• 2020

Heinemann NC, Tischer-Zimmermann S, Wittke TC, Eigendorf J, Kerling A,  Framke T, Melk A, Heuft HG, Blasczyk R, Maecker-Kolhoff B & Eiz-Vesper B (2020): High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?, Journal of Translational Medicine 18, 148.

Lasch F, Karch A, Koch A, Derlin T, Voskrebenzev A, Alsady TM, Hoeper MM, Gall H, Roller F, Harth S, Steiner D, Krombach G, Ghofrani HA, Rengier F, Heußel CP, Grünig E, Beitzke D, Hacker M, Lang IM, Behr J, Bartenstein P, Dinkel J, Schmidt K-H, Kreitner K-F, Frauenfelder T, Ulrich S, Hamer OW, Pfeifer M, Johns CS, Kiely DG, Swift AJ, Wild J, Vogel-Claussen J (2020): Comparison of MRI and VQ-SPECT as a Screening Test for Patients With Suspected CTEPH: CHANGE-MRI Study Design and Rationale. Front. Cardiovasc. Med. 7:51. doi: 10.3389/fcvm.2020.00051

Clausen JD, Nahen N, Horstmann H, Lasch F, Krutsch W, Krettek C, Weber-Spickschen TS (2020): Improving Maximal Strength in the Initial Postoperative Phase After Anterior Cruciate Ligament Reconstruction Surgery: Randomized Controlled Trial of an App-Based Serious Gaming Approach. JMIR Serious Games. 2020;8(1):e14282. DOI:10.2196/14282

Horstmann H, Medico P, Lasch F, Krutsch W, Weber-Spickschen TS (2020): Simplified Measurement of Maximum Strength After Knee Surgery: Application-Based Knee-Training Device Compared to Isokinetic Testing. Open Access Journal of Sports Medicine. 2020:11 43-49. DOI: 10.2147/OAJSM.S214598


  • 2019

von Versen-Höynck F, Häckl S, Selamet Tierney ES, Conrad KP, Baker VL, Winn VD. Maternal Vascular Health in Pregnancy and Postpartum After Assisted Reproduction. Hypertension. 2020 Feb;75(2):549-560. doi: 10.1161/HYPERTENSIONAHA.119.13779. Epub 2019 Dec 16.

Westhoff-Bleck M, Winter L, Aguirre Davila L, Herrmann-Lingen C, Treptau J, Bauersachs J, Bleich S, Kahl KG. Diagnostic evalutation of the hospital depression scale (HADS) and the Beck depression inventory II (BDI-II) in adults with congenital heart disease using a structures clinical interview: Impact of depression severity. Eur J Prev Cardiol. 2019 Jul 26:2047487319865055. doi: 10.1177/2047487319865055.

Wedermeyer H, Yurdyadin C, Hardtke S, Caruntu FA, Curescu MG, Yalcin K, Akarca US, Gürel A, Zeuzem S, Erhardt A, Lüth S, Papatheodoridis GV, Keskin O, Port K, Radu M, Celen MK, Idilman R, Weber K, Stift J, Wittkop U, Hedirich B, Mederacke I, von der Leyen H, Dienes HP, Cornberg M, Koch A, Manns MP, HIDIT-II study team. Peginterferon alfa-2a plus tenofovir disoproxil fumarate for hepatitis D (HIDIT-II): a randomised, plcebo controlled, phase 2 trial. Lancet Infect Dis. 2019 Mar;19(3):275-286. doi: 10.1016/S1473-3099(18)30663-7.

Plaass C, Karch A, Koch A, Wiederhoeft V, Ettinger S, Claassen L, Daniilidis K, Yao D, Stukenborg-Colsman C. Short term results of dynamic splinting for hallux valgus - A prospective randomized study. Foot Ankle Surg. 2019 Jan 21. pii: S1268-7731(18)30246-7. doi: 10.1016/j.fas.2019.01.002.

May M, Framke T, Junker B, Framme C, Pielen A, Schindler C. How and why SGLT2 inhibitors should be explored as potential treatment option in diabetic retinopathy: clinical concept and methodology. Ther Adv Endocrinol Metab. 2019 Dec 11;10:2042018819891886. doi: 10.1177/2042018819891886. eCollection 2019.

Hinken L, Willenborg H, Aguirre Davila L, Daentzer D. Outcome analysis of molding helmet therapy using a classification for differentiation between plagiocephaly, brachycephaly and combination of both. J Craniomaxillofac Surg. 2019 May;47(5):720-725. doi: 10.1016/j.jcms.2019.01.011. Epub 2019 Jan 17.

