013;720(1-3):227-236
Originalpublikation
Barth,H. ; Bigalke,H. ; Gerhard,R. ;
Bakterielle Toxine (Kap. 42)
Stuttgart,,2013;():1157-1180
Buchbeitrag, Monografie
Bigalke,H.
Botulinum toxin: application, safety, and limitations
Germany,Curr.Top.Microbiol.Immunol.,2013;364():307-317
Originalpublikation
Chatterji,B. ; Pich,A.
MALDI imaging mass spectrometry and analysis of endogenous peptides
England,Expert Rev.Proteomics,2013;10(4):381-388
Originalpublikation
Gerhard,R. ; Frenzel,E. ; Goy,S. ; Olling,A.
Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain ,,J.Med.Microbiol.,2013;62(9):1414-1422
Originalpublikation
Höltje,M. ; Schulze,S. ; Strotmeier,J. ; Mahrhold,S. ; Richter,K. ; Binz,T. ; Bigalke,H. ; Ahnert-Hilger,G. ; Rummel,A.
Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons ,,Toxicon,2013;75C():108-121
Originalpublikation
Huelsenbeck,S. C. ; Roggenkamp,D. ; May,M. ; Huelsenbeck,J. ; Brakebusch,C. ; Rottner,K. ; Ladwein,M. ; Just,I. ; Fritz,G. ; Schmidt,G. ; Genth,H.
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Netherlands,Int.J.Biochem.Cell Biol.,2013;45(8):1767-1775
Originalpublikation
Lee,K. ; Gu,S. ; Jin,L. ; Le,T. T. ; Cheng,L. W. ; Strotmeier,J. ; Kruel,A. M. ; Yao,G. ; Perry,K. ; Rummel,A. ; Jin,R.
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity
United States,PLoS Pathog.,2013;9(10):e1003690-
Originalpublikation
Mahrhold,S. ; Strotmeier,J. ; Garcia-Rodriguez,C. ; Lou,J. ; Marks,J. D. ; Rummel,A. ; Binz,T.
Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E
England,Biochem.J.,2013;453(1):37-47
Originalpublikation
May,M. ; Wang,T. ; Müller,M. ; Genth,H.
Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470
Switzerland,Toxins (Basel),2013;5(1):106-119
Originalpublikation
Pirazzini,M. ; Henke,T. ; Rossetto,O. ; Mahrhold,S. ; Krez,N. ; Rummel,A. ; Montecucco,C. ; Binz,T.
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
Netherlands,FEBS Lett.,2013;587(23):3831-3836
Originalpublikation
Rangrez,A. Y. ; Bernt,A. ; Poyanmehr,R. ; Harazin,V. ; Boomgaarden,I. ; Kuhn,C. ; Rohrbeck,A. ; Frank,D. ; Frey,N.
Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy
United States,J.Cell Biol.,2013;203(4):643-656
Originalpublikation
Rummel,A.
Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity
Germany,Curr.Top.Microbiol.Immunol.,2013;364():61-90
Originalpublikation
Scherr,M. ; Elder,A. ; Battmer,K. ; Barzan,D. ; Bomken,S. ; Ricke-Hoch,M. ; Schröder,A. ; Venturini,L. ; Blair,H. J. ; Vormoor,J. ; Ottmann,O. ; Ganser,A. ; Pich,A. ; Hilfiker-Kleiner,D. ; Heidenreich,O. ; Eder,M. ;
Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia ,,Leukemia,2014;28(3):554-565
Originalpublikation
Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P.
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
United States,PLoS Pathog.,2013;9(11):e1003746-
Originalpublikation
Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P.
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
United States,PLoS Pathog.,2013;9(11):e1003746-
Originalpublikation
Steffen,A. ; Ladwein,M. ; Dimchev,G. A. ; Hein,A. ; Schwenkmezger,L. ; Arens,S. ; Ladwein,K. I. ; Holleboom,J. M. ; Schur,F. ; Small,J. V. ; Schwarz,J. ; Gerhard,R. ; Faix,J. ; Stradal,T. E. ; Brakebusch,C. ; Rottner,K.
Rac function is critical for cell migration but not required for spreading and focal adhesion formation ,,J.Cell.Sci.,2013;126(Pt.20):4572-4588
Originalpublikation
Stevens,G. B. ; Silver,D. A. ; Zgaga-Griesz,A. ; Bessler,W. G. ; Vashist,S. K. ; Patel,P. ; Achazi,K. ; Strotmeier,J. ; Worbs,S. ; Dorner,M. B. ; Dorner,B. G. ; Pauly,D. ; Rummel,A. ; Urban,G. A. ; Krueger,M.
Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity ,,Analyst,2013;138(20):6154-6162
Originalpublikation
Willjes,G. ; Mahrhold,S. ; Strotmeier,J. ; Eichner,T. ; Rummel,A. ; Binz,T.
Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity
United States,Biochemistry,2013;52(22):3930-3938
Originalpublikation
Zeiser,J. ; Gerhard,R. ; Just,I. ; Pich,A.
Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques ,,J.Proteome Res.,2013;12(4):1604-1618
Originalpublikation
Völker,Anne Katrin
Identifizierung und Charakterisierung der Rezeptorbindungstaschen von Botulinum Neurotoxin Serotyp D (BoNTD) ,,,2013;():Getr. Zählung Ill., graph. Darst.-
Dissertation
Benski,Anastasia ;
Analysis of C3bot exoenzyme-dependent ADP-ribosylation of smal Rho-GTPases by Mass Spectrometry ,,,2013;():-
Masterarbeit
Hüls,Corinna
Intrazelluläre Assoziation funtioneller Domänen von Clostridium difficile Toxin A ,,,2013;():-
Masterarbeit
Raasch,Sabine
Hemmung clostridialer glucosylierender Toxine durch tauro- und glucokonjugierte Gallensäuren ,,,2013;():-
Masterarbeit
Ulfig,Anneli
Untersuchung von endogenen Peptiden in Rattenhirnen mittels MALDI Imaging and LC-MS ,,,2013;():-
Masterarbeit
Völkening,Lea
Neutralisierende Wirkung tauro- und glycokonjugierter Gallensäuren auf Clostridium difficile Toxin B ,,,2013;():-
Masterarbeit
Wohlan,Katharina
Rho-abhängige und unabhängige Wirkung von Clostridium difficile Toxin B auf den Zellzyklus ,,,2013;():-
Masterarbeit
Bollenbach,Alexander
Identifizierung der aktivitätsmindernden Aminosäuren der Botulinum Neurotoxin Subtypen A4 und A8 (Chemnitz Stamm) ,,,2012;():-
Bachelorarbeit
Weigt,David
Die Wirkung der Zytotoxisch Nekrotisierenden Faktoren aus Yersinia pseudotuberculosis und Escherichia coli auf die epitheliale Barrierefunktion von kultivierten Nierenepithelzellen ,,,2012;():-
Bachelorarbeit
Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L.
Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons.
Front Cell Neurosci 2012;6;43
Originalpublikation
Baron,J. ; Blex,C. ; Rohrbeck,A. ; Rachakonda,S. K. ; Birnbaumer,L. ; Ahnert-Hilger,G. ; Brunk,I.
The alpha-subunit of the trimeric GTPase Go2 regulates axonal growth ,,J.Neurochem.,2013;124(6):782-794
Originalpublikation
Bigalke H, Frevert J.
Botulinum toxin A: dose and immune response.
Int J Rehabil Res 2012;35(2);93
Originalpublikation
Boetzkes,A. ; Felkel,K. W. ; Zeiser,J. ; Jochim,N. ; Just,I. ; Pich,A.
Secretome analysis of Clostridium difficile strains
Germany,Arch.Microbiol.,2012;194(8):675-687
Originalpublikation
Brandes V, Schelle I, Brinkmann S, Schulz F, Schwarz J, Gerhard R, Genth H.
Protection from C. difficile Toxin B-catalysed Rac/Cdc42 glucosylation by tauroursodeioxycholic acid-induced Rac/Cdc42 phosphorylation.
Biol Chem 2012;1;393(1-2);77-84
Originalpublikation
Chiaradia,E. ; Avellini,L. ; Tartaglia,M. ; Gaiti,A. ; Just,I. ; Scoppetta,F. ; Czentnar,Z. ; Pich,A.
Proteomic evaluation of sheep serum proteins
England,BMC Vet.Res.,2012;8():66-
Originalpublikation
Debez,A. ; Braun,H. P. ; Pich,A. ; Taamalli,W. ; Koyro,H. W. ; Abdelly,C. ; Huchzermeyer,B.
Proteomic and physiological responses of the halophyte Cakile maritima to moderate salinity at the germinative and vegetative stages
Netherlands,J.Proteomics,2012;75(18):5667-5694
Originalpublikation
Gu,S. ; Rumpel,S. ; Zhou,J. ; Strotmeier,J. ; Bigalke,H. ; Perry,K. ; Shoemaker,C. B. ; Rummel,A. ; Jin,R.
Botulinum neurotoxin is shielded by NTNHA in an interlocked complex
United States,Science,2012;335(6071):977-981
Originalpublikation
Hammerschmidt,A. ; Chatterji,B. ; Zeiser,J. ; Schröder,A. ; Genieser,H. G. ; Pich,A. ; Kaever,V. ; Schwede,F. ; Wolter,S. ; Seifert,R.
Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose
United States,PLoS One,2012;7(7):e39848-
Originalpublikation
Hefter,H. ; Hartmann,C. ; Kahlen,U. ; Moll,M. ; Bigalke,H.
Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins--a single cohort 4-year follow-up study
England,BMJ Open,2012;2(4):10.1136/bmjopen-2011-000646. Print 2012
Originalpublikation
Huelsenbeck,J. ; May,M. ; Schulz,F. ; Schelle,I. ; Ronkina,N. ; Hohenegger,M. ; Fritz,G. ; Just,I. ; Gerhard,R. ; Genth,H.
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin
Netherlands,FEBS Lett.,2012;586(20):3665-3673
Originalpublikation
Hülsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Tallini K.
C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury
Neurotherapeutics 2012;9;185-198
Originalpublikation
Katsch,K. ; de Jong,S. J. ; Albrecht,J. C. ; Steger,J. ; Genth,H. ; Posern,G. ; Biesinger,B.
Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
England,Cell.Commun.Signal.,2012;10(1):5-811X-10-5
Originalpublikation
May,M. ; Kolbe,T. ; Wang,T. ; Schmidt,G. ; Genth,H.
Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis
United States,J.Signal.Transduct,2012;2012():570183-
Originalpublikation
Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R.
Release of TcdA and TcdB from Clostridium cdi 630 is not affected by functional inactivation of the tcdE gene.
Microb Pathog 2012;52(1);92-100
Originalpublikation
Rohrbeck,A. ; Kolbe,T. ; Hagemann,S. ; Genth,H. ; Just,I.
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q
England,FEBS J.,2012;279(15):2657-2671
Originalpublikation
Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC.
Inhibition of macrophage migration by C. botulinum exoenzym C3
Naumyn-Schmiedebergs's Arch Pharmacol 2012;385(9);883-90. May29 [Epub ahead of print]
Originalpublikation
Schwarz,J. ; Proff,J. ; Hävemeier,A. ; Ladwein,M. ; Rottner,K. ; Barlag,B. ; Pich,A. ; Tatge,H. ; Just,I. ; Gerhard,R.
Serine-71 phosphorylation of rac1 modulates downstream signaling
United States,PLoS One,2012;7(9):e44358-
Originalpublikation
Strotmeier,J. ; Willjes,G. ; Binz,T. ; Rummel,A.
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity
Netherlands,FEBS Lett.,2012;586(4):310-313
Originalpublikation
Weigoldt,M. ; Meens,J. ; Bange,F. C. ; Pich,A. ; Gerlach,G. F. ; Goethe,R.
Metabolic adaptation of Mycobacterium avium subsp. paratuberculosis to the gut environment ,,Microbiology,2013;159(Pt.2):380-391
Originalpublikation
Wellhöner,H. ; Weiss,A. ; Schulz,A. ; Adermann,K. ; Braitbard,O. ; Bar-Sinai,A. ; Hochman,J.
Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates
England,J.Drug Target.,2012;20(5):445-452
Originalpublikation
Euler,Friederike Christina
Bedeutung der Autoproteolyse für die intrazelluläre Wirkung von Clostridium difficile Toxin A ,,,2011;():50 Bl.-
Dissertation
Fritsch,Cornelia
Bindung und Aufnahme von Clostridium botulinum C3 Exoenzym in F98-Zellen ,,,2012;():97 Bl.-
Dissertation
Janzen,Constantin
Identifizierung der SV2-Bindungstasche in der H CC -Domäne von Botulinum Neurotoxin Serotyp A ,,,2012;():[2], 73 Bl.-
Dissertation
Lica,Marta Anna
Unterschiede in der biologischen Wirkung des Clostridium difficile Toxin B in proliferierenden und nicht-proliferierenden Zellen ,,,2011;():[1], 275-283, 10-25 Bl.-
Dissertation
Roggenkamp,Dennis
Funktionelle Charakterisierung der Interaktion von Hautzellen und neuronalen Zellen in gesunder und gestresster Haut ,,,2011;():VI S., S. 7-94, IV S.-
Dissertation
Schröder,Anke
Effekte des C3 Exoenzyms aus Clostridium botulinum auf das Proteom muriner Hippocampuszellen ,,,2012;():VI, 107 Bl. Ill., graph. Darst.-
Dissertation
Zeiser,Johannes
Das Substratspektrum clostridialer glukosylierender Toxine und die Auswirkungen auf das Proteom von Colonozyten ,,,2012;():[7], 3 - 106, [20] Bl.-
Dissertation
Brinkmann,Sophie
Cdk 1 abhängige Phosphorylierung des Rac GEF Proteins beta-Pix ,,,2012;():-
Masterarbeit
Doberenz,Sebastian ;
Kinetische Analyse der Toxin A vermittelten Glukosylierung kleiner GTPasen ,,,2012;():-
Masterarbeit
Edeling,Maria
Funktionelle Charakterisierung von Renalen Tubuluszellen in einem Modell für diabetische Nephropathie ,,,2012;():-
Masterarbeit
Findeisen,Katja
Neutralisation von Clostridium difficile Toxin B durch Tauro-konjugierte-Gallensäuren ,,,2012;():-
Masterarbeit
Krüger,Jonas
Ribosomale Proteomanalyse C3 Exoenzym behandelter Zellen ,,,2012;():-
Masterarbeit
Nolte,Annika
Die Rac1-induzierte Hochregulation von Frizzled-Rezeptoren ,,,2012;():-
Masterarbeit
Rataj,Dennis
Beteiligung von CIC-5 an der zellulären Aufnahme der clostridialen Toxine TcdA und TcdA1-1874 ,,,2012;():-
Masterarbeit
Boer U, Lohrenz A, Klingenberg M, Pich A, Haverich A, Wilhelmi M.
