daily lives. Our research focuses on developing next generation adeno-associated virus (AAV)-based gene therapies to protect and restore hearing by targeting those highly specialized cells. AAV vectors

encoded Ca2+ indicators in the cytosol and the ER. Utilizing adeno-associated viruses (AAVs), you will target the ER structure to manipulate its shape and mimic a diseased state. Employing Spinning-disc

approaches. Recombinant viral systems including lentiviruses or adeno-associated viruses (AAV) are commonly used for gene delivery both in vivo and in vitro . These viral systems allow for the overexpression

Eine kürzlich publizierte Arbeit konnte durch eine Injektion von Adeno-assoziierten (AAV) Viren als Vehikel für CRISPR-Cas9 die Korrektur der seltenen Stoffwechselerkrankung Tyrosinämie im Versuchtier

C. Front Immunol 2022;13:1119363 DOI: 10.3389/fimmu.2022.1119363 Adeno-Associated Virus Vector Design-Moving the Adeno-Associated Virus to a Bioengineered Therapeutic Nanoparticle. Jäschke N, Büning H. [...] 2022;10:801870 DOI: 10.3389/fbioe.2022.801870 Development of an adeno-associated viral vector-based DNA vaccine as a novel strategy for cancer immunotherapy. Franke, Ann-Christin (Dr. rer. nat.) [...] . eCollection 2020 Jun 12. Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives Ulrich T Hacker, Martin Bentler,

Hematology) Project: Exploring the concept of antigen-decorated Adeno-associated virus (AAV) vector vaccines as therapeutic and-tumor vaccine Laxmi Lokeshwarrao Kata , INDIA, Kata.Laxmi @ mh-hannover.de

Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template. iScience. 2020 Jan 24;23(1):100764. 4. Illig D, Navratil M, Kelečić

-, lenti- and alpharetroviruses (Melanie Galla, Axel Schambach), adeno-associated virus (AAV) (Hildegard Büning) and chromosome-based vectors to support recombinase-mediated cassette exchange (RMCE)

loss. As delivery vehicles, we employ both lentiviral vectors and adeno-associated viral vectors. The project is divided into three main work packages. In the first work package, inherited gene mutations [...] undertaken to establish targeting strategies for both lentiviral and adeno-associated viral vectors that would allow selective modification of specific inner ear cells to further increase treatment efficacy

Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template. iScience. 2020;23(1):100764. Song G, Yuan Q, Dai Z, Tsay HC, Shen