Hemmings R, Koch A. Commentary on: Subgroup analysis and interpretation for phase 3 confirmatory trials: White Paper of the EFSPI/PSI working group on subgroup analysis by Dane, Sepncer, Rosenkranz, Lipkovich, and Parke. Pharm Stat. 2019 Mar;18(2):140-144. doi: 10.1002/pst.1935.

Byng D, Lutter JI, Wacker ME, Jörres RA, Liu X, Karrasch S, Schulz H, Vogelmeier C, Holle R. Determinants of healthcare utilization and costs in COPD patients: first longitudinal results from the German COPD cohort COSYCONET. Int J Chron Obstruct Pulmon Dis. 2019 Jul 5;14:1423-1439. doi: 10.2147/COPD.S201899. eCollection 2019.

Bravo MC, Lopez-Ortego P, Sanchez L, Madero R, Cabanas F, Koch A, Rojas-Anaya H, Rabe H, Pellicer A. Validity of Biomarkers of Early Circulatory Impairment to Predict Outcome: A Retrospective Analysis. Front Pediatr. 2019 May 29;7:212. doi: 10.3389/fped.2019.00212. eCollection 2019.

Albrecht UV, Framke T, von Jan U. Quality Awareness and Its Influence on the Evaluation of App Meta-Information by Physicians: Validation Study. JMIR Mhealth Uhealth. 2019 Nov 18;7(11):e16442. doi:10.2196/16442.

Trudzinski FC, Algudrah M, Omlor A, Zewinger S, Fliser D, Speer T, Seiler F, Biertz F, Koch A, Vogelmeier C, Welte T, Watz H, Waschki B, Fähndrich S, Jörres R, Bals R (2019): Consequences of chronic kidney disease in chronic obstructive pulmonary disease. Respiratory Research. 2019 Jul 12;20(1):151. doi:10.1186/s12931-019-1107-x.

Aguirre Dávila L, Weber K, Bavendiek U, Bauersachs J, Wittes J, Yusuf S, Koch A (2019): Digoxin–mortality: randomized vs. observational comparison in the DIG trial. European Heart Journal, , ehz395,

Bavendiek U, Berliner D, Aguirre Dávila L, Schwab J, Maier L, Philipp SA, Rieht A, Westenfeld R, Piorkowski C, Weber K, Hänselmann A, Oldhafer M, Schallhorn S, von der Leyen H, Schröder C, Veltmann C, Störks S, Böhm M, Koch A, Bauersachs J, DIGIT-HF Investigators and Committees (2019): Rationale and design of the DIGIT-HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double-blind, placebo-controlled study. Eur J Heart Fail. 2019 May;21(5):676-684. doi:10.1002/ejhf.1452

Häckl S, Koch A, Lasch F (2019): Empirical evaluation of the implementation of the EMA guideline on missing data in confirmatory clinical trials: Specification of mixed models for longitudinal data in study protocols. Pharmaceutical Statistics. 2019; 1– 9. doi: 10.1002/pst.1964.

Heusser K, Tank J, Holz O, May M, Brinkmann J, Engeli S, Diedrich A, Framke T, Koch A, Großhennig A, Jan Danser AH, Sweep FCGJ, Schindler C, Schwarz K, Krug N, Jordan J, Hohlfeld JM. Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans. Sci Rep. 2019 Mar 6;9(1):3641. doi: 10.1038/s41598-019-40343-w.

Bräsen JH, Mederacke YS, Schmitz J, Diahovets K, Khalifa A, Hartleben B, Person F, Wiech T, Steenbergen E, Großhennig A, Manns MP, Schmitt R, Mederacke I (2019): Cholemic nephropathy causes acute kidney injury and is accompanied by loss of aquaporin 2 in collecting ducts. Hepatology. 2019 May;69(5):2107-2119. doi: 10.1002/hep.30499. Epub 2019 Mar 14.

Lasch F, Weber K, Koch A (2019): Commentary: On the levels of patient selection in registry-based randomized controlled trials. Trials; 20(1):100. doi: 10.1186/s13063-019-3214-x.


  • 2018

Baier C, Ipaktchi R, Schwab F, Smith A, Liu X, Ebadi E, Limbourg A, Mett TR, Bange FC, Vogt PM (2018): Universal decolonization with octenidine: First experiences in a tertiary burn intensive care unit. Burns Open, 2018. Available from:

Weber K, Hemmings R, Koch A (2018): How to usw prior knowledge and still give new data a chance?, Pharmaceutical Statistics, 2018 Jul;17(4):329-341. doi: 10.1002/pst.1862. Epub 2018 Apr 17.