The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts.
Biomaterials 2011;32;9730-9737
Originalpublikation
Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Federov PC.
The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells.PLoS Pathog 2011;7(12)
Originalpublikation
Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.
Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B
Naunyn Schmiedebergs Arch Pharmacol 2011;383;285-295
Originalpublikation
Höltje M, Just I, Ahnert-Hilger G.
Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration.
Ann Anat 2011;193(4);314-320
Originalpublikation
Jochim N, Gerhard R, Just I, Pich A.
Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotype-coded protein labeling and LC-MALDI.
Proteome Sci 2011;9;48
Originalpublikation
Lica M, Schulz F, Schelle I, May M, Just I, Genth H.
Difference in the biological effects of Clostridium difficile B in profilerating and non-proliferating cells.
Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);275-283
Originalpublikation
Mueller MQ, Zeiser JJ, Dreiocker F, Pich A, Schaefer M, Sinz A.
An universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis.
Rapid Commun Mass Spectrom 2011;25(1);155-161
Originalpublikation
Nölle A, Zeug A, van Bergeijk, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, Omer J, Srivastrav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P.
The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.
Human molecular genetics 2011;15;20(24);4865-4878
Originalpublikation
Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R.
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A.
PLoS One 2011;18;6(3) e17623
Originalpublikation
Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, v. Neuhoff N.
Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology.
Lung Cancer 2011;72(1);136-138
Originalpublikation
Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP.
The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication.
Nat Cell Biol 2011;13(8);1004-1009
Originalpublikation
Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D.
Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion.
J Cell Science 2011;15;124(Pt18);3066-73
Originalpublikation
Rummel A, Mahrhold S, Bigalke H, Binz T.
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
FEBS J 2011;278(23);4506-4515
Originalpublikation
Rummel,A.
Molecular biology of Clostridium botulinum organism and botulinum neurotoxins, insight into the molecular machinery involved in Clostridium botulinum neurotoxity ,Hauppauge, N.Y.,,2011;():37-70
Buchbeitrag, Monografie
Rummel,A. ; Mahrhold,S. ; Bigalke,H. ; Binz,T.
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin ,,FEBS J.,2011;278(23):4506-4515 10.1111/j.1742-4658.2011.08196.x
Originalpublikation
Schacht T, Unger C, Pich A, Wydra K.
Endo- and exopolygalacturonases of Ralstonia solanacearum are inhibited by polygalacturonase-inhibiting protein (PGIP) activity in tomato stem extracts.
Plant Physiol Biochem 2011;49(4);377-387
Originalpublikation
Schulte-Baukloh H, Herholz J, Bigalke H, Miller K, Knispel HH.
Results of a BoNT/A Antibody Study in Children and Adolescents after Onabotulinumtoxin A (Botox(R)) Detrusor Injection.
Urol Int 2011;87(4);434-438
Originalpublikation
Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol Microbiol 2011;81(1);143-156
Originalpublikation
Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N.
Proteomic Bronchiolitis Obliterans Syndrome Risk Monitoring in Lung Transplant Recipients.
Transplantation 2011;92(4);477-485
Originalpublikation
Zeiser J, Klodmann J, Braun HP, Gerhard R, Just I, Pich A.
Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis.
Journal of Proteomics 2011;75;469-479
Originalpublikation
Felkel,Katharina-Wiebke
LC-MS basierte Sekretomanalyse verschiedener Clostridium difficile Stämme ,,,2010;():104 Bl.-
Dissertation
Halabi Cabezon,Ismael
Aufhebung des zytopathischen Effekts von Clostridium difficile Toxin B durch Rac1 Aktivierung ,,,2010;():3751-3756, 7-20 Bl.-
Dissertation
Jochim,Nelli
LC-MS-basierte globale Proteomanalyse von Colonzellen nach Behandlung mit clostridialen glucosylierenden Toxinen ,,,2011;():XVII, 124 Bl.-
Dissertation
Kreimeyer,Isa
Die autoproteolytische Spaltung beeinflusst den zytotoxischen Effekt von Clostridium difficile Toxin A ,,,2010;():36 Bl.-
Dissertation
Lücke,Nina
Sekretomanalyse der hämatopoetischen Progenitorzelllinie DKmix ,,,2010;():46 Bl.-
Dissertation
May,Martin
Role of Rac1 and PAK in the regulation of G2-M transition and mitotic cell rounding ,,,2011;():[7], 79 Bl.-
Dissertation
Schrader,Merle
Korrelation der C. difficile Toxin A-induzierten Apoptose mit der Hochregulation des GTP-bindenden Proteins RhoB ,,,2011;():62 Bl.-
Dissertation
Werner,Stefan
Charakterisierung der zellulären Aufnahme von C. botulinum C3-Exoenzym ,,,2010;():[3], 86 Bl.-
Dissertation
Dickhut,Clarissa
Bildgebende Massenspektrometrie zur histologischen Analyse von Geweben ,,,2010;():-
Masterarbeit
Frenzel,Eileen
Charakterisierung der zellulären Aufnahme der C. difficile Toxine TcdA und TcdA1-1874 ,,,2010;():-
Masterarbeit
Lentes,Jana
Auswirkungen der GTP-Beladung auf die Glucosylierung von Rho Proteinen durch Clostridien Toxine ,,,2011;():-
Bachelorarbeit
Adler,S. ; Bicker,G. ; Bigalke,H. ; Bishop,C. ; Blumel,J. ; Dressler,D. ; Fitzgerald,J. ; Gessler,F. ; Heuschen,H. ; Kegel,B. ; Luch,A. ; Milne,C. ; Pickett,A. ; Ratsch,H. ; Ruhdel,I. ; Sesardic,D. ; Stephens,M. ; Stiens,G. ; Thornton,P. D. ; Thürmer,R. ; Vey,M. ; Spielmann,H. ; Grune,B. ; Liebsch,M.
The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting
England,Altern.Lab.Anim.,2010;38(4):315-330
Originalpublikation
Backert S, Kenny B, Gerhard R, Tegtmeyer N, Bran S.
PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function.
Gut Microbes 2010;1(2);94-99
Originalpublikation
Dahal,D. ; Pich,A. ; Braun,H. P. ; Wydra,K.
Analysis of cell wall proteins regulated in stem of susceptible and resistant tomato species after inoculation with Ralstonia solanacearum: a proteomic approach
Netherlands,Plant Mol.Biol.,2010;73(6):643-658
10.1007/s11103-010-9646-z
Originalpublikation
Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B.
SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.
