Publikationen
Berichtsjahr 2024
Harries,Dennis
Funktionelle Unterschiede isolierter Kardiomyozyten von Patienten mit hypertropher Kardiomyopathie, mit Aortenstenose sowie von Donoren
2023, Berichtsjahr: 2024| ID: RefID:42366-harries2023funktionelle
Huhnt,Helen Elisabeth
Auswirkungen der Mutation S456Y in der Schalter-II-Region von Myosin II auf den ATP-Umsatz einzelner Moleküle
2022, 69 Blätter : Illustrationen, Diagramme, Volltext:http://doi.org/10.26068/mhhrpm/20240603-007
Berichtsjahr: 2024| ID: RefID:42362-huhnt2022auswirkungen
Kröhn,Simon
Kontrolle der Myosinisoformexpression in Kardiomyozyten aus humanen embryonalen Stammzellen
2022, Berichtsjahr: 2024| ID: RefID:42258-kröhn2022kontrolle
Berichtsjahr 2022
Burkart,Valentin Gregor
Burst-like Transkription von TNNI3 und MYBPC3 als Ursache von Heterogenität zwischen Kardiomyozyten in Patienten mit Hypertropher Kardiomyopathie
2021,- X, 138 Blätter : Illustrationen, Diagramme, Volltext:http://doi.org/10.26068/mhhrpm/20230102-003
Berichtsjahr: 2022| ID: RefID:25314-burkart2021burst-like
Nayak,Arnab
Power of SUMO: small ubiquitin-like modifier (SUMO) in cellular physiology and pathophysiology
2022, Habilitation, Berichtsjahr: 2022| ID: RefID:42169-nayak2022power
Werkman,Christoph
Funktionelle Auswirkungen der Punktmutation R723G in der Myosin-Kopfdomäne bei familiärer hypertropher Kardiomyopathie Untersuchung am Einzelmolekül mittels optischer Falle
2021, - iv, 94 Blätter : Illustrationen, Diagramme, Volltext:http://doi.org/10.26068/mhhrpm/20220727-002
Berichtsjahr: 2022| ID: RefID:24809-werkman2021funktionelle
Berichtsjahr 2020
Aldag-Niebling,David
Familiäre Hypertrophe Kardiomyopathie Haploinsuffizienz und Zell- zu Zell-Variabilität in Funktion und Proteinexpression bei einer Mutation im kardialen Myosin-bindenden Protein C
2019, Berichtsjahr: 2020| ID: RefID:18383-aldag-niebling2019familiäre
Ernstberger,Pia
Ungleiche allelische Expression bei Mutationen im MYH7-Gen bei Hypertropher Kardiomyopathie : mRNA-Quantifizierung der A200V-Mutation
2019,- 93 Blätter : Illustrationen, Diagramme,Volltext:http://doi.org/10.26068/mhhrpm/20200504-003
Berichtsjahr: 2020| ID: RefID:18957-ernstberger2019ungleiche
Kowalski,Kathrin
Nachweis einer burst-like Transkription von MYH6 und MYH7 in humanen Kardiomyozyten
2019, Berichtsjahr: 2020| ID: RefID:16616-kowalski2019nachweis
Lesch,Elisa
Auswirkungen der krankheits-assoziierten Tau-Protein-Mutation ΔK280 auf die Kinesinfunktion
2019, Berichtsjahr: 2020| ID: RefID:16752-lesch2019auswirkungen
Mayer,Anne-Kathrin
Allelische Imbalance der MYH7-mRNA von Zelle zu Zelle in humanen Kardiomyozyten
2019, Berichtsjahr: 2020| ID: RefID:16903-mayer2019allelische
Weber,Natalie
Kardiomyozyten aus humanen induzierten pluripotenten Stammzellen als ein In-vitro-Modell der hypertrophen Kardiomyopathie
2020, 31, 16, 34 Seiten, Seite 788- 802, 1 ungezählte Seite, 110 Seiten : Illustr, Volltext:http://doi.org/10.26068/mhhrpm/20211122-006
Berichtsjahr: 2020| ID: RefID:18096-weber2020kardiomyozyten
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Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes,
Bushra Khan, Chiara Lanzuolo, Valentina Rosti, Philina Santarelli, Andreas Pich,Theresia Kraft, Mamta Amrute-Nayak, Arnab Nayak, IScience in press, Available online 10 September 2024, 110913, https://doi.org/10.1016/j.isci.2024.110913, Link Journal -
PyChelator: a Python-based Colab and web application for metal chelator calculations, Emrulla Spahiu, Esra Kastrati & Mamta Amrute-Nayak, BMC Bioinformatics volume 25, Article number: 239 (2024), DOI: 10.1186/s12859-024-05858-8, Pubmed
