Immunological processes play an important role in the development of neuropsychiatric disorders and are, therefore, increasingly considered in psychiatric diseases models and experimental therapeutic approaches. Moreover, numerous neuroimmunological diseases like autoimmune encephalitis or multiple sclerosis (40% psychiatric comorbidity) are characterized by cognitive, motivational and affective symptom complexes and do thus require an interdisciplinary approach. Etiologically based diagnostics are crucial for the characterization of psychiatric disorders with neuroimmunological changes and allow for a precise and personalized treatment. Cerebrospinal fluid (CSF) analysis is a fundamental component of differential diagnostics and of high interest if an identification of new biomarkers is desired.
Aims of the research group
The main focus of the research group is to investigate the interactions between the immune system, neuronal processes and psychopathology, particularly focussing on CSF research and its molecular characterization (epigenetics).
The consortium aims to analyze cerebrospinal fluid markers to enable appropiate phenotyping and subtyping of psychiatric diseases (Liquorforschungsverbund des Norddeutschen Psychiatrieverbundes, see also here). Current retrospective analyses include the characterization of virological and autoantibody-mediated diseases and their association with clinical parameters.
Hansen N, Lipp M, Vogelgsang J, Vukovich R, Zindler T, Luedecke D, Gingele S, Malchow B, Frieling H, Kühn S, Denk J, Gallinat J, Skripuletz T, Moschny N, Fiehler J, Riedel C, Wiedemann K, Wattjes MP, Zerr I, Esselmann E, Bleich S, Wiltfang J, Neyazi A, CAP (Cerebrospinal Fluid Analysis in Psychiatry) Consortium. Autoantibody-associated psychiatric symptoms and syndromes in adults: A narrative review and proposed diagnostic approach. Brain, Behavior, & Immunity - Health, 2020. 9:100154. DOI
This observational study investigates psychiatric effects and their association with peripheral inflammation as well as epigenetic changes in nerve growth factors in patients undergoing IVIG treatment. Particular focus is put on the assessment of fatigue, concentration and affective symptoms during the course of treatment.
Within the framework of the "Prospective Multiple Sclerosis Cohort" (Prof. Dr. med. Thomas Skripuletz, Department of Neurology), psychiatric symptoms in patients with a clinically isolated syndrome or initial diagnosis of multiple sclerosis are investigated and their association with structural and neuroinflammatory parameters assessed.
Cooperations within Hannover Medical School
Department of Neurology, Prof. Dr. Thomas Skripuletz
Department of Neurology, Dr. Stefan Gingele
Department of Diagnostic and Interventional Neuroradiology, Prof. Dr. Mike Wattjes
Laboratory for Molecular Neurosciences, Dr. Kirsten Jahn, PhD
- University Medicine Göttingen, Department of Psychiatry and Psychotherapy, PD. Dr. Niels Hansen
University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Dr. Daniel Lüdecke
Main research interests
- Emotionally unstable personality disorders
- Psychological sequelae after trauma