laboratory into clinical application in humans. "Not only scientific success, but also transfer competence is a key success criterion for a Fraunhofer institute. For this reason, I am extremely pleased to [...] group of the Institute for Molecular and Translational Therapeutic Strategies has now discovered a way to block this way for the corona virus. The study under the direction of the institute director Professor [...] modified viral vector for the therapy, which acts as a gene shuttle transporting the genetic information for H19 selectively into the heart muscle cells, where the blueprint for the lncRNA is directly
Weiterbildung zum Facharzt für Humangenetik bei Prof. Dr. Claus R. Bartram, Institut für Humangenetik der Ruprecht-Karls-Universität Heidelberg und Habilitation für das Fach Humangenetik mit dem Thema „Genomische [...] g. Qualifikation: Fachärztin für Humangenetik Mitgliedschaften: Deutsche Gesellschaft für Humangenetik GfH European Society of Human Genetics ESHG European Society for Paediatric Nephrology ESPN Gesellschaft [...] Hannover Institut für Humangenetik OE 6300 Carl-Neuberg-Str. 1 D-30625 Hannover Tel.: +49 511 532-7751 Fax: +49 511 532-18520 E-Mail Team Lebenslauf (CV) Ruthild Weber studierte Humanmedizin an der Ru
senescence in human iPSC-derived endothelial cells Induced pluripotent stem cells (iPSCs) are considered as potentially superior cell source for in vitro assays & cell therapies. Since protocols for differentiation [...] premature senescence in hiPSC-ECs for improving differentiation protocols and overcoming senescence for production of better proliferating ECs lacking senescence phenotype for use in cell therapy. Our studies [...] as a modifier for Cystic Fibrosis lung phenotype utilizing CF-patient specific human induced pluripotent stem cells Cystic fibrosis (CF), also known as Mucoviscidosis, is a rare genetic disorder that causes
data reporting, we will thereby provide the basis for in silico models of the human brain that allow for predictions of adaptive processes in the human brain. (Reverse) Translation: By employing the parallel [...] plasticity as a prerequisite for flexible behavior. Therefore, pathology-driven changes in the ability for homeostatic plasticity expression might represent a hallmark for the development of clinical symptoms [...] neuroanatomists, human neocortical tissue – explanted during tumor or epilepsy surgery for medical or procedural indication – is used to investigate single-cell features in the human brain. Together with
data reporting, we will thereby provide the basis for in silico models of the human brain that allow for predictions of adaptive processes in the human brain. (Reverse) Translation: By employing the parallel [...] plasticity as a prerequisite for flexible behavior. Therefore, pathology-driven changes in the ability for homeostatic plasticity expression might represent a hallmark for the development of clinical symptoms [...] neuroanatomists, human neocortical tissue – explanted during tumor or epilepsy surgery for medical or procedural indication – is used to investigate single-cell features in the human brain. Together with
T, von Einem J: Major tegument protein pp65 of human cytomegalovirus is required for the incorporation of pUL69 and pUL97 into the virus particle and for viral growth in macrophages. J Virol 2009; 83(6): [...] Schlegelberger B, Kreipe H, Lehmann U: Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer. J Pathol 2009; 217(5): 620-32 [...] D, Lück HJ, Kreipe H, Schlegelberger B: Histopathological criteria and selection algorithms for BRCA1 genetic testing. Cancer Genet Cytogenet 2009; 189(2): 105-11 Ganzenmueller T, Henke-Gendo C, Schlue
the human complement regulatory protein CD59. Xenotransplantation 2006; 13(4): 345-56 Doe JY, Funk M, Mengel M, Doehring E, Ehrich JH: Nephrotic syndrome in African children: lack of evidence for 'tropical [...] Winkler M, Haverich A, Wiebe K: Hyperacute rejection in ex vivo-perfused porcine lungs transgenic for human complement regulatory proteins. Transpl Int 2006; 19(3): 225-232 Rifai K, Flemming P, Manns MP, [...] surrogate marker for estrogen receptor-negative carcinomas. Lab Invest 2006; 86(3): 246-53 Traub F, Mengel M, Lück HJ, Kreipe HH, von Wasielewski R: Progostic impact of Skp2 and p27 in human breast cancer
of a functional promoter of the human plakoglobin gene. Eur J Endocrinol 2001; 145(5): 625-33 Roth-Eichhorn S, Heitmann B, Flemming P, Kubicka S, Trautwein C: Evidence for the decreased expression of the [...] Kispert A, von Wasielewski R, Brabant G: Identification of a Wnt/beta catenin signaling pathway in human thyroid cells. Endocrinology 2001; 142(12): 5261-6 Hogemann D, Flemming P, Kreipe H, Galanski M: [...] Flemming P, Yamamoto M, Shimahara Y, Yamaoka Y, Fukumoto M: Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma. J Hepathol 2001; 35(2): 235-44 Nave H, Mössinger E, Feist
Together with Philipp Altrock and Arne Traulsen from the Max Planck Institute for Evolutionary Biology, we have developed a unique model for lobular carcinoma in situ (LCIS) of the mammary gland. The model [...] immunohistochemical markers for the differential diagnosis between collagenous spherulosis and adenoid-cystic carcinoma of the mammary gland. Her study has been published in Human Pathology . https://www. [...] trial in the Journal of the National Cancer Institute . This collaboration with the AG clinical studies in breast cancer investigated different regimes for neoadjuvant chemotherapy. www.ncbi.nlm.nih.g
MHH-internal cooperations Institute for Human Genetics Institute for Clinical Biochemistry Institute of Virology Clinic for Ophthalmology Clinic for Anaesthesiology Clinic for ear, nose and throat medicine [...] information systems can be used for specific research questions. We have supplemented this system with large patient registries for special indications (for example, a registry for the special outpatient clinic [...] Epigenetic regulation of BDNFIV upon antidepressant treatment Establishment of Gene panel for therapy response for antidepressant treatment Effect of antidepressants on BDNF secretion by neurons and reuptake