- Protein-free media for cardiac differentiation of hPSCs in 2000 mL suspension culture, Nils Kriedemann, Felix Manstein, Carlos A. Hernandez-Bautista, Kevin Ullmann, Wiebke Triebert, Annika Franke, Mira Mertens, Inês Carvalheira Arnaut Pombeiro, Stein, Andreas Leffler, Merlin Witte, Tamari Askurava, Veronika Fricke, Ina Gruh, Birgit Piep, Kathrin Kowalski, Theresia Kraft, Robert Zweigerdt, Stem Cell Research & Therapy May 2024, DOI: 10.21203/rs.3.rs-4420108/v1, Research gate, Pubmed
- Oscillatory work and the step that generates force in single myofibrils from rabbit psoas, M. Kawai and B. Iorga, Pflugers Arch - Eur J Physiol 2024, April 1, https://doi.org/10.1007/s00424-024-02935, Pubmed
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Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival, Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee, Maximilian Fuchs, Ke Xiao, Wen Pan, Sarah Cushman, Christopher Jahn, Malte Juchem, Hannah Jill Hunkler, Giuseppe Cipriano, Bjarne Jürgens, Kevin Schmidt, Sonja Groß, Mira Jung, Jeannine Hoepfner, Natalie Weber, Roger Foo, Andreas Pich, Robert Zweigerdt, Theresia Kraft, Thomas Thum, Christian Bär, Basic Res Cardiol, 2024 Apr 19 doi: 10.1007/s00395-024-01048-y. Online ahead of print., Pubmed
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Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases A2, Alfredo Jesús López‑Dávila · Bruno Lomonte · José María Gutiérrez, Journal of Muscle Research and Cell Motility 23 July 2023 / Accepted: 7 November 2023, https://doi.org/10.1007/s10974-023-09662-4, PubMed
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Nonsense mediated decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients, Valentin Burkart, Kathrin Kowalski, Alina Disch, Denise Hilfiker-Kleiner , Sean Lal , Cristobal dos Remedios, Andreas Perrot, Andre Zeug, Evgeni Ponimaskin, Maike Kosanke, Oliver Dittrich-Breiholz, Theresia Kraft, Judith Montag, Journal of Molecular and Cellular Cardiology Volume 185 (2023) pages: 26–37, https://doi.org/10.1016/j.yjmcc.2023.09.008, Online ahead of print, PubMed
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Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin., Osten F, Löscher W, Gericke B., Toxicol Appl Pharmacol. 2023 Nov 15;479:116712. doi: 10.1016/j.taap.2023.116712. Epub 2023 Oct 10. PMID: 37820772. PubMed
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Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes, Osten, F., Weber, N., Wendland, M., Holler, T., Piep, B., Kröhn, S., Teske, J., Bodenschatz, A.K., Devadas, S.B., Menge, K.S., Chatterjee, S., Schwanke, K., Kosanke, M., Montag, J., Thum, T., Zweigerdt, R., Kraft, T., Iorga, B., and Meissner, J.D. (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377, Online ahead of print, PubMed
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Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus, Alfredo Jesús López-Dávila, Natalie Weber, Arnab Nayak, Leon Fritz, Kian Rami Moustafa, Luis Vincens Gand, Enke Wehry, Theresia Kraft, Thomas Thum, Julián Fernández, José María Gutiérrez, Bruno Lomonte, Pflugers Arch. 2023 Jul 20. DOI: 10.1007/s00424-023-02840-w, Online ahead of print. PubMed
- Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective, Bushra Khan, Luis Vincens Gand, Mamta Amrute-Nayak, Arnab Nayak, , Cells, 2023 Feb 17;12(4):644, doi: 10.3390/cells12040644, PubMed
- Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease, Souvik Kar, Andrea Perrelli, Kiran Kumar Bali, Raffaella Mastrocola Arpita Kar, Bushra Khan, Luis Gand, Arnab Nayak, Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio
Francesco Retta, Genes & Diseases, Available online 3 April 2023 ScienceDirect, doi.org/10.1016/j.gendis.2023.02.045, PubMed
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SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy,
Mamta Amrute-Nayak, Luis Vincens Gand, Bushra Khan, Tim Holler, Ekaterini Kefalakes, Maike Kosanke, Theresia Kraft, and Arnab Nayak,