Lingner H, Blase L, Großhennig A, Schmiemann G (2018):Manual therapy applied by general practitioners for nonspecific low back pain: results of the ManRück pilot-study. Chiropr Man Therap. 2018 Sep 3;26:39. doi: 10.1186/s12998-018-0202-2. eCollection 2018.


  • 2017

Hasdemir DB, Aguirre Davila L, Schweitzer N, Meyer BC, Koch A, Vogel A, Wacker F, Rodt T (2017): Evaluation of CT Vascularization Patterns for Survival Prognosis in Patients With Hepatocellular Carcinoma Treated by Conventional TACE. Diagn Interv Radiol 2017; 23: 217-222. DOI: 10.5152/dir.2016.16006

Schweitzer N, Fischer M, Kirstein MM, Berhane S, Kottas M, Sinn M, Gonzalez-Carmona MA, Balta Z, Weismuller TJ, Strassburg CP, Reineke-Plaass T, Bektas H, Manns MP, Johnson P, Weinmann A, Vogel A (2017): Risk estimation for biliary tract cancer: Development and validation of a prognostic store. Liver Int. 2017 Dec;37(12):1852-1860. doi: 10.1111/liv.13517. Epub 2017 Jul 28.

Weber K, Lasch F, Koch A. New research strategy with ambiguous implications: A comment on 'Planning future studies based on the conditional power of a meta-analysis' , Statistics in Medicine, accepted, DOI: 10.1002/sim.7595.

Wacker ME, Kitzing K, Jörres RA, Leidl R, Schulz H, Karrasch S, Karch A, Koch A, Vogelmeier CF, Holle R. The contribution of symptoms and comorbidities to the economic impact of COPD: an analysis of the German COSYCONET cohort.  Int J Chron Obstruct Pulmon Dis. 2017 Dec 4;12:3437-3448. doi: 10.2147/COPD.S141852.

Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, Soriano JB, de Torres JP, Agusti A, Atalay NB, Billington J, Boutou AK, Brighenti-Zogg S, Chaplin E, Coster S, Dodd JW, Dürr S, Fernandez-Villar A, Groenen MTJ, Guimarães M, Hejduk K, Higgins V, Hopkinson NS, Horita N, Houben-Wilke S, Janssen DJA, Jehn M, Joerres R, Karch A, Kelly JL, Kim YI, Kimura H, Koblizek V, Kocks JH, Kon SSC, Kwon N, Ladeira I, Lee SD, Leuppi JD, Locantore N, Lopez-Campos JL, D-C Man W, Maricic L, Mendoza L, Miedinger D, Mihaltan F, Minami S, van der Molen T, Murrells TJ, Nakken N, Nishijima Y, Norman IJ, Novotna B, O'Donnell DE, Ogata Y, Pereira ED, Piercy J, Price D, Pothirat C, Raghavan N, Ringbaek T, Sajkov D, Sigari N, Singh S, Small M, da Silva GF, Tanner RJ, Tsiligianni IG, Tulek B, Tzanakis N, Vanfleteren LEGW, Watz H, Webb KA, Wouters EFM, Xie GG, Yoshikawa M, Spruit MA. Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc. 2017 Dec 1; 18(12):1097.e11-1097.e24. doi: 10.1016/j.jamda.2017.09.003.


  • 2016

Houben-Wilke S, Jörres RA, Bals R, Franssen FM, Gläser S, Holle R, Karch A, Koch A, Magnussen H, Obst A, Schulz H, Spruit MA, Wacker ME, Welte T, Wouters EF, Vogelmeier C, Watz H: Peripheral Artery Disease and its Clinical Relevance in Patients with COPD in the COSYCONET Study. Am J Respir Crit Care Med. 2017 Jan 15;195(2):189-197. doi: 10.1164/rccm.201602-0354OC.

Jakubovski E, Reichert C, Karch A, Buddensiek N, Breuer D, Müller-Vahl K: The ONLINE-TICS Study Protocol: A Randomized Observer-Blind Clinical Trial to Demonstrate the Efficacy and Safety of Internet-Delivered Behavioral Treatment for Adults with Chronic Tic Disorders. Front Psychiatry; 7:119. doi: 10.3389/fpsyt.2016.00119.