Proc Natl Acad Sci USA 2010;107(42);18197-18201
Originalpublikation
Genth H, Just I.
Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease.
Eur J Cell Biol 2010;12(4);Epub ahead of print
Originalpublikation
Genth H, Schulz F, Just I.
Gluscosylation of Rho/Ras Proteins by Lethal Toxin - Implication of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease.
Open Toxinology 2010;3;13-18
Originalpublikation
Just I, Hülsenbeck SC, Genth H.
Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent.
Open Toxinology 2010;3;19-23
Originalpublikation
Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M.
Therapeutic effects of Clostridium botulinum C3 exoenzyme.
Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);247-52; Epub 2010
Übersicht
Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R.
Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A.
Naunyn Schmiedebergs Arch Pharmacol 2010;11(3); Epub 2010
Originalpublikation
Krückeberg J, Just I, Möbs D, Matthies H, Fischer V.
Mehrwert erkannt, Defizite gebannt? - die quantitative Analyse elektronisch verfasster Klausuren an der Medizinischen Hochschule Hannover.
GMA [Hrsg.]: Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA). Bochum, 23.-25.09.2010
Vortrag
Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A.
Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix.
Rapid Commun Mass Spectrom 2010;24(5);561-570
Originalpublikation
Naue N, Fedorov R, Pich A, Manstein DJ, Curth U.
Site-directed mutagenesis of the {chi} subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.
Nucleic Acids Res 2010;23(10); Epub ahead of print
Originalpublikation
Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem J 2010;431(2):207-216
Originalpublikation
Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, Genth H, Klos A.
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac.
PLoS One 2010;5(3)
Originalpublikation
Häfner,Kirstin
Kompetitionsexperimente am Maus-Hemidiaphragma-Assay zur Identifizierung von Proteinrezeptoren der clostridiellen Neurotoxine: SV2 vermittelt die Aufnahme von BoNT/F in neuronale Zellen ,,,2010;():-
Dissertation
Lange,Oliver
Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A : much ado about nothing? ,,,2010;():213 - 218, 16 Bl.-
Dissertation
Nottrott,Stefanie
Die Clostridium difficile Toxin A-induzierte Apoptose ist unabhängig von p53, aber abhängig von der Glucosylierung von Rho-GTPasen ,,,2010;():[1], 33 Bl.-
Dissertation
Supthut,Hauke
Intra- und extrazelluläre Faktoren, die die Sensitivität von CHO-Zellen gegenüber Clostridium difficile Toxin B bestimmen ,,,2009;():89 Bl.-
Dissertation
Barlag,Britta
Beteiligung von IQGAP und MRCK an der Phospho-Rac1-vermittelten Filopodienbildung ,,,2010;():-
Masterarbeit
Goy,Sebastian
Bedeutung der Rezeptorbindedomäne von Clostridium difficile Toxin A für die Funktionalität ,,,2010;():-
Masterarbeit
Kolbe,Tanja
Wirkung Rho-modifizierter bakterieller Toxine in einem in vitro Modell der Wundheilung ,,,2010;():-
Diplomarbeit
Wang,Tianbang
F-Aktin Depolymerisation durch clostridiale Toxine ,,,2010;():-
Diplomarbeit
Andresen,H. ; Bingel,U. ; Streichert,T. ; Schmoldt,A. ; Zoerner,A. A. ; Tsikas,D. ; Just,I.
Severe glycerol intoxication after Meniere's disease diagnostic--case report and overview of kinetic data
England,Clin.Toxicol.(Phila),2009;47(4):312-316
10.1080/15563650902849123
Originalpublikation
Binz,T. ; Rummel,A.
Cell entry strategy of clostridial neurotoxins
England,J.Neurochem.,2009;109(6):1584-1595
10.1111/j.1471-4159.2009.06093.x
Originalpublikation
Brunger,A. T. ; Rummel,A.
Receptor and substrate interactions of clostridial neurotoxins
England,Toxicon,2009;54(5):550-560
10.1016/j.toxicon.2008.12.027
Originalpublikation
Deplazes,J. ; Fuchs,M. ; Rauser,S. ; Genth,H. ; Lengyel,E. ; Busch,R. ; Luber,B. ;
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation
England,Hum.Mol.Genet.,2009;18(19):3632-3644
10.1093/hmg/ddp312
Originalpublikation
Dreger,S. C. ; Schulz,F. ; Huelsenbeck,J. ; Gerhard,R. ; Hofmann,F. ; Just,I. ; Genth,H.
Killing of Rat Basophilic Leukemia Cells by Lethal Toxin from Clostridium sordellii: Critical Role of Phosphatidylinositide 3'-OH Kinase/Akt Signaling (dagger) ,,Biochemistry,2009;():-
10.1021/bi800708b
Originalpublikation
Genth H, Schulz F, Just I.
Glucosylation of Rho/Ras Proteins by Lethal Toxin - Implications of Actin-Re-Organization and Apoptosis in C. Sordellii-Associated Disease.
The Open Toxinology Journal 2009;2
Abstract
Huelsenbeck,S. C. ; Klose,I. ; Reichenbach,M. ; Huelsenbeck,J. ; Genth,H.
Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin
Netherlands,FEBS Lett.,2009;583(19):3133-3139
10.1016/j.febslet.2009.09.006
Originalpublikation
Huelsenbeck,S. C. ; May,M. ; Schmidt,G. ; Genth,H.
Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis
United States,Cell Motil.Cytoskeleton,2009;66(11):967-975
10.1002/cm.20390
Originalpublikation
Just I, Hülsenbeck SC, Genth H.
Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and an Neurothrophic Agent.
The Open Toxinology Journal 2009;2
Abstract
Kotz,A. ; Wagener,J. ; Engel,J. ; Routier,F. ; Echtenacher,B. ; Pich,A. ; Rohde,M. ; Hoffmann,P. ; Heesemann,J. ; Ebel,F.
The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity ,,Fungal Genet.Biol.,2010;47(2):169-178
10.1016/j.fgb.2009.10.001
Originalpublikation
Lange,O. ; Bigalke,H. ; Dengler,R. ; Wegner,F. ; deGroot,M. ; Wohlfarth,K.
Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing?
United States,Clin.Neuropharmacol.,2009;32(4):213-218
10.1097/WNF.0b013e3181914d0a
Originalpublikation
Mohammadi,B. ; Buhr,N. ; Bigalke,H. ; Krampfl,K. ; Dengler,R. ; Kollewe,K.
A long-term follow-up of botulinum toxin A in cervical dystonia ,,Neurol.Res.,2009;31(5):463-466
10.1179/174313209X405137
Originalpublikation
Mohammadi,B. ; Kollewe,K. ; Wegener,M. ; Bigalke,H. ; Dengler,R.
Experience with long-term treatment with albumin-supplemented botulinum toxin type A
Austria,J.Neural Transm.,2009;116(4):437-441
10.1007/s00702-009-0200-6
Originalpublikation
Nerlich,A. ; Rohde,M. ; Talay,S. R. ; Genth,H. ; Just,I. ; Chhatwal,G. S.
Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism
United States,J.Biol.Chem.,2009;284(30):20319-20328
10.1074/jbc.M109.016501
Originalpublikation
Rummel,A. ; Häfner,K. ; Mahrhold,S. ; Darashchonak,N. ; Holt,M. ; Jahn,R. ; Beermann,S. ; Karnath,T. ; Bigalke,H. ; Binz,T.
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
England,J.Neurochem.,2009;110(6):1942-1954
10.1111/j.1471-4159.2009.06298.x
Originalpublikation
Schoentaube,J. ; Olling,A. ; Tatge,H. ; Just,I. ; Gerhard,R.
Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A ,,Cell.Microbiol.,2009;11(12):1816-1826
10.1111/j.1462-5822.2009.01373.x
Originalpublikation
Schulz,F. ; Just,I. ; Genth,H.
Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid
United States,Biochemistry,2009;48(38):9002-9010
10.1021/bi900964c
Originalpublikation
Sun,X. ; He,X. ; Tzipori,S. ; Gerhard,R. ; Feng,H.
Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages
England,Microb.Pathog.,2009;46(6):298-305
10.1016/j.micpath.2009.03.002
Originalpublikation
von Witzendorff,D. ; Maass,K. ; Pich,A. ; Ebeling,S. ; Kölle,S. ; Kochel,C. ; Ekhlasi-Hundrieser,M. ; Geyer,H. ; Geyer,R. ; Töpfer-Petersen,E.
Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach
Netherlands,Carbohydr.Res.,2009;344(12):1541-1549
10.1016/j.carres.2009.05.002
Originalpublikation
Goltz,Björn
Tetanustoxin und Botulinumtoxin A : Interaktion mit Mastzellen aus der Bauchfellhöhle der Ratte ,,,2008;():IV, 140 S.-
Dissertation
Teichert,Matthias
Charakterisierung von mutiertem Clostridium difficile Toxin A zur Bestimmung von Glucosyltransferase-abhängigen Effekten ,,,2007;():11 Bl.-
Dissertation
Busche,S. ; Descot,A. ; Julien,S. ; Genth,H. ; Posern,G.
Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling
England,J.Cell.Sci.,2008;121(Pt 7):1025-1035
10.1242/jcs.014456
Originalpublikation
Genth,H. ; Dreger,S. C. ; Huelsenbeck,J. ; Just,I.
Clostridium difficile toxins: More than mere inhibitors of Rho proteins
England,Int.J.Biochem.Cell Biol.,2008;40(4):592-597
10.1016/j.biocel.2007.12.014
Originalpublikation
Gerhard,R. ; Nottrott,S. ; Schoentaube,J. ; Tatge,H. ; Olling,A. ; Just,I.
Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells
England,J.Med.Microbiol.,2008;57(Pt 6):765-770
10.1099/jmm.0.47769-0
Originalpublikation
Halabi-Cabezon,I. ; Huelsenbeck,J. ; May,M. ; Ladwein,M. ; Rottner,K. ; Just,I. ; Genth,H.
Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1
Netherlands,FEBS Lett.,2008;582(27):3751-3756
10.1016/j.febslet.2008.10.003
Originalpublikation
Hoffmann,A. ; Hofmann,F. ; Just,I. ; Lehnardt,S. ; Hanisch,U. K. ; Brück,W. ; Kettenmann,H. ; Ahnert-Hilger,G. ; Höltje,M.
Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia
United States,Glia,2008;56(11):1162-1175
10.1002/glia.20687
Originalpublikation
Höltje,M. ; Djalali,S. ; Hofmann,F. ; Münster-Wandowski,A. ; Hendrix,S. ; Boato,F. ; Dreger,S. C. ; Grosse,G. ; Henneberger,C. ; Grantyn,R. ; Just,I. ; Ahnert-Hilger,G.
A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation ,,FASEB J.,2009;23(4):1115-1126/10.1096/fj.08-116855
Originalpublikation
Höltje,M. ; Hofmann,F. ; Lux,R. ; Veh,R. W. ; Just,I. ; Ahnert-Hilger,G.
Glutamate uptake and release by astrocytes are enhanced by Clostridium botulinum C3 protein
United States,J.Biol.Chem.,2008;283(14):9289-9299
10.1074/jbc.M706499200
Originalpublikation
Kamanova,J. ; Kofronova,O. ; Masin,J. ; Genth,H. ; Vojtova,J. ; Linhartova,I. ; Benada,O. ; Just,I. ; Sebo,P.
Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
United States,J.Immunol.,2008;181(8):5587-5597
Originalpublikation
Klisch,K. ; Jeanrond,E. ; Pang,P. C. ; Pich,A. ; Schuler,G. ; Dantzer,V. ; Kowalewski,M. P. ; Dell,A.
A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins
England,Glycobiology,2008;18(1):42-52
10.1093/glycob/cwm113
Originalpublikation
Kühnel,T. S. ; Schulte-Mattler,W. ; Bigalke,H. ; Wohlfarth,K.
Treatment of habitual snoring with botulinum toxin: a pilot study ,,Sleep Breath,2008;12(1):63-68
10.1007/s11325-007-0136-8
Originalpublikation
Muetzelburg,M. V. ; Hofmann,F. ; Just,I. ; Pich,A.
Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis ,,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2009;877(13):1344-1351
10.1016/j.jchromb.2008.12.005
Originalpublikation
Neumann,D. ; Kollewe,C. ; Pich,A. ; Cao,P. ; Resch,K. ; Martin,M. U.
Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation
United States,J.Leukoc.Biol.,2008;84(3):807-813
10.1189/jlb.0507290
Originalpublikation
Sander,L. E. ; Frank,S. P. ; Bolat,S. ; Blank,U. ; Galli,T. ; Bigalke,H. ; Bischoff,S. C. ; Lorentz,A.
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells
Germany,Eur.J.Immunol.,2008;38(3):855-863
10.1002/eji.200737634
Originalpublikation
Schulte-Baukloh,H. ; Bigalke,H. ; Miller,K. ; Heine,G. ; Pape,D. ; Lehmann,J. ; Knispel,H. H.
Botulinum neurotoxin type A in urology: antibodies as a cause of therapy failure
Australia,Int.J.Urol.,2008;15(5):407-15; discussion 415
10.1111/j.1442-2042.2008.02016.x
Originalpublikation
Stolz,A. ; Haines,N. ; Pich,A. ; Irvine,K. D. ; Hokke,C. H. ; Deelder,A. M. ; Gerardy-Schahn,R. ; Wuhrer,M. ; Bakker,H.
Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis
United States,Glycoconj.J.,2008;25(2):167-175
10.1007/s10719-007-9069-5
Originalpublikation
Tschernig,T. ; Neumann,D. ; Pich,A. ; Dorsch,M. ; Pabst,R.
Experimental bronchial asthma - the strength of the species rat
Netherlands,Curr.Drug Targets,2008;9(6):466-469
Originalpublikation
Conrad S, Genth H, Hofmann F, Just I, Skutella T.
Neogenin-RGMa signaling at the growth cone Is BMP-independent and involves RhoA, rock and PKC.
J Biol Chem 2007;282(22);16423-33
Abstract
Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS.
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.
Blood 2007;109(3);1248-1256
Abstract
Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,Schmitt-Kopplin P, Schiffer E.
Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry.
Proteomics 2007;1(7);650-60
Abstract
Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H.
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470.
Inf Immun 2007;75(2);801-809
Abstract
Huelsenbeck J, Dreger S, Gerhard R, Fritz G, Just I, Genth H.
Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile.
Biochemistry 2007;24;46(16);4923-31
Abstract
Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT.
Neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
Biochemistry 2007;46;10685-93
Abstract
Klisch K, Jeanrond E, Pang PC, Pich A, Schuller G, Dantzer V, Kowalewski MP, Dell A.
A tetraantennary glycan with bisecting N-Acetylglucosamine and Sda antigen is the predominant N-glycan on bovine Pregnancy-associated glycoproteins.
Glycobiology 2008;18(1);42-52; Epub 2007
Abstract
Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R.
Clostridium difficile Toxin A and B directly stimulate human mast cells.
Inf Immun 2007;21(5)
Abstract
Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R.
Apoptosis induced by Clostridium difficile Toxin A is p53-independent and tiggered by glucosylation of Rho GTPases.
Apoptosis 2007;12(8);1443-53
Abstract
Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
Identification of the receptor binding site of botulinum neurotoxins B and G proves the double receptor concept.
PNAS 2007;104;359-364
Abstract
Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H.
Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycospingolipid biosynthesis.
Glycoconj J 2008;25(2);167-75; Epub 2007
Abstract
Foster K, Bigalke H, Aoki R.
Botulinum Neurotoxin - From Laboratory to Bedside
Neurotoxicity Research 2006;9;133-140
Abstract
Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R.
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.
FEBS Lett 2006;580;3565-3569
Abstract
Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K.
Cholesterol-dependent pore formation of Clostridium difficile toxin A.
J Biol Chem 2006;281;10808-10815
Abstract
Jin R, Rummel A, Binz T, Brunger AT.
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Nature 2006;444;1092-1095
Abstract
Lee SH, Bigalke H.
Botulinumtoxin – Pharmakologie, Sicherheit und sekundäre Non-Response durch Antikörper
Neuropädiatrie in Klinik und Praxis 2006;5;52-56
Übersicht
Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T.
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
FEBS Lett 2006;Apr3;580(8);2011-4
Abstract
Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal G.S.
Localization of the C3-like ADP-ribosyltransferase from Staphylococcus aureus during baterial invasion of mammalian cells.
Inf Immun 2006;74;3673-3677
Abstract
Rosales RL, Bigalke H, Dressler D.
Pharmacology of botulinum toxin: differences between type A preparations.
Eur J Neurol; 2006;13;2-10
Abstract
Schröder O, Gerhard R, Stein J.
Antibiotic-associated diarrhea
Diarrhö Z Gastroenterol 2006;44(2);193-204
Abstract
Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter, P.
High resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer.
Clin Cancer Res 2006;12;345-52
Abstract
Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R.
Application of mutated Clostridium difficile toxin A for determination of Glucosyltransferase-dependent effects.
Inf Immun 2006;74(10);6006-6010
Abstract
Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF.
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.
Lancet Oncol 2006;7(3);230-40
Abstract
Traub F, Jost M, Hess R, Schorn K, Menzel C, Budde P, Schulz-Knappe P, Lamping N, Pich A, Kreipe H, Tammen H.
Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas.
Lab Invest 2006;86;246-253
Abstract
Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzig M, Neusüß C, Theodorescu D, Root KE, Ross MM, Mischak H.
Biomarker discovery by CE.MS enables sequences analysis via MS/MS with platform-independent separation.
Electrophoresis 2006;27(11);2111-21125
Abstract
Aktories K, Just I.
Clostridial Rho-inhibiting protein toxins.
Curr Top Microbiol Immunol 2005;291;113-145
Abstract
Bigalke H, Rummel A.
Medical aspects of toxin weapons.
Toxicology 2005;30;214(3);210-20. Epub 2005
Abstract
Chalmers MJ, Mackay CL, Hendrickson CL, Wittke S, Walden M, Mischak H, Fliser D, Just I, Marshall AG.
Combined top-down and bottom-up mass spectrometry approach to characterization of biomarkers for renal disease.
Anal Chem 2005;77;7163-7171
Abstract
Czeloth N, Bernhardt G, Hofmann F, Genth H, Förster R.
Sphingosine-1-phosphate mediates migration of mature dendritic cells.
J Immunol 2005; Sep1;175(5);2960-7.
Abstract
Dressler D, Bigalke H.
Botulinum toxin type B de novo therapy of cervical dystonia Frequency of antibody induced therapy failure.
J Neurol 2005 Aug;252(8);904-7
Abstract
Dressler D, Lange M, Bigalke H.
Mouse diaphragm assay for detection of antibodies against botulinum toxin type B.
Mov Disord 2005;20(12);1617-9.
Abstract
Gebhardt T, Gerhard R, Bedoui S, Erpenbeck VJ, Hoffmann MW, Manns MP, Bischoff SC.
beta2-Adrenoceptor-mediated suppression of human intestinal mast cell functions is caused by disruption of filamentous actin dynamics.
Eur J Immunol 2005;35(4);1124-32
Abstract
Gerhard R, Burger S, Tatge H, Genth H, Just I, Hofmann, F.
Comparison of wild type with recombinant Clostridium difficile toxin A.
Microbial Pathogenesis 2005;38(2-3);77-83
Abstract
Gerhard R, Tatge H, Genth H, Thum T, Borlak J, Fritz G, Just, I.
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.
J Biol Chem 2005;280(2);1499-1505
Abstract
Höltje M, Hoffmann A, Hofmann F, Mucke C, Große G, van Rooijen N, Kettenmann H, Just I, Ahnert-Hilger G.
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing
J Neurochem 2005;95(5);1237-48
Abstract
Just I, Gerhard R.
Large clostridial cytotoxins.
Rev Physiol Biochem Pharmaco 2005;152;23-47
Abstract
Klisch K, de Sousa NM, Beckers JF, Leiser R, Pich A.
Pregnancy associated glycoprotein-1, -6, -7, and -17 are major products of bovine binucleate trophoblast giant cells at midpregnancy.
Mol Reprod Dev 2005 Aug;71(4);453-60
Abstract
Rupnik M, Dupuy B, Fairweather NF, Gerding DN, Johnson S, Just, I, Lyerly DM, Popoff MR, Rood JI, Sonenshein AL, Thelestam M, Wren BW, Wilkins TD, von Eichel-Streiber C.
Revised nomenclature of Clostridium difficile toxins and associated genes.
J Med Microbiol 2005;54;113-117
Abstract
Traub F, Feist H, Kreipe HH, Pich A.
SELDI-MS-based expressing profiling of ductal invasive and lobular invasive human breast carcinomas.
Pathol Res Pract 2005;201;763-770
Abstract
Trixier E, Lalanne F, Just I, Galmiche JP, Neunlist M.
Human mucosa/submucosa interactions during intestinal inflammation: involvement of the enteric nervous system in interleukin-8 secretion.
Cell Microbiol 2005;7;1798-1810
Abstract
von Neuhoff N, Pich A.
Mass spectrometry-based methods for biomarker detection and analysis.
Drug Discovery Today: Technologies 2005;2;361-367
Abstract
Yelamanchili SV, Reisinger C, Becher A, Sikorra S, Bigalke H, Binz T, Ahnert-Hilger G.