2022, Cell Reports 41, 111702, https://doi.org/10.1016/j.celrep.2022.111702, PubMed -
Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules,
Jennifer Osten, Maral Mohebbi, Petra Uta, Faramarz Matinmehr, Tianbang Wang, Theresia Kraft, Mamta Amrute-Nayak and Tim Scholz,
J Gen Physiol . 2022 Oct 3;154(10):e202213149. doi: 10.1085/jgp.202213149. Epub 2022 Sep 2, PubMed -
Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy,
Valentin Burkart, Kathrin Kowalski, David Aldag-Niebling, Julia Beck, Dirk Alexander Frick, Tim Holler, Ante Radocaj, Birgit Piep, Andre Zeug, Denise Hilfiker-Kleiner, Cristobal G. dos Remedios, Jolanda van der Velden, Judith Montag and Theresia Kraft,
Front. Cardiovasc. Med., August 2022, Sec. Cardiovascular Biologics and Regenerative Medicin, doi: 10.3389/fcvm.2022.987889, PubMed -
Structural Analysis of microRNAs in Myeloid Cancer Reveals Consensus Motifs
Senol Dogan, Emrulla Spahiu, and Anis Cilic,
Genes 2022, 13(7), 1152; received: 15 May 2022 / Revised: 19 June 2022 / Accepted: 24 June 2022 / Published: 26 June 2022 PubMed - Cardiac ventricular myosin and slow skeletal myosin exhibit dissimilar chemomechanical properties despite bearing the same myosin heavy chain isoform,
Tianbang Wang, Emrulla Spahiu, Jennifer Osten, Florentine Behrens, Fabius Grünhagen, Tim Scholz, Theresia Kraft, Arnab Nayak, Mamta Amrute-Nayak
J Biol Chem . 2022 May 24;102070. doi: 10.1016/j.jbc.2022.102070. [Online ahead of print] PubMed
- Skeletal muscle derived Musclin protects the heart during pathological overload
Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, Felix A Trogisch, Gesine M Dittrich, Andrea Grund, Aya Abouissa, Katja Derlin, Martin Meier, Tim Holler, Mortimer Korf-Klingebiel, Katharina Völker, Tania Garfias Macedo, Cristina Pablo Tortola, Michael Boschmann, Nora Huang, Natali Froese, Carolin Zwadlo, Mona Malek Mohammadi, Xiaojing Luo, Michael Wagner, Julio Cordero, Robert Geffers, Sandor Batkai, Thomas Thum, Nadja Bork, Viacheslav O Nikolaev, Oliver J Müller, Hugo A Katus, Ali El-Armouche, Theresia Kraft, Jochen Springer, Gergana Dobreva, Kai C Wollert, Jens Fielitz, Stephan von Haehling, Michaela Kuhn, Johann Bauersachs, Joerg Heineke
Nat Commun, . 2022 Jan 10;13(1):149, doi: 10.1038/s41467-021-27634-5, PubMed
- AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples from a Patient with Hypertrophic Cardiomyopathy
Edgar Becker, Antonio Francino, Andreas Pich, Andreas Perrot, Theresia Kraft and Ante Radocaj
Front Cardiovasc Med. 2022 Feb 21;9:816330. doi: 10.3389/fcvm.2022.816330. eCollection 2022, PubMed
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Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus,
López-Dávila A.J., Weber N., Kraft, T., Matinmehr F., Arias-Hidalgo M., Fernández J., Lomonte B. & Gutiérrez J. M., Scientific Reports 2021 Sep 30;11(1):19452, doi: 10.1038/s41598-021-98594-5, PubMed -
Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca 2+-ATPase Expression in Cardiomyocytes
Korf-Klingebiel M., Reboll M.R., Polten F., Weber N. , Jäckle F., Wu X., Kallikourdis M., Kunderfranco P., Condorelli G., Giannitsis E., Kustikova O.S., Schambach A., Pich A., Widder J.D., Johann Bauersachs, van den Heuvel J., Kraft T., Wang Y., Wollert K.C.
Circulation. 2021 Aug 10.doi: 10.1161/CIRCULATIONAHA.120.053365 Online ahead of print, PubMed -
Why make a strong muscle weaker?
Iorga B., Kraft T.,
J Gen Physiol, . 2021 Jul 5;153(7):e202112928.doi: 10.1085/jgp.202112928. Epub 2021 Jun 9. PubMed -
MARK4 controls ischaemic heart failure through microtubule detyrosination.
Yu X, Chen X, Amrute-Nayak M, Allgeyer E, Zhao A, Chenoweth H, Clement M, Harrison J, Doreth C, Sirinakis G, Krieg T, Zhou H, Huang H, Tokuraku K, Johnston DS, Mallat Z, Li X.
