Innate Immune Sensing

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors (Hösel et al.)

Please find the paper here: https://onlinelibrary.wiley.com/doi/full/10.1002/hep.24625

Autophagy:

Autophagy determines efficiency of liver-directed gene therapy with adeno-associated viral vectors (Hösel et al.)

Please find the paper here: https://www.ovid.com/jnls/hep/fulltext/10.1002/hep.29176~autophagy-determines-efficiency-of-liverdirected-gene

Endomsomal Escape:

Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles (Stahnke et al.)

Please find the paper here: https://www.sciencedirect.com/science/article/pii/S0042682210006136?via%3Dihub

Vector Uncoating:

Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity (Rossi et al.)

Please find the paper here: https://www.nature.com/articles/s41598-019-40071-1

Receptor Interaction:

Dichotomies in Ex Vivo and In Vivo Performance of Receptor-Binding Mutants of Adeno-Associated Virus Vectors (Olarewaju et al.)

Please find the paper here: https://journals.sagepub.com/doi/10.1177/10430342261465461?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed