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Of these, the E3/10.4K, 14.5K and 14.7K ORFs are present in all species and down-regulate various apoptosis receptors from the cell surface or affect their signaling, while E3/19K is only present in Ads [...] designated E3/49K, is only present in species D Ads. The E3/49K ORF was initially identified in the E3 region of the EKC-causing Ad19a (recently renamed Ad64). Interestingly, E3/49K (also called CR1-beta) [...] E3/49K is a highly glycosylated type I transmembrane protein that migrates with an apparent molecular weight (mr) of 80-100 kDa and as such is the largest E3 protein identified so far. Ad19a E3/49K is

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