Nature. 2021 May 26. doi: 10.1038/s41586-021-03573-5. Online ahead of print. PubMed - Generation of two iPSC clones (MHHi021-A and MHHi021-B) from a patient with hypertrophic cardiomyopathy with p.Arg723Gly mutation in the MYH7 gene
S. Merkert; S. Wunderlich; J. Beier; A. Franke; K. Schwanke; G. Göhring; T. Kraft; A. Francino; R. Zweigerdt; U. Martin
Stem Cell Research ( IF 4.489 ) Pub Date : 2021-02-03 , DOI: 10.1016/j.scr.2021.102208, PubMed
- Phosphate has dual roles in cross-bridge kinetics in rabbit psoas single myofibrils
M. Kawai, R. Stehle, G. Pfitzer and B. Iorga
J. Gen. Physiol. 2021 Vol. 153 No. 3, DOI: 10.1085/jgp.202012755, PubMed
- Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy, Kristina Sonnenschein, Jan Fiedler, David de Gonzalo-Calvo, Ke Xiao, Angelika Pfanne, Annette Just, Carolin Zwadlo, Samira Soltani, Udo Bavendiek, Theresia Kraft, Cristobal Dos Remedios, Serghei Cebotari, Johann Bauersachs, Thomas Thum,
Sci Rep. 2021 Jan 19;11(1):1755, doi: 10.1038/s41598-020-80868-z, PubMed
- Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart
E. Auxerre-Plantié, T. Nielsen, M.Grunert, O.Olejniczak, A. Perrot, C. Özcelik, D. Harries, F. Matinmehr, C. Dos Remedios, Ch. Mühlfeld, T. Kraft, R. Bodmer, G. Vogler, S. R Sperling,
Dis Model Mech 2020 Dec 18;13(12):dmm045377.doi: 10.1242/dmm.045377, PubMed
- Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes.
M. Amrute-Nayak, Gloria Pegoli, T. Holler, A. J. Lopez-Davila, C. Lanzuolo, A. Nayak,
J Cachexia Sarcopenia Muscle, 2020 Dec 10., doi: 10.1002/jcsm.12645. Online ahead of print, PubMed -
The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity.
Lopez Davila A.J., Li Zhu, Fritz L., Kraft T., Chalovich J.M.,
Biochemistry 2020 Oct 19, doi: 10.1021/acs.biochem.0c00499. Online ahead of print, PubMed -
Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy
Viereck,J.; Bührke,A.; Foinquinos,A.; Chatterjee,S.; Kleeberger,J.A.; Xiao,K.; Janssen-Peters,H.; Batkai,S.; Ramanujam,D.; Kraft,T.; Cebotari,S.; Gueler,F.; Beyer,A.M.; Schmitz,J.; Bräsen,J.H.; Schmitto,J.D.; Gyöngyösi,M.; Löser,A.; Hirt,M.N.; Eschenhagen,T.; Engelhardt,S.; Bär,C.; Thum,T.
Eur Heart J, 2020 Sep 21;41(36):3462-3474, doi: 10.1093/eurheartj/ehaa519, PubMed -
A thermophoresis–based biosensor for real–time detection of inorganic phosphate during enzymatic reactions.
Franz P, Gassl V. , Topf A. ,Eckelmann L., Iorga B., Tsiavaliaris G.,
Biosensors and Bioelectronics. 2020 Sep 16;169:112616. doi: 10.1016/j.bios.2020.112616. Online ahead of print PubMed -
Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II.
Wang T, Brenner B, Nayak A, and Amrute-Nayak M.
Nano Letters, 2020 Sep 15. doi: 10.1021/acs.nanolett.0c02960. [Online ahead of print] PubMed -
Stochastic allelic expression as trigger for contractile imbalance in hypertrophic cardiomyopathy.
Montag J, Kraft T. Biophysical Reviews. 2020 Aug;12(4):1055-1064. doi: 10.1007/s12551-020-00719-z. Epub 2020 Jul 13, PubMed -
Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation.
Groen M., López-Dávila A.J, Zittrich S., Pfitzer G. and Stehle R.,
Front. Physiol., 03 June 2020, DOI: 10.3389/fphys.2020.00516, PubMed -
Advanced Single-Cell Mapping Reveals that in hESC Cardiomyocytes Contraction Kinetics and Action Potential Are Independent of Myosin Isoform.
Weber N, Kowalski K, Holler H, Radocaj A, Fischer M, Thiemann S, de la Roche J, Schwanke K, Piep B, Peschel N, Krumm U, Lingk A, Wendland M, Greten S, Schmitto JD, Ismail I, Warnecke G, Zywietz U, Chichkov B, MeißnerJ, Haverich A, Martin U, Brenner B, Zweigerdt R, Kraft T.
Stem Cell Reports. 2020 Apr 13. pii: S2213-6711(20)30105-3. doi: 10.1016/j.stemcr.2020.03.015. [Epub ahead of print] . PubMed, Journal -
Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function.
Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M.
J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774. [Epub ahead of print] . PubMed, Journal -
Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers.
López-Dávila AJ, Chalovich JM, Zittrich S, Piep B, Matinmehr F, Málnási-Csizmadia A, Rauscher AÁ, Kraft T., Brenner B, Stehle R.
Front Physiol. 2020 Mar 24;11:144. doi: 10.3389/fphys.2020.00144. eCollection 2020. PubMed, Journal -
SUMO system - a key regulator in sarcomere organization.
Nayak A, Amrute-Nayak M.
