ausgewählte Publikationen

Niehus SE, Tran DDH, Mischak M, Koch A (2018) Colony-stimulating factor-1 receptor provides a growth advantage in epithelial cancer cell line A431 in the presence of epidermal growth factor receptor inhibitor gefitinib. Cell Signal. 51:191-198

Tran DDH, Kessler C, Niehus SE, Mahnkopf M, Koch A, Tamura T. (2018) Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs. Oncogene 37(1):75-85

Tran DD, Koch A, Allister A, Saran S, Ewald F, Koch M, Nashan B, Tamura T. (2016) Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP). Cell Signal. 28(12):1872-1880

Tran DD, Koch A, Saran S, Armbrecht M, Ewald F, Koch M, Wahlicht T, Wirth D, Braun A, Nashan B, Gaestel M, Tamura T. (2016) Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture. Cell Signal. 28(5):438-447

Saran S, Tran DD, Ewald F, Koch A, Hoffmann A, Koch M, Nashan B, Tamura T. (2016) Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. Oncogene. 35(29):3872-9

Koch A, Saran S, Tran DD, Klebba-Färber S, Thiesler H, Sewald K, Schindler S, Braun A, Klopfleisch R, Tamura T. (2014) Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo. Cell Commun Signal. 12:73

Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T. (2014)  THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100). Nucleic Acids Res. 42(19):12249-60

Saran S, Tran DD, Klebba-Farber S, Moran-Losada P, Wiehlmann L, Koch A, Chopra H, Pabst O, Hoffmann A, Klopfleisch R (2013) THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier. BMC Cell Biol 14(1),51

Tran DDH, Saran S, Dittrich-Breiholz O, Williamson AJK, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T (2013) Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF induced macrophage differentiation. Cell Death Dis 4,e879

Dutta P, Koch A, Breyer B, Schneider H, Dittrich-Breiholz O, Kracht M, and Tamura T (2011) Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC1 (V560G) by transcriptome analysis. BMC Genomics 12,196

Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Färber S, Koch A, Jaworska E, Spooncer E, Gruber AD, Whetton AD, and Tamura T (2010) THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biology, 8:1

Koch A,  Scherr M, Breyer B, Mancini A, Kardinal C, Battmer K, Eder M, and Tamura T (2008) Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover. Oncogene 27, 4678-89

Koch A, Mancini A, El Bounkari O, and Tamura T (2005) The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. Oncogene 24, 3436-47

Mancini A, Koch A, Whetton AD, and Tamura T (2004) The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation and thereby potentiates M-CSF-mediated differentiation. Oncogene 23, 6581-6589

Mancini A, Koch A, Wilms R, and Tamura T (2002) c-Cbl associates directly with the C-terminal tail of the receptor for macrophage colony-stimulating factor, c-fms, and down-regulates this receptor but not the viral oncogene v-Fms. J. Biol. Chem. 277 (17), 14635-40

Stefan M, Koch A, Mancini A, Mohr A, Weidner KM, Nieman H, and Tamura T (2001) Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis. J. Biol. Chem. 276 (5), 3017-23

Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H and Tamura T (2000) Direct Interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase c-Abl, through the activation loop. FEBS Letters, 469 (1), 72-76