The C-terminal transmembrane region of synaptobrevin binds synaptophysin from adult synaptic vesicles.
Eur J Cell Biol. 2005 Apr;84(4);467-75
Abstract
Ahnert-Hilger G, Höltje M, Große G, Pickert G, Mucke C., Nixdorf-Bergweiler B, Boquet P, Hofmann F, Just I
Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurons.
J Neurochem 2004;90;9-18
Abstract
Bigalke H, Dressler D, Jankovic J
Basic and therapeutic aspects of neurotoxins.
Mov Disord 2004;19(S8);1
Abstract
Herrmann J, Geth K, Mall V, Bigalke H, Schulte Monting J, Linder M, Kirschner J, Berweck S, Korinthenberg R, Heinen F, Fietzek UM
Clinical impact of antibody formation to botulinum toxin A in children.
Ann Neurol 2004;55(5);732-5
Abstract
Kaiser T, Wittke S, Just I, Krebs R, Bartel S, Fliser D, Mischak H, Weissinger EM
Capillary electrophoresis coupled to mass spectrometer for automated and robust polypetide determination in body fluids for clinical use.
Electrophoresis 2004;25;2044-2055
Abstract
Makdessi K, Fritsche K, Pich A, Andreesen JR
Identification and characterization of the cytoplasmic tungstate/molybdate-binding protein (Mop) from Eubacterium acidaminophilum.
Arch Microbiol 2004;181;45-51
Abstract
Rauh D, Graentzdoerffer A, Granderath K, Andreesen JR, Pich A
Tungsten-containing aldehyde oxidoreductase of Eubacterium acidaminophilum.
Eur J Biochem 2004;271;212-219
Abstract
Reisinger C, Yelamanchili SV, Hinz B, Mitter D, Becher A, Bigalke H, Ahnert-Hilger G
The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis
J Neurochem 2004;90;1-8
Abstract
Rummel A, Karnath T, Henke T, Bigalke H, Binz T
Synaptotagmins I and II Act as nerve cell receptors for botulinum neurotoxin G.
J Biol Chem 2004;279(29);30865-70
Abstract
Rummel A, Mahrhold S, Bigalke H, Binz T
The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction.
Mol Microbiol 2004;51(3);631-43
Abstract
Tammen H, Mohring T, Kellmann M, Pich A, Kreipe HH, Hess R
Mass spectrometric phenotyping of Val34Leu polymorphism of blood coagulation factor XIII by differential peptide display.
Clin Chem 2004;50;545-551
Abstract
Wohlfarth K, Kampe K, Bigalke H
Pharmacokinetic properties of different formulations of botulinum neurotoxin type A.
Mov Disord 2004 Mar;19(S8);65-7
Abstract
Blumenstein I, Gerhard R, Ries J, Kottra G, Stein J.
Regulation of mastoparan-induced increase of paracellular permeability in T84 cells by RhoA and basolateral potassium channels.
Biochem Pharmacol. 2003 Apr 1;65(7):1151-61.
Abstract
Frisch C, Gerhard R, Aktories K, Hofmann F, Just I.
The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis.
Biochem Biophys Res Commun. 2003 Jan 17;300(3):706-11.
Abstract
Genth H, Gerhard R, Maeda A, Amano M, Kaibuchi K, Aktories K, Just I.
Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex.
J Biol Chem. 2003 Aug 1;278(31):28523-7. Epub 2003 May 15.
Abstract
Genth H, Schmidt M, Gerhard R, Aktories K, Just I.
Activation of phospholipase D1 by ADP-ribosylated RhoA.
Biochem Biophys Res Commun. 2003 Feb 28;302(1):127-32.
Abstract
Gerhard R, John H, Aktories K, Just I.
Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases.
Mol Pharmacol. 2003 Jun;63(6):1349-55.
Abstract
Merz B, Bigalke H, Stoll G, Naumann M.
Botulism type B presenting as pure autonomic dysfunction.
Clin Auton Res. 2003 Oct;13(5):337-8.
Abstract
Neunlist M, Barouk J, Michel K, Just I, Oreshkova T, Schemann M, Galmiche J.
Toxin B of Clostridium difficile activates human VIP submucosal neurons in part via an Il-1{beta}-dependent pathway.
Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G1049-G1055
Abstract
Rummel A, Bade S, Alves J, Bigalke H, Binz T.
Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity.
J Mol Biol. 2003 Feb 21;326(3):835-47.
Abstract
Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne HR.
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis.
J Cell Biol. 2003 Feb 3;160(3):375-85.
Abstract
Bigalke H.
The pharmacology of botulinum toxin
Med Monatsschr Pharm. 2002 Sep;25(9):305-8.
Abstract
Birklein F, Walther D, Bigalke H, Winterholler M, Erbguth F.
Sudomotor testing predicts the presence of neutralizing botulinum A toxin antibodies.
Ann Neurol. 2002 Jul;52(1):68-73.
Abstract
Blersch W, Schulte-Mattler WJ, Przywara S, May A, Bigalke H, Wohlfarth K.
Botulinum toxin A and the cutaneous nociception in humans: a prospective, double-blind, placebo-controlled, randomized study.
J Neurol Sci. 2002 Dec 15;205(1):59-63.
Abstract
Dressler D, Bigalke H.
Botulinum toxin antibody type A titres after cessation of botulinum toxin therapy.
Mov Disord. 2002 Jan;17(1):170-3.
Abstract
Dressler D, Munchau A, Bhatia KP, Quinn NP, Bigalke H.
Antibody-induced botulinum toxin therapy failure: can it be overcome by increased botulinum toxin doses?
Eur Neurol. 2002;47(2):118-21.
Abstract
Schirmer J, Just I, Aktories K.
The ADP-ribosylating mosquitocidal toxin from Bacillus sphaericus: proteolytic activation, enzyme activity, and cytotoxic effects.
J Biol Chem. 2002 Apr 5;277(14):11941-8. Epub 2002 Jan 25.
Abstract
Wilde C, Barth H, Sehr P, Han L, Schmidt M, Just I, Aktories K.
Interaction of the Rho-ADP-ribosylating C3 exoenzyme with RalA.
J Biol Chem. 2002 Apr 26;277(17):14771-6. Epub 2002 Feb 14.
Abstract
Wilde C, Just I, Aktories K.
Structure-function analysis of the Rho-ADP-ribosylating exoenzyme C3stau2 from Staphylococcus aureus.
Biochemistry. 2002 Feb 5;41(5):1539-44.
Abstract
Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K.
Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells.
J Biol Chem. 2001 Apr 6; 276(14): 10670-6.
Abstract
Bigalke H, Wohlfarth K, Irmer A, Dengler R.
Botulinum A toxin: Dysport improvement of biological availability.
Exp Neurol. 2001 Mar;168(1):162-70.
Abstract
Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M.
Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression.
Eur J Immunol. 2001 May; 31(5): 1610-9.
Abstract
Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H.
Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
Infect Immun. 2001 Oct;69(10):6004-11.
Abstract
Just I, Hofmann F, Genth H, Gerhard R.
Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins.
Int J Med Microbiol. 2001 Sep;291(4):243-50.