FEBS J. 2020 Feb 25. doi: 10.1111/febs.15263. [Epub ahead of print] Review. PubMed - Hypertrophic cardiomyopathy MYH7-mutation R723G alters mRNA secondary structure.
Rose J, Kraft T, Brenner B, Montag J.
Physiol Genomics. 2020 Jan 1;52(1):15-19. doi: 10.1152/physiolgenomics.00100.2019. Epub 2019 Dec 2. PubMed, Journal
- Preclinical development of a miR-132 inhibitor for heart failure treatment
Foinquinos A.,Batkai S., Genschel C., Viereck J. , Rump S., Gyöngyösi M., Traxler D., Riesenhuber M., Spannbauer A., Lukovic D., Weber N. Zlabinger K., Hašimbegović E., Winkler J., Fiedler J., Dangwal S., Fischer M. , de la Roche J. , Wojciechowski D., Kraft T., Garamvölgyi R., NeitzelS., Chatterjee S., Yin X.,Bär Ch., Mayr M., Xiao K., Thum T.
Nat Commun 2020 Jan 31;11(1):633.doi: 10.1038/s41467-020-14349-2., PubMed
- Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture
Halloin C, Schwanke K, Löbel W, Franke A, Szepes M, Biswanath S, Wunderlich S, Merkert S, Weber N, Osten F, de la Roche J, Polten F, Wollert K, Kraft T, Fischer M Martin U, Gruh I, Kempf H, Zweigerdt R.
Stem Cell Reports. 2019 Aug 13;13(2):366-379, doi: 10.1016/j.stemcr.2019.06.004. Epub 2019 Jul 25. PubMed
- TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation.
Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M , Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, dos Remedios C, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, & Heineke J
EMBO Mol Med. 2019 Oct;11(10):e10018. doi: 10.15252/emmm.201810018. Epub 2019 Aug 30. PubMed
- A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins.
Walklate J, Ujfalusi Z, Behrens V, King EJ, Geeves MA.
Anal Biochem. 2019 Sep 15;581:113338. doi: 10.1016/j.ab.2019.06.009. Epub 2019 Jun 13. PubMed
- Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia.
Nayak A., Lopez-Davila AJ., Kefalakes E., Holler T., Kraft T., Amrute-Nayak M.
Cell Rep. 2019 May 28;27(9):2725-2736.e4. doi: 10.1016/j.celrep.2019.04.107. PubMed
- Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy.
Kraft T, Montag J.
Pflugers Arch. 2019 May;471(5):719-733. doi: 10.1007/s00424-019-02260-9. Epub 2019 Feb 11. Review. PubMed
- Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor.
Amrute-Nayak, M*, Nayak, A, Steffen, W, Tsiavaliaris, G, Scholz T, Brenner, B
Small. 2019 Feb;15(7):e1804313. doi: 10.1002/smll.201804313. Epub 2019 Jan 18. PubMed, Link Wiley Online Library
- Mg²⁺-free ATP regulates native cytoplasmic dynein’s processivity. Behrens, V.A.*, Walter, W.J.*, Peters, C., Wang, T, Brenner, B., Geeves, M.A., Scholz, T.*, Steffen, W.* (2018), FEBS Letters. doi: 10.1002/1873-3468.13319. Epub 2018 Dec 21. (*geteilte Erst- bzw. Letztautorenschaft) Journal
- Analyzing histological material to determine ajmaline and other drugs using high-performance liquid chromatography/tandem mass spectrometry., Henning K, Dziadosz M, Klintschar M, Piep B, Teske J., Drug Test Anal. 2018 Sep;10(9):1488-1490. doi: 10.1002/dta.2450. Epub 2018 Aug 1. PubMed, Journal
- Efficient Knock-in of a Point Mutation in Porcine Fibroblasts Using the CRISPR/Cas9-GMNN Fusion Gene.,Gerlach M, Kraft T, Brenner B, Petersen B, Niemann H, Montag J., Genes (Basel). 2018 Jun 13;9(6). pii: E296. doi: 10.3390/genes9060296, Journal
- High Intensity High Volume Interval Training Improves Endurance Performance and Induces a Nearly Complete Slow-to-Fast Fiber Transformation on the mRNA Level., Eigendorf J, May M, Friedrich J, Engeli S, Maassen N, Gros G, Meissner JD., Front Physiol. 2018 May 29;9:601. doi: 10.3389/fphys.2018.00601. eCollection 2018., Journal
