Klinische Forschung bei Cystischer Fibrose

Publikationen

Highlights

Quality of live is associated with physical activity and fitness in cystic fibrosis. H. Hebestreit, K. Schmid, S. Kieser, S. Junge, M. Ballmann, K. Roth, A. Hebestreit, T. Schenk, C. Schindler, H.-G. Posselt, S. Kriemler. BCM Pulm Med. 2014 ;14:26.doi:10.1186/1471-2466-14-26.

Long-term effects of a partially supervised conditioning programme in cystic fibrosis. H. Hebestreit, S. Kieser, S. Junge, M. Ballmann, A. Hebestreit, C. Schindler, T. Schenk, H-G Posselt, S Kriemler. Eur Respir J. 2010 .35(3):578-83. Epub 2009 Jul 30.

Lumacaftor- Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR. C. E. Wainwright, J. S. Elborn, B. W. Ramsey, G. Marigowda, X. Huang, M. Cipolli, C. Colombo, J. C. Davies, K. De Boeck, P. A Flume, M. W. Konstan, S. A. McColley, K. McCoy, E. F. McKone, A. Munck, F. Ratjen, S. M. Rowe, D. Waltz, M. P. Boyle, TRAFFIC Study Group; TRANSPORT Study Group. N Engl J Med. 2015;  73(3):220-31.

A phase 3, double-blind, parallel-group study to evaluate the efficacy and safety of tezacaftor in combination with ivacaftor in participants 6 through 11 years of age with cystic fibrosis homozygous for F508del or heterozygous for the F508del-CFTR mutation and a residual function mutation. J. C. Davies, I. Sermet-Gaudelus, L. Naehrlich, R. Scott Harris, D. Campbell, N. Ahluwalia, C. Short, E. Haseltine, P. Panorchan, C. Saunders, C. A. Owen, C. E. Wainwright, VX16-661-115 Investigator Group. J Cyst Fibros. 2020;1569-1993(20)30811-0.

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial. F. Ratjen, C. Hug, G. Marigowda, S. Tian, X. Huang, S. Stanojevic, C. E. Milla, P. D. Robinson, D. Waltz, J. C. Davies, VX14-809-109 investigator group. Lancet Respir Med.2017;5(7):557-567.

Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus. S. Junge, D. Görlich, M. den Reijer, B. Wiedemann, B. Tümmler, H. Ellemunter, A. Dübbers, P. Küster, M. Ballmann, C. Koerner-Rettberg, J. Große-Onnebrink, E. Heuer, W. Sextro, J. G. Mainz, J. Hammermann, J. Riethmüller, U. Graepler-Mainka, D. Staab, B. Wollschläger, R. Szczepanski, A. Schuster, F.-K. Tegtmeyer, S. Sutharsan, A. Wald, J.-R. Nofer, W. van Wamel, K. Becker, G. Peters, B. C. Kahl. PLoS One. 2016 Nov;11(11):e0166220.

Antibiotic Treatment and Age Are Associated With Staphylococcus aureus Carriage Profiles During Persistence in the Airways of Cystic Fibrosis Patients. C. Westphal, D. Görlich, S. Kampmeier, S. Herzog, N. Braun, C. Hitschke, A. Mellmann, G. Peters, B. C. Kahl, Staphylococcal CF Study Group. Front Microbiol. 2020 Feb 26;11:230.

Assessment of a Mobile App by Adolescents and Young Adults With Cystic Fibrosis: Pilot Evaluation. I. Rudolf, K. Pieper, H. Nolte, S. Junge, C. Dopfer, A. Sauer-Heilborn, F.C. Ringshausen, B. Tümmler, U. von Jan, U.-V. Albrecht, J. Fuge, G. Hansen, A.-M. Dittrich. JMIR Mhealth Uhealth.2019 ;7(11):e12442.

Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis. S.Y. Graeber, C. Dopfer, L. Naehrlich, L. Gyulumyan, H. Scheuermann, S. Hirtz, S. Wege, H. Mairbäurl, M. Dorda, R. Hyde, A. Bagheri-Hanson, C. Rueckes-Nilges, S. Fischer, M. A. Mall, B. Tümmler. A J Respir Crit Care Med.2018;197(11):1433-1442.

Intestinal current measurement and nasal potential difference to make a diagnosis of cases with inconclusive CFTR genetics and sweat test. R. Minso, A. Schulz, C. Dopfer, N. Alfeis, A. van Barneveld, L. Makartian-Gyulumyan, G. Hansen, S. Junge, C. Müller, F.C C Ringshausen, A. Sauer-Heilborn, F. Stanke, C. Stolpe, S. Tamm, T. Welte, A.-M. Dittrich, B. Tümmler. BMJ Open Respir Res.2020 ;7(1):e000736.

Preventive Inhalation of Hypertonic Saline in Infants with Cystic Fibrosis (PRESIS). A Randomized, Double-Blind, Controlled StudyM. Stahl, M. O. Wielpütz, I. Ricklefs, C. Dopfer, S. Barth, A. Schlegtendal, S. Y. Graeber, O. Sommerburg, G. Diekmann, J. Hüsing, C. Koerner-Rettberg, L. Nährlich, A.-M. Dittrich, M. V. Kopp, M. A. Mall. Am J Respir Crit Care Med. 2019;199(10):1238-1248.  

Multicentre feasibility of multiple-breath washout in preschool children with cystic fibrosis and other lung diseases. M. Stahl, C. Joachim, I. Kirsch, T. Uselmann, Y. Yu, N. Alfeis, C. Berger, R. Minso, I. Rudolf, C. Stolpe, X. Bovermann, L. Liboschik, A. Steinmetz, D. Tennhardt, F. Dörfler, J. Röhmel, K. Unorji-Frank, C. Rückes-Nilges, B. von Stoutz, L. Naehrlich, M. V. Kopp, A.-M. Dittrich, O. Sommerburg, M. A. Mall. ERJ Open Res. 2020 Oct ;6(4):00408-2020.

Flow Volume Loop and Regional Ventilation Assessment Using Phase-Resolved Functional Lung (PREFUL) MRI: Comparison With 129 Xenon Ventilation MRI and Lung Function Testing. T. F. Kaireit, A. Kern, A. Voskrebenzev, G. H. Pöhler, F. Klimes, L. Behrendt, M. Gutberlet, T. Moher-Alsady, A.-M. Dittrich, F. Wacker , J. Hohlfeld, J. Vogel-Claussen. J Magn Reson Imaging. 2020 Nov; doi: 10.1002/jmri.27452.


Weitere Publikationen Dr. Sibylle Junge 

Weitere Publikationen PD. Dr. Anna-Maria Dittrich