Wacker ME, Jörres RA, Karch A, Koch A, Heinrich J, Karrasch S, Schulz H, Peters A, Gläser S, Ewert R, Baumeister SE, Vogelmeier C, Leidl R, Holle R; COSYCONET study group: Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies. Respir Res.; 17(1):81. doi: 10.1186/s12931-016-0401-0.

Karch A, Koch A, Grünwald V: A phase II trial comparing pazopanib with doxorubicin as first-line treatment in elderly patients with metastatic or advanced soft tissue sarcoma (EPAZ): study protocol for a randomized controlled trial. Trials; 17(1):312. doi: 10.1186/s13063-016-1434-x.

Chatzikyrkou C, Eichler J, Karch A, Clajus C, Scurt FG, Ramackers W, Lehner F, Menne J, Haller H, Mertens PR, Schiffer M: Short- and long-term effects of the use of RAAS blockers immediately after renal transplantation. Blood Press. 2016 May 19:1-9. [Epub ahead of print]

Wacker ME, Jörres RA, Karch A, Wilke S, Heinrich J, Karrasch S, Koch A, Schulz H, Watz H, Leidl R, Vogelmeier C, Holle R; COSYCONET-Consortium: Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities. BMC Pulm Med.; 16(1):70. doi: 10.1186/s12890-016-0238-9.

Karch A, Koch A, Zapf A, Zerr I, Karch A: Partial verification bias and incorporation bias affected accuracy estimates of diagnostic studies for biomarkers that were part of an existing composite gold standard. J Clin Epidemiol. 78:73-82. doi: 10.1016/j.jclinepi.2016.03.022.

Scheper V, Leifholz M, von der Leyen H, Keller M, Denkena U, Koch A, Karch A, Miller J, Lenarz T. ACEMg-mediated hearing preservation in cochlear implant patients receiving different electrode lengths (PROHEARING): study protocol for a randomized controlled trial. Trials. 2016; 17:394. DOI 10.1186/s13063-016-1526-7.

Karch A, Vogelmeier C, Welte T, Bals R, Kauczor HU, Biederer J, Heinrich J, Schulz H, Gläser S, Holle R, Watz H, Korn S, Adaskina N, Biertz F, Vogel C, Vestbo J, Wouters EFM, Rabe KF, Söhler S, Koch A, Jörres RA, for the COSYCONET Study Group. The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline. Respir.Med. 2016; 112(18-24). DOI 10.1016/j.rmed.2016.03.008

Hueper K, Khalifa AA, Bräsen JH, Vo Chieu VD, Gutberlet M, Wintterle S, Lehner F, Richter N, Peperhove M, Tewes S, Weber K, Haller H, Wacker F, Gwinner W, Gueler F, Hartung D. Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation. J.Magn.Reson.Imaging 2016; 44(1):112-121. DOI 10.1002/jmri.25158

Kammer J, Ziesing S, Aguirre Davila L, Bültmann E, Illsinger S, Das AM, Haffner D, Hartmann H. Neurological Manifestations of Mycoplasma pneumoniae Infection in Hospitalized Children and Their Long-Term Follow-Up. Neuropediatrics 2016; 47(5):308-317. DOI 10.1055/s-0036-1584325

Höhn M, von Jan U, Framke T, Albrecht UV. Classification of Health Related Applications. Stud.Health Technol.Inform. 2016; 226:139-142. DOI 10.3233/978-1-61499-664-4-139

Lenzen H, Musmann E, Kottas M, Schönemeier B, Köhnlein T, Manns MP, Lankisch TO. Acute gastrointestinal bleeding cases presenting to the emergency department are associated with age, sex and seasonal and circadian factors. Eur.J.Gastroenterol.Hepatol. 2017; 29(1):78-83. DOI 10.1097/MEG.0000000000000752

Leo F, Bartels S, Mägel L, Framke T, Büsche G, Jonigk D, Christgen M, Lehmann U, Kreipe H. Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer. Virchows Arch. 2016; 469(2):191-201. DOI 10.1007/s00428-016-1950-9

Lueer K, Biller H, Casper A, Windt H, Mueller M, Badorrek P, Haefner D, Framke T, Koch A, Ziehr H, Krug N, Koch W, Hohlfeld JM. Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber. Allergy 2016; 71(12):1693-1700. DOI 10.1111/all.12947

Paparoupa M, Spineli L, Framke T, Ho H, Schuppert F, Gillissen A. Pulmonary Embolism in Pneumonia: Still a Diagnostic Challenge? Results of a Case-Control Study in 100 Patients. Dis.Markers 2016; DOI 10.1155/2016/8682506