- Cross-bridges in slow skeletal muscle: not only slow but also soft, Stehle R., Kraft T. J. Physiol. 2018 Apr 1;596(7):1121-1122. doi: 10.1113/JP275575. Epub 2018 Feb 25. Journal
- Differences in contractile function of myofibrils within human embryonic stem cell derived cardiomyocytes vs. adult ventricular myofibrils are related to distinct sarcomeric protein isoforms, Front. Physiol. | doi: 10.3389/fphys.2017.01111, Iorga B., Schwanke K., Weber N., Wendland M. , Greten S., Piep B., dos Remedios C. G., Martin U., Zweigerdt R., Kraft T. and Bernhard B. Frontiers
- Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs. Montag J, Petersen B, Lucas-Hahn A, Becker E, Harries D, Niemeier H, Brenner B, Kraft T. Sci Rep. 2018 Mar 19;8(1):4786. PubMed
- Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy, Montag J., Kowalski K., Makul M. , Ernstberger P., Radocaj A. , Beck J., Becker E., Tripathi S., Keyser B., Mühlfeld C., Wissel K., Pich A., van der Velden J., dos Remedios C. G. , Perrot A. , Francino A., Navarro-López F., Brenner B.and Kraft T., Front. Physiol., 09 April 2018 Frontiers , PubMed
2017
- Obituary Bernhard Brenner,Chalovich JM, Kraft T, Yu LC. J Muscle Res Cell Motil. 2017 Aug;38(3-4):269-270. doi: 10.1007/s10974-017-9488-2. PubMed
- Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy. Montag J, Syring M, Rose J, Weber AL, Ernstberger P, Mayer AK, Becker E, Keyser B, Dos Remedios C, Perrot A, van der Velden J, Francino A, Navarro-Lopez F, Ho CY, Brenner B, Kraft T. J Muscle Res Cell Motil. 2017 Nov 3. doi: 10.1007/s10974-017-9486-4. PubMed
- The Conserved Lysine-265 Allosterically Modulates Nucleotide- and Actin-binding Site Coupling in Myosin-2., Behrens VA , Münnich S, Adler-Gunzelmann G, Thiel C, Henn A, Latham SL, Taft MH., Sci Rep. 2017 Aug 9;7(1):7650. doi: 10.1038/s41598-017-07933-y. PubMed
- CO2 permeability and carbonic anhydrase activity of rat cardiomyocytes.,Arias-Hidalgo M, Al-Samir S, Weber N, Geers-Knörr C, Gros G, Endeward V., Acta Physiol (Oxf). 2017 Apr 20. doi: 10.1111/apha.12887. Abstract
- MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986. Abstract
2016
- The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function Tobias J. Pfeffer, Florenz Sasse, Christoph F. Schmidt, Stefan Lakämper, Andreas Kirschning, and Tim Scholz Eur J Med Chem, available online 8 February 2016, doi: 10.1016/j.ejmech.2016.02.022
Abstruct
- Postnatal Development of Right Ventricular Myofibrillar Biomechanics in Relation to the Sarcomeric Protein Phenotype in Pediatric Patients with Conotruncal Heart Defects., Elhamine F, Iorga B, Krüger M, Hunger M, Eckhardt J, Sreeram N, Bennink G, Brockmeier K, Pfitzer G, Stehle R., J Am Heart Assoc. 2016 Jun 27;5(6). pii: e003699. doi: 10.1161/JAHA.116.003699. PubMed
- Hypertrophic Cardiomyopathy: Cell-to-Cell Imbalance in Gene Expression and Contraction Force as Trigger for Disease Phenotype Development. Kraft T, Montag J, Radocaj A, Brenner B., Circ Res. 2016 Oct 14;119(9):992-995.
- Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes, Natalie Weber, Kristin Schwanke, Stephan Greten, Meike Wendland, Bogdan Iorga, Martin Fischer, Cornelia Geers-Knörr, Jan Hegermann, Christoph Wrede, Jan Fiedler, Henning Kempf, Annika Franke, Birgit Piep, Angelika Pfanne, Thomas Thum, Martin Ulrich, Bernhard Brenner, Robert Zweigerdt, Theresia Kraft, Basic Res Cardiol. 2016 Nov;111(6):68 PubMed
- Load-dependent modulation of non-muscle myosin-2A function by tropomyosin, Hundt N., Steffen W, Pathan-Chhatbar S., Taft M.H., Manstein D.J. (2016) 4.2. Sci Rep. 6: 20554, 12 pages.