Abstract
Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W.
An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
J Biol Chem. 2001 Jun 8; 276(23): 20451-7.
Abstract
Rollnik JD, Wohlfarth K, Dengler R, Bigalke H.
Neutralizing botulinum toxin type a antibodies: clinical observations in patients with cervical dystonia.
Neurol Clin Neurophysiol. 2001;2001(3):2-4.
Abstract
Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K.
Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress.
Pflugers Arch. 2001 Aug;442(5):675-87.
Abstract
Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S.
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O.
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3185-90.
Abstract
Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I.
A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.
J Biol Chem 2001 Mar 23;276(12):9537-42
Abstract
Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO.
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
FASEB J. 2001 Aug;15(10):1753-63.
Abstract
Bigalke H.
Neuromuskuläre Verbindung – Präsynaptisches Terminal.
Klin. Neurophysiol 2000;31;115-121
Busch C, Hofmann F, Gerhard R, Aktories K.
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.
J Biol Chem. 2000 May 5;275(18):13228-34.
Abstract
Busch C, Schömig K, Hofmann F, Aktories K.
Characterization of the catalytic domain of Clostridium novyi alpha-toxin.
Infect Immun. 2000 Nov;68(11):6378-83.
Abstract
Dressler D, Bigalke H, Rothwell JC.
The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans.
J Neurol. 2000 Aug;247(8):630-2.
Abstract
Dressler D, Dirnberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD.
Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay.
Mov Disord. 2000 Sep;15(5):973-6.
Abstract
Dressler D, Zettl U, Benecke R, Bigalke H.
Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure?
Mov Disord. 2000 Nov;15(6):1279-81.
Abstract
Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P.
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.
EMBO J. 2000 Dec 1;19(23):6361-70.
Abstract
Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I.
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.
Infect Immun. 2000 Mar;68(3):1094-101.
Abstract
Just I, Boquet P
Large clostridial cytotoxins as tools in cell biology.
Curr Top Microbiol Immunol 2000;250;97-107
Review
Just I, Hofmann F, Aktories K
Molecular mode of action of the large clostridial cytotoxins.
Curr Top Microbiol Immunol 2000;250;55-83
Review
Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T.
Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin
Histochem Cell Biol. 2000 Nov;114(5):387-91.
Abstract
Linseman DA, Hofmann F, Fisher SK.
A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase.
J Neurochem. 2000 May;74(5):2010-20.
Abstract
Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W.
Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.
J Neurosci. 2000 Sep 15;20(18):6743-51.
Abstract
Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M.
Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C.
Blood. 2000 Oct 1;96(7):2592-8.
Abstract
Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H.
Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study.
Abstract
Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I.
Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin.
J Mol Biol. 2000 Sep 1;301(5):1091-5.
Abstract
Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M.
Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.
Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9.
Abstract
Wilde C, Genth H, Aktories K, Just I.
Recognition of RhoA by Clostridium botulinum C3 exoenzyme.
J Biol Chem. 2000 Jun 2;275(22):16478-83.
Abstract
Feick P, Gilhaus S, Blum R, Hofmann F, Just I, Schulz I.
Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity.
FEBS Lett. 1999 May 28;451(3):269-74.
Abstract
Fritz G, Just I, Kaina B.
Rho GTPases are over-expressed in human tumors.
Int J Cancer. 1999 May 31;81(5):682-7.
Abstract
Genth H, Aktories K, Just I.
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling.
J Biol Chem. 1999 Oct 8;274(41):29050-6.
Abstract
Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G.
SNARE proteins and rab3A contribute to canalicular formation in parietal cells.
Eur J Cell Biol. 1999 Nov;78(11):779-86.
Abstract
Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK.
Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA.
Br J Pharmacol. 1999 Jul;127(5):1060-3.
Abstract
Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, Hochman J, Wellhoner H.
Isolation, characterization and synthesis of a novel paradaxin isoform.
FEBS Lett. 1998 Sep 18;435(2-3):173-7.
Abstract
Barth H, Hofmann F, Olenik C, Just I, Aktories K.
The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin.
Infect Immun. 1998 Apr;66(4):1364-9.
Abstract
Barth H, Preiss JC, Hofmann F, Aktories K.
Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis.
J Biol Chem. 1998 Nov 6;273(45):29506-11.
Abstract
Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I.
Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli.
Infect Immun. 1998 Apr;66(4):1755-8.
Abstract
Boquet P, Munro P, Fiorentini C, Just I.
Toxins from anaerobic bacteria: speficity and molecular mechanism of action.
Curr Opinion Microbiol 1998;1;66-74
Abstract
Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K.
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins.
J Biol Chem. 1998 Jul 31;273(31):19566-72.
Abstract
Gerhard R, Schmidt G, Hofmann F, Aktories K.
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells.
Infect Immun. 1998 Nov;66(11):5125-31.
Abstract
Herrmann C, Ahmadian MR, Hofmann F, Just I.
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.
J Biol Chem. 1998 Jun 26;273(26):16134-9.
Abstract
Hofmann F, Busch C, Aktories K.
Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition.
Infect Immun. 1998 Mar;66(3):1076-81.
Abstract
Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G.
Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins.
J Physiol. 1998 Jan 1;506 ( Pt 1):83-93.
Abstract
Naumann M, Toyka KV, Mansouri Taleghani B, Ahmadpour J, Reiners K, Bigalke H.
Depletion of neutralising antibodies resensitises a secondary non-responder to botulinum A neurotoxin.
J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):924-7.
Abstract
Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, Hochman J, Wellhoner H.
Translocation of acylated pardaxin into cells.
FEBS Lett. 1998 Nov 27;440(1-2):131-4.
Abstract
Reiser CO, Lanz T, Hofmann F, Hofer G, Rupprecht HD, Goppelt-Struebe M.
Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins.
Biochem J. 1998 Mar 15;330 ( Pt 3):1107-14.
Abstract
Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG.
Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin.
Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):385-92.
Abstract
Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K.
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.
Biochemistry. 1998 Apr 14;37(15):5296-304.
Abstract
Wohlfarth K, Goeschel H, Frevert J, Dengler R, Bigalke H.
Dose standardisation of botulinum toxin: Reply.
Mov Disord. 1998, 13, 750-751.
Abstract
Goschel, H., Wohlfarth, K., Frevert, J., Dengler, R., Bigalke, H.
Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies - therapeutic consequences.
Exp. Neurol. 147, 1997, 96-102.
Abstract
Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krüll, M., Just, I., Aktories, K., von Eichel-Streiber, C., Suttorp, N.
Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function.
Am. J. Physiol. 1997, 272, L38-L43.
Abstract
Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K.
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin.
J. Biol. Chem. 1997, 272, 11074-11078.
Abstract
Olenik, C., Barth, H., Just, I., Aktories, K., Meyer, D.K.
Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain.
Mol. Brain Res. 1997, 52, 272-279.
Abstract
Otto, B., Steusloff, A., Just, I., Aktories, K., Pfitzer, G.
Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle.
J. Physiol. (Lond.), 1997, 496, 317-329.
Abstract
Verschueren, H., de Baetselier, P., de Braekeleer, J., Dewitt, J., Aktories, K., Just, I.
ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells.
Eur. J. Cell Biol. 1997, 73, 182-187.
Abstract
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Abstract