Rios N, Adaskina N, Frömke C, Papendorf F, Schippert C, Koch A, Hillemanns P, Park-Simon TW. The Benefit of Baseline Staging-Risk Assessment of Distant Breast Cancer Metastases by Tumor Stage.
Anticancer Res. 2016; 36(9):4909-4914

Derlin T, Thiele J, Weiberg D, Thackeray JT, Püschel K, Wester HJ, Aguirre Davila L, Larena-Avellaneda A, Daum G, Bengel FM, Schumacher U. Evaluation of 68Ga-Glutamate Carboxypeptidase II Ligand Positron Emission Tomography for Clinical Molecular Imaging of Atherosclerotic Plaque Neovascularization Arterioscler. Thromb.Vasc.Biol. 2016; 36(11):2213-2219. DOI 10.1161/ATVBAHA.116.307701

Klapdor R, Hillemanns P, Wölber L, Jückstock J, Hilpert F, de Gregorio N, Iborra S, Sehouli J, Habermann A, Fürst ST, Strauss HG, Baumann K, Thiel F, Mustea A, Meier W, Harter P, Wimberger P, Hanker L, Schmalfeldt B, Canzler U, Fehm T, Luyten A, Hellriegel M, Kosse J, Heiss C, Hantschmann P, Mallmann P, Tanner B, Pfisterer J, Richter B, Jäger M, Mahner S. Outcome After Sentinel Lymph Node Dissection in Vulvar Cancer: A Subgroup Analysis of the AGO-CaRE-1 Study. Ann.Surg.Oncol. 2016; DOI: 10.1245/s10434-016-5687-0

Lucke T, Herrera R, Wacker M, Holle R, Biertz F, Nowak D, Huber RM, Söhler S, Vogelmeier C, Ficker JH, Muckter H, Jörres RA, COSYCONET-Consortium. Systematic Analysis of Self-Reported Comorbidities in Large Cohort Studies - A Novel Stepwise Approach by Evaluation of Medication. PLoS One 2016; 11(10) DOI 10.1371/journal.pone.0163408

Bormann KH, Weber K, Kloppenburg H, Koch A, Meiser P, Gellrich NC. Perioperative Bromelain Therapy after Wisdom Teeth Extraction - A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study. Phytother.Res. 2016; 30(12):2012-2019. DOI 10.1002/ptr.5707

Könneker S, Broelsch GF, Kuhbier JW, Framke T, Neubert N, Dastagir K, Mett T, Vogt PM, Jokuszies A. Outcome Analysis of End-to-End and End-to-Side Anastomoses in 131 Patients Undergoing Microsurgical Free Flap Reconstruction of the Lower Extremity. J Reconstr Microsurg Open 2016. DOI: 10.1055/s-0036-1593815

Neubert N, Vogt PM, May M, Boyce M, Koenneker S, Budde E, Jokuszies A. Does an Early and Aggressive Combined Wrapping and Dangling Procedure Affect the Clinical Outcome of Lower Extremity Free Flaps?-A Randomized Controlled Prospective Study Using Microdialysis Monitoring. J.Reconstr.Microsurg. 2016; 32(4):262-270. DOI 10.1055/s-0035-1568882

Deterding K, Spinner CD, Schott E, Welzel TM, Gerken G, Klinker H, Spengler U, Wiegand J, Zur Wiesch JS, Pathil A, Cornberg M, Umgelter A, Zöllner C, Zeuzem S, Papkalla A, Weber K, Hardtke S, von der Leyen H, Koch A, von Witzendorff D, Manns MP, Wedemeyer H, HepNet Acute HCV IV Study Group. Ledipasvir plus sofosbuvir fixed-dose combination for 6 weeks in patients with acute hepatitis C virus genotype 1 monoinfection (HepNet Acute HCV IV): an open-label, single-arm, phase 2 study. Lancet Infect.Dis. 2016. DOI:10.1016/S1473-3099(16)30408-X

Wranke A, Serrano BC, Heidrich B, Kirschner J, Bremer B, Lehmann P, Hardtke S, Deterding K, Port K, Westphal M, Manns MP, Cornberg M, Wedemeyer H. Antiviral treatment and liver-related complications in hepatitis delta Hepatology 2016. DOI:10.1002/hep.28876


  • 2015

  • 2014

  • 2013

  • 2012

  • 2011