2015
- Broadband Polarization-maintaining Fiber Optics. Knigge, A., Oechnser, U., Brenner, B. und Scholz, T. (2015), Optik & Photonik, 10: 19–22. doi: 10.1002/opph.201500041 Journal
- Transdermal nicotine application attenuates cardiac dysfunction after severe thermal injury. Leif Claassen, Stephan Papst, T. Kraft, Kerstin Reimers, Christina Stukenborg-Colsman, Peter M. Vogt, Lars Steinstraesser and Andreas D. Niederbichler. BioMedResIntl 2015, PubMed
- Muscle RING-finger 2 and 3 maintain striated-muscle structure and function. Dörte Lodka, Aanchal Pahuja, Cornelia Geers-Knörr, Renate Scheibe, Marcel Nowak, Jida Hamati, Clemens Köhncke, Bettina Purfürst, Tamara Kanashova, Sibylle Schmidt, David J. Glass, Ingo Morano, Arnd Heuser, Theresia Kraft, Rhonda Bassel-Duby, Eric N. Olson, Gunnar Dittmar, Thomas Sommer, Jens Fielitz. Journal of Cachexia, Sarcopenia and Muscle (2015) Published online in Wiley Online Library (wileyonlinelibrary.com) doi: 10.1007/jcsm.12057, Journal
2014
- Familial hypertrophic cardiomyopathy: functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development. Brenner B, Seebohm B, Tripathi S, Montag J, Kraft T (2014): Front Physiol, 5, 392, 1-15. doi: 10.3389/fphys.2014.00392, Pubmed
- Transport and Diffusion of Tau protein in neurons., Scholz, T. und Mandelkow, E. Cell Mol Life Sci. 2014 Aug; 71(16):3139-50. doi: 10.1007/s00018-014-1610-7. Epub 2014 Apr 1. Pubmed
- ATP turnover by individual myosin molecules hints at two conformers of the myosin active site., Amrute-Nayak M1, Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B., Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2536-41. doi: 10.1073/pnas.1316390111. Epub 2014 Feb 3., PubMed
- Molecular mechanism regulating myosin and cardiac functions by ELC., Lossie J, Köhncke C, Mahmoodzadeh S, Steffen W, Canepari M, Maffei M, Taube M, Larchevêque O, Baumert P, Haase H, Bottinelli R, Regitz-Zagrosek V, Morano I., Biochem Biophys Res Commun. 2014 Jul 18;450(1):464-9. doi: 10.1016/j.bbrc.2014.05.142. Epub 2014 Jun 6, Pubmed
- Insights into the Structure and Function of Ciliary and Flagellar Doublet Microtubules: TEKTINS, Ca²⁺-BINDING PROTEINS, AND STABLE PROTOFILAMENTS., Linck R, Fu X, Lin J, Ouch C, Schefter A, Steffen W, Warren P, Nicastro D., J Biol Chem. 2014 Jun 20;289(25):17427-44. doi: 10.1074/jbc.M114.568949. Epub 2014 May 2, Pubmed
- Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation., Witjas-Paalberends ER, Ferrara C, Scellini B, Piroddi N, Montag J, Tesi C, Stienen GJ, Michels M, Ho CY, Kraft T, Poggesi C, van der Velden J., J Physiol. 2014 Aug 1;592(Pt 15):3257-72. doi: 10.1113/jphysiol.2014.274571. Epub 2014 Jun 13, Pubmed
- Inflammatory response to burn trauma: nicotine attenuates proinflammatory cytokine levels., Claassen L, Papst S, Reimers K, Stukenborg-Colsman C, Steinstraesser L, Vogt PM, Kraft T, Niederbichler AD., Eplasty. 2014 Dec 19;14:e46. eCollection 2014
2013
- Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes., Kraft T, Paalberends ER, Boontje NM, Tripathi S, Brandis A, Montag J, Hodgkinson JL, Francino A, Navarro-Lopez F, Brenner B, Stienen GJ, van der Velden J., J Mol Cell Cardiol. 2013 Jan 11. doi:pii: S0022-2828(13)00004-7. 10.1016/j.yjmcc.2013.01.001, PubMed
- MAPKAPK2/3 Regulate SERCA2a Expression and Fiber Type Composition to Modulate Skeletal Muscle and Cardiomyocyte Function., Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ. Mol Cell Biol. 2013 Apr 22. PubMed
- Lipoteichoic acid from Staphylococcus aureus directly affects cardiomyocyte contractility and calcium transients. Mutig, N., Geers-Knoerr, C., Piep, B., Pahuja, A., Vogt, P.M., Brenner, B., Niederbichler, A.D., Kraft, T., Mol Immunol 56 (4): 720–728 (2013). doi: 10.1016/j.molimm.2013.07.007.
- Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function., Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ. Mol Cell Biol. 2013 Jul;33(13):2586-602. Epub 2013 Apr 22. doi: 10.1128/MCB.01692-12.
2012
- Kinetic Mechanism of Ca²⁺-controlled Changes of Skeletal Troponin I in Psoas Myofibrils. Lopez-Davila AJ, Elhamine F, Ruess DF, Papadopoulos S, Iorga B, Kulozik FP, Zittrich S, Solzin J, Pfitzer G, Stehle R. Biophys J. 2012 Sep 19;103(6):1254-64. doi: 10.1016/j.bpj.2012.08.022. PubMed
- ATP binding and cross-bridge detachment steps during full Ca²⁺ activation: comparison of myofibril and muscle fibre mechanics by sinusoidal analysis. Iorga B, Wang L, Stehle R, Pfitzer G, Kawai M. J Physiol. 2012 Jul 15;590(Pt 14):3361-73. Epub 2012 May 14.
- Tau protein diffuses along the microtubule lattice., Hinrichs, M.H., Jalal, A., Brenner, B., Mandelkow, E., Kumar, S. und Scholz, T. (2012) J Biol Chem. 287, 38559-68. Epub 2012 Sep 27, 2012 as doi:10.1074/jbc.M112.369785
- Polarisationserhaltene Faseroptik für die Fluoreszenzmikroskopie. Krischke, A., Oechsner, U., Knothe, C., Brenner, B., und Scholz, T., Laser+Photonik, 2012. 5/2012, 38-41
- Mechanical and kinetic properties of β-cardiac/slow skeletal muscle myosin, Brenner, B., Hahn, N., Hanke, E., Martinmehr, F., Scholz, T., Steffen, W. und Kraft, T. J Muscle Res Cell Motility. published July 31, 2012 as doi:10.1007/s10974-012-9315-8
- Two independent switches regulate cytoplasmic dynein’s processivity and directionality, Wilhelm J. Walter, Michael P. Koonce, Bernhard Brenner, and Walter Steffen PNAS 12. March 2012 Link
- RGBV-Faseroptik für TIRF-Mikroskopie und Biophotonik. Krischke, A., Oechsner, U., Knothe, C., Federau, G., Brenner, B., und Scholz, T., BioPhotonik. 2012. 1/2012, 22-26, Link
- SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway Regalla Kumarswamy, Alexander R. Lyon, Ingo Volkmann, Adam M. Mills, Julia Bretthauer, Aanchal Pahuja, Cornelia Geers-Knörr, Theresia Kraft, Roger J. Hajjar, Kenneth T. Macleod, Sian E. Harding and Thomas Thum, European Heart Journal Advance Access published February 23, 2012 Link
- Effects of Basic Calponin on the Flexural Mechanics and Stability of F-Actin. Cytoskeleton, Jensen,M.H. Watt, J., Hodgkinson, J.L., Gallant, G. Appel,S., El-Mezgueldi, M., Angelini, T.E., Morgan, K.G.,Lehman, W. and Moore, J.R. (2012), PubMed
2011
- Processive behaviour of kinesin observed using micro-fabricated cantilevers. Nanotechnology. Scholz, T., Vicary, J.A., Jeppesen, G.M., Ulcinas, A., Hörber, J.K.H. und Antognozzi, M., 2011 22,095707. Epub 2011 Jan 27. Nanotechnology. 2011 Mar 4;22(9):095707. Epub 2011 Jan 27. PubMed
- Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division. (*equal contribution), Rump, A.*, Scholz, T.*, Thiel, C., Hartmann, F.K., Uta, P., Hinrichs, M.H., Taft, M.H., Tsiavaliaris, G, J Cell Sci. 2011 Jun 28. PubMed
- Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy. Tripathi S, Schultz I, Becker E, Montag J, Borchert B, Francino A, Navarro-Lopez F, Perrot A, Özcelik C, Osterziel KJ, McKenna WJ, Brenner B, Kraft T. Basic Res Cardiol. 2011 Nov;106(6):1041-55. Epub 2011 Jul 19. PubMed
2010
- A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. Circ Res. 2010 Mar 5;106(4):695-704. Epub 2009 Dec 31. PubMed
- Targeted optimization of a protein nanomachine for operation in biohybrid devices. Amrute-Nayak M, Diensthuber RP, Steffen W, Kathmann D, Hartmann FK, Fedorov R, Urbanke C, Manstein DJ, Brenner B, Tsiavaliaris G. Angew Chem Int Ed Engl. 2010;49(2):312-6. PubMed
- The left and right ventricle of a patient with a R723G mutation of the beta-myosin heavy chain and severe hypertrophic cardiomyopathy show no differences in the expression of myosin mRNA., Borchert B, Tripathi S, Francino A, Navarro-Lopez F, Kraft T. Cardiol J. 2010;17(5):518-22. PubMed
- Burn-induced organ dysfunction: vagus nerve stimulation improves cardiac function. Niederbichler AD, Papst S, Claassen L, Jokuszies A, Ipaktchi K, Reimers K, Hirsch T, Steinstraesser L, Kraft T, Vogt PM. Eplasty. 2010 Jun 21;10:e45., PubMed
- Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures. Radtke K, Kieneke D, Wolfstein A, Michael K, Steffen W, Scholz T, Karger A, Sodeik B. PLoS Pathog. 2010 Jul 8;6(7):e1000991. PubMed
- Structure of the hDmc1-ssDNA Filament Reveals the Principles of Its Architecture. Okorokov, A.L, Chaban, Y.L., Bugreev, D.V., Hodgkinson, J., Mazin, A.V., Orlova, E.V. (2010). PloS one, 5 , Issue 1, e8586, 1-14. Link